Detailed information for compound 655190

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.332 | Formula: C19H15FN2O4
  • H donors: 1 H acceptors: 2 LogP: 3.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)cc(c(=Nc1ccccc1F)o2)C(=O)NC(=O)C
  • InChi: 1S/C19H15FN2O4/c1-11(23)21-18(24)14-10-12-9-13(25-2)7-8-17(12)26-19(14)22-16-6-4-3-5-15(16)20/h3-10H,1-2H3,(H,21,23,24)/b22-19-
  • InChiKey: VOASYDXPUVXHKF-QOCHGBHMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 0.0052 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.2733 0.2733
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0031 0.0645 0.8694
Schistosoma mansoni zinc finger protein 0.0052 0.1195 0.1195
Loa Loa (eye worm) inositol-1 0.0035 0.0742 0.1141
Trichomonas vaginalis dynamin, putative 0.0017 0.0278 0.0396
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Brugia malayi Nuclear hormone receptor E75 0.0052 0.1195 0.1872
Brugia malayi Nuclear hormone receptor family member nhr-40 0.011 0.2733 0.4345
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0035 0.0737 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.1195 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.2733 0.4345
Schistosoma mansoni heat shock protein 0.0025 0.047 0.047
Plasmodium falciparum heat shock protein 90, putative 0.014 0.3517 1
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Plasmodium vivax dynamin-like protein, putative 0.0017 0.0278 0.0706
Loa Loa (eye worm) steroid hormone receptor 0.011 0.2733 0.4345
Brugia malayi steroid hormone receptor 0.011 0.2733 0.4345
Schistosoma mansoni heat shock protein 0.0037 0.0797 0.0797
Schistosoma mansoni inositol monophosphatase 0.0035 0.0742 0.0742
Treponema pallidum heat shock protein 90 0.0035 0.0737 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Brugia malayi Nuclear hormone receptor family member nhr-14 0.011 0.2733 0.4345
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0035 0.0737 0.9941
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.011 0.2733 0.2733
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.2733 0.2733
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0797 0.2196
Echinococcus granulosus tumor protein p63 0.0319 0.823 0.823
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Schistosoma mansoni dynamin 0.0019 0.0313 0.0313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.011 0.2733 0.4345
Trichomonas vaginalis dynamin, putative 0.0017 0.0278 0.0396
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.1338 0.1338
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.4039 0.6445
Schistosoma mansoni cpg binding protein 0.0029 0.0578 0.0578
Trichomonas vaginalis mgm1, putative 0.0017 0.0278 0.0396
Schistosoma mansoni thyroid hormone receptor 0.011 0.2733 0.2733
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0742 0.0742
Brugia malayi Dynamin central region family protein 0.0017 0.0278 0.0396
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0052 0.1195 0.1195
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0742 0.9272
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.4039 0.6445
Echinococcus multilocularis nibrin 0.0008 0.0032 0.0032
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.011 0.2733 0.2733
Schistosoma mansoni topbp1 0.0008 0.0032 0.0032
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0742 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.011 0.2733 0.2733
Loa Loa (eye worm) hypothetical protein 0.0058 0.136 0.2136
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Toxoplasma gondii dynamin-related protein DRPB 0.0017 0.0278 0.0706
Mycobacterium ulcerans heat shock protein 90 0.0035 0.0737 0.9941
Brugia malayi Nuclear hormone receptor E75 0.0052 0.1195 0.1872
Echinococcus granulosus retinoic acid receptor rxr beta a 0.011 0.2733 0.2733
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Schistosoma mansoni hypothetical protein 0.0273 0.7032 0.7032
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0742 0.9272
Schistosoma mansoni thyroid hormone receptor 0.011 0.2733 0.2733
Echinococcus granulosus survival motor neuron protein 1 0.0223 0.5706 0.5706
Echinococcus granulosus geminin 0.0273 0.7032 0.7032
Entamoeba histolytica dynamin-like protein 0.0017 0.0278 0.0342
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0797 0.1231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.2733 0.2733
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Brugia malayi nuclear hormone receptor 0.0052 0.1195 0.1872
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0537 0.0813
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Schistosoma mansoni heat shock protein 0.0037 0.0797 0.0797
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.6248 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.011 0.2733 0.4345
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.1176 0.3284
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Schistosoma mansoni nuclear hormone receptor 0.0052 0.1195 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.2733 0.4345
Echinococcus granulosus heat shock protein 90 0.0032 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0058 0.136 0.2136
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.008 0.1927 0.2637
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.4039 0.6445
Loa Loa (eye worm) heat shock protein 75 0.0025 0.047 0.0705
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.5706 0.9128
Schistosoma mansoni endoplasmin 0.0037 0.0797 0.0797
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0578 0.0578
Entamoeba histolytica dynamin-1-like protein, putative 0.0017 0.0278 0.0342
Schistosoma mansoni dynamin 0.0019 0.0313 0.0313
Entamoeba histolytica hypothetical protein 0.008 0.1927 0.2637
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.1023 0.1594
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.1195 0.1195
Trichomonas vaginalis heat shock protein, putative 0.0027 0.053 0.0801
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.1195 0.2904
Leishmania major heat shock protein, putative 0.0025 0.047 0.37
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0035 0.0737 0.8847
Trypanosoma brucei dynamin-1-like protein 0.0017 0.0278 0.3214
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Schistosoma mansoni hypothetical protein 0.0386 1 1
Brugia malayi Inositol-1 0.0035 0.0742 0.1141
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0797 1
Brugia malayi hypothetical protein 0.0058 0.136 0.2136
Echinococcus multilocularis survival motor neuron protein 1 0.0223 0.5706 0.5706
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0017 0.0278 0.0396
Echinococcus granulosus dynamin 1 0.0019 0.0313 0.0313
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0035 0.0742 1
Brugia malayi conserved hypotetical protein 0.0052 0.1195 0.1872
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.4039 0.6445
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0742 0.8928
Onchocerca volvulus 0.0047 0.1053 0.2549
Brugia malayi hypothetical protein 0.0058 0.136 0.2136
Toxoplasma gondii Hsp90 domain-containing protein 0.014 0.3517 1
Schistosoma mansoni nuclear receptor 0.0052 0.1195 0.1195
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0058 0.136 0.136
Echinococcus multilocularis endoplasmin 0.0035 0.0737 0.0737
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0052 0.1195 0.1872
Brugia malayi Hsp90 protein 0.0025 0.047 0.0705
Loa Loa (eye worm) nuclear receptor NHR-67 0.0052 0.1195 0.1872
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0025 0.047 0.1093
Echinococcus multilocularis ecdysone induced protein 78C 0.011 0.2733 0.2733
Onchocerca volvulus 0.011 0.2733 0.6741
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.011 0.2733 0.2733
Brugia malayi nuclear hormone receptor family member odr-7 0.0052 0.1195 0.1872
Plasmodium vivax heat shock protein, putative 0.014 0.3517 1
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0058 0.136 0.136
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.011 0.2733 0.4345
Echinococcus granulosus dynamin 0.0017 0.0278 0.0278
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0656 0.816
Schistosoma mansoni chromosome transmission fidelity factor 0.0008 0.0032 0.0032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.1195 0.1195
Echinococcus multilocularis heat shock protein 90 0.0032 0.0656 0.0656
Giardia lamblia Grp94/Hsp90 0.0035 0.0737 0.0982
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.011 0.2733 0.4345
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Toxoplasma gondii dynamin gtpase 0.0011 0.0123 0.026
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0025 0.047 0.047
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.4039 0.6445
Echinococcus granulosus nuclear receptor nhr 48 0.0052 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0058 0.136 0.2136
Schistosoma mansoni survival motor neuron protein 0.0045 0.1023 0.1023
Onchocerca volvulus 0.0027 0.0537 0.1261
Schistosoma mansoni nuclear receptor nhr-48 0.0052 0.1195 0.1195
Brugia malayi tailless protein 0.0052 0.1195 0.1872
Brugia malayi nuclear receptor RXR 0.0052 0.1195 0.1872
Brugia malayi Nuclear hormone receptor family member nhr-41 0.011 0.2733 0.4345
Echinococcus multilocularis thyroid hormone receptor alpha 0.011 0.2733 0.2733
Brugia malayi hypothetical protein 0.0052 0.1195 0.1872
Schistosoma mansoni nuclear hormone receptor 0.0052 0.1195 0.1195
Giardia lamblia Dynamin 0.0017 0.0278 0.0342
Loa Loa (eye worm) DR-78 0.0052 0.1195 0.1872
Brugia malayi nuclear hormone receptor family member nhr-6 0.0052 0.1195 0.1872
Echinococcus multilocularis tumor protein p63 0.0319 0.823 0.823
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.4266 0.6811
Echinococcus granulosus thyroid hormone receptor alpha 0.0052 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Onchocerca volvulus Bile acid receptor homolog 0.011 0.2733 0.6741
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.4039 0.6445
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.6248 1
Echinococcus multilocularis dynamin 0.0017 0.0278 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.6248 1
Onchocerca volvulus 0.0045 0.1023 0.2473
Brugia malayi Dynamin 0.0019 0.0313 0.0452
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.011 0.2733 0.6741
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.028 0.7218 1
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0797 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.1195 0.2904
Echinococcus granulosus FTZ F1 alpha 0.011 0.2733 0.2733
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0797 1
Brugia malayi ecdysteroid receptor 0.011 0.2733 0.4345
Loa Loa (eye worm) hypothetical protein 0.0058 0.136 0.2136
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.011 0.2733 0.2733
Trichomonas vaginalis dynamin, putative 0.0017 0.0278 0.0396
Schistosoma mansoni cpg binding protein 0.0029 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Brugia malayi nuclear receptor NHR-67 0.0052 0.1195 0.1872
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0742 0.1141
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.136 0.2136
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.011 0.2733 0.4345
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0052 0.1195 0.1195
Plasmodium falciparum dynamin-like protein 0.0017 0.0278 0.0706
Echinococcus multilocularis heat shock protein 90 0.0037 0.0797 0.0797
Brugia malayi nuclear receptor NHR-88 0.011 0.2733 0.4345
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.136 0.2136
Schistosoma mansoni inositol monophosphatase 0.0035 0.0742 0.0742
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0032 0.0656 0.0656
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.011 0.2733 0.4345
Echinococcus multilocularis nuclear receptor nhr 48 0.0052 0.1195 0.1195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.011 0.2733 0.2733
Plasmodium falciparum endoplasmin, putative 0.0027 0.053 0.1429
Schistosoma mansoni retinoic acid receptor RXR 0.011 0.2733 0.2733
Schistosoma mansoni coup transcription factor 0.011 0.2733 0.2733
Brugia malayi orphan nuclear receptor NR2E1 0.0052 0.1195 0.1872
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.2733 0.4345
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.2733 0.2733
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.2733 0.4345
Loa Loa (eye worm) endoplasmin 0.0037 0.0797 0.1231
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0742 0.2036
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0035 0.0737 1
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0656 0.1005
Schistosoma mansoni hypothetical protein 0.0273 0.7032 0.7032
Schistosoma mansoni steroid hormone receptor ad4bp 0.011 0.2733 0.2733
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.2733 0.4345
Chlamydia trachomatis DNA ligase 0.0008 0.0032 0.5
Echinococcus multilocularis geminin 0.0273 0.7032 0.7032
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Trypanosoma cruzi dynamin-1-like protein 0.0017 0.0278 0.3214
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0797 1
Trichomonas vaginalis dynamin, putative 0.0017 0.0278 0.0396
Loa Loa (eye worm) hypothetical protein 0.0047 0.1053 0.1643
Echinococcus multilocularis dynamin 1 0.0019 0.0313 0.0313
Schistosoma mansoni cpg binding protein 0.0027 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Schistosoma mansoni hypothetical protein 0.0042 0.0923 0.0923
Echinococcus granulosus cpg binding protein 0.0029 0.0578 0.0578
Loa Loa (eye worm) DRP-1 protein 0.0017 0.0278 0.0396
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0044 0.0019
Brugia malayi heat shock protein 90 0.0037 0.0797 0.1231
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.4266 0.6811
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0742 0.9272
Loa Loa (eye worm) nuclear hormone receptor 0.0052 0.1195 0.1872
Echinococcus granulosus endoplasmin 0.0035 0.0737 0.0737
Schistosoma mansoni endoplasmin 0.0037 0.0797 0.0797
Schistosoma mansoni dynamin 0.0017 0.0278 0.0278
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0797 0.2196
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0389 0.0575
Brugia malayi hypothetical protein 0.0223 0.5706 0.9128
Trichomonas vaginalis endoplasmin, putative 0.0027 0.053 0.0801
Loa Loa (eye worm) hypothetical protein 0.0058 0.136 0.2136
Brugia malayi photoreceptor-specific nuclear receptor 0.011 0.2733 0.4345
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.6248 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0797 1
Onchocerca volvulus 0.0052 0.1195 0.2904
Brugia malayi Nuclear hormone receptor family member nhr-49 0.011 0.2733 0.4345
Echinococcus multilocularis FTZ F1 alpha 0.011 0.2733 0.2733
Plasmodium falciparum dynamin-like protein 0.0017 0.0278 0.0706
Trypanosoma cruzi heat shock protein, putative 0.0025 0.047 0.5725
Toxoplasma gondii heat shock protein 75, putative 0.0025 0.047 0.1257
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.2733 0.2733
Echinococcus multilocularis dnaJ subfamily B 0.0386 1 1
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Brugia malayi Endoplasmin precursor 0.0037 0.0797 0.1231
Onchocerca volvulus Protein ultraspiracle homolog 0.011 0.2733 0.6741
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.011 0.2733 0.2733
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.2733 0.2733
Schistosoma mansoni hypothetical protein 0.0045 0.1023 0.1023
Plasmodium falciparum heat shock protein 90 0.0037 0.0797 0.2196
Onchocerca volvulus 0.0052 0.1195 0.2904
Echinococcus granulosus heat shock protein 0.0037 0.0797 0.0797
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0244 0.6248 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0025 0.047 0.047
Schistosoma mansoni DNA ligase IV 0.0008 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.011 0.2733 0.4345
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0797 1
Trichomonas vaginalis dynamin, putative 0.0017 0.0278 0.0396
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.1195 0.1195
Brugia malayi Steroid receptor seven-up type 2 0.011 0.2733 0.4345
Brugia malayi hypothetical protein 0.0052 0.1195 0.1872
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0737 0.1135
Echinococcus multilocularis dynamin 1 protein 0.0017 0.0278 0.0278
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.011 0.2733 0.2733
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Brugia malayi nuclear receptor RXR 0.0058 0.136 0.2136
Echinococcus granulosus dynamin 1 protein 0.0017 0.0278 0.0278
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0058 0.136 0.2136
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.136 0.136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0313 0.0452
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0797 0.1065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0044 0.0044
Schistosoma mansoni nuclear hormone receptor 0.011 0.2733 0.2733
Plasmodium vivax dynamin protein, putative 0.0017 0.0278 0.0706
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.011 0.2733 0.2733
Brugia malayi Dynamin 0.0019 0.0313 0.0452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.011 0.2733 0.4345
Brugia malayi Nuclear hormone receptor family member nhr-31 0.011 0.2733 0.4345
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Brugia malayi CXXC zinc finger family protein 0.0027 0.0537 0.0813
Plasmodium vivax heat shock protein 90, putative 0.0025 0.047 0.1257
Toxoplasma gondii dynamin-related protein DRPA 0.0017 0.0278 0.0706
Echinococcus multilocularis replication factor c subunit 1 0.0008 0.0032 0.0032
Trypanosoma brucei dynamin-1-like protein 0.0017 0.0278 0.3214
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0797 0.1065
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0058 0.136 0.136
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.1195 0.1195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.1195 0.1195
Trypanosoma brucei heat shock protein, putative 0.0037 0.0797 1
Echinococcus multilocularis heat shock protein 0.0037 0.0797 0.0797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.011 0.2733 0.4345
Giardia lamblia DNA repair protein RAD52 0.028 0.7218 1
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.6248 1
Echinococcus granulosus ecdysone induced protein 78C 0.011 0.2733 0.2733
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0797 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0052 0.1195 0.1195
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0244 0.6248 1
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0797 0.1231
Trypanosoma brucei heat shock protein 84, putative 0.0025 0.047 0.5725
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0041 0.0014
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0797 0.2196
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0742 0.1141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.2733 0.2733
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0052 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0052 0.1195 0.1872
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.2733 0.4345
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0656 0.0869
Trichomonas vaginalis glucosylceramidase, putative 0.0244 0.6248 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0656 0.816
Brugia malayi ecdysone receptor 0.0052 0.1195 0.1872
Brugia malayi nuclear hormone receptor 0.011 0.2733 0.4345
Schistosoma mansoni RAR-like nuclear receptor 0.011 0.2733 0.2733
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0052 0.1195 0.1872
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0025 0.047 0.061
Echinococcus granulosus heat shock protein 90 0.0037 0.0797 0.0797
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.011 0.2733 0.2733
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Trichomonas vaginalis glucosylceramidase, putative 0.016 0.4039 0.6445
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0797 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.2733 0.4345
Trichomonas vaginalis dynamin, putative 0.0017 0.0278 0.0396
Echinococcus granulosus replication factor c subunit 1 0.0008 0.0032 0.0032
Brugia malayi nuclear receptor NHR-88 0.0052 0.1195 0.1872
Schistosoma mansoni topbp1 0.0008 0.0032 0.0032
Plasmodium falciparum heat shock protein 90, putative 0.0021 0.0389 0.1025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.011 0.2733 0.4345
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0035 0.0742 0.0987
Leishmania major heat shock protein 83-1 0.0037 0.0797 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.011 0.2733 0.2733
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0231 0.2596
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0742 0.0742
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0052 0.1195 0.1195
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0737 0.1135
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0742 0.1141
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0797 1
Echinococcus granulosus nibrin 0.0008 0.0032 0.0032
Plasmodium vivax endoplasmin, putative 0.0037 0.0797 0.2196
Onchocerca volvulus Glucosylceramidase homolog 0.016 0.4039 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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