Detailed information for compound 655267

Basic information

Technical information
  • TDR Targets ID: 655267
  • Name: N-[(3-nitrophenyl)methylideneamino]-2-oxo-1H- quinoline-4-carboxamide
  • MW: 336.302 | Formula: C17H12N4O4
  • H donors: 2 H acceptors: 5 LogP: 2.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc2ccccc2c(c1)C(=O)N/N=C/c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C17H12N4O4/c22-16-9-14(13-6-1-2-7-15(13)19-16)17(23)20-18-10-11-4-3-5-12(8-11)21(24)25/h1-10H,(H,19,22)(H,20,23)/b18-10+
  • InChiKey: ALTWWXAYDWBARZ-VCHYOVAHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(3-nitrophenyl)methyleneamino]-2-oxo-1H-quinoline-4-carboxamide
  • 2-keto-N-[(3-nitrobenzylidene)amino]-1H-quinoline-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0519 0.0654
Leishmania major hypothetical protein, conserved 0.0015 0.0248 0.2629
Echinococcus multilocularis GPCR, family 2 0.0032 0.0773 0.0773
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0027 0.0607 0.0607
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.4342 0.6044
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0301 0.0301
Mycobacterium tuberculosis Carboxylesterase LipT 0.0018 0.034 0.0473
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0036 0.0036
Trichomonas vaginalis esterase, putative 0.0038 0.0943 0.1034
Echinococcus granulosus acetylcholinesterase 0.0107 0.3071 0.3071
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0519 0.1194
Mycobacterium tuberculosis Conserved protein 0.0038 0.0943 0.1312
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0519 0.0722
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5128 0.5626
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0943 0.1312
Schistosoma mansoni gliotactin 0.0018 0.034 0.034
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0943 0.2171
Echinococcus granulosus zinc finger protein 0.0021 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0018 0.0333 0.042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0303 0.0422
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1919 0.2421
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1665 0.1665
Schistosoma mansoni neuroligin 3 (S09 family) 0.0018 0.034 0.034
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0027 0.0607 0.6435
Brugia malayi beta-lactamase 0.0038 0.0943 0.1189
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0873 0.0873
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0301 0.0301
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0519 0.1194
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0517 0.0517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2705 0.2705
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0943 0.0943
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0943 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0354 0.3756
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0018 0.034 0.034
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0519 0.1194
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.7928 0.8699
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.9114 1
Loa Loa (eye worm) carboxylesterase 0.0107 0.3071 0.3873
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0027 0.0607 0.0765
Schistosoma mansoni cpg binding protein 0.0032 0.0762 0.0762
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Onchocerca volvulus 0.0024 0.0519 0.0704
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0943 0.0943
Brugia malayi beta-lactamase family protein 0.0038 0.0943 0.1189
Onchocerca volvulus 0.0018 0.034 0.0461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2705 0.2705
Loa Loa (eye worm) carboxylesterase 0.0018 0.034 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.7928 0.8699
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0773 0.0773
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0333 0.3533
Echinococcus granulosus acetylcholinesterase 0.0107 0.3071 0.3071
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0773 0.0974
Loa Loa (eye worm) hypothetical protein 0.0018 0.034 0.0428
Schistosoma mansoni ap endonuclease 0.0019 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.007 0.1919 0.2421
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0943 0.1034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2907 0.3667
Echinococcus multilocularis zinc finger protein 0.0021 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0038 0.0943 0.1189
Loa Loa (eye worm) histone methyltransferase 0.001 0.0089 0.0112
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0027 0.0607 0.0607
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.7184 1
Schistosoma mansoni ap endonuclease 0.0019 0.0354 0.0354
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.1642 0.1642
Loa Loa (eye worm) hypothetical protein 0.0024 0.0507 0.064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2907 0.3667
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0756 0.4914
Mycobacterium ulcerans carboxylesterase, LipT 0.0018 0.034 0.0782
Onchocerca volvulus 0.0032 0.0756 0.1027
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0018 0.034 0.0473
Echinococcus multilocularis para nitrobenzyl esterase 0.0018 0.034 0.034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0354 0.3756
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5128 0.5626
Loa Loa (eye worm) hypothetical protein 0.0027 0.0607 0.0765
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0027 0.0607 0.0607
Onchocerca volvulus 0.0038 0.0943 0.128
Trypanosoma cruzi ISWI complex protein 0.0015 0.0248 0.2629
Mycobacterium ulcerans hypothetical protein 0.0038 0.0943 0.2171
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0519 0.0569
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0943 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0519 0.1194
Loa Loa (eye worm) beta-lactamase 0.0038 0.0943 0.1189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0333 0.042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.1642 0.1642
Loa Loa (eye worm) hypothetical protein 0.0038 0.0943 0.1189
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0354 0.0389
Toxoplasma gondii ABC1 family protein 0.0038 0.0943 0.6124
Loa Loa (eye worm) hypothetical protein 0.0018 0.034 0.0428
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1703 0.2148
Loa Loa (eye worm) hypothetical protein 0.0107 0.3071 0.3873
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2907 0.3667
Schistosoma mansoni hypothetical protein 0.0032 0.0773 0.0773
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0354 0.0447
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0038 0.0943 0.1189
Echinococcus granulosus tar DNA binding protein 0.0063 0.1703 0.1703
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0519 0.0569
Echinococcus multilocularis carboxylesterase 5A 0.0107 0.3071 0.3071
Brugia malayi Bromodomain containing protein 0.0076 0.2106 0.2656
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Brugia malayi Carboxylesterase family protein 0.0107 0.3071 0.3873
Onchocerca volvulus 0.0018 0.034 0.0461
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0018 0.034 0.034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0519 0.1194
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0049 0.1273 0.1606
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0032 0.0773 0.0974
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0036 0.0036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0943 0.1312
Loa Loa (eye worm) hypothetical protein 0.0018 0.034 0.0428
Toxoplasma gondii transporter, cation channel family protein 0.0027 0.0607 0.394
Loa Loa (eye worm) voltage-dependent calcium channel 0.0027 0.0607 0.0765
Loa Loa (eye worm) hypothetical protein 0.0018 0.0333 0.042
Loa Loa (eye worm) hypothetical protein 0.0018 0.034 0.0428
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0517 0.0517
Onchocerca volvulus 0.0247 0.7365 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0519 0.0654
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0333 0.0767
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0354 0.3756
Brugia malayi Pre-SET motif family protein 0.0032 0.0756 0.0954
Brugia malayi Carboxylesterase family protein 0.0018 0.034 0.0428
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0036 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0519 0.0722
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0027 0.0607 0.0607
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.9114 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0943 0.1312
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.7928 0.8699
Mycobacterium ulcerans beta-lactamase 0.0038 0.0943 0.2171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0333 0.042
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0943 0.1034
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0018 0.034 0.034
Schistosoma mansoni BC026374 protein (S09 family) 0.0018 0.034 0.034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.4342 1
Schistosoma mansoni hypothetical protein 0.007 0.1919 0.1919
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0143 0.018
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0519 0.1194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.1273 0.1273
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0519 0.5502
Schistosoma mansoni biogenic amine (5HT) receptor 0.0333 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2705 0.2705
Loa Loa (eye worm) hypothetical protein 0.0107 0.3071 0.3873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2705 0.2705
Echinococcus granulosus voltage dependent calcium channel 0.0027 0.0607 0.0607
Mycobacterium tuberculosis Conserved protein 0.0038 0.0943 0.1312
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0519 0.1194
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0018 0.034 0.034
Brugia malayi RNA binding protein 0.0063 0.1703 0.2148
Schistosoma mansoni hypothetical protein 0.002 0.0409 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.7928 0.8699
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0333 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0027 0.0607 0.0607
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.7928 0.8699
Brugia malayi Bromodomain containing protein 0.0038 0.0945 0.1191
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0943 0.1034
Brugia malayi beta-lactamase family protein 0.0038 0.0943 0.1189
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5128 0.5626
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0018 0.034 0.0373
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0354 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0519 0.1194
Mycobacterium tuberculosis Conserved protein 0.0038 0.0943 0.1312
Loa Loa (eye worm) hypothetical protein 0.0018 0.034 0.0428
Toxoplasma gondii exonuclease III APE 0.0019 0.0354 0.23
Loa Loa (eye worm) hypothetical protein 0.0038 0.0943 0.1189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0303 0.0422
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0027 0.0607 0.0607
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0943 0.2171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0333 0.042
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.7928 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0354 1
Schistosoma mansoni zinc finger protein 0.0015 0.0248 0.0248
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0089 0.0089
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0354 0.0816
Leishmania major hypothetical protein, conserved 0.0038 0.0943 1
Brugia malayi PHD-finger family protein 0.0026 0.0589 0.0742
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0333 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0354 0.0447
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0027 0.0607 0.6435
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.6447 0.8132
Echinococcus multilocularis voltage dependent calcium channel 0.0027 0.0607 0.0607
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0354 0.0354
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0303 0.0422
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0519 0.0569
Brugia malayi Carboxylesterase family protein 0.0018 0.034 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5128 0.5626
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0702 0.0702
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0943 0.1034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0773 0.0773
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0018 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0943 0.1189
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0354 0.0389
Loa Loa (eye worm) carboxylesterase 0.0018 0.034 0.0428
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.2705 0.3412
Schistosoma mansoni bromodomain containing protein 0.0064 0.1751 0.1751
Mycobacterium leprae Probable lipase LipE 0.0038 0.0943 0.2171
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1703 0.1703
Echinococcus multilocularis neuroligin 0.0018 0.034 0.034
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.5128 0.6962
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0943 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5128 0.5626
Loa Loa (eye worm) hypothetical protein 0.0038 0.0947 0.1194
Toxoplasma gondii hypothetical protein 0.0024 0.0507 0.3296
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0409 0.0516
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.5416 0.5942
Schistosoma mansoni acetylcholinesterase 0.0018 0.034 0.034
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0943 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0943 0.2171
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0943 0.1312
Echinococcus multilocularis BC026374 protein (S09 family) 0.0018 0.034 0.034
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1703 0.1703
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.2705 0.3412
Brugia malayi Carboxylesterase family protein 0.0018 0.034 0.0428
Brugia malayi TAR-binding protein 0.0063 0.1703 0.2148
Schistosoma mansoni cpg binding protein 0.0028 0.0654 0.0654
Trichomonas vaginalis spcc417.12 protein, putative 0.0018 0.034 0.0373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0773 0.0773
Onchocerca volvulus 0.0028 0.0654 0.0888
Schistosoma mansoni voltage-gated cation channel 0.0027 0.0607 0.0607
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0654 0.0825
Loa Loa (eye worm) hypothetical protein 0.007 0.1927 0.243
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0773 0.0974
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0036 0.0036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0943 0.1189
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.9114 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0773 0.0773
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.1273 0.1273
Plasmodium vivax SET domain protein, putative 0.0032 0.0756 0.8024
Echinococcus granulosus voltage dependent calcium channel 0.0027 0.0607 0.0607
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1703 0.2148
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.5416 0.5942
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Schistosoma mansoni hypothetical protein 0.0032 0.0773 0.0773
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0519 0.0654
Trichomonas vaginalis set domain proteins, putative 0.0247 0.7365 0.8081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0519 0.0654
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1703 0.1703
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0027 0.0607 0.0607
Onchocerca volvulus 0.0038 0.0943 0.128
Echinococcus multilocularis acetylcholinesterase 0.0107 0.3071 0.3071
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0027 0.0607 0.0607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0303 0.0422
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.9114 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0027 0.0607 0.0607
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.032 0.0403
Echinococcus granulosus BC026374 protein S09 family 0.0018 0.034 0.034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0943 0.1189
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0943 0.1034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.1273 0.1273
Trypanosoma brucei ISWI complex protein 0.0015 0.0248 0.2629
Schistosoma mansoni hypothetical protein 0.0032 0.0773 0.0773
Schistosoma mansoni cpg binding protein 0.0032 0.0762 0.0762
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0333 0.0464
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0943 0.1312
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1703 0.1703
Brugia malayi CXXC zinc finger family protein 0.0028 0.0654 0.0825
Trypanosoma cruzi ISWI complex protein 0.0015 0.0248 0.2629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2705 0.2705
Echinococcus granulosus GPCR family 2 0.0032 0.0773 0.0773
Echinococcus granulosus para nitrobenzyl esterase 0.0018 0.034 0.034
Schistosoma mansoni hypothetical protein 0.0032 0.0773 0.0773
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0354 0.3756
Loa Loa (eye worm) hypothetical protein 0.0018 0.034 0.0428
Loa Loa (eye worm) hypothetical protein 0.0044 0.1126 0.142
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5128 0.5626
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0519 0.5502
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0943 0.1312
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0354 0.0493
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.4342 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0607 0.0765
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0354 0.0389
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0773 0.0974
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0036 0.0036
Loa Loa (eye worm) RNA binding protein 0.0063 0.1703 0.2148
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.004 0.1018 0.1285
Onchocerca volvulus 0.0018 0.034 0.0461
Brugia malayi Carboxylesterase family protein 0.0107 0.3071 0.3873
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2705 0.2705
Onchocerca volvulus 0.0018 0.034 0.0461
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1703 0.2148
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0519 0.1194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Schistosoma mansoni zinc finger protein 0.0021 0.0427 0.0427
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0301 0.0301
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1539 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.034 0.0428
Schistosoma mansoni hypothetical protein 0.0015 0.0248 0.0248
Loa Loa (eye worm) acetylcholinesterase 1 0.0107 0.3071 0.3873
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0089 0.0089
Mycobacterium ulcerans lipase LipD 0.0038 0.0943 0.2171
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.5128 0.5626
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0018 0.034 0.0473
Brugia malayi hypothetical protein 0.0018 0.034 0.0428
Brugia malayi Pre-SET motif family protein 0.0217 0.6447 0.8132
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0756 0.0756
Onchocerca volvulus 0.0018 0.034 0.0461
Echinococcus multilocularis acetylcholinesterase 0.0107 0.3071 0.3071
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0943 0.1312
Loa Loa (eye worm) hypothetical protein 0.0024 0.0519 0.0654
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0519 0.5502
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0107 0.3071 0.3071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0756 0.0756
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1703 0.1703
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0354 0.3756
Loa Loa (eye worm) calcium channel 0.0027 0.0607 0.0765
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1703 0.1703
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2705 0.2705
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0519 0.1194
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.7928 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.9114 1
Brugia malayi Carboxylesterase family protein 0.0018 0.034 0.0428
Loa Loa (eye worm) hypothetical protein 0.0102 0.2907 0.3667
Echinococcus granulosus carboxylesterase 5A 0.0107 0.3071 0.3071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0873 0.0873
Echinococcus granulosus cpg binding protein 0.0032 0.0762 0.0762
Echinococcus granulosus neuroligin 0.0018 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0507 0.064
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.7928 0.8699
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0027 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0038 0.0943 0.1189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0943 0.0943
Onchocerca volvulus 0.0038 0.0943 0.128
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0354 0.0354
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.1273 0.1273
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0333 0.9405
Loa Loa (eye worm) hypothetical protein 0.0024 0.0519 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0756 0.0756

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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