Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0081 | 0.3118 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.202 | 0.543 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.202 | 0.1406 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0081 | 0.3118 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.202 | 0.543 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0081 | 0.3118 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.202 | 0.1406 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 0.3118 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.3118 | 0.2589 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.202 | 0.202 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3118 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.202 | 0.1406 |
Chlamydia trachomatis | sulfite reductase | 0.005 | 0.0714 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0081 | 0.3118 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.202 | 0.543 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0081 | 0.3118 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.202 | 0.1406 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.202 | 0.1406 |
Brugia malayi | flavodoxin family protein | 0.0081 | 0.3118 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 0.3118 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0081 | 0.3118 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.202 | 0.1406 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0081 | 0.3118 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.202 | 0.543 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0081 | 0.3118 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 0.3118 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.202 | 0.543 |
Trypanosoma cruzi | p450 reductase, putative | 0.0081 | 0.3118 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0081 | 0.3118 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0081 | 0.3118 | 0.2589 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 0.3118 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0081 | 0.3118 | 1 |
Giardia lamblia | Hypothetical protein | 0.0072 | 0.2404 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.005 | 0.0714 | 0.0714 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0072 | 0.2404 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0081 | 0.3118 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 0.3118 | 0.2589 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0081 | 0.3118 | 0.3118 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0081 | 0.3118 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.202 | 0.543 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.