Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0237 | 0.476 | 0.9052 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.015 | 0.2827 | 0.5324 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.0649 | 0.1242 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.015 | 0.2827 | 0.5332 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3638 | 0.6256 |
Schistosoma mansoni | cytochrome P450 | 0.015 | 0.2827 | 0.5883 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.015 | 0.2827 | 0.5332 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0649 | 0.1116 |
Echinococcus granulosus | transcription factor Dp 1 | 0.008 | 0.1269 | 0.2563 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.034 | 0.0584 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.0649 | 0.114 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0.0649 | 0.2137 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.015 | 0.2827 | 0.5332 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0259 | 0.5252 | 0.5221 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3638 | 0.6256 |
Brugia malayi | hypothetical protein | 0.0038 | 0.034 | 0.0276 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0196 | 0.3862 | 0.6641 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0038 | 0.034 | 0.0584 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.015 | 0.2827 | 0.5332 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0026 | 0.0057 | 0.0109 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0237 | 0.476 | 1 |
Brugia malayi | Doublecortin family protein | 0.0038 | 0.034 | 0.0276 |
Schistosoma mansoni | rab6-interacting | 0.0038 | 0.034 | 0.0584 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.0649 | 0.1124 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0138 | 0.2569 | 0.489 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.015 | 0.2827 | 0.5324 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.015 | 0.2827 | 0.5332 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.015 | 0.2827 | 0.5332 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.015 | 0.2827 | 0.5332 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.0649 | 0.1124 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0138 | 0.2569 | 0.4834 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.015 | 0.2827 | 0.5891 |
Brugia malayi | Cytochrome P450 family protein | 0.0365 | 0.761 | 0.7595 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0.0057 | 0.1677 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0237 | 0.476 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.0649 | 0.114 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.015 | 0.2827 | 0.5891 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.015 | 0.2827 | 0.5324 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0026 | 0.0066 | 0.0018 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0138 | 0.2569 | 0.5331 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.015 | 0.2827 | 1 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.015 | 0.2827 | 0.5332 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0138 | 0.2569 | 0.2519 |
Brugia malayi | Cytochrome P450 family protein | 0.0259 | 0.5252 | 0.5221 |
Leishmania major | p450 reductase, putative | 0.0026 | 0.0066 | 0.0126 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.015 | 0.2827 | 0.5383 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0026 | 0.0057 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0259 | 0.5252 | 0.5221 |
Echinococcus multilocularis | 0.015 | 0.2827 | 0.5883 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3638 | 0.6256 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0038 | 0.034 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.0649 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.015 | 0.2827 | 0.5332 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0472 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.015 | 0.2827 | 0.5332 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.015 | 0.2827 | 0.5891 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.0649 | 0.0587 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0138 | 0.2569 | 0.5331 |
Loa Loa (eye worm) | doublecortin family protein | 0.0038 | 0.034 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0038 | 0.034 | 0.0276 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.015 | 0.2827 | 0.5891 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.015 | 0.2827 | 0.5891 |
Schistosoma mansoni | lipoxygenase | 0.0108 | 0.1882 | 0.3868 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.015 | 0.2827 | 0.5891 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1522 | 0.1466 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0138 | 0.2569 | 0.4825 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0138 | 0.2569 | 0.4825 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0057 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0038 | 0.034 | 0.0584 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0026 | 0.0066 | 0.1946 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3638 | 0.6256 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.015 | 0.2827 | 0.5332 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0026 | 0.0066 | 0.0114 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.0649 | 0.1124 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0284 | 0.5816 | 0.5788 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0091 | 0.1522 | 0.3102 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0026 | 0.0066 | 0.0018 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0196 | 0.3862 | 0.6641 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.015 | 0.2827 | 0.5332 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.0649 | 0.1242 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0091 | 0.1522 | 0.3102 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0649 | 0.1116 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0138 | 0.2569 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0026 | 0.0066 | 0.0126 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.015 | 0.2827 | 0.5332 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0038 | 0.034 | 0.0584 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.2827 | 0.5883 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0138 | 0.2569 | 0.2519 |
Brugia malayi | Cytochrome P450 family protein | 0.015 | 0.2827 | 0.278 |
Leishmania major | cytochrome p450-like protein | 0.015 | 0.2827 | 0.5383 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.015 | 0.2827 | 0.5891 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.015 | 0.2827 | 0.5891 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.015 | 0.2827 | 0.5332 |
Leishmania major | cytochrome p450-like protein | 0.0259 | 0.5252 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.015 | 0.2827 | 0.278 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.015 | 0.2827 | 0.5891 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0091 | 0.1522 | 0.3102 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0237 | 0.476 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0186 | 0.3638 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0237 | 0.476 | 0.9052 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0057 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.015 | 0.2827 | 0.5891 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.034 | 0.0276 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0259 | 0.5252 | 0.5221 |
Schistosoma mansoni | lipoxygenase | 0.0038 | 0.034 | 0.0584 |
Schistosoma mansoni | rab6-interacting | 0.0038 | 0.034 | 0.0584 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0038 | 0.034 | 0.0584 |
Mycobacterium leprae | Conserved hypothetical protein | 0.015 | 0.2827 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.015 | 0.2827 | 0.5891 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0026 | 0.0066 | 0.0018 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.015 | 0.2827 | 0.5891 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0649 | 0.1242 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.015 | 0.2827 | 0.5883 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0026 | 0.0066 | 0.0323 |
Mycobacterium leprae | putative cytochrome p450 | 0.015 | 0.2827 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.008 | 0.1269 | 0.2563 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.015 | 0.2827 | 0.5332 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.5816 | 1 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.015 | 0.2827 | 0.5332 |
Schistosoma mansoni | polycystin 1-related | 0.0038 | 0.034 | 0.0584 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.015 | 0.2827 | 0.5332 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3638 | 0.6256 |
Trypanosoma brucei | cytochrome P450, putative | 0.0259 | 0.5252 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0.0649 | 0.1236 |
Onchocerca volvulus | 0.0091 | 0.1522 | 0.3584 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0259 | 0.5252 | 0.5221 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0259 | 0.5252 | 1 |
Echinococcus multilocularis | RUN | 0.0038 | 0.034 | 0.0584 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.015 | 0.2827 | 0.5891 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.0649 | 0.1124 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3638 | 0.6256 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.015 | 0.2827 | 0.5891 |
Brugia malayi | cytochrome P450 | 0.015 | 0.2827 | 0.278 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0038 | 0.034 | 0.0584 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0365 | 0.761 | 0.7595 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.015 | 0.2827 | 0.5332 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0237 | 0.476 | 0.9062 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.5816 | 1 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.015 | 0.2827 | 0.5332 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0091 | 0.1522 | 0.1466 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0649 | 0.1116 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0038 | 0.034 | 0.0584 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0237 | 0.476 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.0649 | 0.1242 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3638 | 0.6256 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0259 | 0.5252 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.0649 | 0.0587 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0237 | 0.476 | 0.4725 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0.0649 | 0.1236 |
Echinococcus granulosus | RUN | 0.0038 | 0.034 | 0.0584 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0217 | 0.4316 | 0.4279 |
Leishmania major | cytochrome p450-like protein | 0.015 | 0.2827 | 0.5383 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0026 | 0.0066 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.034 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1909 | 0.1855 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.015 | 0.2827 | 0.5891 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.0649 | 0.1242 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0649 | 0.1116 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0108 | 0.1882 | 0.3868 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0259 | 0.5252 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0108 | 0.1882 | 0.3868 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.015 | 0.2827 | 0.5891 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.015 | 0.2827 | 0.5891 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.5816 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.5816 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.5816 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0284 | 0.5816 | 1 |
Schistosoma mansoni | loxhd1 | 0.0038 | 0.034 | 0.0584 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.015 | 0.2827 | 0.5891 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0026 | 0.0066 | 0.0018 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.015 | 0.2827 | 0.5891 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.015 | 0.2827 | 0.5332 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0038 | 0.034 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0284 | 0.5816 | 0.5788 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.015 | 0.2827 | 0.5332 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.015 | 0.2827 | 0.5891 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0138 | 0.2569 | 0.5331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 470 nM | Inhibition of binding of [3H]-NECA to adenosine A2 receptor of rat striatal membranes. | ChEMBL. | 2754691 |
Ki (binding) | = 9000 nM | Inhibition of binding of [3H]-N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes. | ChEMBL. | 2754691 |
Ratio (binding) | = 0.052 | Selectivity ratio for A1 receptor to that of A2 receptor in vitro in rat tissues | ChEMBL. | 2754691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.