Detailed information for compound 656378

Basic information

Technical information
  • TDR Targets ID: 656378
  • Name: 7-[(4-chlorophenyl)methoxy]-2,3-dihydro-1H-cy clopenta[c]chromen-4-one
  • MW: 326.774 | Formula: C19H15ClO3
  • H donors: 0 H acceptors: 1 LogP: 4.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)COc1ccc2c(c1)oc(=O)c1c2CCC1
  • InChi: 1S/C19H15ClO3/c20-13-6-4-12(5-7-13)11-22-14-8-9-16-15-2-1-3-17(15)19(21)23-18(16)10-14/h4-10H,1-3,11H2
  • InChiKey: AZSFFSMOOOFXNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(4-chlorobenzyl)oxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one
  • Oprea1_462112
  • 7-(4-Chloro-benzyloxy)-2,3-dihydro-1H-cyclopenta[c]chromen-4-one
  • BAS 00872468
  • AG-690/12888963
  • EU-0005947
  • Oprea1_007324
  • ChemDiv3_001438
  • ZINC00123069
  • ST5447609
  • IDI1_020404

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi follicle stimulating hormone receptor 0.0233 0.2845 0.4848
Brugia malayi steroid hormone receptor 0.002 0.0126 0.0203
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.874 0.874
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0247 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.046 0.046
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0247 0.0907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0126 0.0203
Onchocerca volvulus 0.0026 0.021 0.0871
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0101 0.1062
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0178 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0126 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0126 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0178 0.0478
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0214 0.2603 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Echinococcus granulosus lamin dm0 0.0026 0.021 0.0241
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0809 0.2228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.046 0.0775
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0247 0.0282
Plasmodium falciparum thioredoxin reductase 0.0084 0.095 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0203
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0247 0.0907
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0247 0.2597
Echinococcus granulosus microtubule associated protein 2 0.0694 0.874 1
Schistosoma mansoni hypothetical protein 0.0033 0.0299 0.0342
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0126 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0204 0.0337
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0071 0.0109
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0126 0.0144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0178 0.049
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0203
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0247 0.2597
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0178 0.0292
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.2329 0.891
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0126 0.0203
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0247 0.0892
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0126 0.0144
Brugia malayi hypothetical protein 0.0469 0.586 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0126 0.0203
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0957 0.0957
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0101 0.1062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.046 0.0527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.016
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0126 0.0126
Schistosoma mansoni intermediate filament proteins 0.0026 0.021 0.0241
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0126 0.0126
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0247 0.0892
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.3629 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0203
Loa Loa (eye worm) inositol-1 0.0073 0.0809 0.137
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0126 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0126 0.0203
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0007 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0126 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0109
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0178 0.0478
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.095 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0126 0.0203
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0247 0.0892
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0247 0.0892
Brugia malayi Thioredoxin reductase 0.0084 0.095 0.1611
Echinococcus multilocularis musashi 0.0026 0.021 0.021
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1708 0.6309
Brugia malayi nuclear receptor NHR-88 0.002 0.0126 0.0203
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0809 0.7988
Loa Loa (eye worm) intermediate filament protein 0.0026 0.021 0.0348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0214 0.2603 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0039
Mycobacterium tuberculosis Probable oxidoreductase 0.0214 0.2603 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0711 0.2197
Loa Loa (eye worm) hypothetical protein 0.0024 0.0178 0.0292
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0247 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0126 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0178 0.0292
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0247 0.2597
Echinococcus granulosus FTZ F1 alpha 0.002 0.0126 0.0144
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0247 0.041
Echinococcus multilocularis lamin dm0 0.0026 0.021 0.021
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0247 0.2597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0126 0.0203
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0126 0.0203
Loa Loa (eye worm) hypothetical protein 0.0033 0.0299 0.0499
Brugia malayi nuclear hormone receptor 0.002 0.0126 0.0203
Echinococcus multilocularis GPCR, family 2 0.0015 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0096 0.1095 0.1252
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0126 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0126 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0126 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.046 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0126 0.0203
Mycobacterium ulcerans hypothetical protein 0.0024 0.0178 0.0478
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0071 0.0071
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0247 0.068
Brugia malayi intermediate filament protein 0.0026 0.021 0.0348
Trypanosoma brucei trypanothione reductase 0.0084 0.095 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0496 0.0836
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1708 0.644
Schistosoma mansoni lamin 0.0026 0.021 0.0241
Toxoplasma gondii thioredoxin reductase 0.0084 0.095 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0214 0.2603 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0809 0.8168
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0178 0.0478
Echinococcus multilocularis geminin 0.017 0.2047 0.2047
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0178 0.0478
Schistosoma mansoni thyroid hormone receptor 0.002 0.0126 0.0144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Echinococcus multilocularis lamin 0.0026 0.021 0.021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0126 0.0144
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0126 0.0126
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0809 0.2228
Leishmania major trypanothione reductase 0.0084 0.095 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0178 0.0478
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0126 0.0144
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.016
Schistosoma mansoni thyroid hormone receptor 0.002 0.0126 0.0144
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0809 0.2228
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0148 0.024
Echinococcus granulosus survival motor neuron protein 1 0.0469 0.586 0.6704
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.021 0.0348
Schistosoma mansoni hypothetical protein 0.017 0.2047 0.2342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.046 0.0527
Onchocerca volvulus 0.0024 0.0178 0.0534
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0809 0.2228
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0126 0.0144
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0054 0.008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0126 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0126 0.0203
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0071 0.0109
Loa Loa (eye worm) hypothetical protein 0.0251 0.3074 0.524
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0247 0.0907
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.016
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0126 0.0144
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0126 0.0144
Loa Loa (eye worm) glutathione reductase 0.0084 0.095 0.1611
Mycobacterium tuberculosis Probable reductase 0.0192 0.2329 0.891
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0178 0.0478
Schistosoma mansoni survival motor neuron protein 0.0096 0.1095 0.1252
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0126 0.0126
Schistosoma mansoni nuclear hormone receptor 0.002 0.0126 0.0144
Plasmodium falciparum glutathione reductase 0.0029 0.0247 0.2597
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0126 0.0144
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0126 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.046 0.0527
Schistosoma mansoni hypothetical protein 0.017 0.2047 0.2342
Brugia malayi photoreceptor-specific nuclear receptor 0.0251 0.3074 0.524
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.021 0.0348
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0178 0.0292
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0071 0.0081
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.874 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0007 0.0008
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0247 0.2597
Echinococcus granulosus GPCR family 2 0.0015 0.0071 0.0081
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.095 0.3426
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0101 0.0049
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0178 0.049
Schistosoma mansoni lamin 0.0026 0.021 0.0241
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0711 0.2474
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0126 0.0144
Echinococcus granulosus geminin 0.017 0.2047 0.2342
Plasmodium falciparum glutathione reductase 0.0084 0.095 1
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0126 0.0126
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0007 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0071 0.0109
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0081
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0126 0.0203
Echinococcus granulosus intermediate filament protein 0.0026 0.021 0.0241
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0247 0.0629
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Plasmodium vivax glutathione reductase, putative 0.0084 0.095 1
Schistosoma mansoni inositol monophosphatase 0.0073 0.0809 0.0925
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0957 0.1095
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0299 0.0499
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0809 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.2329 0.891
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.005
Brugia malayi ecdysteroid receptor 0.002 0.0126 0.0203
Onchocerca volvulus 0.0026 0.021 0.0871
Brugia malayi Inositol-1 0.0073 0.0809 0.137
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.3629 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0126 0.0144
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0496 0.0836
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0809 0.4404
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.046 0.0775
Echinococcus multilocularis survival motor neuron protein 1 0.0469 0.586 0.586
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0126 0.0144
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.2329 0.891
Schistosoma mansoni inositol monophosphatase 0.0073 0.0809 0.0925
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0247 0.0247
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.095 0.1611
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0126 0.0203
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0054 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0496 0.0836
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0126 0.0126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0071 0.0081
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.2329 0.887
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.3629 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.1095 0.1858
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.046 0.046
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0178 0.049
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0126 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.021 0.0348
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1708 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0126 0.0203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0178 0.0355
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0469 0.586 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0148 0.024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0071 0.0071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0036 0.0041
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0126 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0178 0.0478
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0247 0.2597
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.095 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3629 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.2329 0.891
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0809 0.8511
Loa Loa (eye worm) hypothetical protein 0.0024 0.0178 0.0292
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0496 0.0836
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.046 0.0527
Echinococcus granulosus lamin 0.0026 0.021 0.0241
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0126 0.0203
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0809 0.7988
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0126 0.0126
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0247 0.068
Schistosoma mansoni coup transcription factor 0.002 0.0126 0.0144
Plasmodium falciparum thioredoxin reductase 0.0029 0.0247 0.2597
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.016
Brugia malayi glutathione reductase 0.0084 0.095 0.1611
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0247 0.068
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0126 0.0144
Onchocerca volvulus 0.0096 0.1095 1
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0178 0.0292
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0126 0.0144
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.3629 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0809 0.7988
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.2845 0.4848
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0809 0.0809
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0126 0.0203
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.2329 0.891
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0809 0.0925
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0126 0.0144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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