Detailed information for compound 656510

Basic information

Technical information
  • TDR Targets ID: 656510
  • Name: 2-(3-bromophenyl)-6,7-dimethoxy-3,1-benzoxazi n-4-one
  • MW: 362.175 | Formula: C16H12BrNO4
  • H donors: 0 H acceptors: 1 LogP: 3.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2nc(oc(=O)c2cc1OC)c1cccc(c1)Br
  • InChi: 1S/C16H12BrNO4/c1-20-13-7-11-12(8-14(13)21-2)18-15(22-16(11)19)9-4-3-5-10(17)6-9/h3-8H,1-2H3
  • InChiKey: DAXBYPGHFZNXQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • EU-0039060
  • Oprea1_336828
  • A2462/0104482
  • CBMicro_004457
  • BIM-0004184.P001
  • 4H-3,1-Benzoxazin-4-one, 2-(3-bromophenyl)-6,7-dimethoxy-
  • 2-(3-Bromophenyl)-6,7-dimethoxy-4H-3,1-benzoxazin-4-one
  • ZINC01010551
  • AN-979/13513025
  • 2-(3-Bromo-phenyl)-6,7-dimethoxy-benzo[d][1,3]oxazin-4-one
  • BAS 01520069
  • Oprea1_325275

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0035 0.0428 0.0428
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0261 0.0252
Brugia malayi CHE-14 protein 0.0049 0.0705 0.0705
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0829 0.0712
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0302 0.0178
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.056 0.0439
Echinococcus multilocularis chromobox protein 1 0.008 0.1345 0.1325
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0146 0.0146
Schistosoma mansoni cpg binding protein 0.0035 0.0428 0.0428
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0126 0.0093
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0263 0.5041 1
Toxoplasma gondii ABC1 family protein 0.0042 0.056 0.0439
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0508 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.11 0.1092
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.04 0.0377
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0126 0.0117
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0563 0.1157
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.056 0.0439
Trypanosoma cruzi GMP reductase 0.0263 0.5041 0.5024
Echinococcus granulosus lamin dm0 0.0027 0.0261 0.0238
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0829 0.0807
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0263 0.5041 0.5041
Trichomonas vaginalis chromobox protein, putative 0.008 0.1345 0.2867
Loa Loa (eye worm) hypothetical protein 0.006 0.0927 0.0919
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0024 0.0014
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0358 0.0358
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.056 0.0537
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0563 0.1157
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0261 0.0261
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0581 0.0581
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.04 0.0277
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.1345 0.1337
Loa Loa (eye worm) GMP reductase 0.0112 0.1989 0.1981
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0121 0.2174 0.193
Echinococcus granulosus lamin 0.0027 0.0261 0.0238
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0829 0.0807
Mycobacterium ulcerans lipase LipD 0.0042 0.056 0.0439
Toxoplasma gondii IMP dehydrogenas 0.0263 0.5041 0.4978
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.04 0.0377
Trichomonas vaginalis esterase, putative 0.0042 0.056 0.115
Giardia lamblia PHD finger protein 15 0.0034 0.04 1
Leishmania major hypothetical protein, conserved 0.0042 0.056 0.0528
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0137 0.0227
Onchocerca volvulus 0.0042 0.056 0.056
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0263 0.5041 0.4978
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.1124 0.1116
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0563 0.1157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0615 0.0593
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0302 0.137
Onchocerca volvulus 0.0042 0.056 0.056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.056 0.0537
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0829 0.0543
Brugia malayi jmjC domain containing protein 0.0043 0.0581 0.0581
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0508 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0126 0.0468
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0581 0.0581
Mycobacterium ulcerans hypothetical protein 0.0042 0.056 0.0439
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.2017 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.1412 0.1302
Echinococcus granulosus GPCR family 2 0.0032 0.0358 0.0336
Echinococcus granulosus expressed conserved protein 0.0107 0.1878 0.1859
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0033 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.056 0.115
Echinococcus granulosus chromobox protein 1 0.008 0.1345 0.1325
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.056 0.056
Echinococcus multilocularis protein dispatched 1 0.0056 0.0845 0.0823
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0263 0.5041 0.4978
Leishmania major inosine-5-monophosphate dehydrogenase 0.0263 0.5041 0.5024
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0842 0.0842
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0842 0.0725
Echinococcus multilocularis lamin dm0 0.0027 0.0261 0.0238
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0263 0.5041 0.5024
Loa Loa (eye worm) hypothetical protein 0.01 0.1739 0.1732
Loa Loa (eye worm) hypothetical protein 0.0122 0.2179 0.2172
Echinococcus multilocularis expressed conserved protein 0.0107 0.1878 0.1859
Echinococcus multilocularis GPCR, family 2 0.0032 0.0358 0.0336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0358 0.0336
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0842 0.0842
Schistosoma mansoni hypothetical protein 0.0032 0.0358 0.0358
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0126 0.0093
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.1412 0.1412
Echinococcus granulosus chromobox protein 1 0.008 0.1345 0.1325
Brugia malayi Probable ClpP-like protease 0.0084 0.1412 0.1412
Loa Loa (eye worm) hypothetical protein 0.0034 0.04 0.0391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0615 0.0615
Schistosoma mansoni hypothetical protein 0.0047 0.067 0.067
Echinococcus granulosus thymidylate synthase 0.0508 1 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0263 0.5041 0.5024
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0112 0.1989 0.1989
Loa Loa (eye worm) hypothetical protein 0.0042 0.056 0.0551
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0615 0.0606
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0263 0.5041 0.5024
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0631 0.1305
Trypanosoma brucei glucosidase, putative 0.0042 0.0563 0.0531
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.056 0.0439
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.3522 0.3507
Loa Loa (eye worm) hypothetical protein 0.0049 0.0705 0.0697
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0563 0.0541
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0563 0.1157
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0508 1 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0112 0.1989 0.1989
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0137 0.0227
Loa Loa (eye worm) hypothetical protein 0.0042 0.056 0.0551
Onchocerca volvulus 0.0508 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0137 0.0227
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.056 0.056
Trypanosoma brucei GMP reductase 0.0263 0.5041 0.5024
Brugia malayi intermediate filament protein 0.0027 0.0261 0.0261
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.1412 0.1392
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0254 0.4856 0.479
Onchocerca volvulus 0.0035 0.0434 0.0434
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0705 0.0683
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.04 0.0277
Loa Loa (eye worm) beta-lactamase 0.0042 0.056 0.0551
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1739 0.1732
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1412 0.1302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0108 0.0108
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0666 0.0644
Brugia malayi jmjC domain containing protein 0.011 0.1948 0.1948
Schistosoma mansoni patched 1 0.0049 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.0042 0.056 0.0551
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0581 0.0559
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0121 0.2174 0.2074
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0126 0.0203
Schistosoma mansoni hypothetical protein 0.0034 0.04 0.04
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0615 0.0615
Schistosoma mansoni hypothetical protein 0.0032 0.0358 0.0358
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.3522 0.3507
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0126 0.0203
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0358 0.0349
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0263 0.5041 0.5024
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0842 0.0821
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0126 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0034 0.04 0.0277
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.2053 0.2053
Brugia malayi hypothetical protein 0.0242 0.461 0.461
Brugia malayi Bromodomain containing protein 0.0034 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0084 0.1412 0.1404
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1739 0.1739
Onchocerca volvulus Alhambra homolog 0.0034 0.04 0.04
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0137 0.0227
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1412 0.1302
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0563 0.1157
Loa Loa (eye worm) thymidylate synthase 0.0508 1 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.056 0.0439
Brugia malayi chromobox protein homolog 3 0.0045 0.0631 0.0631
Echinococcus granulosus cpg binding protein 0.0035 0.0428 0.0405
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1739 0.1739
Mycobacterium ulcerans thymidylate synthase 0.0508 1 1
Brugia malayi GMP reductase 0.0112 0.1989 0.1989
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0563 0.1157
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0563 0.0531
Brugia malayi hypothetical protein 0.0122 0.2179 0.2179
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0263 0.5041 0.5041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0358 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0615 0.0615
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0009 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.056 0.0528
Mycobacterium tuberculosis Hypothetical protein 0.0242 0.461 0.4541
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.11 0.11
Echinococcus granulosus peregrin 0.0034 0.04 0.0377
Brugia malayi beta-lactamase family protein 0.0042 0.056 0.056
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.3004 0.2987
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0705 0.0683
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.1412 0.2616
Schistosoma mansoni hypothetical protein 0.0472 0.9267 0.9267
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0563 0.1157
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0563 0.1157
Trichomonas vaginalis chromobox protein, putative 0.0048 0.07 0.1456
Schistosoma mansoni hypothetical protein 0.0032 0.0358 0.0358
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1412 0.1302
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0563 0.267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0615 0.0615
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0508 1 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0263 0.5041 0.5029
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.3004 0.2987
Schistosoma mansoni cpg binding protein 0.0033 0.039 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0365 0.0724
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0615 0.0593
Schistosoma mansoni hypothetical protein 0.0047 0.067 0.067
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.3522 0.3522
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.056 0.0528
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0067 0.0073
Echinococcus multilocularis chromobox protein 1 0.008 0.1345 0.1325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0056 0.0049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0989 0.0874
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.056 0.115
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.3522 0.3516
Loa Loa (eye worm) IMP dehydrogenase 1 0.0263 0.5041 0.5036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.056 0.0439
Loa Loa (eye worm) hypothetical protein 0.0026 0.0251 0.0242
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0842 0.0812
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0254 0.4856 0.479
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.056 0.0439
Loa Loa (eye worm) hypothetical protein 0.0045 0.0631 0.0622
Schistosoma mansoni ap endonuclease 0.002 0.0126 0.0126
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.056 0.115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0137 0.0227
Brugia malayi CXXC zinc finger family protein 0.0033 0.039 0.039
Trichomonas vaginalis chromobox protein, putative 0.0048 0.07 0.1456
Schistosoma mansoni hypothetical protein 0.0068 0.11 0.11
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.056 0.0551
Mycobacterium tuberculosis Conserved protein 0.0042 0.056 0.0439
Schistosoma mansoni ap endonuclease 0.002 0.0126 0.0126
Onchocerca volvulus Huntingtin homolog 0.0122 0.2179 0.2179
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0563 0.267
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.056 0.0439
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0829 0.0712
Echinococcus multilocularis protein patched 0.0049 0.0705 0.0683
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0302 0.0178
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.056 0.115
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.1412 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.1412 0.1302
Onchocerca volvulus Putative GMP reductase 0.0112 0.1989 0.1989
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0137 0.0227
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0024 0.0024
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0033 0.0033
Echinococcus multilocularis lamin 0.0027 0.0261 0.0238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0358 0.0358
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0581 0.0572
Echinococcus granulosus dnaJ subfamily B 0.0472 0.9267 0.9265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0358 0.0336
Brugia malayi follicle stimulating hormone receptor 0.0248 0.4733 0.4733
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.2017 0.2017
Onchocerca volvulus 0.0027 0.0261 0.0261
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0543 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0631 0.1305
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0142 0.2586 0.2491
Schistosoma mansoni chromobox protein 0.008 0.1345 0.1345
Mycobacterium leprae conserved hypothetical protein 0.0042 0.056 0.0265
Schistosoma mansoni lamin 0.0027 0.0261 0.0261
Brugia malayi beta-lactamase 0.0042 0.056 0.056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.4733 0.4728
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0508 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0615 0.0593
Mycobacterium ulcerans beta-lactamase 0.0042 0.056 0.0439
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.5089 0.5026
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0508 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.07 0.07
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0842 0.0725
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.04 0.0391
Onchocerca volvulus Huntingtin homolog 0.0122 0.2179 0.2179
Plasmodium falciparum phd finger protein, putative 0.0034 0.04 0.0277
Onchocerca volvulus 0.0033 0.039 0.039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0615 0.0593
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.04 0.04
Leishmania major guanosine monophosphate reductase 0.0263 0.5041 0.5024
Loa Loa (eye worm) hypothetical protein 0.0042 0.056 0.0551
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0563 0.0554
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0126 0.0103
Brugia malayi Heterochromatin protein 1 0.008 0.1345 0.1345
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.056 0.0439
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0263 0.5041 0.4886
Loa Loa (eye worm) hypothetical protein 0.0042 0.056 0.0551
Schistosoma mansoni alpha-glucosidase 0.0162 0.2993 0.2993
Mycobacterium leprae Probable lipase LipE 0.0042 0.056 0.0265
Schistosoma mansoni jumonji domain containing protein 0.0088 0.149 0.149
Loa Loa (eye worm) hypothetical protein 0.0035 0.0434 0.0425
Schistosoma mansoni lamin 0.0027 0.0261 0.0261
Schistosoma mansoni hypothetical protein 0.0047 0.067 0.067
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.1948 0.1929
Toxoplasma gondii hypothetical protein 0.0029 0.0302 0.0178
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0842 0.0725
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0563 0.1157
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0142 0.2586 0.2355
Schistosoma mansoni alpha-glucosidase 0.0162 0.2993 0.2993
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.1412 0.1302
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.056 0.056
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0126 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0705 0.1468
Trichomonas vaginalis chromobox protein, putative 0.008 0.1345 0.2867
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0563 0.0541
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0842 0.0821
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1412 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0358 0.0349
Echinococcus multilocularis peregrin 0.0034 0.04 0.0377
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.1141 0.1141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0137 0.0227
Brugia malayi beta-lactamase family protein 0.0042 0.056 0.056
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0126 0.0093
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0631 0.0631
Schistosoma mansoni hypothetical protein 0.0047 0.067 0.067
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0508 1 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.1412 0.1392
Loa Loa (eye worm) hypothetical protein 0.0042 0.056 0.0551
Schistosoma mansoni hypothetical protein 0.0032 0.0358 0.0358
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0705 0.0683
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0261 0.0252
Onchocerca volvulus 0.0042 0.056 0.056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0137 0.0227
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.056 0.0439
Echinococcus multilocularis cpg binding protein 0.0035 0.0428 0.0405
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0563 0.0531
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.2017 0.1998
Trichomonas vaginalis conserved hypothetical protein 0.0242 0.461 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.1948 0.1929
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.1412 0.1144
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0242 0.461 0.4592
Echinococcus multilocularis thymidylate synthase 0.0508 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0358 0.0336
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.039 0.0381
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0767 0.0758
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0508 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.056 0.0439
Schistosoma mansoni chromobox protein 0.008 0.1345 0.1345
Echinococcus multilocularis musashi 0.0027 0.0261 0.0238
Loa Loa (eye worm) hypothetical protein 0.0058 0.0886 0.0877
Trypanosoma cruzi GMP reductase 0.0263 0.5041 0.5024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0261 0.0252
Onchocerca volvulus 0.0027 0.0261 0.0261
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0126 0.0103
Loa Loa (eye worm) hypothetical protein 0.0114 0.2017 0.201
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0254 0.4856 0.479
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0263 0.5041 0.5029
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.056 0.115
Brugia malayi CHD4 protein 0.0015 0.0024 0.0024
Schistosoma mansoni intermediate filament proteins 0.0027 0.0261 0.0261
Schistosoma mansoni alpha glucosidase 0.0042 0.0563 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0067 0.0073
Mycobacterium tuberculosis Conserved protein 0.0042 0.056 0.0439
Brugia malayi PHD-finger family protein 0.0034 0.04 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0365 0.0724
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0666 0.0644
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0705 0.0697
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0563 0.0563
Mycobacterium tuberculosis Conserved protein 0.0042 0.056 0.0439
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.2017 0.1998
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.3522 0.3507
Onchocerca volvulus 0.0109 0.1919 0.1919
Echinococcus granulosus intermediate filament protein 0.0027 0.0261 0.0238
Echinococcus multilocularis dnaJ subfamily B 0.0472 0.9267 0.9265
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.056 0.0528
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.1412 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0563 0.0531
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0508 1 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.2179 0.2172
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0563 0.0442

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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