Detailed information for compound 656541

Basic information

Technical information
  • TDR Targets ID: 656541
  • Name: (3E,5Z)-3,5-bis[(4-methoxyphenyl)methylidene] -1-propylpiperidin-4-one
  • MW: 377.476 | Formula: C24H27NO3
  • H donors: 0 H acceptors: 1 LogP: 4.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CC(=Cc2ccc(cc2)OC)C(=O)C(=Cc2ccc(cc2)OC)C1
  • InChi: 1S/C24H27NO3/c1-4-13-25-16-20(14-18-5-9-22(27-2)10-6-18)24(26)21(17-25)15-19-7-11-23(28-3)12-8-19/h5-12,14-15H,4,13,16-17H2,1-3H3/b20-14-,21-15+
  • InChiKey: KDXKAKJLQVZWKN-TVGQLCNQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3E,5Z)-3,5-bis[(4-methoxyphenyl)methylene]-1-propyl-piperidin-4-one
  • (3E,5Z)-3,5-bis[(4-methoxyphenyl)methylene]-1-propyl-4-piperidinone
  • (3E,5Z)-3,5-bis(4-methoxybenzylidene)-1-propyl-4-piperidone
  • (3E,5Z)-3,5-bis[(4-methoxyphenyl)methylidene]-1-propyl-piperidin-4-one
  • IDI1_020679
  • STOCK2S-24401
  • 3,5-Bis-(4-methoxy-benzylidene)-1-propyl-piperidin-4-one
  • BAS 00615615

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0181 0.2561 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.2089 0.6171
Brugia malayi hypothetical protein 0.0236 0.3363 1
Onchocerca volvulus 0.0029 0.033 0.4698
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0083 0.0074
Schistosoma mansoni hypothetical protein 0.0169 0.2383 0.2375
Echinococcus multilocularis muscleblind protein 0.0149 0.2089 0.2081
Schistosoma mansoni hypothetical protein 0.0048 0.0609 0.06
Loa Loa (eye worm) hypothetical protein 0.0149 0.2089 0.6171
Schistosoma mansoni survival motor neuron protein 0.0048 0.0609 0.06
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0712 0.2538
Echinococcus multilocularis cpg binding protein 0.0031 0.0355 0.0346
Loa Loa (eye worm) hypothetical protein 0.0068 0.0903 0.2607
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.3363 0.3357
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0216 0.0207
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0216 0.0955
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0366 0.0993
Echinococcus multilocularis microtubule associated protein 2 0.0688 1 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.0181 0.2561 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0216 0.0955
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0181 0.2561 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0366 0.0998
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0026
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0216 0.0543
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0216 0.0207
Schistosoma mansoni hypothetical protein 0.0068 0.0903 0.0894
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0216 0.0207
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0107 0.1472 0.5605
Trypanosoma brucei aminopeptidase, putative 0.0021 0.0216 0.0955
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0181 0.2561 1
Brugia malayi Muscleblind-like protein 0.0149 0.2089 0.6173
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0216 0.0547
Echinococcus granulosus muscleblind protein 0.0149 0.2089 0.2081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0144
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0107 0.1472 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0181 0.2561 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0107 0.1472 1
Trichomonas vaginalis hypothetical protein 0.0181 0.2561 1
Toxoplasma gondii leucyl aminopeptidase LAP 0.0107 0.1472 0.5605
Echinococcus granulosus dnaJ subfamily B 0.0414 0.5984 0.5981
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1365 0.3997
Plasmodium falciparum M17 leucyl aminopeptidase 0.0107 0.1472 0.5605
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0216 0.0955
Brugia malayi cytosol aminopeptidase 0.0021 0.0216 0.0547
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0366 0.0357
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0609 0.1728
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0366 0.0357
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0181 0.2561 1
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0181 0.2561 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0083 0.0144
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0107 0.1472 0.5605
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0216 0.0955
Echinococcus granulosus geminin 0.0169 0.2383 0.2375
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.5984 0.5981
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.3363 0.3357
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.033 0.0886
Schistosoma mansoni hypothetical protein 0.0032 0.0366 0.0357
Schistosoma mansoni hypothetical protein 0.0032 0.0366 0.0357
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0366 0.0357
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0083 0.0149
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0216 0.0207
Schistosoma mansoni cpg binding protein 0.0031 0.0355 0.0346
Echinococcus multilocularis GPCR, family 2 0.0032 0.0366 0.0357
Echinococcus granulosus leucine aminopeptidase protein 0.0107 0.1472 0.1464
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0366 0.0357
Echinococcus multilocularis muscleblind protein 1 0.0149 0.2089 0.2081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1365 0.4
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0216 0.0207
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0083 0.5
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0216 0.0955
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1365 0.4
Echinococcus granulosus cpg binding protein 0.0031 0.0355 0.0346
Schistosoma mansoni hypothetical protein 0.0032 0.0366 0.0357
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0216 0.0547
Brugia malayi CXXC zinc finger family protein 0.0029 0.033 0.0891
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0216 0.0543
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0216 0.0955
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0107 0.1472 1
Schistosoma mansoni hypothetical protein 0.0414 0.5984 0.5981
Loa Loa (eye worm) hypothetical protein 0.01 0.1365 0.3997
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0181 0.2561 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0809 0.08
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0107 0.1472 0.5605
Loa Loa (eye worm) hypothetical protein 0.0236 0.3363 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0083 0.0074
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0216 0.0547
Schistosoma mansoni cpg binding protein 0.0031 0.0355 0.0346
Echinococcus granulosus GPCR family 2 0.0032 0.0366 0.0357
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0366 0.0998
Echinococcus multilocularis geminin 0.0169 0.2383 0.2375
Loa Loa (eye worm) oxidoreductase 0.0012 0.0083 0.0144
Schistosoma mansoni cpg binding protein 0.0029 0.033 0.0321
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0083 0.0149
Echinococcus multilocularis leucine aminopeptidase protein 0.0107 0.1472 0.1464
Chlamydia trachomatis cytosol aminopeptidase 0.0107 0.1472 0.5605
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0083 0.0144
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0216 0.0955
Schistosoma mansoni hypothetical protein 0.0032 0.0366 0.0357
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0107 0.1472 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0026
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0216 0.0207
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0216 0.0207
Mycobacterium ulcerans leucyl aminopeptidase 0.0107 0.1472 0.5605
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0903 0.261
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0083 0.0074
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0107 0.1472 0.5605
Loa Loa (eye worm) hypothetical protein 0.0032 0.0366 0.0993
Onchocerca volvulus 0.0048 0.0609 1
Schistosoma mansoni hypothetical protein 0.0169 0.2383 0.2375
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0216 0.0207
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0083 0.0074
Schistosoma mansoni microtubule-associated protein tau 0.0688 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.