Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0565 | 0.2571 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0591 | 0.068 |
Trichomonas vaginalis | hypothetical protein | 0.0194 | 0.7638 | 0.7638 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0565 | 0.9573 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0591 | 0.2686 |
Brugia malayi | Pre-SET motif family protein | 0.0218 | 0.869 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0194 | 0.7638 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.3584 | 0.4125 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0591 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0194 | 0.7638 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.3584 | 0.4125 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0591 | 0.2686 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0515 | 0.8725 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0218 | 0.869 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0194 | 0.7638 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0194 | 0.7638 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0194 | 0.7638 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0194 | 0.7638 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0194 | 0.7638 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0565 | 0.074 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0565 | 0.2571 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0591 | 0.068 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0565 | 0.074 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0194 | 0.7638 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3584 | 0.4125 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0591 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0565 | 0.9573 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0591 | 0.2686 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0591 | 0.2686 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0565 | 0.9573 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0591 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0565 | 0.2571 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0565 | 0.0651 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0565 | 0.2571 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0591 | 0.068 |
Trichomonas vaginalis | set domain proteins, putative | 0.0248 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.3584 | 0.4125 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2199 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0591 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0565 | 0.0651 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.2199 | 0.253 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2199 | 0.253 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0591 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0591 | 0.068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.