Detailed information for compound 656730

Basic information

Technical information
  • TDR Targets ID: 656730
  • Name: (5E)-5-[(2-ethoxyphenyl)methylidene]-1,3-thia zolidine-2,4-dione
  • MW: 249.286 | Formula: C12H11NO3S
  • H donors: 1 H acceptors: 2 LogP: 2.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1/C=C\1/SC(=O)NC1=O
  • InChi: 1S/C12H11NO3S/c1-2-16-9-6-4-3-5-8(9)7-10-11(14)13-12(15)17-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
  • InChiKey: SZHWEOSHMVDMCQ-JXMROGBWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-5-[(2-ethoxyphenyl)methylene]thiazolidine-2,4-dione
  • (5E)-5-(2-ethoxybenzylidene)thiazolidine-2,4-quinone
  • BAS 13119471
  • ZINC01158109
  • 5-(2-Ethoxy-benzylidene)-thiazolidine-2,4-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0326 0.107
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.2157 1
Brugia malayi jmjC domain containing protein 0.0189 0.187 0.9227
Mycobacterium ulcerans hypothetical protein 0.0025 0 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0476 0.1325
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0476 0.2205
Brugia malayi Calcitonin receptor-like protein seb-1 0.0168 0.1636 0.804
Brugia malayi Bromodomain containing protein 0.0058 0.0376 0.1654
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0476 0.5
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0476 0.0476
Echinococcus granulosus tumor protein p63 0.034 0.3591 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0256 0.263 0.7323
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0 0.5
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0256 0.263 0.263
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0376 1
Onchocerca volvulus Alhambra homolog 0.0058 0.0376 0.1424
Schistosoma mansoni jumonji domain containing protein 0.015 0.1428 0.5342
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0476 0.2159
Mycobacterium ulcerans hypothetical protein 0.0025 0 0.5
Onchocerca volvulus 0.023 0.2341 1
Mycobacterium tuberculosis Conserved protein 0.0025 0 0.5
Echinococcus granulosus jumonji domain containing protein 0.008 0.0633 0.1763
Echinococcus multilocularis tumor protein p63 0.034 0.3591 0.3591
Brugia malayi PHD-finger family protein 0.0058 0.0376 0.1654
Echinococcus multilocularis GPCR, family 2 0.0053 0.0326 0.0326
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.1029 0.4966
Schistosoma mansoni hypothetical protein 0.0053 0.0326 0.107
Schistosoma mansoni hypothetical protein 0.0115 0.1029 0.3797
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0168 0.1636 0.6148
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.005 0.005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0376 0.1265
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0157 0.0438
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0376 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0168 0.1636 0.804
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0189 0.187 0.5208
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0514 0.18
Loa Loa (eye worm) hypothetical protein 0.0115 0.1029 0.3797
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0633 0.0633
Trypanosoma brucei hypothetical protein, conserved 0.0214 0.2157 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0476 0.2205
Echinococcus granulosus GPCR family 2 0.0053 0.0326 0.0907
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0376 0.1265
Schistosoma mansoni hypothetical protein 0.0053 0.0326 0.107
Echinococcus granulosus peregrin 0.0058 0.0376 0.1047
Brugia malayi jmjC domain containing protein 0.007 0.0514 0.2354
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0514 0.1432
Leishmania major hypothetical protein, conserved 0.0214 0.2157 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0326 0.107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0326 0.1399
Schistosoma mansoni hypothetical protein 0.0053 0.0326 0.107
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0476 0.1651
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0189 0.187 0.187
Trypanosoma cruzi hypothetical protein, conserved 0.0214 0.2157 1
Giardia lamblia PHD finger protein 15 0.0058 0.0376 0.5
Trichomonas vaginalis set domain proteins, putative 0.023 0.2341 1
Plasmodium falciparum phd finger protein, putative 0.0058 0.0376 0.5
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0286 0.0916
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0256 0.263 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.1636 0.6148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0326 0.0326
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0326 0.0907
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0326 0.1399
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0514 0.18
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.1075 0.3975
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.005 0.0286 0.0916
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0476 0.1651
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0326 0.0907
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0514 0.0514
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0376 1
Onchocerca volvulus 0.005 0.0286 0.1031
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0376 0.0376
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0514 0.18
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2022 0.7646
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.0845 0.3083
Schistosoma mansoni hypothetical protein 0.0053 0.0326 0.107
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.005 0.005
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.005 0.0138
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0476 0.2205
Loa Loa (eye worm) hypothetical protein 0.0058 0.0376 0.1265
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0256 0.263 1
Echinococcus multilocularis peregrin 0.0058 0.0376 0.0376
Schistosoma mansoni hypothetical protein 0.0058 0.0376 0.1265
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0326 0.0326
Brugia malayi Pre-SET motif family protein 0.0202 0.2022 1
Brugia malayi hypothetical protein 0.0118 0.1057 0.5108
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0038 0.0104
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0376 0.1047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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