Detailed information for compound 656797

Basic information

Technical information
  • TDR Targets ID: 656797
  • Name: N4-[(2-nitrophenyl)methylideneamino]-N2,N6-di (phenyl)-1,3,5-triazine-2,4,6-triamine
  • MW: 426.431 | Formula: C22H18N8O2
  • H donors: 3 H acceptors: 5 LogP: 5.5 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccccc1C=NNc1nc(Nc2ccccc2)nc(n1)Nc1ccccc1
  • InChi: 1S/C22H18N8O2/c31-30(32)19-14-8-7-9-16(19)15-23-29-22-27-20(24-17-10-3-1-4-11-17)26-21(28-22)25-18-12-5-2-6-13-18/h1-15H,(H3,24,25,26,27,28,29)/b23-15+
  • InChiKey: PDDAQUCRDFXANJ-HZHRSRAPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N4-[(2-nitrophenyl)methyleneamino]-N2,N6-di(phenyl)-1,3,5-triazine-2,4,6-triamine
  • [4-[(N'E)-N'-(2-nitrobenzylidene)hydrazino]-6-(phenylamino)-s-triazin-2-yl]-phenyl-amine
  • [4-[N'-(2-nitrobenzylidene)hydrazino]-6-(phenylamino)-s-triazin-2-yl]-phenyl-amine
  • A0740/0034535

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0143 0.0138
Schistosoma mansoni hypothetical protein 0.0019 0.0095 0.0094
Schistosoma mansoni hypothetical protein 0.0072 0.1581 0.1651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0143 0.0276
Schistosoma mansoni loxhd1 0.0019 0.0095 0.0094
Mycobacterium ulcerans lipase LipD 0.0036 0.0586 0.1981
Loa Loa (eye worm) hypothetical protein 0.0025 0.0266 0.0522
Echinococcus multilocularis tumor protein p63 0.0369 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0143 0.0286
Loa Loa (eye worm) hypothetical protein 0.0024 0.0246 0.0481
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.061 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0143 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0143 0.0138
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0095 0.009
Onchocerca volvulus 0.0192 0.5006 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0586 0.1162
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0143 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0143 0.0138
Schistosoma mansoni hypothetical protein 0.0033 0.0492 0.051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.018
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0586 0.0945
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0586 0.4179
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0628 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0575 0.8339
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0575 0.0979
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0309 0.2189
Brugia malayi steroid hormone receptor 0.0021 0.0143 0.0286
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0143 0.0138
Entamoeba histolytica hypothetical protein 0.0111 0.2697 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0143 0.0276
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.2794 0.279
Schistosoma mansoni pyruvate kinase 0.0019 0.0078 0.0076
Brugia malayi ecdysteroid receptor 0.0021 0.0143 0.0286
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.061 0.435
Schistosoma mansoni hypothetical protein 0.0033 0.0492 0.051
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0586 0.8668
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0586 0.0945
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.252 0.5035
Brugia malayi Doublecortin family protein 0.0019 0.0095 0.0189
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0575 0.1149
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1395 0.278
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0309 0.0304
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0266 0.0522
Trichomonas vaginalis esterase, putative 0.0036 0.0586 0.8668
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0246 0.1731
Onchocerca volvulus 0.0036 0.0586 0.1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.061 0.435
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0078 0.1204
Schistosoma mansoni tyrosinase precursor 0.0192 0.5006 0.5236
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0143 0.0286
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0575 0.1141
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0628 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0586 0.117
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1395 0.1391
Loa Loa (eye worm) hypothetical protein 0.0054 0.1082 0.2154
Brugia malayi RNA binding protein 0.0064 0.1365 0.2727
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0143 0.0145
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0586 0.9606
Loa Loa (eye worm) ShTK domain-containing protein 0.0192 0.5006 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0575 0.0979
Echinococcus granulosus tar DNA binding protein 0.0064 0.1365 0.1361
Mycobacterium ulcerans hypothetical protein 0.0036 0.0586 0.1981
Schistosoma mansoni rab6-interacting 0.0019 0.0095 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0143 0.0276
Schistosoma mansoni coup transcription factor 0.0021 0.0143 0.0145
Schistosoma mansoni rab6-interacting 0.0019 0.0095 0.0094
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0143 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2127 0.2222
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1365 0.1361
Brugia malayi hypothetical protein 0.0111 0.2697 0.5387
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1365 0.1424
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0628 0.4485
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.061 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.061 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0309 0.488
Schistosoma mansoni polycystin 1-related 0.0019 0.0095 0.0094
Schistosoma mansoni lipoxygenase 0.008 0.1819 0.1899
Brugia malayi ShTK domain containing protein 0.0192 0.5006 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0246 0.3979
Onchocerca volvulus 0.0021 0.0143 0.0099
Leishmania major hypothetical protein, conserved 0.0024 0.0246 0.1731
Echinococcus multilocularis pyruvate kinase 0.0019 0.0078 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276
Brugia malayi hypothetical protein 0.0019 0.0095 0.0189
Brugia malayi hypothetical protein 0.0024 0.0246 0.049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0586 0.0608
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1395 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276
Entamoeba histolytica hypothetical protein 0.0111 0.2697 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1365 0.2727
Loa Loa (eye worm) hypothetical protein 0.0036 0.0586 0.1162
Schistosoma mansoni pyruvate kinase 0.0036 0.0575 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0143 0.0276
Leishmania major hypothetical protein, conserved 0.0036 0.0586 0.4179
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0143 0.0286
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0143 0.0145
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0143 0.0099
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0143 0.0138
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0143 0.0145
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0492 0.0982
Loa Loa (eye worm) hypothetical protein 0.0036 0.0586 0.1162
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.6153 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0492 0.0982
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0586 0.1981
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0143 0.0286
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.252 0.5035
Brugia malayi beta-lactamase 0.0036 0.0586 0.117
Schistosoma mansoni inositol monophosphatase 0.0038 0.0628 0.0653
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0143 0.0276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2127 0.2123
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0192 0.5006 1
Schistosoma mansoni hypothetical protein 0.0111 0.2697 0.2818
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0586 0.0581
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0619 0.0615
Echinococcus granulosus RUN 0.0019 0.0095 0.009
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0143 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0143 0.0138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0143 0.0138
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1581 0.3159
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0575 0.1149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0143 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0246 0.1731
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.061 0.435
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1395 0.2787
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0628 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0192 0.5006 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0246 0.1731
Echinococcus multilocularis pyruvate kinase 0.0019 0.0078 0.0073
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.2697 0.2693
Schistosoma mansoni hypothetical protein 0.0033 0.0492 0.051
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.2697 0.2818
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0575 0.8503
Loa Loa (eye worm) RNA binding protein 0.0064 0.1365 0.272
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.001
Brugia malayi Common central domain of tyrosinase family protein 0.0192 0.5006 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0095 0.1485
Mycobacterium leprae Probable lipase LipE 0.0036 0.0586 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1365 0.1424
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0095 0.009
Schistosoma mansoni tyrosinase precursor 0.0192 0.5006 0.5236
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0575 0.9149
Plasmodium falciparum pyruvate kinase 0.0036 0.0575 0.9432
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1365 0.1424
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0143 0.0286
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0143 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2127 0.2222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0143 0.0145
Plasmodium falciparum flap endonuclease 1 0.0027 0.0309 0.5031
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1395 0.1456
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0586 0.4179
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0628 0.4485
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0143 0.0145
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0628 0.4485
Echinococcus multilocularis pyruvate kinase 0.0036 0.0575 0.0571
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1395 0.1391
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.061 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0143 0.0286
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0143 0.0145
Brugia malayi beta-lactamase family protein 0.0036 0.0586 0.117
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0143 0.0145
Schistosoma mansoni inositol monophosphatase 0.0038 0.0628 0.0653
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0143 0.0145
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.1082 0.1128
Brugia malayi TAR-binding protein 0.0064 0.1365 0.2727
Loa Loa (eye worm) beta-lactamase 0.0036 0.0586 0.1162
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.2794 0.279
Brugia malayi Flap endonuclease-1 0.0027 0.0309 0.0618
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0575 0.1141
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0192 0.5006 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0143 0.0138
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0143 0.0145
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0309 0.4351
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.2127 0.4244
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0143 0.0286
Schistosoma mansoni ap endonuclease 0.0037 0.061 0.0633
Loa Loa (eye worm) hypothetical protein 0.0036 0.0586 0.1162
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0516 0.0831
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0628 1
Schistosoma mansoni hypothetical protein 0.0353 0.9557 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.061 0.121
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0586 0.1162
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0586 0.0945
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0628 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0078 0.1204
Schistosoma mansoni ap endonuclease 0.0037 0.061 0.0633
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1395 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0143 0.0138
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0095 0.1485
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1395 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0586 0.1981
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0078 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0143 0.0286
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0192 0.5006 1
Onchocerca volvulus 0.0192 0.5006 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0628 0.1491
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2847 0.5682
Onchocerca volvulus 0.0192 0.5006 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0492 0.0487
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0492 0.0487
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0492 0.0974
Echinococcus granulosus GPCR family 2 0.0033 0.0492 0.0487
Loa Loa (eye worm) hypothetical protein 0.0036 0.0586 0.1162
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0628 0.4485
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0492 0.0487
Mycobacterium tuberculosis Conserved protein 0.0036 0.0586 0.0945
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0309 0.0609
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0575 0.4103
Loa Loa (eye worm) hypothetical protein 0.0033 0.0492 0.0974
Schistosoma mansoni pyruvate kinase 0.0036 0.0575 0.0597
Loa Loa (eye worm) tyrosinase 1 0.0192 0.5006 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0143 0.0286
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0628 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.061 0.0984
Echinococcus granulosus geminin 0.0353 0.9557 0.9557
Toxoplasma gondii exonuclease III APE 0.0037 0.061 0.97
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.061 0.9415
Echinococcus granulosus pyruvate kinase 0.0019 0.0078 0.0073
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0246 0.3859
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0586 0.8668
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1395 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0143 0.0286
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0586 0.0945
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0143 0.0286
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0575 0.4103
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1365 0.1424
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0492 0.0487
Loa Loa (eye worm) hypothetical protein 0.0192 0.5006 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0095 0.009
Brugia malayi hypothetical protein 0.0019 0.0095 0.0189
Onchocerca volvulus 0.0192 0.5006 1
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0309 0.5031
Echinococcus multilocularis pyruvate kinase 0.0028 0.036 0.0355
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0143 0.0099
Loa Loa (eye worm) hypothetical protein 0.0036 0.0575 0.1141
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0586 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0586 0.4179
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.061 0.1218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.2127 0.2123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0143 0.0286
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0095 0.009
Schistosoma mansoni flap endonuclease-1 0.0024 0.0237 0.0243
Echinococcus granulosus pyruvate kinase 0.0019 0.0078 0.0073
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0628 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0143 0.0286
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0246 0.3979
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0586 0.0608
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.061 0.0605
Schistosoma mansoni hypothetical protein 0.0033 0.0492 0.051
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0586 0.0945
Schistosoma mansoni hypothetical protein 0.0353 0.9557 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0143 0.0138
Echinococcus multilocularis GPCR, family 2 0.0033 0.0492 0.0487
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276
Brugia malayi Inositol-1 0.0038 0.0628 0.1255
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.2697 0.2693
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0586 0.8668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0143 0.0276
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0586 0.0945
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0143 0.0138
Brugia malayi nuclear hormone receptor 0.0021 0.0143 0.0286
Mycobacterium tuberculosis Conserved protein 0.0036 0.0586 0.0945
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0619 0.0615
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0309 0.0178
Echinococcus granulosus flap endonuclease 1 0.0027 0.0309 0.0304
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0095 0.009
Loa Loa (eye worm) inositol-1 0.0038 0.0628 0.1247
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0309 0.2189
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0309 0.2189
Echinococcus multilocularis pyruvate kinase 0.0036 0.0575 0.0571
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.2127 0.425
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0143 0.0138
Mycobacterium tuberculosis Conserved protein 0.0036 0.0586 0.0945
Echinococcus granulosus pyruvate kinase 0.0036 0.0575 0.0571
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.061 0.9415
Echinococcus granulosus pyruvate kinase 0.0019 0.0078 0.0073
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.061 0.435
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.061 0.0605
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0575 0.1141
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0143 0.0286
Chlamydia trachomatis pyruvate kinase 0.0036 0.0575 0.5
Toxoplasma gondii ABC1 family protein 0.0036 0.0586 0.9318
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0586 0.0581
Onchocerca volvulus 0.0054 0.1082 0.201
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.061 0.5
Loa Loa (eye worm) hypothetical protein 0.0192 0.5006 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2847 0.5682
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0143 0.0138
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0143 0.0138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.252 0.503
Echinococcus granulosus pyruvate kinase 0.0036 0.0575 0.0571
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2127 0.2123
Schistosoma mansoni lipoxygenase 0.0114 0.2794 0.292
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1365 0.1424
Leishmania major pyruvate kinase 0.0036 0.0575 0.4103
Onchocerca volvulus 0.0036 0.0586 0.1
Giardia lamblia Pyruvate kinase 0.0036 0.0575 0.9354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0143 0.0276
Entamoeba histolytica hypothetical protein 0.0111 0.2697 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0143 0.0138
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0575 0.0979
Brugia malayi beta-lactamase family protein 0.0036 0.0586 0.117
Leishmania major pyruvate kinase 0.0036 0.0575 0.4103
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0246 0.3979
Echinococcus multilocularis geminin 0.0353 0.9557 0.9557
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0586 0.8668
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1365 0.272
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0575 0.4103
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1365 0.272
Brugia malayi nuclear receptor NHR-88 0.0021 0.0143 0.0286
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0575 0.0928
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.2127 0.2222
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0586 0.1162
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1395 0.4646
Echinococcus multilocularis RUN 0.0019 0.0095 0.009
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0575 0.4103
Onchocerca volvulus 0.0036 0.0586 0.1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0586 0.0945
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0192 0.5006 1
Entamoeba histolytica hypothetical protein 0.0111 0.2697 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1581 0.3153
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0095 0.018
Brugia malayi MH2 domain containing protein 0.0116 0.2847 0.5686
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0575 0.8339
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.061 0.6476
Mycobacterium ulcerans beta-lactamase 0.0036 0.0586 0.1981
Loa Loa (eye worm) hypothetical protein 0.0105 0.252 0.503
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0628 0.0624
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.2127 0.2123
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0095 0.009
Echinococcus multilocularis pyruvate kinase 0.0019 0.0078 0.0073
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0143 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0143 0.0286
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0143 0.0145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0143 0.0145
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0575 0.9432
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0586 0.8668
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0276

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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