Detailed information for compound 657024

Basic information

Technical information
  • TDR Targets ID: 657024
  • Name: 4-[(Z)-[4-(2-methoxyphenyl)piperazin-1-yl]imi nomethyl]-N,N-dimethylaniline
  • MW: 338.447 | Formula: C20H26N4O
  • H donors: 0 H acceptors: 0 LogP: 3.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)N=Cc1ccc(cc1)N(C)C
  • InChi: 1S/C20H26N4O/c1-22(2)18-10-8-17(9-11-18)16-21-24-14-12-23(13-15-24)19-6-4-5-7-20(19)25-3/h4-11,16H,12-15H2,1-3H3/b21-16-
  • InChiKey: WUTRXVOJLOUWFC-PGMHBOJBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(Z)-[4-(2-methoxyphenyl)piperazin-1-yl]iminomethyl]-N,N-dimethyl-aniline
  • 4-[(Z)-[4-(2-methoxyphenyl)-1-piperazinyl]iminomethyl]-N,N-dimethylaniline
  • [4-[(Z)-[4-(2-methoxyphenyl)piperazin-1-yl]iminomethyl]phenyl]-dimethyl-amine
  • ZINC00230044
  • BIM-0035964.P001
  • ST5420800

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0646 0.067
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0701 0.1158
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0912 0.1499
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0081 0.0081
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0293 0.3584 0.3584
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0455 0.0455
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0081 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0084 0.077 0.1825
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0122 0.0122
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0109 0.0181
Brugia malayi Calcitonin receptor-like protein seb-1 0.0568 0.729 0.7565
Brugia malayi Cytochrome P450 family protein 0.0058 0.0414 0.043
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0646 0.1062
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0425 0.0441
Brugia malayi Inositol-1 0.0079 0.0701 0.0727
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0646 0.1518
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0146 0.0146
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0104 0.1041 0.2551
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0293 0.3584 0.5922
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0293 0.3584 0.3584
Loa Loa (eye worm) hypothetical protein 0.0075 0.0646 0.067
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0104 0.1041 0.2551
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.0031 0.0031
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0701 0.0701
Mycobacterium tuberculosis Conserved protein 0.0075 0.0646 0.1062
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0031 0.0032
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0293 0.3584 0.8781
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0784 0.1289
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0589 0.1644
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0081 0.0081
Brugia malayi steroid hormone receptor 0.0033 0.0081 0.0084
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.018 0.2059 0.2059
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0455 0.0455
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.099 0.099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.018 0.2059 0.2136
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0131 0.1404 1
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0066 0.0529 0.0874
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0104 0.1041 0.2905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.099 0.099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0081 0.0084
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0784 0.1289
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0029 0.0031 0.0031
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0081 0.0081
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0329 0.0329
Brugia malayi ecdysteroid receptor 0.0033 0.0081 0.0084
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0075 0.0646 0.067
Brugia malayi mbt repeat family protein 0.0051 0.0329 0.0342
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3489 0.8536
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0081 0.0084
Mycobacterium ulcerans hypothetical protein 0.0075 0.0646 0.1582
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0425 0.0425
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0093 0.0892 0.0925
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0568 0.729 0.7565
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0293 0.3584 0.3584
Toxoplasma gondii thioredoxin reductase 0.0037 0.014 0.014
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0455 0.0748
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0081 0.0084
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0104 0.1041 0.1041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0081 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0081 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.082 0.1949
Brugia malayi Heterochromatin protein 1 0.0084 0.077 0.0799
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0104 0.1041 0.1041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.037 0.037
Brugia malayi Cytochrome P450 family protein 0.0035 0.0109 0.0113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.099 0.1027
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0104 0.1041 0.1041
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0081 0.0081
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0081 0.0081
Toxoplasma gondii carbamoylphosphate synthetase 0.0066 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0342
Mycobacterium tuberculosis Conserved protein 0.0075 0.0646 0.1062
Schistosoma mansoni coup transcription factor 0.0033 0.0081 0.0081
Brugia malayi beta-lactamase 0.0075 0.0646 0.067
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0135 0.014
Toxoplasma gondii ABC1 family protein 0.0075 0.0646 0.0646
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0081 0.0081
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0701 0.1716
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0104 0.1041 0.3233
Echinococcus granulosus chromobox protein 1 0.0084 0.077 0.077
Loa Loa (eye worm) inositol-1 0.0079 0.0701 0.0727
Brugia malayi glutathione reductase 0.0037 0.014 0.0145
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0104 0.1041 0.172
Brugia malayi glutaminase DH11.1 0.033 0.4082 0.4236
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0104 0.1041 0.2905
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0646 0.1518
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0104 0.1041 0.1041
Onchocerca volvulus 0.0075 0.0646 0.1657
Loa Loa (eye worm) hypothetical protein 0.0054 0.037 0.0384
Onchocerca volvulus 0.0075 0.0646 0.1657
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0066 0.0529 0.0874
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0646 0.1518
Loa Loa (eye worm) hypothetical protein 0.0059 0.0425 0.0441
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0066 0.0529 0.0529
Schistosoma mansoni chromobox protein 0.0084 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0568 0.729 0.7565
Loa Loa (eye worm) glutaminase 0.033 0.4082 0.4236
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.077 1 1
Leishmania major carbamoyl-phosphate synthase, putative 0.0066 0.0529 0.0529
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0081 0.0081
Echinococcus granulosus chromobox protein 1 0.0084 0.077 0.077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.037 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0087 0.0138
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0081 0.0081
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0104 0.1041 0.172
Brugia malayi Bromodomain containing protein 0.0041 0.0193 0.02
Brugia malayi Pre-SET motif family protein 0.0036 0.0122 0.0127
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0109 0.0113
Trichomonas vaginalis chromobox protein, putative 0.0084 0.077 0.1825
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.099 0.099
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0081 0.0084
Leishmania major trypanothione reductase 0.0037 0.014 0.014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0081 0.0081
Brugia malayi mbt repeat family protein 0.0051 0.0329 0.0342
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0081 0.0084
Loa Loa (eye worm) hypothetical protein 0.0046 0.0256 0.0266
Schistosoma mansoni inositol monophosphatase 0.0079 0.0701 0.0701
Brugia malayi Thioredoxin reductase 0.0037 0.014 0.0145
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0109 0.0113
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0293 0.3584 0.8781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.099 0.099
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.077 1 1
Trypanosoma brucei unspecified product 0.0193 0.2232 0.2232
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.077 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0646 0.1518
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.077 0.0799
Loa Loa (eye worm) hypothetical protein 0.0076 0.0664 0.0689
Loa Loa (eye worm) glutaminase 2 0.033 0.4082 0.4236
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0293 0.3584 0.3584
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Brugia malayi beta-lactamase family protein 0.0075 0.0646 0.067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3021 0.3135
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0701 0.0701
Loa Loa (eye worm) hypothetical protein 0.0075 0.0646 0.067
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0104 0.1041 0.2551
Loa Loa (eye worm) hypothetical protein 0.0389 0.4869 0.5052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.099 0.099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0081 0.0081
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0081 0.0081
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.2365 0.2365
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0329 0.0329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0455 0.1114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0081 0.0084
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0293 0.3584 0.3584
Onchocerca volvulus 0.005 0.0308 0.0665
Schistosoma mansoni aspartate carbamoyltransferase 0.0066 0.0529 0.0529
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0646 0.0646
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0425 0.0425
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.0031 0.0031
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0081 0.0081
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0293 0.3584 1
Schistosoma mansoni hypothetical protein 0.018 0.2059 0.2059
Schistosoma mansoni acetyl-CoA carboxylase 0.077 1 1
Onchocerca volvulus 0.0051 0.0329 0.0729
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0784 0.1289
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0087 0.0138
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0066 0.0529 0.0529
Leishmania major carboxylase, putative 0.0293 0.3584 0.3584
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0504 0.0504
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0701 0.1955
Onchocerca volvulus 0.0075 0.0646 0.1657
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.014 0.023
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0293 0.3584 0.3584
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0081 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0081 0.0081
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.014 0.0145
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0504 0.0504
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0329 0.0329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0455 0.1114
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0081 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0646 0.0905
Schistosoma mansoni chromobox protein 0.0084 0.077 0.077
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0646 0.1067
Brugia malayi latrophilin 2 splice variant baaae 0.0389 0.4869 0.5052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0568 0.729 0.7565
Loa Loa (eye worm) T-complex protein 1 0.0029 0.0031 0.0032
Plasmodium vivax SET domain protein, putative 0.0036 0.0122 0.0172
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0066 0.0529 0.0742
Loa Loa (eye worm) hypothetical protein 0.018 0.2059 0.2136
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0293 0.3584 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0701 0.0701
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0109 0.0113
Mycobacterium ulcerans glutaminase 0.033 0.4082 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0912 0.2544
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0701 0.0701
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0104 0.1041 0.1712
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0455 0.0455
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.018 0.2059 0.2059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0081 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0081 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.099 0.099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0081 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0122 0.0122
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.014 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0308 0.0308
Mycobacterium tuberculosis Conserved protein 0.0075 0.0646 0.1062
Trichomonas vaginalis chromobox protein, putative 0.0051 0.032 0.0715
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0081 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0646 0.0646
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0081 0.0084
Schistosoma mansoni pyruvate carboxylase 0.0293 0.3584 0.3584
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0646 0.1801
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0646 0.0646
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0029 0.0031 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0194 0.0201
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0701 0.1654
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0081 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0455 0.0455
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0081 0.0081
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.037 0.037
Plasmodium falciparum glutathione reductase 0.0037 0.014 0.0196
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0701 0.1654
Echinococcus multilocularis chromobox protein 1 0.0084 0.077 0.077
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0081 0.0081
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0031 0.0031
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0104 0.1041 0.2551
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0104 0.1041 0.2551
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0557 0.7136 1
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0066 0.0529 0.1296
Brugia malayi Latrophilin receptor protein 2 0.018 0.2059 0.2136
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0104 0.1041 0.2905
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0081 0.0081
Echinococcus multilocularis chromobox protein 1 0.0084 0.077 0.077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0159 0.0159
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0109 0.0109
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0329 0.0329
Brugia malayi nuclear hormone receptor 0.0033 0.0081 0.0084
Mycobacterium leprae Probable lipase LipE 0.0075 0.0646 0.1801
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0109 0.0181
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.0031 0.0031
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.0031 0.0043
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.0031 0.0032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0105 0.0105
Mycobacterium tuberculosis Probable reductase 0.0085 0.0784 0.1289
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.0031 0.0031
Trypanosoma brucei acetyl-CoA carboxylase 0.077 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0104 0.1041 0.1041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0081 0.0084
Mycobacterium ulcerans pyruvate carboxylase 0.0293 0.3584 0.8781
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0455 0.1114
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0293 0.3584 0.5922
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0081 0.0084
Schistosoma mansoni inositol monophosphatase 0.0079 0.0701 0.0701
Loa Loa (eye worm) hypothetical protein 0.0075 0.0646 0.067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0784 0.1289
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0081 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0646 0.1062
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0425 0.0425
Trichomonas vaginalis chromobox protein, putative 0.0051 0.032 0.0715
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0293 0.3584 0.3584
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0104 0.1041 0.172
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0743 0.9637 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0081 0.0081
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.032 0.0702
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0425 0.0425
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0646 0.1062
Loa Loa (eye worm) beta-lactamase 0.0075 0.0646 0.067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0272 0.0282
Loa Loa (eye worm) MBCTL1 0.0059 0.0425 0.0441
Loa Loa (eye worm) hypothetical protein 0.0075 0.0646 0.067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.037 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0081 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Toxoplasma gondii pyruvate carboxylase 0.0293 0.3584 0.3584
Brugia malayi nuclear receptor NHR-88 0.0033 0.0081 0.0084
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0104 0.1041 0.1041
Trichomonas vaginalis glutaminase, putative 0.033 0.4082 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0701 0.1654
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0104 0.1041 0.1712
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0701 0.0701
Treponema pallidum pyruvate carboxylase subunit B 0.0027 0 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.014 0.0196
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0093 0.0892 0.0925
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0104 0.1041 0.2551
Onchocerca volvulus 0.0037 0.0135 0.0158
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.018 0.2059 0.2059
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0029 0.0031 0.0043
Brugia malayi Carboxyl transferase domain containing protein 0.0743 0.9637 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.6081 1
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0081 0.0084
Schistosoma mansoni hypothetical protein 0.0389 0.4869 0.4869
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0081 0.0084
Brugia malayi beta-lactamase family protein 0.0075 0.0646 0.067
Schistosoma mansoni glutaminase 0.033 0.4082 0.4082
Plasmodium falciparum thioredoxin reductase 0.0037 0.014 0.0196
Brugia malayi Bromodomain containing protein 0.0081 0.0726 0.0753
Schistosoma mansoni hypothetical protein 0.018 0.2059 0.2059
Chlamydia trachomatis biotin carboxylase 0.0266 0.3221 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0293 0.3584 0.8781
Brugia malayi Pre-SET motif family protein 0.0251 0.3021 0.3135
Trypanosoma cruzi acetyl-CoA carboxylase 0.0476 0.6053 1
Onchocerca volvulus 0.0286 0.3489 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0081 0.0084
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0646 0.1062
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0784 0.2187
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0159 0.0159
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0784 0.1289
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0646 0.1067
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0557 0.7136 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0589 0.0969
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Schistosoma mansoni bromodomain containing protein 0.0068 0.0556 0.0556
Brugia malayi chromobox protein homolog 3 0.0047 0.0272 0.0282
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.2365 0.2365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.099 0.099
Schistosoma mansoni hypothetical protein 0.018 0.2059 0.2059
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0329 0.0342
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0414 0.043
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0081 0.0084
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0329 0.0329
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0455 0.0455
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0646 0.1062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0646 0.067
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0455 0.0455
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0701 0.1158
Mycobacterium ulcerans beta-lactamase 0.0075 0.0646 0.1582
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0272 0.0596
Leishmania major hypothetical protein, conserved 0.0075 0.0646 0.0646
Plasmodium vivax glutathione reductase, putative 0.0037 0.014 0.0196
Loa Loa (eye worm) latrophilin receptor protein 2 0.018 0.2059 0.2136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0081 0.0081
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0081 0.0081
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0293 0.3584 0.5894
Mycobacterium ulcerans lipase LipD 0.0075 0.0646 0.1582
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0084
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0646 0.1062
Schistosoma mansoni hypothetical protein 0.0313 0.3846 0.3846
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0131 0.1404 1
Leishmania major acetyl-CoA carboxylase, putative 0.077 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0646 0.1582
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0081 0.0081
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0081 0.0081
Leishmania major cytochrome p450-like protein 0.0035 0.0109 0.0109
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0104 0.1041 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0081 0.0084
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.018 0.2059 0.2059
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0272 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0081 0.0084
Brugia malayi Cytochrome P450 family protein 0.0035 0.0109 0.0113
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0646 0.1518
Loa Loa (eye worm) hypothetical protein 0.0044 0.0228 0.0237
Loa Loa (eye worm) glutathione reductase 0.0037 0.014 0.0145
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0109 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0081 0.0084
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0066 0.0529 0.0529
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0701 0.4877
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0646 0.1582
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0272 0.056
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.018 0.2059 0.2059
Plasmodium falciparum carbamoyl phosphate synthetase 0.0066 0.0529 0.0742
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0066 0.0529 0.1476
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.099 0.1027
Echinococcus granulosus GPCR family 2 0.018 0.2059 0.2059
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0912 0.1499
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0081 0.0081
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0329 0.0729
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0104 0.1041 0.2905
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0081 0.0084
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0293 0.3584 0.5894
Trichomonas vaginalis esterase, putative 0.0075 0.0646 0.1518
Loa Loa (eye worm) hypothetical protein 0.0075 0.0646 0.067
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0646 0.0646
Trypanosoma brucei trypanothione reductase 0.0037 0.014 0.014
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0646 0.1062
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0912 0.1499
Echinococcus multilocularis GPCR, family 2 0.018 0.2059 0.2059

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.