Detailed information for compound 657102

Basic information

Technical information
  • TDR Targets ID: 657102
  • Name: 5-(3-ethoxyphenyl)-N-[(3-nitrophenyl)methylid eneamino]-2H-pyrazole-3-carboxamide
  • MW: 379.369 | Formula: C19H17N5O4
  • H donors: 2 H acceptors: 4 LogP: 2.6 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1)c1n[nH]c(c1)C(=O)N/N=C/c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C19H17N5O4/c1-2-28-16-8-4-6-14(10-16)17-11-18(22-21-17)19(25)23-20-12-13-5-3-7-15(9-13)24(26)27/h3-12H,2H2,1H3,(H,21,22)(H,23,25)/b20-12+
  • InChiKey: DVRMIHPQEIXMQP-UDWIEESQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(3-ethoxyphenyl)-N-[(3-nitrophenyl)methyleneamino]-2H-pyrazole-3-carboxamide
  • 5-(3-ethoxyphenyl)-N-[(3-nitrobenzylidene)amino]-2H-pyrazole-3-carboxamide
  • ST023165

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0037 0.1276 0.2401
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.437 0.8342
Brugia malayi TAR-binding protein 0.0066 0.316 0.5943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.4768 0.4272
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1043 0.1961
Loa Loa (eye worm) hypothetical protein 0.003 0.0865 0.057
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.1302 1
Schistosoma mansoni hypothetical protein 0.0171 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.4768 0.4272
Schistosoma mansoni tar DNA-binding protein 0.0066 0.316 0.2512
Schistosoma mansoni tar DNA-binding protein 0.0066 0.316 0.2512
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.5248 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.437 0.8342
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0865 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.4768 0.4272
Brugia malayi Bromodomain containing protein 0.003 0.0865 0.1626
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.5248 0.4798
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.1334 0.0514
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.1276 0.0451
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.2031 0.3079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.4768 0.4272
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.5248 0.9871
Schistosoma mansoni hypothetical protein 0.0033 0.1043 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0066 0.316 0.2512
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.1276 0.1456
Schistosoma mansoni kinase 0.005 0.213 0.1385
Loa Loa (eye worm) hypothetical protein 0.0048 0.2031 0.3079
Schistosoma mansoni hypothetical protein 0.0035 0.1185 0.0351
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.1302 0.1511
Mycobacterium tuberculosis Probable reductase 0.0084 0.437 0.8342
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.1631 0.0839
Trypanosoma brucei trypanothione reductase 0.0037 0.1302 0.1511
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.1276 0.0451
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0865 0.3771
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.2031 0.382
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.4979 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.437 0.8342
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0865 0.3771
Brugia malayi PHD-finger family protein 0.003 0.0865 0.1626
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1185 0.0351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.4768 0.4272
Schistosoma mansoni jumonji domain containing protein 0.0079 0.4 0.3432
Brugia malayi jmjC domain containing protein 0.0099 0.5317 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.5248 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.437 0.8342
Plasmodium vivax glutathione reductase, putative 0.0037 0.1302 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.5248 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.5248 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.5248 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.316 0.2512
Brugia malayi hypothetical protein 0.0026 0.06 0.1128
Loa Loa (eye worm) hypothetical protein 0.0033 0.1043 0.0953
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.1276 0.0451
Loa Loa (eye worm) hypothetical protein 0.0052 0.2263 0.3578
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.4768 0.8967
Echinococcus multilocularis geminin 0.0171 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.5248 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.1302 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.1302 0.1511
Leishmania major trypanothione reductase 0.0037 0.1302 0.1511
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.4768 0.4272
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.437 0.8342
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.5248 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.5248 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.4768 0.4272
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.5317 0.4874
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.5248 0.4798
Brugia malayi Thioredoxin reductase 0.0037 0.1302 0.2449
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.4979 1
Brugia malayi glutathione reductase 0.0037 0.1302 0.2449
Plasmodium falciparum glutathione reductase 0.0037 0.1302 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.2031 0.382
Loa Loa (eye worm) TAR-binding protein 0.0066 0.316 0.5507
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.2948 0.5053
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.4979 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.316 0.5943
Brugia malayi hypothetical protein 0.0035 0.1185 0.2229
Echinococcus granulosus jumonji domain containing protein 0.0042 0.1631 0.0839
Plasmodium falciparum phd finger protein, putative 0.003 0.0865 0.3771
Loa Loa (eye worm) RNA binding protein 0.0066 0.316 0.5507
Plasmodium vivax hypothetical protein, conserved 0.003 0.0865 0.3771
Giardia lamblia Kinase, PLK 0.0098 0.5248 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.5248 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.4768 0.8967
Toxoplasma gondii thioredoxin reductase 0.0037 0.1302 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1185 0.0351
Brugia malayi RNA binding protein 0.0066 0.316 0.5943
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.5248 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.5248 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.5248 0.4798
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.4979 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.1302 0.1511
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.5248 1
Trypanosoma brucei polo-like protein kinase 0.0098 0.5248 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.316 0.2512
Schistosoma mansoni hypothetical protein 0.0171 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.5248 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.316 0.2512
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.316 0.5507
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.1276 0.0451
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.1334 0.0514
Echinococcus granulosus tar DNA binding protein 0.0066 0.316 0.2512
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1185 0.0351
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.5317 0.4874

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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