Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0148 | 0.5199 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0603 | 0.0603 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.8298 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0745 | 0.0126 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0679 | 0.0818 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0679 | 0.0441 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0679 | 0.0679 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0679 | 0.0441 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1223 | 0.1223 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0679 | 0.0679 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0249 | 0.03 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0679 | 0.1186 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0679 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1223 | 0.0999 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0679 | 0.0679 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0249 | 0.0249 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0106 | 0.35 | 0.5383 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0679 | 0.0679 |
Echinococcus multilocularis | geminin | 0.0166 | 0.5919 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0745 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0679 | 0.0818 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0249 | 0.03 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0056 | 0.1491 | 0.2268 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0745 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0106 | 0.35 | 0.4218 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0249 | 0.0249 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0679 | 0.008 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.0679 | 0.0869 | |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0056 | 0.1491 | 0.2604 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0745 | 0.0509 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0162 | 0.5726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5199 | 0.5199 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0056 | 0.1491 | 0.2604 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0249 | 0.0249 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0679 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0249 | 0.0249 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 0.5726 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0679 | 0.0679 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0249 | 0.0249 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0745 | 0.0126 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0679 | 0.0679 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 0.5726 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0249 | 0.0249 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0106 | 0.35 | 0.5383 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0679 | 0.0818 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0679 | 0.008 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 0.9631 |
Onchocerca volvulus | 0.0035 | 0.0679 | 0.0869 | |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0162 | 0.5726 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.5919 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.8932 | 0.8932 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0679 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0162 | 0.5726 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0679 | 0.0679 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0745 | 0.015 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0679 | 0.0679 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0242 | 0.8932 | 0.8905 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0679 | 0.0679 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0745 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0679 | 0.0441 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0679 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1223 | 0.1223 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.5726 | 0.5726 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0679 | 0.0818 |
Brugia malayi | Probable ClpP-like protease | 0.0162 | 0.5726 | 0.5617 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0162 | 0.5726 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0603 | 0.0364 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0679 | 0.0785 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0249 | 0.0249 |
Onchocerca volvulus | 0.0035 | 0.0679 | 0.0869 | |
Toxoplasma gondii | hypothetical protein | 0.0056 | 0.1491 | 0.1609 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0679 | 0.0818 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0679 | 0.0785 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0679 | 0.0441 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5919 | 0.5657 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0679 | 0.0679 |
Schistosoma mansoni | glutaminase | 0.0268 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 0.9631 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0106 | 0.35 | 0.5936 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1223 | 0.0999 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0106 | 0.35 | 0.4218 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5919 | 0.5657 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0162 | 0.5726 | 0.5452 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0162 | 0.5726 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0679 | 0.0818 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0679 | 0.0818 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0679 | 0.0818 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0679 | 0.0818 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0745 | 0.015 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0679 | 0.0818 |
Brugia malayi | hypothetical protein | 0.0148 | 0.5199 | 0.5077 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0745 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.