Detailed information for compound 657136

Basic information

Technical information
  • TDR Targets ID: 657136
  • Name: 1-(4-methylsulfanylphenyl)-N-(4-phenylpiperaz in-1-yl)methanimine
  • MW: 311.444 | Formula: C18H21N3S
  • H donors: 0 H acceptors: 0 LogP: 4.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)C=NN1CCN(CC1)c1ccccc1
  • InChi: 1S/C18H21N3S/c1-22-18-9-7-16(8-10-18)15-19-21-13-11-20(12-14-21)17-5-3-2-4-6-17/h2-10,15H,11-14H2,1H3/b19-15-
  • InChiKey: FEUJFHLHUSWSKD-CYVLTUHYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(methylthio)phenyl]-N-(4-phenyl-1-piperazinyl)methanimine
  • (Z)-[4-(methylthio)benzylidene]-(4-phenylpiperazin-1-yl)amine
  • ZINC00136459

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0191 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni pyruvate kinase 0.0035 0.0211 0.0211
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0397 0.0397
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0504 0.5964 1
Plasmodium falciparum phd finger protein, putative 0.0033 0.0183 0.1487
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium falciparum serine repeat antigen 5 0.0034 0.0191 0.1556
Entamoeba histolytica hypothetical protein 0.0034 0.0191 0.0962
Schistosoma mansoni pyruvate kinase 0.0035 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0084 0.0807 0.1343
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0397 0.0397
Echinococcus granulosus lysine specific demethylase 5A 0.0171 0.1881 0.1881
Echinococcus granulosus phd:f box containing protein 0.0045 0.0332 0.0332
Plasmodium falciparum serine repeat antigen 3 0.0034 0.0191 0.1556
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0611 0.0611
Brugia malayi hypothetical protein 0.0079 0.075 0.1106
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0191 0.0153
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0211 0.1066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0118 0.1228 0.5805
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0611 0.2268
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0191 0.0153
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0211 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Echinococcus multilocularis lysine specific demethylase 6a 0.0045 0.0332 0.0332
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0191 0.0309
Loa Loa (eye worm) hypothetical protein 0.0051 0.0404 0.0666
Brugia malayi Cathepsin L-like precursor 0.0084 0.0807 0.1205
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0807 0.6291
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0047 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0057 0.0482 0.0798
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0179 0.1977 0.3093
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1259 0.1259
Schistosoma mansoni jumonji domain containing protein 0.0045 0.0332 0.0332
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0611 0.087
Chlamydia trachomatis pyruvate kinase 0.0035 0.0211 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.0695 0.1156
Brugia malayi jmjC domain containing protein 0.0238 0.2692 0.4419
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0034 0.0191 0.1556
Loa Loa (eye worm) hypothetical protein 0.0118 0.1228 0.2049
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0397 0.0397
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.042 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax vivapain-1 0.0068 0.0611 0.4979
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0191 0.212 1
Schistosoma mansoni cathepsin F (C01 family) 0.0118 0.1228 0.1228
Schistosoma mansoni bromodomain containing protein 0.0067 0.0599 0.0599
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0191 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0613 0.1018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0171 0.1881 0.1881
Echinococcus granulosus tumor protein p63 0.0357 0.4162 0.4162
Toxoplasma gondii cathepsin CPC1 0.0034 0.0191 0.0966
Echinococcus multilocularis cathepsin L cysteine protease 0.0118 0.1228 0.1228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0371 0.0371
Toxoplasma gondii preprocathepsin c precursor, putative 0.0034 0.0191 0.0966
Echinococcus granulosus muscleblind protein 0.0158 0.1716 0.1716
Entamoeba histolytica cysteine protease, putative 0.0118 0.1228 0.9925
Onchocerca volvulus 0.0118 0.1228 0.5405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0504 0.5964 0.5964
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0211 0.5
Schistosoma mansoni hypothetical protein 0.0079 0.075 0.075
Echinococcus multilocularis protein dispatched 1 0.0058 0.0492 0.0492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni protein phosphatase 2C 0.0045 0.0332 0.0332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0321
Onchocerca volvulus 0.0118 0.1228 0.5405
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0191 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0611 0.0611
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0211 0.0342
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0332 0.0244
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.1543 0.1543
Echinococcus granulosus cathepsin b 0.0504 0.5964 0.5964
Schistosoma mansoni phd/f-box containing protein 0.0045 0.0332 0.0332
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0238 0.2692 0.2692
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0482 0.0482
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0404 0.0666
Toxoplasma gondii cathepsin CPC2 0.0034 0.0191 0.0966
Loa Loa (eye worm) hypothetical protein 0.0033 0.0177 0.0286
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0191 0.0191
Echinococcus granulosus cathepsin L cysteine proteinase 0.0118 0.1228 0.1228
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0244 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0045 0.0332 0.0546
Plasmodium falciparum serine repeat antigen 7 0.0034 0.0191 0.1556
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0482 0.0482
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0191 0.1556
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0034 0.0191 0.1556
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0183 0.0924
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0244 0.0244
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Schistosoma mansoni zinc finger protein 0.0021 0.0032 0.0032
Plasmodium falciparum serine repeat antigen 4 0.0034 0.0191 0.1556
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0198 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3281 0.3281
Onchocerca volvulus 0.0058 0.0492 0.1621
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0034 0.0191 0.1556
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0118 0.1228 0.2049
Brugia malayi Bromodomain containing protein 0.0041 0.0275 0.0296
Entamoeba histolytica cysteine proteinase 1, putative 0.0068 0.0611 0.4596
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1236 0.1236
Loa Loa (eye worm) hypothetical protein 0.0045 0.0332 0.0546
Echinococcus granulosus pyruvate kinase 0.0035 0.0211 0.0211
Onchocerca volvulus 0.0052 0.042 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Echinococcus multilocularis zinc finger protein 0.0021 0.0032 0.0032
Echinococcus granulosus lamin 0.0033 0.0177 0.0177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0504 0.5964 0.5964
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0045 0.0332 0.0332
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0045 0.0332 0.0687
Echinococcus multilocularis cysteine protease 0.0118 0.1228 0.1228
Echinococcus granulosus cathepsin l1 0.0118 0.1228 0.1228
Entamoeba histolytica cysteine proteinase, putative 0.0118 0.1228 0.9925
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0332 0.0546
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0118 0.1228 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1716 0.2869
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0371 0.0612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Loa Loa (eye worm) hypothetical protein 0.0062 0.0544 0.0902
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0211 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0371 0.0371
Brugia malayi CHE-14 protein 0.0051 0.0404 0.0516
Giardia lamblia Cathepsin L-like protease 0.0034 0.0191 0.0966
Plasmodium vivax unspecified product 0.0034 0.0191 0.1556
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.1411 0.1411
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0552 0.0552
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0332 0.0546
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0211 0.0187
Onchocerca volvulus 0.0118 0.1228 0.5405
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Schistosoma mansoni cathepsin F (C01 family) 0.0118 0.1228 0.1228
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Trypanosoma cruzi cysteine protease, putative 0.0068 0.0611 0.0728
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0321
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1236 0.1936
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0179 0.1977 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0211 0.5
Plasmodium vivax vivapain-3 0.0068 0.0611 0.4979
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Loa Loa (eye worm) hypothetical protein 0.0084 0.0807 0.1343
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0179 0.1977 0.1977
Schistosoma mansoni patched 1 0.0051 0.0404 0.0404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Brugia malayi Cathepsin L-like cysteine proteinase 0.0084 0.0807 0.1205
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0183 0.0183
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0504 0.5964 0.5964
Echinococcus multilocularis expressed conserved protein 0.0112 0.1148 0.1148
Echinococcus multilocularis JmjC domain containing protein 4 0.0045 0.0332 0.0332
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0179 0.1977 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0034 0.0191 0.1556
Echinococcus multilocularis cathepsin L 0.0068 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0091 0.0895 0.1491
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0118 0.1228 0.2049
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0198 0.0165
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0321
Echinococcus multilocularis muscleblind protein 0.0158 0.1716 0.1716
Loa Loa (eye worm) ctsf protein 0.0118 0.1228 0.2049
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0045 0.0332 0.168
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0177 0.0286
Toxoplasma gondii cathepsin CPL 0.0118 0.1228 0.6211
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.2217 0.2217
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0404 0.0404
Onchocerca volvulus Cathepsin F homolog 0.0118 0.1228 0.5405
Loa Loa (eye worm) MBCTL1 0.0057 0.0482 0.0798
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Entamoeba histolytica cysteine proteinase 2 0.0068 0.0611 0.4596
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Echinococcus granulosus JmjC domain containing protein 4 0.0045 0.0332 0.0332
Echinococcus granulosus cathepsin L 0.0034 0.0191 0.0191
Echinococcus granulosus peregrin 0.0035 0.0213 0.0213
Onchocerca volvulus Cathepsin L homolog 0.0118 0.1228 0.5405
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0611 0.0728
Plasmodium vivax vivapain-2 0.0118 0.1228 1
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1236 0.1236
Echinococcus multilocularis lysine specific demethylase 5A 0.0169 0.1856 0.1856
Plasmodium vivax unspecified product 0.0068 0.0611 0.4979
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0482 0.065
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0211 0.0172
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0034 0.0191 0.1556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1862 0.1862
Plasmodium falciparum serine repeat antigen 9 0.0034 0.0191 0.1556
Schistosoma mansoni phosphatidylserine receptor 0.0045 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Onchocerca volvulus 0.0118 0.1228 0.5405
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Plasmodium falciparum serine repeat antigen 2 0.0034 0.0191 0.1556
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0191 0.0153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0183 0.0295
Plasmodium vivax unspecified product 0.0034 0.0198 0.1613
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Echinococcus multilocularis geminin 0.0179 0.1977 0.1977
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Plasmodium falciparum cysteine proteinase falcipain 3 0.0118 0.1228 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0084 0.0807 0.1068
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Giardia lamblia Cathepsin B precursor 0.0179 0.1977 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0371 0.0371
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni lamin 0.0033 0.0177 0.0177
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0191 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Loa Loa (eye worm) cysteine protease 0.0118 0.1228 0.2049
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.007 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Plasmodium falciparum serine repeat antigen 6 0.0034 0.0191 0.1556
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0611 0.0728
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0191 0.1556
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0492 0.0667
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0068 0.0611 0.0728
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0034 0.0191 0.0191
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Schistosoma mansoni hypothetical protein 0.0307 0.354 0.354
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0183 0.0295
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0397 0.0397
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0611 0.0611
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0211 0.5
Echinococcus multilocularis cathepsin L 0.0034 0.0191 0.0191
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0191 0.0966
Loa Loa (eye worm) jmjC domain-containing protein 0.0171 0.1881 0.3146
Brugia malayi cathepsin L-like cysteine proteinase 0.0034 0.0191 0.0153
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0191 0.0966
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0211 0.0342
Loa Loa (eye worm) hypothetical protein 0.0032 0.017 0.0274
Loa Loa (eye worm) hypothetical protein 0.0043 0.0306 0.0503
Brugia malayi hypothetical protein 0.0286 0.3281 0.5423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0611 0.2353
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Onchocerca volvulus 0.005 0.0397 0.113
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0047 0.0357 0.0357
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Brugia malayi mbt repeat family protein 0.005 0.0397 0.0504
Loa Loa (eye worm) hypothetical protein 0.0084 0.0807 0.1343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0611 0.2353
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0177 0.0286
Echinococcus multilocularis jumonji domain containing 1A 0.0045 0.0332 0.0332
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0191 0.0309
Giardia lamblia Cathepsin B precursor 0.0179 0.1977 1
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium falciparum serine repeat antigen 1 0.0034 0.0191 0.1556
Echinococcus granulosus lamin dm0 0.0033 0.0177 0.0177
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1543 0.1543
Echinococcus multilocularis pyruvate kinase 0.0035 0.0211 0.0211
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1543 0.1543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0807 0.3452
Schistosoma mansoni lamin 0.0033 0.0177 0.0177
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Echinococcus granulosus cathepsin L cysteine protease 0.0068 0.0611 0.0611
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0371 0.0461
Plasmodium falciparum serine repeat antigen 8 0.0034 0.0191 0.1556
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Echinococcus granulosus cathepsin l1 0.0084 0.0807 0.0807
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0034 0.0191 0.1556
Schistosoma mansoni hypothetical protein 0.0033 0.0183 0.0183
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0482 0.0482
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0183 0.0183
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Brugia malayi mbt repeat family protein 0.005 0.0397 0.0504
Echinococcus multilocularis musashi 0.0033 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0611 0.2268
Echinococcus multilocularis phd:f box containing protein 0.0045 0.0332 0.0332
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0238 0.2692 0.2692
Echinococcus granulosus jumonji domain containing 1A 0.0045 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0122
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0046 0.0065
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Giardia lamblia PHD finger protein 15 0.0033 0.0183 0.0924
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0211 0.0034
Echinococcus multilocularis lamin 0.0033 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.0342
Brugia malayi PHD-finger family protein 0.0033 0.0183 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0807 0.3452
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0552 0.0552
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0332 0.0244
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0191 0.0966
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0341 0.0341
Leishmania major cysteine peptidase A (CPA) 0.0118 0.1228 0.5758
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0034 0.0191 0.0966
Giardia lamblia Hypothetical protein 0.0034 0.0191 0.0966
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0034 0.0191 0.1556
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0183 0.0924
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Brugia malayi cathepsin L-like precursor 0.0084 0.0807 0.1205
Echinococcus granulosus geminin 0.0179 0.1977 0.1977
Schistosoma mansoni intermediate filament proteins 0.0033 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0058 0.0492 0.0492
Trypanosoma cruzi cruzipain precursor, putative 0.0034 0.0198 0.0012
Leishmania major hypothetical protein, conserved 0.0045 0.0332 0.0687
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0034 0.0198 0.0165
Schistosoma mansoni survival motor neuron protein 0.0058 0.0492 0.0492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0371 0.0371
Echinococcus multilocularis cathepsin b 0.0504 0.5964 0.5964
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.0654
Loa Loa (eye worm) hypothetical protein 0.0191 0.212 0.3547
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0371 0.0371
Onchocerca volvulus 0.0084 0.0807 0.3242
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0504 0.5964 0.5964
Brugia malayi Cathepsin L-like precursor 0.0084 0.0807 0.1205
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0397 0.0654
Giardia lamblia Cathepsin L-like protease 0.0034 0.0191 0.0966
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0397 0.0397
Schistosoma mansoni cathepsin S (C01 family) 0.0034 0.0191 0.0191
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0177 0.013
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Onchocerca volvulus Alhambra homolog 0.0033 0.0183 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Brugia malayi Papain family cysteine protease containing protein 0.0118 0.1228 0.1921
Schistosoma mansoni cathepsin C 0.0034 0.0191 0.0191
Echinococcus multilocularis cathepsin L cysteine protease 0.0118 0.1228 0.1228
Schistosoma mansoni hypothetical protein 0.0133 0.1411 0.1411
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0034 0.0191 0.0153
Echinococcus granulosus cysteine protease 0.0068 0.0611 0.0611
Brugia malayi intermediate filament protein 0.0033 0.0177 0.013
Onchocerca volvulus 0.0034 0.0191 0.007
Brugia malayi fibroinase precursor 0.0034 0.0191 0.0153
Schistosoma mansoni cathepsin s 0.0034 0.0198 0.0198
Giardia lamblia Pyruvate kinase 0.0035 0.0211 0.1066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0341 0.0341
Echinococcus multilocularis cathepsin b 0.0504 0.5964 0.5964
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.007 0.007
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0045 0.0332 0.168
Schistosoma mansoni hypothetical protein 0.0179 0.1977 0.1977
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Loa Loa (eye worm) hypothetical protein 0.0286 0.3281 0.5495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Trypanosoma brucei cysteine peptidase C (CPC) 0.0179 0.1977 1
Onchocerca volvulus 0.0118 0.1228 0.5405
Schistosoma mansoni cathepsin F (C01 family) 0.0084 0.0807 0.0807
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0118 0.1228 1
Echinococcus granulosus cathepsin L 0.0068 0.0611 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0183 0.1487
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0034 0.0191 0.1556
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0211 0.0342
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0611 0.087
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1716 0.1716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Brugia malayi Muscleblind-like protein 0.0158 0.1716 0.2755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax vivapain-2 0.0118 0.1228 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0118 0.1228 0.1228
Loa Loa (eye worm) hypothetical protein 0.0504 0.5964 1
Trypanosoma cruzi cruzipain precursor, putative 0.0118 0.1228 0.1795
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0451
Schistosoma mansoni hypothetical protein 0.0022 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0397 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0118 0.1228 0.1228
Loa Loa (eye worm) hypothetical protein 0.0052 0.042 0.0692
Giardia lamblia Hypothetical protein 0.0034 0.0191 0.0966
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0404 0.1191
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1862 0.1862
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0034 0.0191 0.0309
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0191 0.0153
Plasmodium falciparum cysteine proteinase falcipain 1 0.0068 0.0611 0.4979
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0611 0.0728
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0191 0.0962
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0034 0.0191 0.1556
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0397 0.113
Loa Loa (eye worm) hypothetical protein 0.0119 0.1236 0.2063
Loa Loa (eye worm) cathepsin B 0.0179 0.1977 0.3306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Echinococcus granulosus cathepsin b 0.0504 0.5964 0.5964
Onchocerca volvulus Cathepsin L homolog 0.0118 0.1228 0.5405
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Schistosoma mansoni cathepsin B (C01 family) 0.0034 0.0191 0.0191
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.008 0.0122
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.075 0.075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni jumonji/arid domain-containing protein 0.0171 0.1881 0.1881
Echinococcus multilocularis lamin dm0 0.0033 0.0177 0.0177
Echinococcus granulosus zinc finger protein 0.0021 0.0032 0.0032
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0211 0.0187
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.075 0.075
Echinococcus multilocularis pyruvate kinase 0.0035 0.0211 0.0211
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0371 0.0371
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Onchocerca volvulus 0.0118 0.1228 0.5405
Giardia lamblia Cathepsin B precursor 0.0179 0.1977 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.1411 0.1411
Echinococcus multilocularis cysteine protease 0.0118 0.1228 0.1228
Entamoeba histolytica cysteine proteinase, putative 0.0118 0.1228 0.9925
Plasmodium falciparum JmjC domain-containing protein, putative 0.0045 0.0332 0.2705
Brugia malayi Bromodomain containing protein 0.0079 0.0751 0.1109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0211 0.1716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0404 0.0404
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Brugia malayi jmjC domain containing protein 0.0171 0.1881 0.3036
Echinococcus multilocularis pyruvate kinase 0.0028 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0179 0.1977 0.1977
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0191 0.0153
Echinococcus granulosus expressed conserved protein 0.0112 0.1148 0.1148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0034 0.0191 0.1556
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0045 0.0331 0.0544
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Plasmodium vivax JmjC domain containing protein 0.0045 0.0332 0.2705
Brugia malayi Bromodomain containing protein 0.0035 0.0213 0.0191
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.007 0.007
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0191 0.1556
Echinococcus multilocularis peregrin 0.0035 0.0213 0.0213
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Brugia malayi N-terminal motif family protein 0.0191 0.212 0.3444
Echinococcus granulosus lysine specific demethylase 6a 0.0045 0.0332 0.0332
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0211 0.011
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3281 0.3281
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0332 0.0546
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Plasmodium falciparum pyruvate kinase 0.0035 0.0211 0.1716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Brugia malayi cathepsin L precursor 0.0034 0.0191 0.0153
Echinococcus granulosus pyruvate kinase 0.0035 0.0211 0.0211
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0183 0.0183
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0034 0.0191 0.0191
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0482 0.0482
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.2217 0.2217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Brugia malayi cathepsin B-like cysteine proteinase 0.0504 0.5964 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0211 0.0034
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.075 0.075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni jumonji domain containing protein 0.0215 0.2419 0.2419
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1236 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0198 0.0165
Toxoplasma gondii cathepsin B 0.0179 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1716 0.2869
Onchocerca volvulus 0.0118 0.1228 0.5405
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0211 0.011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0198 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0371 0.0371
Echinococcus granulosus cathepsin l cysteine peptidase 0.0118 0.1228 0.1228
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Loa Loa (eye worm) fibroinase 0.0118 0.1228 0.2049
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0191 0.1556
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0034 0.0191 0.1556
Echinococcus multilocularis tumor protein p63 0.0357 0.4162 0.4162
Echinococcus multilocularis protein patched 0.0051 0.0404 0.0404
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Giardia lamblia Encystation-specific protease 0.0034 0.0191 0.0966

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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