Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0221 | 0.034 | 0.034 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0376 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0376 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.9604 | 0.9604 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | GnHR receptor homolog | 0.0221 | 0.034 | 0.5 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0221 | 0.034 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0222 | 0.0396 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0221 | 0.034 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | neuropeptide F receptor | 0.0221 | 0.034 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Dopamine receptor protein 2 | 0.0221 | 0.034 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0221 | 0.034 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0221 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Dopamine receptor protein 1 | 0.0221 | 0.034 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0221 | 0.034 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0376 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Serotonin receptor | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Dopamine receptor | 0.0221 | 0.034 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0376 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0221 | 0.034 | 0.034 |
Giardia lamblia | Hypothetical protein | 0.0222 | 0.0396 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0222 | 0.0396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0221 | 0.034 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0221 | 0.034 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0222 | 0.0396 | 0.5 |
Onchocerca volvulus | 0.0376 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | AKH receptor | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0221 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | putative neuropeptide receptor | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0221 | 0.034 | 0.5 |
Brugia malayi | RE15519p | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | Serotonin receptor | 0.0221 | 0.034 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Brugia malayi | hypothetical protein | 0.0221 | 0.034 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0221 | 0.034 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Mycobacterium ulcerans | hypothetical protein | 0.0222 | 0.0396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.034 | 0.034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus (SFCO-1a) | ChEMBL. | 2502627 |
MIC (functional) | = 8 ug ml-1 | In vitro minimum inhibitory concentration against Enterococcus faecalis (STCO-19) | ChEMBL. | 2502627 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.