Detailed information for compound 658168

Basic information

Technical information
  • TDR Targets ID: 658168
  • Name: (Z)-(2-bromobenzylidene)-[4-(2-chlorobenzyl)p iperazin-1-yl]amine
  • MW: 392.721 | Formula: C18H19BrClN3
  • H donors: 0 H acceptors: 0 LogP: 4.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1CN1CCN(CC1)N=Cc1ccccc1Br
  • InChi: 1S/C18H19BrClN3/c19-17-7-3-1-5-15(17)13-21-23-11-9-22(10-12-23)14-16-6-2-4-8-18(16)20/h1-8,13H,9-12,14H2/b21-13-
  • InChiKey: FLTQNBFKEVWGHR-BKUYFWCQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.074 0.1118
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0144 0.0218
Schistosoma mansoni glutaminase 0.027 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.2501 0.235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.1709 0.2583
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0118 0.4192 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.1709 0.2583
Loa Loa (eye worm) hypothetical protein 0.0029 0.0782 0.0664
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.2148 0.2148
Brugia malayi RNA binding protein 0.0074 0.2501 0.235
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0074 0.2501 0.378
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0672 0.0484
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0672 0.0554
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.101 0.1525
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0013 0.0144 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2501 0.2501
Onchocerca volvulus 0.0029 0.0782 0.0137
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0198 0.0074
Plasmodium falciparum MO15-related protein kinase 0.0118 0.4192 0.5
Brugia malayi Latrophilin receptor protein 2 0.0035 0.101 0.0828
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.101 0.1525
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.101 0.0828
Echinococcus granulosus tar DNA binding protein 0.0074 0.2501 0.378
Echinococcus granulosus lamin dm0 0.0027 0.0672 0.1016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.753 0.7499
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.2148 1
Loa Loa (eye worm) RNA binding protein 0.0074 0.2501 0.2406
Echinococcus multilocularis musashi 0.0027 0.0672 0.1016
Echinococcus multilocularis geminin 0.0182 0.6618 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.2148 0.2148
Brugia malayi glutaminase DH11.1 0.027 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.101 0.101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.2148 0.2148
Echinococcus granulosus GPCR family 2 0.0035 0.101 0.1525
Echinococcus multilocularis lamin 0.0027 0.0672 0.1016
Brugia malayi intermediate filament protein 0.0027 0.0672 0.0484
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0782 0.1181
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0782 0.1181
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.2148 0.3245
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.101 0.0895
Schistosoma mansoni hypothetical protein 0.0076 0.2586 0.2586
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0672 0.0554
Loa Loa (eye worm) hypothetical protein 0.0026 0.0654 0.0535
Echinococcus granulosus intermediate filament protein 0.0027 0.0672 0.1016
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0144 0.0218
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.101 0.1525
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1709 0.1709
Brugia malayi TAR-binding protein 0.0074 0.2501 0.235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.1709 0.2583
Echinococcus multilocularis GPCR, family 2 0.0035 0.101 0.1525
Schistosoma mansoni hypothetical protein 0.0035 0.101 0.101
Brugia malayi Pre-SET motif family protein 0.0205 0.753 0.748
Trichomonas vaginalis glutaminase, putative 0.027 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.101 0.101
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2501 0.2501
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.3944 0.3867
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0782 0.0782
Brugia malayi hypothetical protein 0.0121 0.4289 0.4174
Schistosoma mansoni hypothetical protein 0.0182 0.6618 0.6618
Loa Loa (eye worm) hypothetical protein 0.0035 0.101 0.0895
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0782 0.0782
Brugia malayi Pre-SET motif family protein 0.0029 0.0782 0.0595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1709 0.1709
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.1709 0.1542
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2501 0.2501
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.2148 0.5
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0121 0.4289 0.4217
Mycobacterium ulcerans glutaminase 0.027 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.2501 0.2406
Schistosoma mansoni hypothetical protein 0.0182 0.6618 0.6618
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.2148 0.2148
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.3944 0.3821
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.2586 0.2436
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0782 0.0782
Onchocerca volvulus Huntingtin homolog 0.0121 0.4289 0.4552
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0782 0.0782
Loa Loa (eye worm) TAR-binding protein 0.0074 0.2501 0.2406
Schistosoma mansoni lamin 0.0027 0.0672 0.0672
Schistosoma mansoni intermediate filament proteins 0.0027 0.0672 0.0672
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.2148 0.4392
Schistosoma mansoni hypothetical protein 0.0035 0.101 0.101
Echinococcus multilocularis lamin dm0 0.0027 0.0672 0.1016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0672 0.0554
Loa Loa (eye worm) hypothetical protein 0.0121 0.4289 0.4217
Onchocerca volvulus Huntingtin homolog 0.0121 0.4289 0.4552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.1709 0.1709
Loa Loa (eye worm) glutaminase 0.027 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.2148 0.3245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.1709 0.2583
Schistosoma mansoni lamin 0.0027 0.0672 0.0672
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.2148 0.2148
Echinococcus granulosus lamin 0.0027 0.0672 0.1016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.101 0.1525
Trichomonas vaginalis set domain proteins, putative 0.0234 0.8619 0.8619
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.1709 0.1604
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0111 0.3892 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.3944 0.3821
Loa Loa (eye worm) hypothetical protein 0.0076 0.2586 0.2491
Echinococcus granulosus geminin 0.0182 0.6618 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.3944 0.3867
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0782 0.1181
Onchocerca volvulus 0.0234 0.8619 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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