Detailed information for compound 658246

Basic information

Technical information
  • TDR Targets ID: 658246
  • Name: N-[2-(3-chlorophenyl)-1,3-benzoxazol-5-yl]-3, 4,5-trimethoxybenzamide
  • MW: 438.86 | Formula: C23H19ClN2O5
  • H donors: 1 H acceptors: 2 LogP: 4.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)Nc1ccc2c(c1)nc(o2)c1cccc(c1)Cl
  • InChi: 1S/C23H19ClN2O5/c1-28-19-10-14(11-20(29-2)21(19)30-3)22(27)25-16-7-8-18-17(12-16)26-23(31-18)13-5-4-6-15(24)9-13/h4-12H,1-3H3,(H,25,27)
  • InChiKey: IYJDVXHRKDWDCA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(3-chlorophenyl)-1,3-benzoxazol-5-yl]-3,4,5-trimethoxy-benzamide
  • TULIP026695
  • Oprea1_779133
  • ChemDiv1_001559

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0481 0.0481
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0022 0.0282 0.0334
Plasmodium vivax PST-A protein 0.0022 0.0282 0.0334
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0248 0.0294
Trypanosoma brucei unspecified product 0.0014 0.01 0.0118
Plasmodium vivax PST-A protein 0.0022 0.0282 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Echinococcus multilocularis dna polymerase eta 0.002 0.0248 0.0248
Echinococcus granulosus dna polymerase kappa 0.002 0.0248 0.0248
Mycobacterium ulcerans hypothetical protein 0.0369 0.8445 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0902 0.0902
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0046 0.0054
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0759 0.0759
Onchocerca volvulus Alhambra homolog 0.003 0.0481 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0481 0.0481
Brugia malayi jmjC domain containing protein 0.0038 0.0671 0.0671
Schistosoma mansoni hypothetical protein 0.0031 0.0505 0.0505
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0053 0.1005 0.1005
Plasmodium vivax PST-A protein 0.0022 0.0282 0.0334
Trypanosoma brucei unspecified product 0.0014 0.01 0.0118
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0053 0.1005 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.1031 0.9401
Brugia malayi PHD-finger family protein 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0435 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.268 0.268
Schistosoma mansoni peptidase 0.0022 0.0282 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0248 0.0294
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0248 0.0248
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0022 0.0282 0.2571
Schistosoma mansoni hypothetical protein 0.0067 0.1356 0.1356
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0282 0.0334
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0053 0.1005 0.0923
Giardia lamblia PHD finger protein 15 0.003 0.0481 0.2978
Trypanosoma brucei protein kinase, putative 0.0054 0.1031 0.1221
Brugia malayi Bromodomain containing protein 0.003 0.0481 0.0481
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0282 0.0334
Echinococcus granulosus abhydrolase domain containing 3 0.0022 0.0282 0.0282
Schistosoma mansoni fatty-acid amide hydrolase 0.0435 1 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0481 0.0481
Schistosoma mansoni amidase 0.0435 1 1
Schistosoma mansoni hypothetical protein 0.0051 0.0964 0.0964
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0022 0.0282 0.0334
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1031 0.1221
Plasmodium falciparum prodrug activation and resistance esterase 0.0022 0.0282 0.0334
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.1031 0.1221
Brugia malayi jmjC domain containing protein 0.0099 0.2098 0.2098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.2091 0.2091
Mycobacterium ulcerans hypothetical protein 0.0022 0.0282 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0505 0.0505
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0481 0.4388
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0177 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0282 0.0041
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0282 0.0041
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0053 0.1005 0.5
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0248 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.01 0.0118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0505 0.0505
Entamoeba histolytica hypothetical protein 0.0022 0.0282 0.0041
Toxoplasma gondii hypothetical protein 0.0022 0.0282 0.2571
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0282 0.0041
Echinococcus multilocularis abhydrolase domain containing 3 0.0022 0.0282 0.0282
Echinococcus granulosus abhydrolase domain containing protein 13 0.0022 0.0282 0.0282
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.2098 0.2098
Mycobacterium ulcerans amidase 0.0053 0.1005 0.0923
Echinococcus granulosus Phospholipase carboxylesterase 0.0022 0.0282 0.0282
Plasmodium vivax unspecified product 0.0022 0.0282 0.0334
Brugia malayi MH2 domain containing protein 0.0124 0.268 0.268
Plasmodium falciparum BEM46-like protein, putative 0.0022 0.0282 0.0334
Schistosoma mansoni hypothetical protein 0.0031 0.0505 0.0505
Mycobacterium ulcerans amidase 0.0053 0.1005 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1238 0.1238
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0671 0.0671
Brugia malayi hypothetical protein 0.0249 0.562 0.562
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0481 0.0481
Brugia malayi Amidase family protein 0.0053 0.1005 0.1005
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1031 0.0955
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0282 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0248 0.0248
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0282 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0282 0.0334
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0217 0.0217
Trypanosoma cruzi amidase, putative 0.0053 0.1005 0.1189
Echinococcus multilocularis GPCR, family 2 0.0031 0.0505 0.0505
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0505 0.0505
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0282 0.0334
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0248 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Brugia malayi Amidase family protein 0.0053 0.1005 0.1005
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0248 0.0248
Entamoeba histolytica ;Alias 0.0022 0.0282 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0053 0.1005 0.0923
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0505 0.0505
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0631 0.0631
Mycobacterium ulcerans amidase 0.0053 0.1005 0.0923
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0053 0.1005 0.0923
Schistosoma mansoni DNA polymerase eta 0.002 0.0248 0.0248
Echinococcus multilocularis cpg binding protein 0.0031 0.051 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1255 0.1255
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0248 0.0294
Brugia malayi MAP kinase sur-1 0.0054 0.1031 0.1031
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0022 0.0282 0.0334
Leishmania major hypothetical protein, conserved 0.0022 0.0282 0.0334
Brugia malayi putative amidase 0.0053 0.1005 0.1005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.2091 0.2091
Plasmodium vivax lysophospholipase, putative 0.0022 0.0282 0.0334
Plasmodium vivax lysophospholipase, putative 0.0022 0.0282 0.0334
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.562 0.562
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.8445 1
Schistosoma mansoni jumonji domain containing protein 0.0079 0.1619 0.1619
Plasmodium falciparum phd finger protein, putative 0.003 0.0481 0.057
Schistosoma mansoni cpg binding protein 0.0031 0.051 0.051
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0282 0.0282
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0248 0.0294
Schistosoma mansoni cpg binding protein 0.0031 0.051 0.051
Brugia malayi MGC83647 protein 0.0022 0.0282 0.0282
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.1031 0.1031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0902 0.0902
Plasmodium vivax lysophospholipase, putative 0.0022 0.0282 0.0334
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0471 0.0471
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0282 0.0334
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1031 0.0955
Trypanosoma brucei monoglyceride lipase, putative 0.0369 0.8445 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0671 0.0671
Echinococcus granulosus GPCR family 2 0.0031 0.0505 0.0505
Plasmodium falciparum lysophospholipase, putative 0.0369 0.8445 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.1031 0.1031
Toxoplasma gondii protein c14orf29, putative 0.0022 0.0282 0.2571
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Echinococcus granulosus cpg binding protein 0.0031 0.051 0.051
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.003 0.0471 0.0471
Echinococcus multilocularis Phospholipase carboxylesterase 0.0022 0.0282 0.0282
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0282 0.0334
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0053 0.1005 0.1189
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0022 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0099 0.2091 0.2091
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0248 0.0294
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0282 0.0334
Schistosoma mansoni fatty-acid amide hydrolase 0.0053 0.1005 0.1005
Brugia malayi PHD-finger family protein 0.003 0.0481 0.0481
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0282 0.0041
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0248 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.01 0.0118
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0022 0.0282 0.0334
Mycobacterium ulcerans lysophospholipase 0.0369 0.8445 1
Plasmodium vivax PST-A protein 0.0369 0.8445 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0369 0.8445 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0053 0.1005 0.1005
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0022 0.0282 0.0334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0282 0.0282
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.1031 0.1031
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.1031 0.1221
Echinococcus multilocularis peregrin 0.003 0.0481 0.0481
Trypanosoma brucei unspecified product 0.002 0.0248 0.0294
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0282 0.0041
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0022 0.0282 0.0334
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0053 0.1005 0.1005
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0369 0.8445 1
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0053 0.1005 0.0923
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1356 0.1356
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.8445 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Mycobacterium ulcerans amidase 0.0053 0.1005 0.0923
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0022 0.0282 0.2571
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0248 0.0248
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0022 0.0282 0.0282
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0369 0.8445 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0902 0.0902
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0282 0.0041
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1097 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0902 0.0902
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.1031 0.1221
Plasmodium vivax hypothetical protein, conserved 0.003 0.0481 0.057
Trypanosoma cruzi serine peptidase, putative 0.0022 0.0282 0.0334
Loa Loa (eye worm) hypothetical protein 0.0067 0.1356 0.1356
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.1031 0.1031
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0435 1 1
Entamoeba histolytica hypothetical protein 0.0022 0.0282 0.0041
Toxoplasma gondii hypothetical protein 0.0022 0.0282 0.2571
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0282 0.0334
Mycobacterium ulcerans hydrolase 0.0022 0.0282 0.0041
Schistosoma mansoni hypothetical protein 0.0031 0.0505 0.0505
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0053 0.1005 0.1189
Schistosoma mansoni hypothetical protein 0.001 0.0003 0.0003
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0369 0.8445 1
Schistosoma mansoni hypothetical protein 0.0031 0.0505 0.0505
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0282 0.0334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0902 0.0902
Loa Loa (eye worm) hypothetical protein 0.0022 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0052 0.0989 0.0989
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0282 0.0334
Plasmodium falciparum lysophospholipase, putative 0.0369 0.8445 1
Plasmodium vivax PST-A protein 0.0022 0.0282 0.0334
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.1031 0.1031
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0003 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0505 0.0505
Echinococcus granulosus fatty acid amide hydrolase 1 0.0435 1 1
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0053 0.1005 0.0923
Trypanosoma cruzi amidase, putative 0.0053 0.1005 0.1189
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0053 0.1005 0.1189
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0053 0.1005 0.1005
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.004 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Schistosoma mansoni survival motor neuron protein 0.0051 0.0964 0.0964
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0022 0.0282 0.0434
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0481 0.4388
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0248 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Toxoplasma gondii peptidase S15, putative 0.0022 0.0282 0.2571
Plasmodium vivax PST-A protein 0.0022 0.0282 0.0334
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0435 1 1
Schistosoma mansoni hypothetical protein 0.003 0.0481 0.0481
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0282 0.0334
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.562 0.562
Brugia malayi CXXC zinc finger family protein 0.003 0.0471 0.0471
Mycobacterium ulcerans peptide amidase, GatA 0.0053 0.1005 0.0923
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0022 0.0282 0.0334
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0369 0.8445 1
Loa Loa (eye worm) hypothetical protein 0.0249 0.562 0.562
Trypanosoma brucei monoglyceride lipase, putative 0.0369 0.8445 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0003 0.0003
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.1031 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0053 0.1005 0.1005
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.01 0.0118
Plasmodium vivax unspecified product 0.0022 0.0282 0.0334
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.2098 0.2098
Leishmania major DNA polymerase eta, putative 0.002 0.0248 0.0294
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0282 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0902 0.0902
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0248 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0282 0.0041
Brugia malayi MGC79044 protein 0.0022 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Leishmania major hypothetical protein, conserved 0.0053 0.1005 0.1189
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0282 0.0334
Mycobacterium tuberculosis Possible lysophospholipase 0.0369 0.8445 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0902 0.0902
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0282 0.0041
Toxoplasma gondii phospholipase 0.0022 0.0282 0.2571
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0022 0.0282 0.0041
Echinococcus granulosus peregrin 0.003 0.0481 0.0481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0902 0.0902
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0248 0.0294
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0964 0.0964
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0053 0.1005 0.0923
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0759 0.0759
Onchocerca volvulus 0.0051 0.0964 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0248 0.0294
Trypanosoma cruzi serine peptidase, putative 0.0022 0.0282 0.0334
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0369 0.8445 1
Brugia malayi Protein C20orf22 0.0022 0.0282 0.0282
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0248 0.0294
Plasmodium falciparum lysophospholipase, putative 0.0369 0.8445 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Leishmania major monoglyceride lipase, putative 0.0369 0.8445 1
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1031 0.1031
Mycobacterium ulcerans amidase 0.0053 0.1005 0.0923
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0505 0.0505
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0282 0.0282
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0022 0.0282 0.2571
Toxoplasma gondii hypothetical protein 0.0022 0.0282 0.2571
Trypanosoma cruzi monoglyceride lipase, putative 0.0369 0.8445 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.004 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0505 0.0505
Plasmodium falciparum esterase, putative 0.0022 0.0282 0.0334
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1031 0.0955
Plasmodium falciparum exported lipase 1 0.0022 0.0282 0.0334
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0282 0.0334
Leishmania major hypothetical protein, conserved 0.0022 0.0282 0.0334
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0022 0.0282 0.0334
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0053 0.1005 1
Plasmodium falciparum esterase, putative 0.0369 0.8445 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0248 0.0294
Brugia malayi AF-10 protein 0.001 0.0003 0.0003
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.1031 0.1221
Plasmodium falciparum epoxide hydrolase 2 0.0022 0.0282 0.0334
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0282 0.0334
Plasmodium falciparum exported lipase 2 0.0022 0.0282 0.0334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0282 0.0282
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0481 0.0481
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1031 0.0955
Mycobacterium ulcerans hypothetical protein 0.0022 0.0282 0.0041
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0282 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.268 0.268
Plasmodium falciparum esterase, putative 0.0022 0.0282 0.0334
Echinococcus granulosus fatty acid amide hydrolase 1 0.0435 1 1
Toxoplasma gondii hypothetical protein 0.0022 0.0282 0.2571
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0248 0.0248
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1031 0.1221
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0369 0.8445 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0369 0.8445 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0505 0.0505
Loa Loa (eye worm) amidase 0.0053 0.1005 0.1005
Echinococcus multilocularis dna polymerase kappa 0.002 0.0248 0.0248
Loa Loa (eye worm) amidase 0.0053 0.1005 0.1005
Toxoplasma gondii phospholipase/carboxylesterase 0.0022 0.0282 0.2571
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0671 0.0671
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0282 0.0041
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0369 0.8445 1
Echinococcus granulosus dna polymerase eta 0.002 0.0248 0.0248
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.2091 0.2091
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.1031 0.1221
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0671 0.0671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0902 0.0902

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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