Detailed information for compound 658354

Basic information

Technical information
  • TDR Targets ID: 658354
  • Name: (4Z)-2-(4-methoxy-3-nitrophenyl)-4-[(E)-3-(2- methoxyphenyl)prop-2-enylidene]-1,3-oxazol-5- one
  • MW: 380.351 | Formula: C20H16N2O6
  • H donors: 0 H acceptors: 3 LogP: 3.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C=CC=C1N=C(OC1=O)c1ccc(c(c1)[N+](=O)[O-])OC
  • InChi: 1S/C20H16N2O6/c1-26-17-9-4-3-6-13(17)7-5-8-15-20(23)28-19(21-15)14-10-11-18(27-2)16(12-14)22(24)25/h3-12H,1-2H3/b7-5+,15-8-
  • InChiKey: CJDQPGNSTUQUKT-VAKPMEJFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxy-3-nitrophenyl)-4-[3-(2-methoxyphenyl)prop-2-enylidene]-1,3-oxazol-5-one
  • 2-(4-methoxy-3-nitro-phenyl)-4-[3-(2-methoxyphenyl)prop-2-enylidene]oxazol-5-one
  • (4Z)-2-(4-methoxy-3-nitro-phenyl)-4-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]oxazol-5-one
  • 2-(4-methoxy-3-nitrophenyl)-4-[3-(2-methoxyphenyl)prop-2-enylidene]-5-oxazolone
  • (4Z)-2-(4-methoxy-3-nitrophenyl)-4-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]-5-oxazolone
  • (4Z)-2-(4-methoxy-3-nitro-phenyl)-4-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]-1,3-oxazol-5-one
  • 2-(4-methoxy-3-nitro-phenyl)-4-[3-(2-methoxyphenyl)prop-2-enylidene]-1,3-oxazol-5-one
  • ZINC04644328

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0818 0.3174
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.3586 0.4853
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0998 0.412
Onchocerca volvulus 0.0243 0.761 1
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0148 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.0092
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0345 0.0345
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0818 0.0932
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0251 0.0392
Brugia malayi intermediate filament protein 0.0028 0.0539 0.0709
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.2211 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0171 0.0112
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.1322 0.2616
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0194
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0519 0.1708
Echinococcus granulosus lamin dm0 0.0028 0.0539 0.0539
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0148 0.0148
Brugia malayi RNA, U transporter 1 0.0084 0.2392 0.3149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.031 0.031
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0345 0.1243
Onchocerca volvulus 0.0017 0.0183 0.024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0818 0.0818
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.428 0.428
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1571 0.1571
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.031 0.0408
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.119 0.6568
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.031 0.0408
Loa Loa (eye worm) hypothetical protein 0.0102 0.2982 0.2982
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0818 0.0932
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0069
Echinococcus granulosus phd:f box containing protein 0.0016 0.0148 0.0148
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0818 0.0932
Onchocerca volvulus 0.0028 0.0539 0.0708
Onchocerca volvulus 0.0036 0.0818 0.1075
Loa Loa (eye worm) hypothetical protein 0.0036 0.0818 0.0818
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3797 0.3797
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.031 0.0243
Leishmania major trypanothione reductase 0.0047 0.119 0.6568
Schistosoma mansoni lamin 0.0028 0.0539 0.0539
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0691 0.0691
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.3189 0.429
Loa Loa (eye worm) ctsf protein 0.0017 0.0183 0.0183
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.1571 0.1513
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.1396 0.1396
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0691 0.0909
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1634 0.1634
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0345 0.0957
Schistosoma mansoni thyroid hormone receptor 0.0021 0.031 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.031 0.031
Echinococcus multilocularis GPCR, family 2 0.0032 0.0691 0.0627
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0251 0.05
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.031 0.031
Plasmodium vivax vivapain-2 0.0017 0.0183 0.017
Schistosoma mansoni hypothetical protein 0.0049 0.1255 0.1255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1165 0.1165
Schistosoma mansoni ap endonuclease 0.0019 0.0251 0.0251
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0032 0.0691 0.0691
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.428 0.4241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.031 0.031
Plasmodium vivax importin-beta 2, putative 0.003 0.0602 0.22
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1165 0.1104
Schistosoma mansoni lamin 0.0028 0.0539 0.0539
Mycobacterium ulcerans lipase LipD 0.0036 0.0818 0.3174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0345 0.1243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0171 0.0146
Schistosoma mansoni jumonji domain containing protein 0.0059 0.1571 0.1571
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.119 0.119
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.022
Schistosoma mansoni hypothetical protein 0.0174 0.5339 0.5339
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0183 0.2067
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3797 0.3797
Onchocerca volvulus 0.0021 0.031 0.0407
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0345 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.031 0.0408
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.2211 0.2157
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0818 0.1075
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0183 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1165 0.1165
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0171 0.0146
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0818 0.1077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0818 0.0818
Schistosoma mansoni hypothetical protein 0.0032 0.0691 0.0691
Leishmania major GTP-binding protein, putative 0.0022 0.0345 0.1243
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0251 0.05
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.119 0.5055
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1634 0.9361
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.031 0.031
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0183 0.017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0636 0.0571
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.031 0.031
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.024
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0148 0.0148
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.022
Loa Loa (eye worm) hypothetical protein 0.0078 0.2211 0.2211
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1735 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1634 0.7172
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.031 0.0408
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0691 0.0627
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.3586 0.4853
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.0032 0.0691 0.0691
Schistosoma mansoni intermediate filament proteins 0.0028 0.0539 0.0539
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0539 0.0539
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.3189 0.429
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0148 0.0148
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0242 0.7596 0.7596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Trypanosoma brucei trypanothione reductase 0.0047 0.119 0.6568
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.119 0.1459
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.031 0.0243
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0183 0.0115
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0817 0.0817
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.031 0.031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1165 0.1534
Loa Loa (eye worm) TAR-binding protein 0.0127 0.3797 0.3797
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.1322 0.1262
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3797 0.3797
Schistosoma mansoni hypothetical protein 0.0032 0.0691 0.0691
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1571 0.1571
Leishmania major cathepsin L-like protease 0.0064 0.1735 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.031 0.0408
Schistosoma mansoni nuclear hormone receptor 0.0021 0.031 0.031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0028 0.0539 0.0539
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0345 0.0957
Echinococcus multilocularis tar DNA binding protein 0.0127 0.3797 0.3754
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.031 0.031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1523 0.663
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.1285 0.7162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0818 0.0818
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0884 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0818 0.4224
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0183 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.031 0.031
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.2211 0.5514
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0817 0.0817
Schistosoma mansoni survival motor neuron protein 0.0049 0.1255 0.1255
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0691 0.0691
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0251 0.1121
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0818 0.4224
Loa Loa (eye worm) RNA binding protein 0.0127 0.3797 0.3797
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0251 0.0329
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Toxoplasma gondii thioredoxin reductase 0.0047 0.119 0.5055
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0818 0.1075
Onchocerca volvulus 0.0036 0.0818 0.1075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.1571 0.1513
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.031 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0418 0.0549
Onchocerca volvulus 0.0017 0.0183 0.024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0599 0.0599
Plasmodium falciparum thioredoxin reductase 0.0047 0.119 0.5055
Plasmodium falciparum thioredoxin reductase 0.0016 0.0171 0.0112
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0148 0.008
Onchocerca volvulus 0.0049 0.1255 0.1649
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0183 0.024
Toxoplasma gondii exonuclease III APE 0.0019 0.0251 0.05
Loa Loa (eye worm) beta-lactamase 0.0036 0.0818 0.0818
Echinococcus multilocularis muscleblind protein 1 0.0152 0.4643 0.4606
Brugia malayi beta-lactamase family protein 0.0036 0.0818 0.1077
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0519 0.1801
Brugia malayi jmjC domain containing protein 0.0059 0.1571 0.2068
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1255 0.1652
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0183 0.0183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0052
Plasmodium falciparum importin beta, putative 0.003 0.0602 0.22
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.031 0.031
Echinococcus multilocularis muscleblind protein 0.0152 0.4643 0.4606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.031 0.031
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0171 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0818 0.0755
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0183 0.2067
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0602 0.22
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0183 0.0183
Schistosoma mansoni ran 0.0022 0.0345 0.0345
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0171
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0818 0.0818
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.0092
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.016 0.008
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.2211 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0345 0.1243
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0884 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0171 0.0112
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0171 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.031 0.0408
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0539 0.0709
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2982 0.3926
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.031 0.0408
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.031 0.0408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0636 0.0636
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0183 0.017
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.016 0.0061
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.2211 0.2211
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0183 0.0115
Brugia malayi hypothetical protein 0.0242 0.7596 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0183 0.0183
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.016 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2982 0.3926
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0052
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.016 0.008
Echinococcus granulosus muscleblind protein 0.0152 0.4643 0.4643
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0251 0.0649
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0171 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.031 0.0243
Loa Loa (eye worm) glutathione reductase 0.0047 0.119 0.119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0636 0.0636
Brugia malayi nuclear hormone receptor 0.0021 0.031 0.0408
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0818 0.0932
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0884 0.3568
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0251 0.033
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0171 0.0225
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0148 0.008
Mycobacterium tuberculosis Conserved protein 0.0036 0.0818 0.0932
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1165 0.1165
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Entamoeba histolytica cysteine protease, putative 0.0017 0.0183 0.2067
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0251 0.0392
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0998 0.412
Brugia malayi Importin beta-1 subunit 0.003 0.0602 0.0792
Mycobacterium tuberculosis Conserved protein 0.0036 0.0818 0.0932
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0183 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Echinococcus granulosus tar DNA binding protein 0.0127 0.3797 0.3797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1165 0.1165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0636 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.031 0.0408
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.3797 0.4998
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0146
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1634 0.1634
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.031 0.0243
Echinococcus multilocularis importin subunit beta 1 0.003 0.0602 0.0537
Echinococcus multilocularis cysteine protease 0.0017 0.0183 0.0115
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.016 0.0092
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0148 0.0148
Trichomonas vaginalis set domain proteins, putative 0.0243 0.761 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.031 0.031
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0171 0.0112
Brugia malayi RNA binding protein 0.0127 0.3797 0.4998
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0251 0.0649
Entamoeba histolytica hypothetical protein 0.0024 0.0418 0.4728
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.3189 0.8705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.016 0.0061
Brugia malayi Pre-SET motif family protein 0.0213 0.6641 0.8743
Loa Loa (eye worm) hypothetical protein 0.0152 0.4643 0.4643
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Entamoeba histolytica hypothetical protein 0.0036 0.0817 0.9248
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.031 0.031
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.024
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0183 0.0183
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1165 0.1165
Onchocerca volvulus 0.0017 0.0183 0.024
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.3586 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0818 0.0818
Schistosoma mansoni hypothetical protein 0.0174 0.5339 0.5339
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0171 0.0224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0183 0.0115
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.1571 0.1571
Brugia malayi Pre-SET motif family protein 0.0031 0.0636 0.0837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.119 0.113
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.2211 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.031 0.031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0691 0.0627
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.031 0.0408
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0345 0.0957
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1735 1
Toxoplasma gondii cathepsin CPL 0.0017 0.0183 0.017
Plasmodium vivax SET domain protein, putative 0.0031 0.0636 0.2366
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0602 0.2859
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0117 0.0154
Echinococcus granulosus lamin 0.0028 0.0539 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.031 0.0408
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.016 0.016
Echinococcus granulosus GPCR family 2 0.0032 0.0691 0.0691
Schistosoma mansoni hypothetical protein 0.0036 0.0817 0.0817
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3797 0.3797
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Loa Loa (eye worm) cysteine protease 0.0017 0.0183 0.0183
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0146
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0117 0.0117
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.1523 0.8664
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.031 0.0407
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0251 0.0128
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.031 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.031 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.031 0.0408
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0171 0.0146
Brugia malayi TAR-binding protein 0.0127 0.3797 0.4998
Brugia malayi nuclear receptor NHR-88 0.0021 0.031 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.2211 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0148
Trichomonas vaginalis ran, putative 0.0022 0.0345 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.031 0.0408
Plasmodium vivax vivapain-2 0.0017 0.0183 0.017
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.016 0.016
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0818 0.0932
Brugia malayi Thioredoxin reductase 0.0047 0.119 0.1567
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.1523 0.193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.031 0.031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0636 0.0571
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0183 0.0183
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0818 0.3174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.2211 0.2211
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0103
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.031 0.031
Brugia malayi Isocitrate dehydrogenase 0.0016 0.016 0.0211
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0027 0.0036
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0251 0.0183
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0691 0.0909
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0183 0.017
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0183 0.0115
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0148 0.0148
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.031 0.0243
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.1523 0.663
Loa Loa (eye worm) hypothetical protein 0.0152 0.4643 0.4643
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.016 0.0061
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0818 0.0975
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.2211 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0345 0.0345
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0183 0.024
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.016 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Schistosoma mansoni thyroid hormone receptor 0.0021 0.031 0.031
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0148 0.0148
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0251 0.0392
Onchocerca volvulus 0.0017 0.0183 0.024
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0183 0.022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.016 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0818 0.1075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.031 0.031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.2211 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.3189 0.429
Brugia malayi Muscleblind-like protein 0.0152 0.4643 0.6112
Brugia malayi steroid hormone receptor 0.0021 0.031 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.031 0.0408
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1523 0.1523
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1634 0.1634
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0818 0.1075
Loa Loa (eye worm) hypothetical protein 0.0036 0.0818 0.0818
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1571 0.1571
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0522 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.1322 0.1645
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0148 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0148 0.0148
Leishmania major importin beta-1 subunit, putative 0.0024 0.0418 0.1702
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1735 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2982 0.2982
Entamoeba histolytica hypothetical protein 0.0036 0.0817 0.9248
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.031 0.031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.2211 1
Schistosoma mansoni ap endonuclease 0.0019 0.0251 0.0251
Onchocerca volvulus 0.0017 0.0183 0.024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.722 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0148
Onchocerca volvulus 0.0036 0.0818 0.1075
Echinococcus granulosus cathepsin l1 0.0017 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Entamoeba histolytica Ran family GTPase 0.0022 0.0345 0.3905
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0519 0.1801
Loa Loa (eye worm) hypothetical protein 0.0036 0.0818 0.0818
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0171 0.0146
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.022
Trichomonas vaginalis esterase, putative 0.0036 0.0818 0.1075
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.1322 0.1645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Leishmania major cathepsin L-like protease 0.0064 0.1735 1
Onchocerca volvulus 0.0028 0.0539 0.0708
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.2211 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0171 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0818 0.0818
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0418 0.0549
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0251 0.0649
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0251 0.0649
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1634 0.7204
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0171
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0818 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0818 0.325
Schistosoma mansoni hypothetical protein 0.0315 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.031 0.0407
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0171 0.0015
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0998 0.0998
Loa Loa (eye worm) acetyltransferase 0.0141 0.428 0.428
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0171 0.0112
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.016 0.0092
Schistosoma mansoni hypothetical protein 0.007 0.1922 0.1922
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0998 0.1311
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.6641 0.6641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Echinococcus multilocularis geminin 0.0174 0.5339 0.5306
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0818 0.4224
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0818 0.0932
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.7596 0.7596
Loa Loa (eye worm) hypothetical protein 0.007 0.1922 0.1922
Mycobacterium tuberculosis Probable reductase 0.0108 0.3189 0.429
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1634 0.1576
Onchocerca volvulus 0.0017 0.0183 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0998 0.1311
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.1571 0.1571
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.1523 0.1465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024
Onchocerca volvulus 0.0017 0.0183 0.024
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3797 0.3797
Schistosoma mansoni ran 0.0022 0.0345 0.0345
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0636 0.0636
Schistosoma mansoni coup transcription factor 0.0021 0.031 0.031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0817 0.0754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.031 0.031
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0418 0.1702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1165 0.1165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0636 0.0636
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0345 0.0454
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1523 0.2005
Brugia malayi beta-lactamase family protein 0.0036 0.0818 0.1077
Echinococcus multilocularis snurportin 1 0.0315 1 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0148 0.0148
Onchocerca volvulus 0.0031 0.0636 0.0835
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.031 0.0243
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.031 0.0243
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0636 0.2366
Echinococcus multilocularis musashi 0.0028 0.0539 0.0473
Brugia malayi beta-lactamase 0.0036 0.0818 0.1077
Mycobacterium tuberculosis Conserved protein 0.0036 0.0818 0.0932
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0251 0.2837
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.415 0.415
Loa Loa (eye worm) hypothetical protein 0.003 0.0602 0.0602
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0171 0.0146
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0171 0.0224
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.1523 0.1523
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0171 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0017 0.0183 0.0183
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.3797 0.3797
Brugia malayi jmjC domain containing protein 0.0059 0.1571 0.2068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.119 0.119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.031 0.0408
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.2211 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0251 0.0251
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.031 0.031
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.428 0.5635
Toxoplasma gondii ABC1 family protein 0.0036 0.0818 0.325
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.1553 0.8849
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.3189 0.429
Schistosoma mansoni importin beta-1 0.003 0.0602 0.0602
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0183 0.0183
Entamoeba histolytica hypothetical protein 0.0036 0.0817 0.9248
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1735 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.031 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1165 0.1104
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0027 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0251 0.0329
Mycobacterium ulcerans beta-lactamase 0.0036 0.0818 0.3174
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0148 0.0148
Leishmania major hypothetical protein, conserved 0.0036 0.0818 0.4224
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0194
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1922 0.253
Echinococcus multilocularis lamin 0.0028 0.0539 0.0473
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.7596 0.758
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.022
Entamoeba histolytica hypothetical protein 0.0036 0.0817 0.9248
Brugia malayi glutathione reductase 0.0047 0.119 0.1567
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.3189 0.429
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0418 0.0549
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0998 0.412
Brugia malayi ecdysteroid receptor 0.0021 0.031 0.0408
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.0092
Echinococcus granulosus geminin 0.0174 0.5339 0.5339
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1634 0.2087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Plasmodium vivax glutathione reductase, putative 0.0047 0.119 0.5055
Mycobacterium ulcerans hypothetical protein 0.0036 0.0818 0.3174
Echinococcus granulosus intermediate filament protein 0.0028 0.0539 0.0539
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Echinococcus multilocularis cysteine protease 0.0017 0.0183 0.0115
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0251 0.0251
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0148 0.008
Leishmania major cathepsin L-like protease 0.0064 0.1735 1
Toxoplasma gondii hypothetical protein 0.0027 0.0519 0.1801
Brugia malayi Probable ClpP-like protease 0.0078 0.2211 0.291
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.016 0.016
Plasmodium falciparum glutathione reductase 0.0016 0.0171 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1634 0.7172
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0345 0.2444
Loa Loa (eye worm) fibroinase 0.0017 0.0183 0.0183
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0818 0.1075
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.016 0.008
Plasmodium falciparum glutathione reductase 0.0047 0.119 0.5055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0818 0.0975
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0602 0.2859
Echinococcus multilocularis lamin dm0 0.0028 0.0539 0.0473
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1634 0.7172
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.2211 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.3586 0.4853
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0183 0.022
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0183 0.024
Brugia malayi hypothetical protein 0.0036 0.0817 0.1076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1735 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.031 0.031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0691 0.0691
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.1322 0.1322
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.024
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.031 0.0407
Brugia malayi isocitrate dehydrogenase 0.0016 0.016 0.0211
Echinococcus granulosus importin subunit beta 1 0.003 0.0602 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.024

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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