TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.62 | Formula: C16H10ClIN2O2
H donors: 1 H acceptors: 2 LogP: 4.89 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1nc(c(o1)O)C=Nc1ccccc1I
InChi: 1S/C16H10ClIN2O2/c17-11-7-5-10(6-8-11)15-20-14(16(21)22-15)9-19-13-4-2-1-3-12(13)18/h1-9,21H
InChiKey: JUUDTEIBLJAHST-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Giardia lamblia	Aldose reductase	0.0094	0.275	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0155	0.0155
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0155	0.0155
Echinococcus multilocularis	carbonic anhydrase	0.0112	0.3303	0.3303
Trypanosoma brucei	aldo-keto reductase, putative	0.0094	0.275	0.2439
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0155	0.0169
Schistosoma mansoni	carbonic anhydrase-related	0.0112	0.3303	0.3303
Leishmania major	aldo-keto reductase-like protein	0.0094	0.275	0.2439
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0155	0.0155
Schistosoma mansoni	ferritin	0.0009	0.0109	0.0109
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0155	0.0169
Schistosoma mansoni	hypothetical protein	0.0037	0.0969	0.0969
Onchocerca volvulus		0.0094	0.275	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0027	0.0673	0.2137
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0009	0.0109	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Echinococcus multilocularis	aldehyde reductase	0.0067	0.1903	0.1903
Echinococcus granulosus	aldehyde reductase	0.0067	0.1903	0.1903
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0155	0.0155
Trichomonas vaginalis	aldo/keto reductase, putative	0.0094	0.275	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0094	0.275	1
Trypanosoma brucei	prostaglandin f synthase	0.0094	0.275	0.2439
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0094	0.275	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0155	0.0155
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0112	0.3303	0.3594
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Toxoplasma gondii	hypothetical protein	0.0112	0.3303	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0673	0.2137
Trypanosoma brucei	carbonic anhydrase-like protein	0.03	0.919	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0155	0.0169
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0155	0.0155
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0155	0.0155
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0155	0.0169
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0155	0.0169
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0094	0.275	0.2993
Echinococcus multilocularis	kelch ECH associated protein 1	0.0096	0.2827	0.2827
Onchocerca volvulus		0.0094	0.275	1
Schistosoma mansoni	aldo-keto reductase	0.0094	0.275	0.275
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1214	0.1214
Echinococcus multilocularis	ferritin	0.0009	0.0109	0.0109
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0094	0.275	0.2439
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0094	0.275	0.2993
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0155	0.0169
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Schistosoma mansoni	ferritin light chain	0.0009	0.0109	0.0109
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0326	1	1
Treponema pallidum	bacterioferrin (TpF1)	0.0009	0.0109	0.5
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.03	0.919	0.919
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0155	0.0155
Schistosoma mansoni	ferritin	0.0009	0.0109	0.0109
Echinococcus granulosus	carbonic anhydrase	0.0112	0.3303	0.3303
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3303	0.3594
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0027	0.0673	0.0673
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0112	0.3303	0.3594
Brugia malayi	nuclear hormone receptor	0.0011	0.0155	0.0169
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0155	0.0169
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.275	1
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0027	0.0673	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Echinococcus granulosus	carbonic anhydrase II	0.03	0.919	0.919
Schistosoma mansoni	carbonic anhydrase-related	0.0112	0.3303	0.3303
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.03	0.919	0.919
Entamoeba histolytica	hypothetical protein	0.0037	0.0969	0.1425
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0155	0.0169
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1214	0.1214
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0155	0.0169
Entamoeba histolytica	aldose reductase, putative	0.0094	0.275	1
Schistosoma mansoni	alkaline phosphatase	0.0326	1	1
Echinococcus granulosus	aldo keto reductase	0.0094	0.275	0.275
Echinococcus multilocularis	expressed protein	0.0009	0.0109	0.0109
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0155	0.0169
Trichomonas vaginalis	aldo/keto reductase, putative	0.0094	0.275	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0155	0.0155
Echinococcus multilocularis	kelch ECH associated protein 1	0.0096	0.2827	0.2827
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0155	0.0169
Leishmania major	prostaglandin f synthase, putative	0.0094	0.275	0.2439
Loa Loa (eye worm)	oxidoreductase	0.0094	0.275	0.2993
Schistosoma mansoni	ferritin	0.0009	0.0109	0.0109
Onchocerca volvulus		0.0094	0.275	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0027	0.0673	0.0732
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0155	0.0169
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0969	0.0969
Brugia malayi	NADH-dependent xylose reductase	0.0027	0.0673	0.0732
Brugia malayi	ecdysteroid receptor	0.0011	0.0155	0.0169
Schistosoma mansoni	hypothetical protein	0.0112	0.3303	0.3303
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0155	0.0169
Schistosoma mansoni	pol-related	0.0094	0.275	0.275
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0673	0.2137
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0112	0.3303	0.3594
Schistosoma mansoni	carbonic anhydrase	0.0112	0.3303	0.3303
Echinococcus multilocularis	carbonic anhydrase II	0.03	0.919	0.919
Schistosoma mansoni	carbonic anhydrase-related	0.0112	0.3303	0.3303
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0326	1	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.03	0.919	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0155	0.0169
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0155	0.0155
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0155	0.0155
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0094	0.275	0.2439
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Mycobacterium ulcerans	oxidoreductase	0.0094	0.275	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0094	0.275	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0094	0.275	1
Echinococcus multilocularis	carbonic anhydrase	0.0112	0.3303	0.3303
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1214	0.1321
Echinococcus multilocularis	aldo keto reductase	0.0094	0.275	0.275
Trypanosoma cruzi	aldo/keto reductase, putative	0.0094	0.275	0.2439
Schistosoma mansoni	aldo-keto reductase	0.0094	0.275	0.275
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0155	0.0155
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0112	0.3303	0.3594
Echinococcus granulosus	voltage gated potassium channel subunit	0.0027	0.0673	0.0673
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0155	0.0155
Schistosoma mansoni	potassium channel beta	0.0027	0.0673	0.0673
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0155	0.0155
Leishmania major	carbonic anhydrase-like protein	0.03	0.919	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0094	0.275	0.2993
Echinococcus granulosus	ferritin	0.0009	0.0109	0.0109
Trichomonas vaginalis	aldo-keto reductase, putative	0.0027	0.0673	0.2137
Loa Loa (eye worm)	oxidoreductase	0.0094	0.275	0.2993
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0155	0.0169
Onchocerca volvulus		0.0027	0.0673	0.1995
Echinococcus multilocularis	alkaline phosphatase	0.0326	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Trichomonas vaginalis	aldo-keto reductase, putative	0.0027	0.0673	0.2137
Loa Loa (eye worm)	oxidoreductase	0.0094	0.275	0.2993
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Echinococcus granulosus	aldo keto reductase	0.0094	0.275	0.275
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0094	0.275	0.2993
Echinococcus granulosus	carbonic anhydrase	0.0112	0.3303	0.3303
Echinococcus granulosus	expressed protein	0.0009	0.0109	0.0109
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Trichomonas vaginalis	aldo/keto reductase, putative	0.0094	0.275	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0169
Plasmodium falciparum	carbonic anhydrase	0.0112	0.3303	1
Schistosoma mansoni	alkaline phosphatase	0.0326	1	1
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0096	0.2827	0.2827
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0155	0.0155
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.03	0.919	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0155	0.0155
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0326	1	1
Onchocerca volvulus		0.0094	0.275	1
Echinococcus granulosus	carbonic anhydrase	0.0112	0.3303	0.3303
Entamoeba histolytica	hypothetical protein	0.0037	0.0969	0.1425
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Entamoeba histolytica	hypothetical protein	0.0037	0.0969	0.1425
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0155	0.0155
Echinococcus granulosus	kelch ECH associated protein 1	0.0096	0.2827	0.2827
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0155	0.0155
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0155	0.0155
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1214	0.1214
Echinococcus multilocularis	aldo keto reductase	0.0094	0.275	0.275
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0155	0.0169
Echinococcus multilocularis	aldo keto reductase	0.0094	0.275	0.275
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0155	0.0169
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1214	0.1214
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1214	0.1214
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0155	0.0169
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0094	0.275	0.2993
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Mycobacterium leprae	Possible oxidoreductase	0.0027	0.0673	0.2137
Trypanosoma cruzi	aldo-keto reductase	0.0094	0.275	0.2439
Schistosoma mansoni	apoferritin-2	0.0009	0.0109	0.0109
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Mycobacterium tuberculosis	Conserved protein	0.0027	0.0673	0.2137
Entamoeba histolytica	aldose reductase, putative	0.0094	0.275	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1214	0.1214
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0112	0.3303	0.3594
Schistosoma mansoni	ferritin light chain	0.0009	0.0109	0.0109
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0155	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3303	0.3594
Brugia malayi	hypothetical protein	0.0037	0.0969	0.1054
Entamoeba histolytica	aldose reductase, putative	0.0094	0.275	1
Echinococcus multilocularis	aldo keto reductase	0.0094	0.275	0.275
Loa Loa (eye worm)	oxidoreductase	0.0094	0.275	0.2993
Schistosoma mansoni	apoferritin-2	0.0009	0.0109	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0155	0.0169
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0155	0.0169
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Echinococcus granulosus	hypothetical protein	0.0094	0.275	0.275
Echinococcus granulosus	alkaline phosphatase	0.0326	1	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.03	0.919	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0155	0.0155
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0326	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Brugia malayi	steroid hormone receptor	0.0011	0.0155	0.0169
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0969	0.0969
Echinococcus multilocularis	Kelch repeat type 1	0.0096	0.2835	0.2835
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0155	0.0169
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0027	0.0673	0.0673
Loa Loa (eye worm)	oxidoreductase	0.0094	0.275	0.2993
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0969	0.0969
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0096	0.2827	0.2827
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0155	0.0155
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1214	0.1214
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0155	0.0155
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0155	0.0155
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0155	0.0155
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0094	0.275	0.275
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.03	0.919	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1214	0.1321
Schistosoma mansoni	coup transcription factor	0.0011	0.0155	0.0155
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0155	0.0155
Plasmodium vivax	aldehyde reductase, putative	0.0027	0.0673	0.5
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.03	0.919	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Echinococcus granulosus	aldo keto reductase	0.0094	0.275	0.275
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0027	0.0673	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0112	0.3303	0.3594
Echinococcus multilocularis	carbonic anhydrase	0.0112	0.3303	0.3303
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0155	0.0169
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0155	0.0155
Entamoeba histolytica	hypothetical protein	0.0037	0.0969	0.1425
Schistosoma mansoni	hypothetical protein	0.0096	0.2835	0.2835
Onchocerca volvulus		0.0094	0.275	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0155	0.0169
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0155	0.0155
Toxoplasma gondii	aldose reductase, putative	0.0094	0.275	0.7899
Giardia lamblia	Aldose reductase	0.0094	0.275	0.5
Schistosoma mansoni	hypothetical protein	0.017	0.5112	0.5112
Onchocerca volvulus		0.0094	0.275	1
Schistosoma mansoni	ferritin	0.0009	0.0109	0.0109
Mycobacterium leprae	Conserved hypothetical protein	0.0067	0.1903	0.6794
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0155	0.0169
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.03	0.919	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0027	0.0673	0.2137
Trichomonas vaginalis	aldo-keto reductase, putative	0.0094	0.275	1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0112	0.3303	0.3594
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0155	0.0155
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0155	0.0155
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0326	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0094	0.275	0.275

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 658384