Detailed information for compound 658477

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.049 | Formula: C14H10BrIN2O3
  • H donors: 1 H acceptors: 3 LogP: 4.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(c(c1)C(=O)Nc1ccc(cc1C)[N+](=O)[O-])I
  • InChi: 1S/C14H10BrIN2O3/c1-8-6-10(18(20)21)3-5-13(8)17-14(19)11-7-9(15)2-4-12(11)16/h2-7H,1H3,(H,17,19)
  • InChiKey: HJYLIKPZGHZFPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus snurportin 1 0.0305 0.1888 0.1877
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.155 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7733
Echinococcus multilocularis Excitatory amino acid transporter 0.155 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0037 0.0024
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0086 0.0074
Echinococcus granulosus Excitatory amino acid transporter 0.155 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.1107 0.1095
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.006
Mycobacterium tuberculosis Conserved protein 0.0076 0.0397 0.0375
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.1327 0.1315
Loa Loa (eye worm) hypothetical protein 0.0219 0.1327 0.1327
Trypanosoma brucei carbonic anhydrase-like protein 0.0589 0.3742 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0397 0.0384
Loa Loa (eye worm) hypothetical protein 0.0049 0.0222 0.0222
Echinococcus multilocularis neutral amino acid transporter A 0.155 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0037 0.01
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0397 0.0384
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0461 0.044
Plasmodium vivax SET domain protein, putative 0.003 0.0094 0.1919
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.013 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0094 0.0081
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.1327 0.1327
Echinococcus multilocularis neutral amino acid transporter A 0.155 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.006
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0076 0.0397 0.0397
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0094 0.0551
Loa Loa (eye worm) hypothetical protein 0.0219 0.1327 0.1327
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0239 0.0226
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0094 0.0081
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0589 0.3742 0.3742
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0094
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0397 0.0375
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.1555 0.1555
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0222 0.0209
Trypanosoma brucei glucosidase, putative 0.0041 0.0168 0.0449
Brugia malayi MH1 domain containing protein 0.0017 0.0013 0.0013
Plasmodium vivax glutathione reductase, putative 0.0038 0.0146 0.3304
Echinococcus multilocularis excitatory amino acid transporter 2 0.155 1 1
Brugia malayi glutathione reductase 0.0038 0.0146 0.0146
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0769 1
Echinococcus multilocularis Excitatory amino acid transporter 0.155 1 1
Echinococcus granulosus carbonic anhydrase 0.0219 0.1327 0.1315
Schistosoma mansoni hypothetical protein 0.0169 0.1002 0.099
Brugia malayi MH1 domain containing protein 0.0017 0.0013 0.0013
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0687 0.4377 0.437
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0037
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0064 0.0319
Chlamydia trachomatis glutamate symporter 0.155 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0397 0.2755
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0397 0.2755
Echinococcus granulosus importin subunit beta 1 0.0029 0.0086 0.0074
Brugia malayi Thioredoxin reductase 0.0038 0.0146 0.0146
Trichomonas vaginalis set domain proteins, putative 0.0236 0.144 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0146 0.0124
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7733
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0524 0.0502
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0168 0.1167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0149 0.0137
Echinococcus granulosus geminin 0.0169 0.1002 0.099
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0168 0.0155
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0146 0.0391
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0239 0.0239
Loa Loa (eye worm) glutathione reductase 0.0038 0.0146 0.0146
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.155 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0461 0.044
Schistosoma mansoni hypothetical protein 0.0169 0.1002 0.099
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0461 0.044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0397 0.0384
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0524 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.1341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0769 1
Echinococcus granulosus excitatory amino acid transporter 2 0.155 1 1
Plasmodium falciparum glutathione reductase 0.0038 0.0146 0.0948
Brugia malayi beta-lactamase 0.0076 0.0397 0.0397
Echinococcus multilocularis carbonic anhydrase II 0.0589 0.3742 0.3733
Schistosoma mansoni ran 0.0021 0.0037 0.0024
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0171
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7733
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0094 0.0081
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.155 1 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0687 0.4377 0.437
Echinococcus granulosus neutral amino acid transporter 0.155 1 1
Echinococcus multilocularis snurportin 1 0.0305 0.1888 0.1877
Echinococcus multilocularis carbonic anhydrase 0.0219 0.1327 0.1315
Loa Loa (eye worm) beta-lactamase 0.0076 0.0397 0.0397
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.1327 0.1327
Plasmodium falciparum importin beta, putative 0.0029 0.0086 0.049
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0589 0.3742 0.3742
Loa Loa (eye worm) Smad1 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0076 0.0397 0.0397
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0769 0.0748
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0171
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.1107 0.1095
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0168 0.0168
Echinococcus granulosus neutral amino acid transporter A 0.155 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0397 0.5014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0524 0.0502
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0397 0.0375
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.0171
Onchocerca volvulus Excitatory amino acid transporter homolog 0.155 1 1
Toxoplasma gondii hypothetical protein 0.0219 0.1327 1
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.1327 0.1315
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0219 0.1327 0.1327
Echinococcus granulosus excitatory amino acid transporter 3 0.155 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.1107 0.1107
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1253 0.1253
Onchocerca volvulus 0.0107 0.0598 0.0598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0239 0.0226
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0397 0.0375
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0037 0.01
Brugia malayi Pre-SET motif family protein 0.0208 0.1253 0.1253
Plasmodium vivax importin-beta 2, putative 0.0029 0.0086 0.1708
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0487 0.3072 0.3057
Treponema pallidum glutamate/aspartate transporter 0.0687 0.4377 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0168 0.0168
Mycobacterium tuberculosis Probable reductase 0.0086 0.0461 0.044
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0037 0.01
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0064 0.1112
Treponema pallidum glutamate transporter 0.0687 0.4377 1
Brugia malayi beta-lactamase family protein 0.0076 0.0397 0.0397
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0146 0.3304
Echinococcus granulosus tumor protein p63 0.0337 0.2097 0.2087
Onchocerca volvulus 0.0236 0.144 0.144
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0168 0.0449
Brugia malayi Muscleblind-like protein 0.0318 0.1971 0.1971
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0461 0.044
Echinococcus granulosus carbonic anhydrase 0.0219 0.1327 0.1315
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0168 0.0155
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0051 0.0356
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0094 0.0081
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0168 1
Onchocerca volvulus 0.0076 0.0397 0.0397
Echinococcus granulosus Excitatory amino acid transporter 0.155 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0094 0.0081
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.155 1 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0687 0.4377 0.437
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0769 0.5724
Plasmodium falciparum thioredoxin reductase 0.0038 0.0146 0.0948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0239 0.0226
Echinococcus multilocularis excitatory amino acid transporter 3 0.155 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.1555 0.1555
Loa Loa (eye worm) hypothetical protein 0.0318 0.1971 0.1971
Loa Loa (eye worm) excitatory amino acid transporter 0.155 1 1
Schistosoma mansoni alpha-glucosidase 0.0159 0.0939 0.0927
Leishmania major GTP-binding protein, putative 0.0021 0.0037 0.01
Leishmania major hypothetical protein, conserved 0.0076 0.0397 0.106
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0168 0.1167
Brugia malayi Pre-SET motif family protein 0.003 0.0094 0.0094
Plasmodium falciparum carbonic anhydrase 0.0219 0.1327 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0397 0.0397
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0319
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0113
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0397 0.106
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0769 0.0757
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0168 0.1167
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0149 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0168 0.1167
Echinococcus granulosus carbonic anhydrase 0.0219 0.1327 0.1315
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0589 0.3742 0.3733
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0168 0.0449
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0037 0.0113
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0086 0.0231
Schistosoma mansoni ran 0.0021 0.0037 0.0024
Onchocerca volvulus 0.0076 0.0397 0.0397
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0239 0.0226
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0156
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0397 0.0375
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0397 0.0375
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0494 0.3121 0.3121
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0397 0.2755
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0239 0.0226
Toxoplasma gondii thioredoxin reductase 0.0038 0.0146 0.0948
Loa Loa (eye worm) hypothetical protein 0.0076 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.013 0.0117
Brugia malayi MH2 domain containing protein 0.0254 0.1555 0.1555
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.1888 0.1888
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0461 0.044
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0168 0.1116
Trichomonas vaginalis esterase, putative 0.0076 0.0397 0.2755
Echinococcus multilocularis sodium:dicarboxylate symporter 0.155 1 1
Echinococcus multilocularis carbonic anhydrase 0.0219 0.1327 0.1315
Brugia malayi RNA, U transporter 1 0.0081 0.043 0.043
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0687 0.4377 0.437
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0239 0.0239
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0168 0.1167
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0219 0.1327 0.1327
Brugia malayi MH2 domain containing protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.1107 0.1107
Schistosoma mansoni alpha-glucosidase 0.0159 0.0939 0.0927
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0397 0.0375
Mycobacterium ulcerans beta-lactamase 0.0076 0.0397 0.5014
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.1107 0.1095
Echinococcus multilocularis muscleblind protein 0.0318 0.1971 0.1961
Loa Loa (eye worm) hypothetical protein 0.0318 0.1971 0.1971
Brugia malayi MH2 domain containing protein 0.0017 0.0013 0.0013
Trichomonas vaginalis ran, putative 0.0021 0.0037 0.0259
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0397 0.2755
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 0.0037
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0064 0.0171
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0589 0.3742 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0051 0.0356
Echinococcus multilocularis neutral amino acid transporter A 0.155 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0094 0.0081
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7733
Schistosoma mansoni hypothetical protein 0.0219 0.1327 0.1315
Echinococcus granulosus carbonic anhydrase II 0.0589 0.3742 0.3733
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0397 0.106
Schistosoma mansoni alpha glucosidase 0.0041 0.0168 0.0155
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0397 0.0375
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0769 0.0757
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0168 1
Echinococcus granulosus muscleblind protein 0.0318 0.1971 0.1961
Schistosoma mansoni hypothetical protein 0.0305 0.1888 0.1877
Onchocerca volvulus 0.003 0.0094 0.0094
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) carbonic anhydrase 3 0.0589 0.3742 0.3742
Echinococcus multilocularis carbonic anhydrase 0.0219 0.1327 0.1315
Toxoplasma gondii ABC1 family protein 0.0076 0.0397 0.287
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0397 0.2755
Loa Loa (eye worm) hypothetical protein 0.0076 0.0397 0.0397
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0086 0.049
Schistosoma mansoni importin beta-1 0.0029 0.0086 0.0074
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0013 0.0013
Echinococcus multilocularis geminin 0.0169 0.1002 0.099
Brugia malayi hypothetical protein 0.0025 0.0064 0.0064
Brugia malayi Smad1 0.0017 0.0013 0.0013
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0037 0.0395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0239 0.0226
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0397 0.0397
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0156
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0168 0.1167
Leishmania major trypanothione reductase 0.0038 0.0146 0.0391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0239 0.0226
Loa Loa (eye worm) hypothetical protein 0.0076 0.0397 0.0397
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0051 0.0356
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0051 0.0137
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0589 0.3742 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0319
Brugia malayi follicle stimulating hormone receptor 0.0494 0.3121 0.3121
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0769 0.0757
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.013 0.0117
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0397 0.0397
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0219 0.1327 0.1327
Mycobacterium ulcerans lipase LipD 0.0076 0.0397 0.5014
Echinococcus multilocularis excitatory amino acid transporter 2 0.155 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0769 0.2055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0094 0.0081
Echinococcus multilocularis muscleblind protein 1 0.0318 0.1971 0.1961
Entamoeba histolytica hypothetical protein 0.0023 0.0051 0.3049
Echinococcus granulosus excitatory amino acid transporter 2 0.155 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0589 0.3742 0.3742
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0589 0.3742 0.3733
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0168 0.1167
Mycobacterium ulcerans hypothetical protein 0.0076 0.0397 0.5014
Loa Loa (eye worm) hypothetical protein 0.0219 0.1327 0.1327
Schistosoma mansoni hypothetical protein 0.0035 0.013 0.0117
Onchocerca volvulus 0.0049 0.0222 0.0222
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0769 0.0757
Brugia malayi hypothetical protein 0.0016 0.0006 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0397 0.0384
Brugia malayi beta-lactamase family protein 0.0076 0.0397 0.0397
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0168 0.0449
Schistosoma mansoni carbonic anhydrase 0.0219 0.1327 0.1315
Leishmania major importin beta-1 subunit, putative 0.0023 0.0051 0.0137
Leishmania major carbonic anhydrase-like protein 0.0589 0.3742 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0064
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0168 0.1167
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0023
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.1327 0.1327
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0037 0.0024
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.1327 0.1315
Echinococcus granulosus neutral amino acid transporter A 0.155 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0086 0.0231
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0769 1
Onchocerca volvulus 0.0076 0.0397 0.0397
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.006
Trypanosoma brucei trypanothione reductase 0.0038 0.0146 0.0391
Echinococcus multilocularis tumor protein p63 0.0337 0.2097 0.2087
Brugia malayi Importin beta-1 subunit 0.0029 0.0086 0.0086
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.001
Brugia malayi hypothetical protein 0.0035 0.013 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0397 0.106
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0087 0.0074
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0037 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0037 0.222
Echinococcus granulosus sodium:dicarboxylate symporter 0.155 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0524 0.0502
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0168 0.1167
Mycobacterium tuberculosis Conserved protein 0.0076 0.0397 0.0375
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0397 1
Mycobacterium tuberculosis Conserved protein 0.0076 0.0397 0.0375
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0461 0.5073
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0397 0.5014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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