Detailed information for compound 658479

Basic information

Technical information
  • TDR Targets ID: 658479
  • Name: 4-chloro-N-(3-chloro-4-methoxyphenyl)-3-nitro benzamide
  • MW: 341.146 | Formula: C14H10Cl2N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)NC(=O)c1ccc(c(c1)[N+](=O)[O-])Cl
  • InChi: 1S/C14H10Cl2N2O4/c1-22-13-5-3-9(7-11(13)16)17-14(19)8-2-4-10(15)12(6-8)18(20)21/h2-7H,1H3,(H,17,19)
  • InChiKey: FOPGEUMGQYXPOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-(3-chloro-4-methoxy-phenyl)-3-nitro-benzamide
  • Oprea1_485614
  • ZINC00259758

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0824 0.4373
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0178 0.0259
Echinococcus granulosus Excitatory amino acid transporter 0.0763 0.4777 0.5433
Plasmodium falciparum importin beta, putative 0.006 0.028 1
Schistosoma mansoni hypothetical protein 0.0039 0.0149 0.0169
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.006 0.028 0.0543
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0824 0.0937
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0029 0.0017
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.012 0.0136
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0029 0.0033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0362 0.0896
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0139 0.0139
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0101 0.0168
Echinococcus multilocularis excitatory amino acid transporter 3 0.0763 0.4777 0.4777
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0362 0.1802
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0178 0.0178
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0362 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0029 0.0014
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0029 0.0017
Echinococcus granulosus geminin 0.0172 0.0994 0.1131
Leishmania major hypothetical protein, conserved 0.0025 0.0054 0.0085
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0183 0.1064 0.5714
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0029 0.0033
Loa Loa (eye worm) excitatory amino acid transporter 0.0763 0.4777 1
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0265 0.0301
Schistosoma mansoni hypothetical protein 0.0039 0.0149 0.0169
Echinococcus granulosus sodium:dicarboxylate symporter 0.0763 0.4777 0.5433
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0178 0.0778
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0791 0.1152
Plasmodium falciparum thioredoxin reductase 0.0037 0.0136 0.3625
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0362 0.0412
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0504 0.0647
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.012 0.0205
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0903 0.0903
Schistosoma mansoni hypothetical protein 0.0032 0.0101 0.0115
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0763 0.4777 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0443 0.054
Mycobacterium tuberculosis Conserved protein 0.0145 0.0824 0.121
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.1342 0.2776
Schistosoma mansoni hypothetical protein 0.0172 0.0994 0.1131
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0207 0.0337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Mycobacterium ulcerans hypothetical protein 0.016 0.0916 0.5153
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.0824 0.121
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0029 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0029 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0916 0.1373
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0362 0.0412
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0029 0.0017
Entamoeba histolytica Ran family GTPase 0.0044 0.0178 0.0366
Brugia malayi follicle stimulating hormone receptor 0.0226 0.1342 0.2778
Echinococcus granulosus GPCR family 2 0.0032 0.0101 0.0115
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0362 0.0896
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0198 0.0374
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0516 0.0586
Toxoplasma gondii thioredoxin reductase 0.0037 0.0136 0.0809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0029 0.0014
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0158 0.0158
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0101 0.0165
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0101 0.0101
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.2803 0.2803
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Echinococcus multilocularis neutral amino acid transporter A 0.0763 0.4777 0.4777
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0264 0.1256
Leishmania major hypothetical protein, conserved 0.0145 0.0824 0.4373
Brugia malayi MH2 domain containing protein 0.0115 0.0634 0.1289
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0137 0.0156
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0824 0.2559
Loa Loa (eye worm) hypothetical protein 0.0145 0.0824 0.1685
Echinococcus multilocularis Excitatory amino acid transporter 0.0763 0.4777 0.4777
Echinococcus multilocularis muscleblind protein 1 0.0307 0.1859 0.1859
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0259 0.0294
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.012 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0806 0.505 0.505
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0362 0.1509
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.028 0.028
Brugia malayi glutaminase DH11.1 0.0274 0.1649 0.3424
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0229 0.1359 0.2813
Mycobacterium tuberculosis Conserved protein 0.0145 0.0824 0.121
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0239 0.0457
Echinococcus granulosus excitatory amino acid transporter 2 0.0763 0.4777 0.5433
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0813 0.4314
Echinococcus granulosus tumor susceptibility gene 101 protein 0.007 0.0342 0.0389
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0136 0.0541
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0634 0.1287
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0338 0.0667
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Brugia malayi Thioredoxin reductase 0.0037 0.0136 0.0242
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0169 0.0723
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0137 0.108
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0285 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0029 0.0017
Echinococcus granulosus snurportin 1 0.064 0.3989 0.4536
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1833 1
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0634 0.1287
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0506 0.0506
Mycobacterium ulcerans lipase LipD 0.0145 0.0824 0.4539
Echinococcus granulosus cpg binding protein 0.006 0.0279 0.0317
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0158 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0029 0.0033
Loa Loa (eye worm) glutathione reductase 0.0037 0.0136 0.0239
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0285 0.0324
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.007 0.0342 0.0342
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0228 0.1055
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0763 0.4777 0.8165
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1378 0.1567
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0443 0.054
Plasmodium vivax glutathione reductase, putative 0.0037 0.0136 0.1062
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.1727 0.8271
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0362 0.1802
Treponema pallidum glutamate/aspartate transporter 0.0338 0.206 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0137 0.0548
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.0824 0.4539
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.012 0.0022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.1727 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0824 0.1685
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0338 0.206 0.2342
Echinococcus multilocularis expressed conserved protein 0.009 0.0469 0.0469
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0824 0.2559
Echinococcus granulosus expressed conserved protein 0.009 0.0469 0.0534
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0265 0.0265
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0285 0.0324
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0443 0.054
Schistosoma mansoni hypothetical protein 0.0806 0.505 0.5743
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0029 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.028 0.0319
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.012 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1359 0.1545
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.012 0.0022
Onchocerca volvulus 0.0091 0.0478 0.0947
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0207 0.0337
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0763 0.4777 0.4777
Treponema pallidum glutamate transporter 0.0338 0.206 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0137 0.0548
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0903 0.1855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0029 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0029 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Echinococcus multilocularis excitatory amino acid transporter 2 0.0763 0.4777 0.4777
Schistosoma mansoni ap endonuclease 0.0038 0.0137 0.0156
Brugia malayi Importin beta-1 subunit 0.006 0.028 0.0545
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0264 0.0264
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0101 0.0115
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0136 0.0239
Toxoplasma gondii exonuclease III APE 0.0038 0.0137 0.0823
Brugia malayi Muscleblind-like protein 0.0307 0.1859 0.3865
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.1833 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0139 0.0158
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0265 0.0301
Toxoplasma gondii aldehyde dehydrogenase 0.0183 0.1064 1
Echinococcus granulosus excitatory amino acid transporter 3 0.0763 0.4777 0.5433
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0542 0.1094
Schistosoma mansoni hypothetical protein 0.0069 0.0338 0.0384
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1378 0.1378
Toxoplasma gondii hypothetical protein 0.0049 0.0209 0.153
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0824 1
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0763 0.4777 0.4777
Brugia malayi nuclear hormone receptor 0.0021 0.0029 0.0017
Echinococcus granulosus Excitatory amino acid transporter 0.0763 0.4777 0.5433
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0178 0.123
Brugia malayi jmjC domain containing protein 0.0061 0.0285 0.0557
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0768 0.0768
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0362 0.0362
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0029 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.1064 0.121
Echinococcus multilocularis excitatory amino acid transporter 2 0.0763 0.4777 0.4777
Schistosoma mansoni hypothetical protein 0.0032 0.0101 0.0115
Loa Loa (eye worm) hypothetical protein 0.006 0.028 0.0542
Schistosoma mansoni patched 1 0.0041 0.0158 0.018
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0137 0.0548
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0029 0.0033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0137 0.0242
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0178 0.1615
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0029 0.0017
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.02 0.0497
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0029 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0029 0.0033
Onchocerca volvulus 0.0468 0.2889 0.6023
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0029 0.0029
Schistosoma mansoni ap endonuclease 0.0038 0.0137 0.0156
Schistosoma mansoni hypothetical protein 0.0039 0.0149 0.0169
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0137 0.0245
Echinococcus granulosus neutral amino acid transporter A 0.0763 0.4777 0.5433
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0362 0.0412
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.0824 0.1685
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0029 0.0017
Echinococcus granulosus dnaJ subfamily B 0.0806 0.505 0.5743
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0362 0.0412
Schistosoma mansoni importin beta-1 0.006 0.028 0.0318
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.012 0.0022
Onchocerca volvulus 0.0057 0.0258 0.0483
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0307 0.1859 0.3863
Echinococcus multilocularis neutral amino acid transporter A 0.0763 0.4777 0.4777
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0169 0.0723
Schistosoma mansoni glutaminase 0.0274 0.1649 0.1876
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0763 0.4777 1
Brugia malayi Excitatory amino acid transporter 0.0763 0.4777 1
Echinococcus multilocularis importin subunit beta 1 0.006 0.028 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1359 0.1545
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Onchocerca volvulus 0.0145 0.0824 0.1674
Mycobacterium ulcerans glutaminase 0.0274 0.1649 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0229 0.1359 0.2811
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.1359 0.1359
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0032 0.0101 0.0115
Echinococcus granulosus microtubule associated protein 2 0.1391 0.8793 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0137 0.3686
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0207 0.0938
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0791 0.9137
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.0824 0.121
Brugia malayi RNA, U transporter 1 0.017 0.0986 0.203
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0264 0.03
Trichomonas vaginalis ran, putative 0.0044 0.0178 0.0234
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.012 0.045
Brugia malayi Pre-SET motif family protein 0.006 0.028 0.0546
Schistosoma mansoni hypothetical protein 0.0172 0.0994 0.1131
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.0824 0.4539
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0903 0.1852
Echinococcus multilocularis neutral amino acid transporter A 0.0763 0.4777 0.4777
Loa Loa (eye worm) beta-lactamase 0.0145 0.0824 0.1685
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0029 0.0029
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0504 0.1603
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0158 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0029 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.1359 0.1545
Mycobacterium tuberculosis Conserved protein 0.0145 0.0824 0.121
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0029 0.0033
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0169 0.0723
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.012 0.0648
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.1727 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0029 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0029 0.0033
Brugia malayi steroid hormone receptor 0.0021 0.0029 0.0017
Chlamydia trachomatis glutamate symporter 0.0763 0.4777 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.028 0.0319
Echinococcus granulosus muscleblind protein 0.0307 0.1859 0.2114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0178 0.0778
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0338 0.206 0.2342
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0054 0.0085
Brugia malayi CHE-14 protein 0.0041 0.0158 0.0289
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0137 0.0086
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0264 0.0839
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0824 0.2559
Schistosoma mansoni cpg binding protein 0.0057 0.0258 0.0294
Echinococcus multilocularis protein patched 0.0041 0.0158 0.0158
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0169 0.0723
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0763 0.4777 0.5433
Plasmodium vivax SET domain protein, putative 0.006 0.028 0.2939
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0264 0.03
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.064 0.3989 0.8342
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0029 0.0029
Echinococcus granulosus neuropeptide s receptor 0.0454 0.2803 0.3187
Trichomonas vaginalis glutaminase, putative 0.0274 0.1649 0.5534
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0362 0.1802
Echinococcus multilocularis cpg binding protein 0.006 0.0279 0.0279
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0443 0.054
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0768 0.0873
Echinococcus multilocularis protein dispatched 1 0.0047 0.0195 0.0195
Brugia malayi hypothetical protein 0.0232 0.1378 0.2853
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.1359 0.1359
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0158 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1359 0.1545
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0068
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.0824 0.121
Loa Loa (eye worm) hypothetical protein 0.0145 0.0824 0.1685
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.1064 0.6129
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0029 0.0033
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.0824 0.0937
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0029 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0824 0.2559
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0165
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.1064 0.6129
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0178 0.0332
Schistosoma mansoni cpg binding protein 0.006 0.0279 0.0317
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.028 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0029 0.0029
Schistosoma mansoni survival motor neuron protein 0.0047 0.0198 0.0226
Schistosoma mansoni tsg101-related 0.0058 0.0268 0.0304
Plasmodium vivax importin-beta 2, putative 0.006 0.028 0.2931
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0029 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.0824 0.121
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0029 0.0033
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0338 0.206 0.206
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0443 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0029 0.0014
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0183 0.1064 0.1064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0824 0.0937
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0506 0.0576
Onchocerca volvulus 0.0047 0.0198 0.0357
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0285 0.0324
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.1833 1
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0158 0.018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.0824 0.121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.1359 0.1545
Echinococcus multilocularis Excitatory amino acid transporter 0.0763 0.4777 0.4777
Loa Loa (eye worm) glutaminase 2 0.0274 0.1649 0.3422
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Onchocerca volvulus 0.006 0.028 0.053
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0264 0.0839
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0504 0.0647
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.2803 0.2803
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0264 0.0226
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0678 0.0771
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.0824 0.1688
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0054 0.0085
Mycobacterium ulcerans beta-lactamase 0.0145 0.0824 0.4539
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0158 0.0286
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.012 0.045
Trichomonas vaginalis esterase, putative 0.0145 0.0824 0.2559
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0265 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.028 0.0319
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0504 0.0647
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0183 0.1064 0.1633
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0101 0.0542 0.1094
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0362 0.0718
Trypanosoma brucei glucosidase, putative 0.0035 0.012 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0362 0.0896
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1833 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.012 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0029 0.0033
Brugia malayi beta-lactamase family protein 0.0145 0.0824 0.1688
Brugia malayi hypothetical protein 0.0025 0.0054 0.0071
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.028 0.2239
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0903 0.0903
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.012 0.0022
Echinococcus multilocularis muscleblind protein 0.0307 0.1859 0.1859
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0136 0.1062
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.0824 0.0824
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0824 0.4373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Echinococcus granulosus neutral amino acid transporter A 0.0763 0.4777 0.5433
Plasmodium falciparum glutathione reductase 0.0037 0.0136 0.3625
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0506 0.1021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0029 0.0029
Leishmania major importin beta-1 subunit, putative 0.0049 0.0207 0.0938
Echinococcus granulosus neutral amino acid transporter 0.0763 0.4777 0.5433
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0137 0.0548
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0824 0.4373
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0101 0.0168
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0207 0.0337
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0029 0.0033
Schistosoma mansoni alpha-glucosidase 0.0135 0.0763 0.0867
Schistosoma mansoni ran 0.0044 0.0178 0.0203
Loa Loa (eye worm) hypothetical protein 0.0145 0.0824 0.1685
Brugia malayi Pre-SET motif family protein 0.0411 0.2526 0.5268
Loa Loa (eye worm) hypothetical protein 0.0145 0.0824 0.1685
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.012 0.045
Schistosoma mansoni alpha glucosidase 0.0035 0.012 0.0136
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0362 0.0715
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0029 0.0014
Schistosoma mansoni hypothetical protein 0.0047 0.0198 0.0226
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0542 0.1097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Brugia malayi nuclear receptor NHR-88 0.0021 0.0029 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.028 0.0319
Schistosoma mansoni hypothetical protein 0.064 0.3989 0.4536
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0178 0.0203
Schistosoma mansoni microtubule-associated protein tau 0.1391 0.8793 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0029 0.0033
Schistosoma mansoni tsg101-related 0.0058 0.0268 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0232 0.1378 0.2851
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.1064 0.6129
Mycobacterium ulcerans hypothetical protein 0.0145 0.0824 0.4539
Schistosoma mansoni hypothetical protein 0.0039 0.0149 0.0169
Schistosoma mansoni cpg binding protein 0.006 0.0279 0.0317
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0338 0.206 0.206
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0362 0.1415
Brugia malayi ecdysteroid receptor 0.0021 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.005 0.0217 0.041
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0029 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0029 0.0017
Echinococcus multilocularis GPCR, family 2 0.0032 0.0101 0.0101
Loa Loa (eye worm) glutaminase 0.0274 0.1649 0.3422
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0029 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0101 0.0101
Leishmania major GTP-binding protein, putative 0.0044 0.0178 0.0778
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0029 0.0033
Brugia malayi jmjC domain containing protein 0.0058 0.0265 0.0513
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0903 0.1027
Echinococcus granulosus excitatory amino acid transporter 2 0.0763 0.4777 0.5433
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0258 0.0496
Brugia malayi CXXC zinc finger family protein 0.0057 0.0258 0.0499
Loa Loa (eye worm) hypothetical protein 0.0095 0.0506 0.1018
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.0824 0.121
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0824 0.1685
Brugia malayi beta-lactamase 0.0145 0.0824 0.1688
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0137 0.0002
Onchocerca volvulus 0.0145 0.0824 0.1674
Schistosoma mansoni ran 0.0044 0.0178 0.0203
Schistosoma mansoni tsg101-related 0.0047 0.02 0.0227
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.028 0.2233
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0362 0.0362
Onchocerca volvulus 0.0145 0.0824 0.1674
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0029 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0101 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.028 0.1342
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0178 0.5511
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0137 0.011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0029 0.0033
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0813 0.4314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0029 0.0017
Echinococcus multilocularis snurportin 1 0.064 0.3989 0.3989
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.028 0.1342
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0264 0.0512
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0183 0.1064 0.121
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.2526 0.5267
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.028 0.0319
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.0824 0.121
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0791 0.4321
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0029 0.0029
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0178 0.0329
Entamoeba histolytica hypothetical protein 0.0049 0.0207 0.0544
Mycobacterium tuberculosis Probable reductase 0.0085 0.0443 0.054
Brugia malayi glutathione reductase 0.0037 0.0136 0.0242
Schistosoma mansoni alpha-glucosidase 0.0135 0.0763 0.0867
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0362 0.1802
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0542 0.1097
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0824 0.2559
Trichomonas vaginalis set domain proteins, putative 0.0468 0.2889 1
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.2803 0.3187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0029 0.0014
Schistosoma mansoni hypothetical protein 0.0032 0.0101 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1727 0.5815
Brugia malayi hypothetical protein 0.007 0.0342 0.0676
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.1064 0.121
Leishmania major trypanothione reductase 0.0037 0.0136 0.0541
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.012 0.0022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0596 0.5362
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0054 0.0085
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0506 0.2405
Mycobacterium leprae Probable lipase LipE 0.0145 0.0824 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0813 0.4314
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0178 0.0778
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.007 0.0342 0.0673
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.1727 1
Brugia malayi beta-lactamase family protein 0.0145 0.0824 0.1688
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0029 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0069 0.0338 0.0664
Loa Loa (eye worm) hypothetical protein 0.0307 0.1859 0.3863
Echinococcus multilocularis geminin 0.0172 0.0994 0.0994
Echinococcus multilocularis microtubule associated protein 2 0.1391 0.8793 0.8793
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.012 0.0022
Toxoplasma gondii ABC1 family protein 0.0145 0.0824 0.7619
Trypanosoma brucei trypanothione reductase 0.0037 0.0136 0.0541
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0926 0.582 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0137 0.0086
Schistosoma mansoni coup transcription factor 0.0021 0.0029 0.0033
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.012 0.0208
Echinococcus granulosus importin subunit beta 1 0.006 0.028 0.0318

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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