Detailed information for compound 658514

Basic information

Technical information
  • TDR Targets ID: 658514
  • Name: (3Z)-3-[(4-chlorophenyl)methylidene]-5-phenyl furan-2-one
  • MW: 282.721 | Formula: C17H11ClO2
  • H donors: 0 H acceptors: 1 LogP: 4.61 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)/C=C\1/C=C(OC1=O)c1ccccc1
  • InChi: 1S/C17H11ClO2/c18-15-8-6-12(7-9-15)10-14-11-16(20-17(14)19)13-4-2-1-3-5-13/h1-11H/b14-10-
  • InChiKey: OOBPYNGHMHREFX-UVTDQMKNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(4-chlorophenyl)methylidene]-5-phenylfuran-2-one
  • (3Z)-3-[(4-chlorophenyl)methylene]-5-phenyl-furan-2-one
  • 3-[(4-chlorophenyl)methylene]-5-phenyl-furan-2-one
  • 3-[(4-chlorophenyl)methylene]-5-phenyl-2-furanone
  • (3Z)-3-[(4-chlorophenyl)methylene]-5-phenyl-2-furanone
  • 3-(4-chlorobenzylidene)-5-phenyl-furan-2-one
  • (3Z)-3-(4-chlorobenzylidene)-5-phenyl-furan-2-one
  • 3-[(4-chlorophenyl)methylidene]-5-phenyl-furan-2-one
  • (3Z)-3-[(4-chlorophenyl)methylidene]-5-phenyl-furan-2-one
  • 13294-94-5
  • ST5185015
  • ZINC00129995
  • ChemDiv3_000949
  • NSC140717
  • IDI1_019915

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0096 0.0053
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0169 0.0242
Echinococcus granulosus chromobox protein 1 0.0067 0.1057 0.1519
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.012 0.0172
Toxoplasma gondii ABC1 family protein 0.0035 0.0472 0.043
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0038 0.0533 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0947 0.6873
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.012 0.0172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.1223
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0457 0.0657
Onchocerca volvulus 0.0034 0.0457 0.7761
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0947 0.1306
Brugia malayi Cytochrome P450 family protein 0.0013 0.0071 0.0205
Mycobacterium ulcerans lipase LipD 0.0035 0.0472 0.0403
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Loa Loa (eye worm) hypothetical protein 0.003 0.0378 0.2743
Brugia malayi nuclear receptor NHR-67 0.0016 0.0134 0.0676
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Echinococcus granulosus dnaJ subfamily B 0.0395 0.6957 1
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0038 0.0533 0.0465
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0576 0.0535
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0457 0.0657
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0564 1 1
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1057 0.1018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0169 0.018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0712 0.517
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0472 0.0403
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0947 0.6771
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0134 0.013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0472 0.3423
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0457 0.0598
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0117 0.1942 0.2792
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0533 0.0465
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0457 0.3317
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0472 0.0678
Echinococcus multilocularis Chromo domain 0.0011 0.0044 0.0063
Leishmania major hypothetical protein, conserved 0.0035 0.0472 0.4507
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0457 0.0657
Echinococcus granulosus Chromobox protein 3 0.0011 0.0044 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0157 0.0114
Loa Loa (eye worm) retinol dehydrogenase 12 0.0038 0.0533 0.387
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0457 0.0657
Loa Loa (eye worm) hypothetical protein 0.0035 0.0472 0.3423
Echinococcus granulosus chromobox protein 2 0.0011 0.0044 0.0063
Mycobacterium ulcerans beta-lactamase 0.0035 0.0472 0.0403
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0457 0.3097
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0038 0.0533 1
Brugia malayi ecdysone receptor 0.0016 0.0134 0.0676
Loa Loa (eye worm) hypothetical protein 0.0035 0.0472 0.3423
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0472 0.3423
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0157 0.0114
Echinococcus granulosus Chromo domain 0.0011 0.0044 0.0063
Onchocerca volvulus 0.0028 0.0345 0.5656
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0134 0.013
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0457 0.0657
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0959 0.092
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0472 0.8665
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0947 0.1361
Echinococcus granulosus cpg binding protein 0.0029 0.0373 0.0537
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0318
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0345 0.2503
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0472 0.043
Onchocerca volvulus 0.0038 0.0533 0.9194
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0134 0.0972
Brugia malayi nuclear receptor RXR 0.0018 0.0169 0.0935
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0038 0.0533 0.0766
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0947 0.1306
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0169 0.018
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0564 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0457 0.7761
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0134 0.0192
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0318
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0457 0.3097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0134 0.0192
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0134 0.0972
Echinococcus granulosus tar DNA binding protein 0.0061 0.0947 0.1361
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0072 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0959 0.1324
Mycobacterium tuberculosis Possible oxidoreductase 0.0038 0.0533 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.1223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Mycobacterium ulcerans oxidoreductase 0.0038 0.0533 0.0465
Schistosoma mansoni hypothetical protein 0.0015 0.012 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0157 0.0114
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0959 0.1379
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0038 0.0533 0.0065
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0959 0.1324
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0457 0.0657
Brugia malayi chromobox protein homolog 3 0.0038 0.0525 0.3604
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0457 0.0598
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0134 0.013
Echinococcus multilocularis chromobox protein 1 0.0067 0.1057 0.1519
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.012 0.0172
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0038 0.0533 0.0065
Trypanosoma brucei oxidoreductase-like protein 0.0038 0.0533 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0157 0.0114
Leishmania major pteridine reductase 1 0.0038 0.0533 0.5202
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0525 0.0483
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.1223
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0134 0.0676
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0457 0.3097
Onchocerca volvulus 0.0035 0.0472 0.8035
Brugia malayi ecdysteroid receptor 0.0034 0.0457 0.3097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0457 0.3317
Brugia malayi beta-lactamase 0.0035 0.0472 0.3207
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0525 0.0483
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0472 0.0403
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0564 1 1
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0038 0.0533 0.0492
Brugia malayi nuclear receptor NHR-88 0.0016 0.0134 0.0676
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0038 0.0533 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0457 0.3317
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0533 0.0465
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0472 0.043
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.6957 1
Echinococcus multilocularis chromobox protein 1 0.0067 0.1057 0.1519
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0472 0.0619
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0457 0.0657
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.1057 0.7672
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0472 0.043
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0457 0.3097
Trichomonas vaginalis hypothetical protein 0.0564 1 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0038 0.0533 0.0465
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0457 0.0657
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Brugia malayi RNA binding protein 0.0061 0.0947 0.6771
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Schistosoma mansoni retinoic acid receptor RXR 0.0134 0.2265 0.3213
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0134 0.0676
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0134 0.0192
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0038 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0533 0.387
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0533 0.0465
Loa Loa (eye worm) DR-78 0.0016 0.0134 0.0972
Brugia malayi hypothetical protein 0.0018 0.0169 0.0935
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0472 0.0678
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0472 0.043
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0134 0.013
Schistosoma mansoni chromobox protein 0.0067 0.1057 0.1465
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Trypanosoma brucei pteridine reductase 1 0.0038 0.0533 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0038 0.0533 1
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0038 0.0533 0.0492
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0959 0.0895
Loa Loa (eye worm) hypothetical protein 0.0015 0.012 0.0869
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0134 0.0192
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0457 0.0598
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0457 0.3097
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0472 0.043
Onchocerca volvulus 0.003 0.0378 0.6276
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0134 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0457 0.3097
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0533 0.3669
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0134 0.013
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0038 0.0533 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Schistosoma mansoni eyes absent homolog 0.0085 0.1378 0.1929
Schistosoma mansoni hypothetical protein 0.0033 0.0438 0.057
Brugia malayi conserved hypotetical protein 0.0016 0.0134 0.0676
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0457 0.3097
Plasmodium falciparum enoyl-acyl carrier reductase 0.0564 1 1
Schistosoma mansoni cpg binding protein 0.0029 0.0373 0.0477
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0457 0.7761
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0318
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0326 0.0284
Schistosoma mansoni chromobox protein 0.0067 0.1057 0.1465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0457 0.3317
Brugia malayi tailless protein 0.0016 0.0134 0.0676
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.1223
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0457 0.0598
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0457 0.3317
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0959 0.0512
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0038 0.0533 0.0065
Onchocerca volvulus 0.0016 0.0134 0.1693
Loa Loa (eye worm) hypothetical protein 0.0035 0.0472 0.3423
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0038 0.0533 0.5202
Schistosoma mansoni cpg binding protein 0.0028 0.0345 0.0435
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0038 0.0533 0.0708
Loa Loa (eye worm) helicase 0.0011 0.0044 0.0318
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0134 0.0192
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0038 0.0533 0.5202
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0457 0.3097
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.012 0.0869
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1057 0.1018
Echinococcus multilocularis chromobox protein 2 0.0011 0.0044 0.0063
Brugia malayi Latrophilin receptor protein 2 0.0015 0.012 0.057
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0457 0.0657
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0134 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0457 0.0657
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0134 0.0676
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0472 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0326 0.0284
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0169 0.0935
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0038 0.0533 0.5202
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0457 0.0657
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0134 0.2265 0.3256
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0038 0.0533 1
Brugia malayi nuclear hormone receptor 0.0016 0.0134 0.0676
Brugia malayi Heterochromatin protein 1 0.0067 0.1057 0.7595
Onchocerca volvulus 0.0038 0.0533 0.9194
Schistosoma mansoni nuclear receptor 0.0016 0.0134 0.013
Onchocerca volvulus 0.0016 0.0134 0.1693
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0533 0.0465
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0055 0.0016
Brugia malayi SET domain containing protein 0.0012 0.0055 0.0082
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0457 0.0657
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0038 0.0533 0.387
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0712 0.517
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0564 1 1
Schistosoma mansoni coup transcription factor 0.0034 0.0457 0.0598
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0044 0.0063
Schistosoma mansoni dihydropteridine reductase 0.0038 0.0533 0.0708
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0947 0.1306
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0457 0.0598
Loa Loa (eye worm) beta-lactamase 0.0035 0.0472 0.3423
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0457 0.3097
Brugia malayi hypothetical protein 0.0016 0.0134 0.0676
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Echinococcus granulosus GPCR family 2 0.0015 0.012 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0457 0.3097
Loa Loa (eye worm) hypothetical protein 0.0085 0.1378 1
Onchocerca volvulus 0.0012 0.0055 0.0205
Loa Loa (eye worm) hypothetical protein 0.0035 0.0472 0.3423
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0457 0.7761
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0038 0.0533 0.0465
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0533 0.3669
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0044 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0457 0.3097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0157 0.0114
Brugia malayi CHD4 protein 0.0013 0.0072 0.0213
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0038 0.0533 0.0065
Schistosoma mansoni cpg binding protein 0.0029 0.0373 0.0477
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0038 0.0533 0.0492
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0134 0.0192
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0905 0.1245
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0457 0.3097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0712 0.5012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0438 0.318
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0318
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0457 0.0598
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0533 0.0465
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0071 0.0516
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0071 0.0516
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0038 0.0533 0.0766
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0457 0.0598
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0947 0.1306
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0947 0.6873
Schistosoma mansoni hypothetical protein 0.0395 0.6957 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0169 0.1223
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0157 0.0114
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0457 0.0598
Brugia malayi nuclear receptor RXR 0.0016 0.0134 0.0676
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.012 0.0172
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0564 1 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.0533 0.387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Onchocerca volvulus 0.0035 0.0472 0.8035
Trichomonas vaginalis esterase, putative 0.0035 0.0472 0.043
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0457 0.3097
Brugia malayi hypothetical protein 0.0016 0.0134 0.0676
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0472 0.043
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0134 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0457 0.3317
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0134 0.0676
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.012 0.057
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0134 0.1693
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0457 0.0657
Brugia malayi nuclear receptor NHR-88 0.0034 0.0457 0.3097
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.3845 0.354
Loa Loa (eye worm) RNA binding protein 0.0061 0.0947 0.6873
Brugia malayi beta-lactamase family protein 0.0035 0.0472 0.3207
Brugia malayi hypothetical protein 0.0085 0.1378 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0564 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0457 0.0598
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0038 0.0533 0.0492
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0472 0.8665
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0169 0.0242
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0576 0.0535
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0157 0.0114
Brugia malayi beta-lactamase family protein 0.0035 0.0472 0.3207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0157 0.0114
Loa Loa (eye worm) hypothetical protein 0.0085 0.1378 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0947 0.1306
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0438 0.2956
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0134 0.1693
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0472 0.3207
Loa Loa (eye worm) hypothetical protein 0.0038 0.0525 0.3808
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0072 0.0104
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0712 0.5012
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0134 0.0972
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0457 0.3097
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0104 0.0061
Brugia malayi nuclear hormone receptor 0.0034 0.0457 0.3097
Echinococcus granulosus chromobox protein 1 0.0067 0.1057 0.1519
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0071 0.0516
Echinococcus multilocularis cpg binding protein 0.0029 0.0373 0.0537
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0525 0.9031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0792 0.0751
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0457 0.0598
Schistosoma mansoni hypothetical protein 0.0015 0.012 0.011
Mycobacterium ulcerans hypothetical protein 0.0035 0.0472 0.0403
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0134 0.0192
Loa Loa (eye worm) hypothetical protein 0.0035 0.0472 0.3423
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0169 0.0935
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.1223
Brugia malayi CXXC zinc finger family protein 0.0028 0.0345 0.2257
Echinococcus multilocularis GPCR, family 2 0.0015 0.012 0.0172
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0959 0.1379
Brugia malayi Cytochrome P450 family protein 0.0013 0.0071 0.0205
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0457 0.3097
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0457 0.3317
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0457 0.0657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0457 0.3317
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0959 0.0895
Onchocerca volvulus 0.0035 0.0472 0.8035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Brugia malayi hypothetical protein 0.0018 0.0169 0.0935
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0533 0.0065
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0045
Brugia malayi steroid hormone receptor 0.0034 0.0457 0.3097
Brugia malayi TAR-binding protein 0.0061 0.0947 0.6771
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0065
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0072 0.0104
Schistosoma mansoni hypothetical protein 0.0015 0.012 0.011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0457 0.3097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0959 0.0895
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0065
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0134 0.0192
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0457 0.0657
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0134 0.0676
Schistosoma mansoni hypothetical protein 0.0015 0.012 0.011
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0533 0.0465
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0533 0.0465
Schistosoma mansoni zinc finger protein 0.0016 0.0134 0.013
Schistosoma mansoni nuclear receptor 0.0016 0.0134 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0104 0.0061
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0134 0.0676
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.3317
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0472 0.8665
Mycobacterium tuberculosis Possible oxidoreductase 0.0038 0.0533 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0134 0.0972
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0044 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0457 0.0657
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0072 0.0524
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0457 0.0657
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0576 1
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0038 0.0533 0.0492
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0318
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0457 0.0598
Leishmania major oxidoreductase-like protein 0.0038 0.0533 0.5202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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