Detailed information for compound 658614

Basic information

Technical information
  • TDR Targets ID: 658614
  • Name: methyl 2-[[2-(4-chlorophenoxy)acetyl]amino]-4 ,5,6,7-tetrahydro-1-benzothiophene-3-carboxyl ate
  • MW: 379.858 | Formula: C18H18ClNO4S
  • H donors: 1 H acceptors: 2 LogP: 5.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(NC(=O)COc2ccc(cc2)Cl)sc2c1CCCC2
  • InChi: 1S/C18H18ClNO4S/c1-23-18(22)16-13-4-2-3-5-14(13)25-17(16)20-15(21)10-24-12-8-6-11(19)7-9-12/h6-9H,2-5,10H2,1H3,(H,20,21)
  • InChiKey: HDXLHHLVALHNOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[[2-(4-chlorophenoxy)acetyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
  • 2-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid methyl ester
  • 2-[[2-(4-chlorophenoxy)acetyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid methyl ester
  • methyl 2-[2-(4-chlorophenoxy)ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
  • ZINC00631652
  • AG-690/11152176
  • BAS 00472785
  • ST026383
  • ARONIS000648

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.0313 0.2146 0.2135
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0183 0.1167
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0432 0.0408
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0183 0.0442
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0837 0.0824
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0432 0.1043
Toxoplasma gondii ABC1 family protein 0.0075 0.0432 0.2821
Echinococcus multilocularis carbonic anhydrase 0.0219 0.1468 0.1456
Loa Loa (eye worm) carbonic anhydrase 3 0.059 0.4137 0.4137
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0014 0.0014
Onchocerca volvulus 0.0029 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0301 0.2057 0.2046
Echinococcus multilocularis geminin 0.0167 0.109 0.1077
Schistosoma mansoni importin beta-1 0.0028 0.0094 0.008
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0014 0.0014
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0094 0.0484
Loa Loa (eye worm) hypothetical protein 0.0075 0.0432 0.0432
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0432 0.2756
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0041 0.0401
Brugia malayi Smad1 0.0017 0.0014 0.0014
Brugia malayi hypothetical protein 0.0025 0.007 0.007
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.0014
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0219 0.1468 0.1468
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0183 0.0183
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.026 0.026
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.1204 0.1191
Mycobacterium ulcerans beta-lactamase 0.0075 0.0432 0.5013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0432 0.0408
Schistosoma mansoni alpha-glucosidase 0.0157 0.1021 0.1008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0182 0.1204 0.1204
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0041 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0432 0.2756
Trichomonas vaginalis ran, putative 0.0021 0.0041 0.0261
Loa Loa (eye worm) hypothetical protein 0.0313 0.2146 0.2146
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.0014
Echinococcus multilocularis muscleblind protein 0.0313 0.2146 0.2135
Echinococcus granulosus carbonic anhydrase II 0.059 0.4137 0.4129
Schistosoma mansoni hypothetical protein 0.0219 0.1468 0.1456
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.7742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0103 0.0089
Echinococcus multilocularis neutral amino acid transporter A 0.1406 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0056 0.0358
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.007 0.0169
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.059 0.4137 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.026 0.0246
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0432 0.2756
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0432 0.0408
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0487 0.3395 0.3395
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0432 0.0408
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0157
Plasmodium falciparum glutathione reductase 0.0037 0.0159 0.0932
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0502 0.0478
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.2057 0.2057
Brugia malayi MH2 domain containing protein 0.025 0.1692 0.1692
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.7742
Loa Loa (eye worm) hypothetical protein 0.0075 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0094
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0025 0.001
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0623 0.4372 0.4364
Trichomonas vaginalis esterase, putative 0.0075 0.0432 0.2756
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1406 1 1
Echinococcus multilocularis carbonic anhydrase 0.0219 0.1468 0.1456
Brugia malayi RNA, U transporter 1 0.008 0.0468 0.0468
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0183 0.1096
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0432 0.1043
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0041 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.0314
Loa Loa (eye worm) hypothetical protein 0.0075 0.0432 0.0432
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0183 0.1167
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0159 0.0384
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0183 0.1167
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0837 0.0824
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0041 0.0113
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0094 0.0228
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0183 0.0169
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.059 0.4137 0.4129
Echinococcus granulosus carbonic anhydrase 0.0219 0.1468 0.1456
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.026 0.0246
Onchocerca volvulus 0.0075 0.0432 0.0432
Schistosoma mansoni ran 0.0021 0.0041 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0432 0.1043
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.7742
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.001
Brugia malayi Importin beta-1 subunit 0.0028 0.0094 0.0094
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0095 0.0081
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0183 0.1167
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.057 0.0547
Echinococcus granulosus sodium:dicarboxylate symporter 0.1406 1 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0041 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0041 0.2235
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0432 0.5013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0502 0.5071
Mycobacterium tuberculosis Conserved protein 0.0075 0.0432 0.0408
Mycobacterium tuberculosis Conserved protein 0.0075 0.0432 0.0408
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0432 1
Schistosoma mansoni carbonic anhydrase 0.0219 0.1468 0.1456
Leishmania major importin beta-1 subunit, putative 0.0023 0.0056 0.0135
Echinococcus granulosus neutral amino acid transporter A 0.1406 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.1468 0.1456
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0041 0.0027
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.1468 0.1468
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0183 0.1167
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.007
Leishmania major carbonic anhydrase-like protein 0.059 0.4137 1
Echinococcus multilocularis tumor protein p63 0.0332 0.2281 0.227
Leishmania major trypanothione reductase 0.0037 0.0159 0.0384
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0025 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0837 1
Onchocerca volvulus 0.0075 0.0432 0.0432
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0094 0.0228
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0219 0.1468 0.1468
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0432 0.0432
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0141 0.0127
Echinococcus granulosus excitatory amino acid transporter 2 0.1406 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0056 0.3066
Echinococcus multilocularis muscleblind protein 1 0.0313 0.2146 0.2135
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0103 0.0089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0837 0.2022
Echinococcus multilocularis excitatory amino acid transporter 2 0.1406 1 1
Mycobacterium ulcerans lipase LipD 0.0075 0.0432 0.5013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0141 0.0127
Loa Loa (eye worm) hypothetical protein 0.0219 0.1468 0.1468
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0183 0.1167
Mycobacterium ulcerans hypothetical protein 0.0075 0.0432 0.5013
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.059 0.4137 0.4129
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.059 0.4137 0.4137
Trypanosoma brucei glucosidase, putative 0.004 0.0183 0.0442
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0432 0.0418
Brugia malayi hypothetical protein 0.0016 0.0007 0.0007
Brugia malayi beta-lactamase family protein 0.0075 0.0432 0.0432
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0837 0.0824
Onchocerca volvulus 0.0049 0.0241 0.0241
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0025 0.0157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0432 0.0432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.026 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.026 0.0246
Trypanosoma brucei trypanothione reductase 0.0037 0.0159 0.0384
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0432 0.0432
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0837 0.0824
Brugia malayi follicle stimulating hormone receptor 0.0487 0.3395 0.3395
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.0314
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.059 0.4137 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0056 0.0135
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0056 0.0358
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.057 0.0547
Brugia malayi hypothetical protein 0.0035 0.0141 0.0141
Echinococcus granulosus geminin 0.0167 0.109 0.1077
Toxoplasma gondii thioredoxin reductase 0.0037 0.0159 0.0932
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0183 0.1167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0025 0.001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0502 0.0478
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1406 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0163 0.0149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.026 0.026
Brugia malayi Thioredoxin reductase 0.0037 0.0159 0.0159
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0183 0.0169
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0837 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0025 0.1342
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.057 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0432 0.0418
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0502 0.0478
Schistosoma mansoni hypothetical protein 0.0167 0.109 0.1077
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0837 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1406 1 1
Plasmodium vivax glutathione reductase, putative 0.0037 0.0159 0.3304
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.0014
Plasmodium falciparum thioredoxin reductase 0.0037 0.0159 0.0932
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0041 0.0041
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0623 0.4372 0.4364
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0167 0.109 0.1077
Echinococcus granulosus carbonic anhydrase 0.0219 0.1468 0.1456
Echinococcus multilocularis Excitatory amino acid transporter 0.1406 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0159 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0432 0.2756
Echinococcus granulosus importin subunit beta 1 0.0028 0.0094 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0432 0.2756
Chlamydia trachomatis glutamate symporter 0.1406 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.007 0.0314
Brugia malayi glutathione reductase 0.0037 0.0159 0.0159
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1567 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0141 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0103 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0103 0.0089
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0163 0.0149
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0025 0.0059
Echinococcus multilocularis neutral amino acid transporter A 0.1406 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.1468 0.1468
Brugia malayi Pre-SET motif family protein 0.0029 0.0103 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.026 0.0246
Loa Loa (eye worm) hypothetical protein 0.0219 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0075 0.0432 0.0432
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.1692 0.1692
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0241 0.0227
Schistosoma mansoni alpha glucosidase 0.004 0.0183 0.0169
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0432 0.0408
Plasmodium vivax SET domain protein, putative 0.0029 0.0103 0.1918
Brugia malayi Putative carbonic anhydrase 5 precursor 0.059 0.4137 0.4137
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0041 0.0027
Entamoeba histolytica hypothetical protein 0.0035 0.0141 0.7742
Echinococcus multilocularis Excitatory amino acid transporter 0.1406 1 1
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1406 1 1
Echinococcus granulosus snurportin 1 0.0301 0.2057 0.2046
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.1468 0.1456
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0059
Mycobacterium tuberculosis Conserved protein 0.0075 0.0432 0.0408
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.1204 0.1191
Echinococcus granulosus Excitatory amino acid transporter 0.1406 1 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0094 0.008
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0041 0.0099
Echinococcus multilocularis neutral amino acid transporter A 0.1406 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0241 0.0241
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0432 0.0418
Trypanosoma brucei carbonic anhydrase-like protein 0.059 0.4137 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.1468 0.1468
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0502 0.0478
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0432 0.0418
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1406 1 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0623 0.4372 0.4364
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0103 0.0089
Echinococcus multilocularis excitatory amino acid transporter 3 0.1406 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.026 0.0246
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0159 0.0159
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0837 0.5627
Loa Loa (eye worm) hypothetical protein 0.0313 0.2146 0.2146
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.1692 0.1692
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0103 0.0541
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0183 0.1167
Plasmodium falciparum carbonic anhydrase 0.0219 0.1468 1
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.001
Leishmania major hypothetical protein, conserved 0.0075 0.0432 0.1043
Leishmania major GTP-binding protein, putative 0.0021 0.0041 0.0099
Schistosoma mansoni alpha-glucosidase 0.0157 0.1021 0.1008
Loa Loa (eye worm) excitatory amino acid transporter 0.1406 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0183 0.0442
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0025 0.0025
Treponema pallidum glutamate/aspartate transporter 0.0623 0.4372 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.3343 0.3326
Plasmodium vivax importin-beta 2, putative 0.0028 0.0094 0.1716
Brugia malayi Pre-SET motif family protein 0.0205 0.1363 0.1363
Treponema pallidum glutamate transporter 0.0623 0.4372 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.007 0.1111
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0041 0.0099
Mycobacterium tuberculosis Probable reductase 0.0085 0.0502 0.0478
Echinococcus granulosus carbonic anhydrase 0.0219 0.1468 0.1456
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0502 0.0478
Brugia malayi Muscleblind-like protein 0.0313 0.2146 0.2146
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0183 0.1167
Onchocerca volvulus 0.0233 0.1567 0.1567
Echinococcus granulosus tumor protein p63 0.0332 0.2281 0.227
Loa Loa (eye worm) glutathione reductase 0.0037 0.0159 0.0159
Brugia malayi beta-lactamase family protein 0.0075 0.0432 0.0432
Echinococcus granulosus Excitatory amino acid transporter 0.1406 1 1
Onchocerca volvulus 0.0075 0.0432 0.0432
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0183 0.0442
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0056 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0103 0.0089
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0183 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.057 0.0547
Echinococcus granulosus neutral amino acid transporter A 0.1406 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0432 0.5013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0183 0.0183
Echinococcus granulosus lysosomal alpha glucosidase 0.0182 0.1204 0.1191
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.0169
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0837 0.0814
Loa Loa (eye worm) hypothetical protein 0.0075 0.0432 0.0432
Toxoplasma gondii hypothetical protein 0.0219 0.1468 1
Leishmania major hypothetical protein, conserved 0.0025 0.007 0.0169
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1406 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0432 0.0408
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1363 0.1363
Brugia malayi Glycosyl hydrolases family 31 protein 0.0182 0.1204 0.1204
Echinococcus granulosus excitatory amino acid transporter 3 0.1406 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0219 0.1468 0.1468
Schistosoma mansoni carbonic anhydrase-related 0.0219 0.1468 0.1456
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0041 0.0099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.0059
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0432 0.0408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.026 0.0246
Onchocerca volvulus 0.0106 0.0651 0.0651
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.0169
Schistosoma mansoni hypothetical protein 0.0035 0.0141 0.0127
Schistosoma mansoni ran 0.0021 0.0041 0.0027
Echinococcus multilocularis carbonic anhydrase II 0.059 0.4137 0.4129
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0159 0.3304
Brugia malayi beta-lactamase 0.0075 0.0432 0.0432
Echinococcus granulosus excitatory amino acid transporter 2 0.1406 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.1468 0.1468
Loa Loa (eye worm) beta-lactamase 0.0075 0.0432 0.0432
Echinococcus granulosus neutral amino acid transporter 0.1406 1 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0623 0.4372 0.4364
Echinococcus multilocularis carbonic anhydrase 0.0219 0.1468 0.1456
Echinococcus multilocularis snurportin 1 0.0301 0.2057 0.2046
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0103 0.0089
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1406 1 1
Plasmodium falciparum importin beta, putative 0.0028 0.0094 0.0484
Loa Loa (eye worm) Smad1 0.0017 0.0014 0.0014
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.059 0.4137 0.4137

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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