Detailed information for compound 658650

Basic information

Technical information
  • TDR Targets ID: 658650
  • Name: ethyl 2-[3-(4-methoxyphenyl)prop-2-enoylamino ]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-car boxylate
  • MW: 371.45 | Formula: C20H21NO4S
  • H donors: 1 H acceptors: 2 LogP: 4.63 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)C=Cc2ccc(cc2)OC)sc2c1CCC2
  • InChi: 1S/C20H21NO4S/c1-3-25-20(23)18-15-5-4-6-16(15)26-19(18)21-17(22)12-9-13-7-10-14(24-2)11-8-13/h7-12H,3-6H2,1-2H3,(H,21,22)/b12-9+
  • InChiKey: DIGBJTPKSMGMFP-FMIVXFBMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[[(E)-3-(4-methoxyphenyl)prop-2-enoyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxylate
  • 2-[[3-(4-methoxyphenyl)-1-oxoprop-2-enyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxylic acid ethyl ester
  • 2-[[(E)-3-(4-methoxyphenyl)-1-oxoprop-2-enyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxylic acid ethyl ester
  • 2-[[3-(4-methoxyphenyl)acryloyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxylic acid ethyl ester
  • 2-[[(E)-3-(4-methoxyphenyl)acryloyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxylic acid ethyl ester
  • IFLab1_001029
  • BAS 00685818
  • ZINC00799688
  • STOCK2S-69785

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0057 0.0082
Brugia malayi hypothetical protein 0.0204 0.0838 0.1203
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0022 0.0015 0.0149
Echinococcus multilocularis excitatory amino acid transporter 2 0.1558 0.6968 0.6968
Brugia malayi Inositol-1 0.0035 0.0077 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0419 0.1594
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0134 0.0523 0.075
Echinococcus multilocularis carbonic anhydrase 0.0222 0.0922 0.0922
Echinococcus multilocularis chromobox protein 1 0.006 0.019 0.019
Brugia malayi MH2 domain containing protein 0.0032 0.0059 0.0085
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0014 0.0021
Echinococcus multilocularis excitatory amino acid transporter 3 0.1558 0.6968 0.6968
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0057 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0043 0.0456
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0102 0.0102
Plasmodium vivax SET domain protein, putative 0.003 0.0052 0.122
Echinococcus granulosus lamin dm0 0.0051 0.0147 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0173 0.0701 0.1006
Schistosoma mansoni smad1 5 8 and 0.0032 0.0059 0.0085
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0047 0.0131 0.141
Trypanosoma brucei protein kinase, putative 0.0047 0.0131 0.0495
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0082 0.0117
Echinococcus multilocularis muscleblind protein 0.0322 0.1375 0.1375
Brugia malayi jmjC domain containing protein 0.0022 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0052 0.0153 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0034
Echinococcus multilocularis jumonji domain containing 1A 0.0022 0.0015 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0117 0.0446 0.064
Loa Loa (eye worm) aspartyl protease 6 0.0053 0.0157 0.0225
Brugia malayi hypothetical protein 0.0028 0.0043 0.0062
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0014 0.0141
Loa Loa (eye worm) hypothetical protein 0.0053 0.0157 0.0225
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0035 0.0319
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0057 0.0057
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1558 0.6968 0.6968
Schistosoma mansoni survival motor neuron protein 0.0145 0.0575 0.0825
Echinococcus multilocularis mitogen activated protein kinase 0.0047 0.0131 0.0131
Echinococcus granulosus survival motor neuron protein 1 0.0713 0.3145 0.4513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0031 0.0044
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1558 0.6968 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1558 0.6968 0.6968
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0057 0.0082
Echinococcus granulosus mitogen activated protein kinase 0.0047 0.0131 0.0188
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0057 0.0082
Onchocerca volvulus 0.0051 0.0147 0.0211
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0057 0.0082
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0047 0.0131 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0057 0.0082
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.069 0.3042 0.4366
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Schistosoma mansoni ap endonuclease 0.0019 0.0001 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0057 0.0082
Brugia malayi Excitatory amino acid transporter 0.1558 0.6968 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0031 0.0322
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0057 0.0082
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0022 0.0015 0.0052
Leishmania major trypanothione reductase 0.0038 0.0087 0.0328
Echinococcus granulosus neutral amino acid transporter 0.1558 0.6968 1
Echinococcus granulosus JmjC domain containing protein 4 0.0022 0.0015 0.0022
Echinococcus granulosus carbonic anhydrase 0.0222 0.0922 0.1322
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0057 0.0082
Brugia malayi beta-lactamase family protein 0.0111 0.0419 0.0602
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0047 0.0131 0.0495
Loa Loa (eye worm) transcription factor SMAD2 0.0463 0.201 0.2885
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0598 0.2623 0.3765
Schistosoma mansoni coup transcription factor 0.0031 0.0057 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0131 0.122
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0102 0.095
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0529 1
Treponema pallidum fructose-bisphosphate aldolase 0.0254 0.1065 0.3498
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1558 0.6968 1
Plasmodium vivax plasmepsin V, putative 0.0053 0.0157 0.3726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0057 0.0082
Brugia malayi hypothetical protein 0.0713 0.3145 0.4513
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0021
Echinococcus granulosus carbonic anhydrase II 0.0598 0.2623 0.3765
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Brugia malayi glutathione reductase 0.0038 0.0087 0.0125
Plasmodium falciparum glutathione reductase 0.0038 0.0087 0.0934
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0286 0.0411
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0001 0.0002
Brugia malayi steroid hormone receptor 0.0031 0.0057 0.0082
Onchocerca volvulus 0.0031 0.0057 0.0082
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0047 0.0131 0.0495
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0419 0.3929
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0043 0.016
Schistosoma mansoni hypothetical protein 0.0219 0.0907 0.1301
Mycobacterium leprae Probable lipase LipE 0.0111 0.0419 0.8606
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0529 1
Schistosoma mansoni phosphatidylserine receptor 0.0022 0.0015 0.0022
Plasmodium falciparum importin beta, putative 0.0032 0.0063 0.0671
Echinococcus granulosus excitatory amino acid transporter 2 0.1558 0.6968 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0015 0.0022
Mycobacterium tuberculosis Conserved protein 0.0111 0.0419 0.06
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0053 0.0157 0.0157
Mycobacterium tuberculosis Conserved protein 0.0111 0.0419 0.06
Loa Loa (eye worm) hypothetical protein 0.0101 0.0375 0.0538
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0057 0.0082
Brugia malayi Intermediate filament tail domain containing protein 0.0051 0.0147 0.0211
Plasmodium vivax glutathione reductase, putative 0.0038 0.0087 0.2055
Brugia malayi RNA, U transporter 1 0.0092 0.0333 0.0479
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0419 0.8606
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0057 0.0057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0254 0.1065 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0053 0.0157 0.0225
Echinococcus granulosus intermediate filament protein 0.0051 0.0147 0.0211
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0057 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0015 0.0022
Brugia malayi MH2 domain containing protein 0.0463 0.201 0.2885
Loa Loa (eye worm) hypothetical protein 0.0111 0.0419 0.0602
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0101 0.0375 0.0538
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0057 0.0057
Brugia malayi MAP kinase sur-1 0.0047 0.0131 0.0188
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0021
Echinococcus granulosus geminin 0.0498 0.2172 0.3117
Chlamydia trachomatis glutamate symporter 0.1558 0.6968 1
Brugia malayi Muscleblind-like protein 0.0322 0.1375 0.1973
Leishmania major hypothetical protein, conserved 0.0022 0.0015 0.0052
Loa Loa (eye worm) hypothetical protein 0.0111 0.0419 0.0602
Plasmodium vivax aspartyl proteinase, putative 0.0053 0.0157 0.3726
Echinococcus granulosus excitatory amino acid transporter 3 0.1558 0.6968 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.069 0.3042 0.4366
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.1482 0.2127
Trichomonas vaginalis ran, putative 0.0022 0.0014 0.0122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0087 0.0125
Echinococcus granulosus peregrin 0.0025 0.0031 0.0044
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0028 0.0028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0864 0.124
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0014 0.0311
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0035 0.0319
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0057 0.0082
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0052 0.0052
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0222 0.0922 0.1322
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0102 0.0386
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0063 0.0235
Echinococcus granulosus lamin 0.0051 0.0147 0.0211
Echinococcus granulosus phd:f box containing protein 0.0022 0.0015 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0057 0.0082
Schistosoma mansoni cathepsin D (A01 family) 0.0053 0.0157 0.0225
Echinococcus granulosus carbonic anhydrase 0.0222 0.0922 0.1322
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0031 0.0044
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0043 0.1005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0419 0.06
Echinococcus multilocularis neutral amino acid transporter A 0.1558 0.6968 0.6968
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0087 0.0328
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0419 0.0602
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0015 0.0022
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0102 0.095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Plasmodium falciparum plasmepsin VI 0.0053 0.0157 0.1693
Loa Loa (eye worm) hypothetical protein 0.0222 0.0922 0.1322
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0057 0.0082
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0059 0.0085
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0419 0.06
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1558 0.6968 1
Toxoplasma gondii ABC1 family protein 0.0111 0.0419 0.4543
Echinococcus granulosus tumor protein p63 0.1011 0.4496 0.6451
Loa Loa (eye worm) intermediate filament protein 0.0051 0.0147 0.0211
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0053 0.0157 0.1464
Echinococcus granulosus excitatory amino acid transporter 2 0.1558 0.6968 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.1375 0.1973
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0306 0.0437
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0173 0.0701 0.1006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0147 0.0211
Trichomonas vaginalis chromobox protein, putative 0.006 0.019 0.1776
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0057 0.0082
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0419 0.1594
Schistosoma mansoni biogenic amine (5HT) receptor 0.0419 0.1815 0.2604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0053
Echinococcus multilocularis Smad4 0.0032 0.0059 0.0059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0057 0.0082
Echinococcus granulosus snurportin 1 0.0346 0.1482 0.2127
Plasmodium vivax JmjC domain containing protein 0.0022 0.0015 0.0327
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0034
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0057 0.0082
Brugia malayi Heterochromatin protein 1 0.006 0.019 0.0273
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0131 0.122
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0102 0.095
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0102 0.0386
Echinococcus multilocularis phd:f box containing protein 0.0022 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0057 0.0082
Echinococcus granulosus GPCR family 2 0.0101 0.0375 0.0538
Echinococcus multilocularis sodium:dicarboxylate symporter 0.069 0.3042 0.3042
Schistosoma mansoni smad1 5 8 and 0.0032 0.0059 0.0085
Onchocerca volvulus 0.0111 0.0419 0.0602
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0124 0.0478 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0053 0.0157 0.0225
Onchocerca volvulus 0.0111 0.0419 0.0602
Loa Loa (eye worm) beta-lactamase 0.0111 0.0419 0.0602
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0222 0.0922 0.1322
Brugia malayi hypothetical protein 0.0053 0.0157 0.0225
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0057 0.0082
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0027 0.004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0111 0.0419 0.0602
Mycobacterium tuberculosis Conserved protein 0.0111 0.0419 0.06
Echinococcus granulosus Smad4 0.0032 0.0059 0.0085
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0057 0.0082
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0102 0.095
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0047 0.0131 0.0495
Brugia malayi nuclear receptor NHR-88 0.0031 0.0057 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0057 0.0082
Treponema pallidum glutamate transporter 0.069 0.3042 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0101 0.0375 0.0375
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0286 0.0411
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0057 0.0082
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0057 0.0082
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0015 0.0015
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0022 0.0015 0.0022
Schistosoma mansoni ran 0.0022 0.0014 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0043 0.0456
Toxoplasma gondii aspartyl protease ASP3 0.0053 0.0157 0.1693
Loa Loa (eye worm) hypothetical protein 0.0222 0.0922 0.1322
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0122
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0131 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0057 0.0082
Echinococcus multilocularis JmjC domain containing protein 4 0.0022 0.0015 0.0015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0755 0.0755
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0052 0.0052
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0077 0.0708
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0063 0.0235
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0053 0.0157 0.1693
Onchocerca volvulus 0.0027 0.0037 0.0053
Plasmodium falciparum plasmepsin V 0.0053 0.0157 0.1693
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0077 0.0819
Brugia malayi ecdysteroid receptor 0.0031 0.0057 0.0082
Echinococcus multilocularis excitatory amino acid transporter 2 0.1558 0.6968 0.6968
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0025 0.0223
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0059 0.0059
Leishmania major hypothetical protein, conserved 0.0111 0.0419 0.1594
Echinococcus granulosus importin subunit beta 1 0.0032 0.0063 0.0091
Loa Loa (eye worm) hypothetical protein 0.0053 0.0157 0.0225
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0035 0.0077 0.0108
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0419 0.3929
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0598 0.2623 0.3765
Brugia malayi jmjC domain containing protein 0.0022 0.0015 0.0022
Mycobacterium tuberculosis Probable reductase 0.0086 0.0306 0.0437
Entamoeba histolytica hypothetical protein 0.0026 0.0035 0.0319
Loa Loa (eye worm) hypothetical protein 0.005 0.0143 0.0205
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0135 0.0529 0.0759
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0141
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0529 0.0759
Entamoeba histolytica hypothetical protein 0.0204 0.0838 0.7868
Plasmodium falciparum plasmepsin VIII, putative 0.0053 0.0157 0.1693
Loa Loa (eye worm) hypothetical protein 0.0111 0.0419 0.0602
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0087 0.2055
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0131 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0057 0.0082
Trichomonas vaginalis esterase, putative 0.0111 0.0419 0.3929
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0035 0.0319
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0102 0.095
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0087 0.0123
Schistosoma mansoni hypothetical protein 0.0498 0.2172 0.3117
Loa Loa (eye worm) hypothetical protein 0.0219 0.0907 0.1301
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0077 0.0708
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0135 0.0529 0.0529
Brugia malayi jmjC domain containing protein 0.0082 0.0286 0.0411
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0102 0.0147
Echinococcus granulosus neutral amino acid transporter A 0.1558 0.6968 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0025 0.0223
Toxoplasma gondii aspartyl protease 0.0053 0.0157 0.1693
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0102 0.095
Schistosoma mansoni ran 0.0022 0.0014 0.0021
Entamoeba histolytica hypothetical protein 0.0204 0.0838 0.7868
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.0755 0.1083
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0102 0.095
Echinococcus multilocularis musashi 0.0051 0.0147 0.0147
Plasmodium falciparum thioredoxin reductase 0.0038 0.0087 0.0934
Onchocerca volvulus 0.0148 0.0587 0.0842
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.009 0.009
Mycobacterium ulcerans hypothetical protein 0.0111 0.0419 0.7928
Brugia malayi jmjC domain containing protein 0.0022 0.0015 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0419 0.3929
Brugia malayi nuclear hormone receptor 0.0031 0.0057 0.0082
Plasmodium falciparum JmjC domain-containing protein, putative 0.0022 0.0015 0.0149
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0419 0.06
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0031 0.0322
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0419 0.7928
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0306 0.0437
Loa Loa (eye worm) hypothetical protein 0.032 0.1365 0.1959
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0077 0.0287
Loa Loa (eye worm) hypothetical protein 0.0111 0.0419 0.0602
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0419 0.0602
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0222 0.0922 0.1322
Loa Loa (eye worm) hypothetical protein 0.0111 0.0419 0.0602
Brugia malayi MH1 domain containing protein 0.0032 0.0059 0.0085
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0598 0.2623 0.3765
Leishmania major hypothetical protein, conserved 0.0028 0.0043 0.016
Loa Loa (eye worm) hypothetical protein 0.0713 0.3145 0.4513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Schistosoma mansoni aldehyde dehydrogenase 0.0135 0.0529 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0057 0.0082
Echinococcus multilocularis geminin 0.0498 0.2172 0.2172
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.035 0.6937
Schistosoma mansoni jumonji domain containing protein 0.0022 0.0015 0.0022
Brugia malayi cytoplasmic intermediate filament protein 0.0027 0.004 0.0057
Brugia malayi MH1 domain containing protein 0.0032 0.0059 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0286 0.0411
Echinococcus granulosus smad 0.0032 0.0059 0.0085
Brugia malayi jmjC domain containing protein 0.0022 0.0015 0.0022
Brugia malayi Pepsin A precursor 0.0053 0.0157 0.0225
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0014 0.005
Schistosoma mansoni alpha-glucosidase 0.0159 0.0638 0.0916
Schistosoma mansoni lamin 0.0051 0.0147 0.0211
Loa Loa (eye worm) Smad1 0.0032 0.0059 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0057 0.0082
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0755 0.0755
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0057 0.0082
Plasmodium vivax aspartyl proteinase, putative 0.0053 0.0157 0.3726
Echinococcus granulosus mitogen activated protein kinase 3 0.0047 0.0131 0.0188
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0598 0.2623 0.3765
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0077 0.011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0509 0.2223 0.319
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.035 0.05
Leishmania major carbonic anhydrase-like protein 0.0598 0.2623 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.032 0.1365 0.1959
Mycobacterium tuberculosis Possible penicillin-binding protein 0.071 0.313 0.449
Echinococcus multilocularis lysine specific demethylase 5A 0.0082 0.0286 0.0286
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0051 0.0147 0.0211
Echinococcus multilocularis neutral amino acid transporter A 0.1558 0.6968 0.6968
Schistosoma mansoni lamin 0.0051 0.0147 0.0211
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Schistosoma mansoni intermediate filament proteins 0.0051 0.0147 0.0211
Plasmodium falciparum carbonic anhydrase 0.0222 0.0922 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0035 0.013
Echinococcus granulosus chromobox protein 1 0.006 0.019 0.0273
Brugia malayi chromobox protein homolog 3 0.0034 0.007 0.01
Echinococcus multilocularis snurportin 1 0.0346 0.1482 0.1482
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0043 0.0456
Echinococcus granulosus sodium:dicarboxylate symporter 0.1558 0.6968 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0059 0.0085
Onchocerca volvulus 0.0238 0.0995 0.1428
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0014 0.005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.032 0.1365 0.1959
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0102 0.0147
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Schistosoma mansoni carbonic anhydrase 0.0222 0.0922 0.1322
Schistosoma mansoni hypothetical protein 0.0145 0.0575 0.0825
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0102 0.0147
Echinococcus granulosus chromobox protein 1 0.006 0.019 0.0273
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0419 0.06
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0419 0.06
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0052 0.0075
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0059 0.0085
Brugia malayi jmjC domain containing protein 0.0134 0.0523 0.075
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.035 0.05
Schistosoma mansoni hypothetical protein 0.0498 0.2172 0.3117
Brugia malayi Calcitonin receptor-like protein seb-1 0.032 0.1365 0.1959
Echinococcus multilocularis survival motor neuron protein 1 0.0713 0.3145 0.3145
Echinococcus multilocularis lamin 0.0051 0.0147 0.0147
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0057 0.0082
Plasmodium vivax aspartyl protease, putative 0.0053 0.0157 0.3726
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0052 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0131 0.122
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0077 0.0708
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0306 0.0437
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0057 0.0082
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0001 0.0002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0047 0.0131 0.0188
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0044
Schistosoma mansoni cathepsin D (A01 family) 0.0053 0.0157 0.0225
Brugia malayi MH2 domain containing protein 0.0032 0.0059 0.0085
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.035 0.05
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0059 0.0059
Echinococcus multilocularis tumor protein p63 0.1011 0.4496 0.4496
Brugia malayi Importin beta-1 subunit 0.0032 0.0063 0.0091
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0419 0.0419
Plasmodium falciparum phd finger protein, putative 0.0025 0.0031 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0057 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0043 0.016
Schistosoma mansoni inositol monophosphatase 0.0035 0.0077 0.011
Toxoplasma gondii aspartyl protease ASP1 0.0053 0.0157 0.1693
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0419 0.0602
Loa Loa (eye worm) latrophilin receptor protein 2 0.0101 0.0375 0.0538
Loa Loa (eye worm) hypothetical protein 0.003 0.0052 0.0075
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0222 0.0922 0.1322
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0053 0.0157 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0419 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0057 0.0082
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0057 0.0057
Plasmodium falciparum plasmepsin VII 0.0053 0.0157 0.1693
Echinococcus multilocularis chromobox protein 1 0.006 0.019 0.019
Echinococcus multilocularis mitogen activated protein kinase 3 0.0047 0.0131 0.0131
Schistosoma mansoni memapsin-2 (A01 family) 0.1324 0.591 0.8481
Schistosoma mansoni Smad4 0.0032 0.0059 0.0085
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0057 0.0057
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0059 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0219 0.0907 0.1301
Trypanosoma brucei carbonic anhydrase-like protein 0.0598 0.2623 1
Echinococcus multilocularis muscleblind protein 1 0.0322 0.1375 0.1375
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0102 0.095
Giardia lamblia Kinase, CMGC MAPK 0.0047 0.0131 0.122
Echinococcus multilocularis carbonic anhydrase II 0.0598 0.2623 0.2623
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0419 0.1815 0.1815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0057 0.0082
Brugia malayi Latrophilin receptor protein 2 0.0101 0.0375 0.0538
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0173 0.0701 0.1006
Schistosoma mansoni hypothetical protein 0.0101 0.0375 0.0538
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0131 0.122
Echinococcus multilocularis jumonji domain containing protein 0.0035 0.0076 0.0076
Schistosoma mansoni alpha glucosidase 0.0041 0.0102 0.0147
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0043 0.016
Echinococcus granulosus neutral amino acid transporter A 0.1558 0.6968 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0102 0.095
Schistosoma mansoni hypothetical protein 0.0346 0.1482 0.2127
Schistosoma mansoni hypothetical protein 0.0101 0.0375 0.0538
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0419 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0102 0.095
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0101 0.0375 0.0538
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0124 0.0478 0.9032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0135 0.0529 1
Mycobacterium ulcerans lipase LipD 0.0111 0.0419 0.7928
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0015 0.0022
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.069 0.3042 0.3042
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0014 0.005
Onchocerca volvulus 0.0107 0.0401 0.0576
Echinococcus multilocularis Excitatory amino acid transporter 0.1558 0.6968 0.6968
Onchocerca volvulus 0.004 0.0097 0.0139
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0053 0.0157 0.0225
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0057 0.0057
Loa Loa (eye worm) excitatory amino acid transporter 0.1558 0.6968 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0173 0.0701 0.1006
Plasmodium vivax plasmepsin IV, putative 0.0053 0.0157 0.3726
Giardia lamblia PHD finger protein 15 0.0025 0.0031 0.0279
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0306 0.5896
Entamoeba histolytica hypothetical protein 0.0204 0.0838 0.7868
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0077 0.0287
Schistosoma mansoni transcription factor LCR-F1 0.0204 0.0838 0.1203
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0047 0.0131 0.0495
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0101 0.0375 0.0538
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0022 0.0015 0.0149
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0419 0.3929
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0419 0.06
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.009 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0057 0.0082
Echinococcus multilocularis lysine specific demethylase 6a 0.0022 0.0015 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0082 0.0754
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0222 0.0922 0.1322
Mycobacterium ulcerans beta-lactamase 0.0111 0.0419 0.7928
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0022 0.0015 0.0052
Onchocerca volvulus 0.0111 0.0419 0.0602
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0148 0.0587 0.0842
Schistosoma mansoni carbonic anhydrase-related 0.0222 0.0922 0.1322
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0091
Schistosoma mansoni carbonic anhydrase-related 0.0222 0.0922 0.1322
Brugia malayi Pre-SET motif family protein 0.0209 0.0864 0.124
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0222 0.0922 0.1322
Plasmodium falciparum plasmepsin III 0.0053 0.0157 0.1693
Loa Loa (eye worm) hypothetical protein 0.0053 0.0157 0.0225
Loa Loa (eye worm) inositol-1 0.0035 0.0077 0.011
Schistosoma mansoni inositol monophosphatase 0.0035 0.0077 0.011
Schistosoma mansoni carbonic anhydrase-related 0.0222 0.0922 0.1322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0052 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0419 0.3929
Entamoeba histolytica Ran family GTPase 0.0022 0.0014 0.0122
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1558 0.6968 1
Onchocerca volvulus 0.0051 0.0147 0.0211
Onchocerca volvulus Alhambra homolog 0.0025 0.0031 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0173 0.0701 0.0701
Trypanosoma brucei trypanothione reductase 0.0038 0.0087 0.0328
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0131 0.0495
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0022 0.0015 0.0052
Echinococcus multilocularis smad 0.0032 0.0059 0.0059
Trypanosoma brucei glucosidase, putative 0.0041 0.0102 0.0386
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0063 0.0063
Schistosoma mansoni cellular tumor antigen P53 0.0148 0.0587 0.0842
Echinococcus multilocularis GPCR, family 2 0.0101 0.0375 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0057 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0102 0.0386
Echinococcus granulosus Excitatory amino acid transporter 0.1558 0.6968 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0134 0.0523 0.0523
Echinococcus granulosus Excitatory amino acid transporter 0.1558 0.6968 1
Schistosoma mansoni hypothetical protein 0.0222 0.0922 0.1322
Schistosoma mansoni hypothetical protein 0.0101 0.0375 0.0538
Brugia malayi follicle stimulating hormone receptor 0.0509 0.2223 0.319
Loa Loa (eye worm) hypothetical protein 0.0322 0.1375 0.1973
Toxoplasma gondii thioredoxin reductase 0.0038 0.0087 0.0934
Schistosoma mansoni hypothetical protein 0.0025 0.0031 0.0044
Schistosoma mansoni protein phosphatase 2C 0.0022 0.0015 0.0022
Schistosoma mansoni phd/f-box containing protein 0.0022 0.0015 0.0022
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0031 0.0031
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0598 0.2623 1
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0057 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0173 0.0701 0.1006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.0575 0.0825
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0035 0.0077 0.0708
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0102 0.095
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0031 0.0709
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0097 0.0139
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0028 0.004
Plasmodium falciparum plasmepsin I 0.0053 0.0157 0.1693
Brugia malayi beta-lactamase family protein 0.0111 0.0419 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0173 0.0701 0.1006
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0001 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0419 0.0602
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0057 0.0082
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0124 0.0478 0.0683
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0059 0.0085
Leishmania major importin beta-1 subunit, putative 0.0026 0.0035 0.013
Trichomonas vaginalis chromobox protein, putative 0.006 0.019 0.1776
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0598 0.2623 1
Echinococcus granulosus carbonic anhydrase 0.0222 0.0922 0.1322
Loa Loa (eye worm) hypothetical protein 0.0057 0.0175 0.025
Schistosoma mansoni chromobox protein 0.006 0.019 0.0273
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0057 0.0082
Toxoplasma gondii aldehyde dehydrogenase 0.0135 0.0529 0.573
Plasmodium falciparum plasmepsin II 0.0053 0.0157 0.1693
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0306 0.0437
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0077 0.1429
Plasmodium vivax importin-beta 2, putative 0.0032 0.0063 0.1476
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0419 0.1594
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0057 0.0082
Onchocerca volvulus 0.0053 0.0157 0.0225
Echinococcus multilocularis neutral amino acid transporter A 0.1558 0.6968 0.6968
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0204 0.0838 0.1203
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0135 0.0529 0.2011
Onchocerca volvulus 0.0145 0.0575 0.0825
Entamoeba histolytica hypothetical protein 0.0204 0.0838 0.7868
Brugia malayi Pre-SET motif family protein 0.003 0.0052 0.0075
Schistosoma mansoni importin beta-1 0.0032 0.0063 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Brugia malayi Thioredoxin reductase 0.0038 0.0087 0.0125
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.006 0.0084
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0047 0.0068
Plasmodium falciparum plasmepsin IV 0.0053 0.0157 0.1693
Loa Loa (eye worm) glutathione reductase 0.0038 0.0087 0.0125
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0254 0.1065 1
Echinococcus granulosus muscleblind protein 0.0322 0.1375 0.1973
Brugia malayi hypothetical protein 0.0053 0.0157 0.0225
Treponema pallidum glutamate/aspartate transporter 0.069 0.3042 1
Loa Loa (eye worm) heterochromatin protein 1 0.006 0.019 0.0273
Schistosoma mansoni smad1 5 8 and 0.0032 0.0059 0.0085
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Toxoplasma gondii hypothetical protein 0.0222 0.0922 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0598 0.2623 0.3765
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0077 0.0287
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Brugia malayi PHD-finger family protein 0.0025 0.0031 0.0044
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.0755 0.1083
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0102 0.1099
Loa Loa (eye worm) hypothetical protein 0.0034 0.007 0.01
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0057 0.0082
Brugia malayi Bromodomain containing protein 0.0025 0.0031 0.0044
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0031 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0057 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0052 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0057 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.007 0.0644
Schistosoma mansoni hypothetical protein 0.0101 0.0375 0.0538
Loa Loa (eye worm) MH2 domain-containing protein 0.0463 0.201 0.2885
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.007 0.0644
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0419 0.7928
Echinococcus granulosus biogenic amine 5HT receptor 0.0419 0.1815 0.2604
Echinococcus multilocularis Excitatory amino acid transporter 0.1558 0.6968 0.6968
Schistosoma mansoni chromobox protein 0.006 0.019 0.0273
Brugia malayi aspartic protease BmAsp-1, identical 0.0053 0.0157 0.0225
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.0755 0.1083
Leishmania major GTP-binding protein, putative 0.0022 0.0014 0.005
Schistosoma mansoni smad 0.0032 0.0059 0.0085
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0222 0.0922 0.1322
Loa Loa (eye worm) carbonic anhydrase 3 0.0598 0.2623 0.3765
Onchocerca volvulus 0.0053 0.0157 0.0225
Brugia malayi Smad1 0.0032 0.0059 0.0085
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0135 0.0529 0.0757
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0052 0.0554
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0053 0.0157 0.1693
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0057 0.0082
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0173 0.0701 0.1006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0077 0.0287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0204 0.0838 0.0838
Echinococcus granulosus lysine specific demethylase 6a 0.0022 0.0015 0.0022
Echinococcus multilocularis lamin dm0 0.0051 0.0147 0.0147
Plasmodium falciparum plasmepsin IX 0.0053 0.0157 0.1693
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0306 0.0437
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0053 0.0157 0.0225
Echinococcus granulosus lysine specific demethylase 5A 0.0082 0.0286 0.0411
Schistosoma mansoni ap endonuclease 0.0019 0.0001 0.0002
Echinococcus multilocularis carbonic anhydrase 0.0222 0.0922 0.0922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0173 0.0701 0.0701
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0082 0.0754
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0063 0.0671
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0057 0.0057
Schistosoma mansoni alpha-glucosidase 0.0159 0.0638 0.0916
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0057 0.0082
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0014 0.0014
Plasmodium vivax aspartyl protease, putative 0.0053 0.0157 0.3726
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0053 0.0157 0.0225
Echinococcus multilocularis peregrin 0.0025 0.0031 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.1065 1
Brugia malayi beta-lactamase 0.0111 0.0419 0.0602
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0419 0.06
Echinococcus multilocularis carbonic anhydrase 0.0222 0.0922 0.0922
Schistosoma mansoni hypothetical protein 0.0204 0.0838 0.1203
Echinococcus granulosus jumonji domain containing protein 0.0035 0.0076 0.0109
Giardia lamblia Fructose-bisphosphate aldolase 0.0254 0.1065 1
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0995 0.9341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0057 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0057 0.0057
Plasmodium falciparum plasmepsin X 0.0053 0.0157 0.1693
Brugia malayi intermediate filament protein 0.0051 0.0147 0.0211
Echinococcus granulosus jumonji domain containing 1A 0.0022 0.0015 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0101 0.0375 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0057 0.0082
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.007 0.01
Plasmodium vivax aspartyl protease, putative 0.0053 0.0157 0.3726

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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