Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0026 | 0.1132 | 0.1098 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.004 | 0.2245 | 0.2215 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0104 | 0.7405 | 0.7395 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.2316 | 0.2286 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1132 | 0.1098 |
Brugia malayi | hypothetical protein | 0.0071 | 0.4767 | 0.564 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2197 | 0.1623 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0107 | 0.7694 | 0.7685 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0107 | 0.7694 | 0.7685 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0107 | 0.7694 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.7694 | 0.923 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.8336 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.6328 | 0.6313 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.4767 | 0.4747 |
Echinococcus granulosus | lamin | 0.0026 | 0.1132 | 0.1098 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.6328 | 0.6313 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.4757 | 0.5524 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1093 | 0.1312 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.4757 | 0.4737 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.6328 | 0.759 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.4757 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2316 | 0.2778 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0136 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 0.1132 | 0.5 | |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0095 | 0.6703 | 0.669 |
Onchocerca volvulus | 0.0026 | 0.1132 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1132 | 0.1358 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.6328 | 0.7917 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.6328 | 0.7917 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1132 | 0.1098 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.2316 | 0.2286 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1956 | 0.2346 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.4767 | 0.554 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.2316 | 0.2778 |
Echinococcus multilocularis | expressed conserved protein | 0.0089 | 0.6237 | 0.6222 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.8336 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0104 | 0.7405 | 0.7395 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0039 | 0.0046 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0095 | 0.6703 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.6328 | 0.6313 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.6821 | 0.867 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0095 | 0.6703 | 0.669 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1132 | 0.1358 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.004 | 0.2245 | 0.2215 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.2316 | 0.2286 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1132 | 0.1199 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.8336 | 1 |
Brugia malayi | Transient-receptor-potential like protein | 0.004 | 0.2245 | 0.2559 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.4757 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3058 | 0.3668 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2245 | 0.2693 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1132 | 0.1098 |
Schistosoma mansoni | transient receptor potential channel | 0.0107 | 0.7694 | 1 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.2316 | 0.2645 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.6328 | 0.7917 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0095 | 0.6703 | 0.8004 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.4767 | 0.554 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.4757 | 0.4737 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.2316 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.2782 | 0.2754 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0151 | 0.0181 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2197 | 0.1623 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.4468 | 0.5359 |
Echinococcus granulosus | expressed conserved protein | 0.0089 | 0.6237 | 0.6222 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.6703 | 0.804 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1132 | 0.1199 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.6328 | 0.7546 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1132 | 0.1358 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.2316 | 0.2286 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1132 | 0.1098 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.6328 | 0.6313 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2197 | 0.1623 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.2316 | 0.1804 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.4757 | 0.5524 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2197 | 0.1623 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.4767 | 0.4747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.