Detailed information for compound 658990

Basic information

Technical information
  • TDR Targets ID: 658990
  • Name: N-(4-chlorophenyl)-4-iodo-2-methylpyrazole-3- carboxamide
  • MW: 361.566 | Formula: C11H9ClIN3O
  • H donors: 1 H acceptors: 2 LogP: 2.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)c1c(I)cnn1C
  • InChi: 1S/C11H9ClIN3O/c1-16-10(9(13)6-14-16)11(17)15-8-4-2-7(12)3-5-8/h2-6H,1H3,(H,15,17)
  • InChiKey: VCAMDLRDQSCGEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-4-iodo-2-methyl-pyrazole-3-carboxamide
  • N-(4-chlorophenyl)-4-iodo-2-methyl-3-pyrazolecarboxamide
  • STOCK2S-19706
  • ZINC02302759
  • EU-0074695

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0033 0.1482 0.1627
Mycobacterium ulcerans DNA polymerase IV 0.002 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.5294 0.5816
Mycobacterium ulcerans DNA polymerase IV 0.002 0 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.4909 0.4909
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.9104 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.9104 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.9104 0.9104
Schistosoma mansoni tar DNA-binding protein 0.0064 0.5294 0.5816
Loa Loa (eye worm) hypothetical protein 0.0051 0.3658 0.3658
Echinococcus multilocularis GPCR, family 2 0.0033 0.1482 0.1605
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.9229 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1859 0.2042
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0 0.5
Brugia malayi jmjC domain containing protein 0.0036 0.1859 0.1859
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.9104 1
Brugia malayi TAR-binding protein 0.0064 0.5294 0.5294
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.9104 0.9104
Echinococcus multilocularis peregrin 0.003 0.1108 0.1201
Loa Loa (eye worm) hypothetical protein 0.0103 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.1482 0.1627
Loa Loa (eye worm) hypothetical protein 0.0071 0.6057 0.6057
Echinococcus granulosus tar DNA binding protein 0.0064 0.5294 0.5736
Schistosoma mansoni hypothetical protein 0.0033 0.1482 0.1627
Trypanosoma brucei polo-like protein kinase 0.0096 0.9104 1
Schistosoma mansoni jumonji domain containing protein 0.0077 0.6827 0.7499
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.1859 0.2014
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.1108 0.1201
Schistosoma mansoni hypothetical protein 0.003 0.1108 0.1217
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.1482 0.1482
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.9104 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.5294 0.5816
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.9104 1
Schistosoma mansoni hypothetical protein 0.0071 0.6057 0.6653
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.9104 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.5294 0.5736
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.9104 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.1482 0.1605
Loa Loa (eye worm) hypothetical protein 0.0033 0.1482 0.1482
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.1482 0.1605
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.3264 0.3585
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.5294 0.5294
Echinococcus granulosus GPCR family 2 0.0033 0.1482 0.1605
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.9104 0.9864
Brugia malayi RNA binding protein 0.0064 0.5294 0.5294
Schistosoma mansoni kinase 0.0049 0.3416 0.3753
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.9104 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.1108 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.1482 0.1482
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.2506 0.2715
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.9104 1
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.9104 1
Brugia malayi PHD-finger family protein 0.003 0.1108 0.1108
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.1108 0.1201
Brugia malayi Bromodomain containing protein 0.003 0.1108 0.1108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.1482 0.1605
Giardia lamblia Kinase, PLK 0.0096 0.9104 1
Brugia malayi jmjC domain containing protein 0.0097 0.9229 0.9229
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.9104 0.9864
Loa Loa (eye worm) PHD-finger family protein 0.003 0.1108 0.1108
Plasmodium falciparum phd finger protein, putative 0.003 0.1108 0.5
Loa Loa (eye worm) TAR-binding protein 0.0064 0.5294 0.5294
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.1108 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.1108 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0064 0.5294 0.5816
Giardia lamblia PHD finger protein 15 0.003 0.1108 0.1217
Schistosoma mansoni tar DNA-binding protein 0.0064 0.5294 0.5816
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.1482 0.1605
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.1859 0.2014
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.5294 0.5294
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.9104 1
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.6057 0.6057
Brugia malayi Latrophilin receptor protein 2 0.0033 0.1482 0.1482
Echinococcus granulosus peregrin 0.003 0.1108 0.1201
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.9229 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.1108 0.1217
Loa Loa (eye worm) RNA binding protein 0.0064 0.5294 0.5294
Echinococcus granulosus jumonji domain containing protein 0.0041 0.2506 0.2715
Schistosoma mansoni hypothetical protein 0.0033 0.1482 0.1627
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.3264 0.3585
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.1859 0.1859
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.9104 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.9104 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1859 0.2042
Plasmodium vivax hypothetical protein, conserved 0.003 0.1108 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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