Detailed information for compound 659200

Basic information

Technical information
  • TDR Targets ID: 659200
  • Name: 4-chloro-3-nitro-N-(2-pyridin-4-yl-1,3-benzox azol-5-yl)benzamide
  • MW: 394.768 | Formula: C19H11ClN4O4
  • H donors: 1 H acceptors: 5 LogP: 3.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)[N+](=O)[O-])Cl)Nc1ccc2c(c1)nc(o2)c1ccncc1
  • InChi: 1S/C19H11ClN4O4/c20-14-3-1-12(9-16(14)24(26)27)18(25)22-13-2-4-17-15(10-13)23-19(28-17)11-5-7-21-8-6-11/h1-10H,(H,22,25)
  • InChiKey: KATYJMGKFMQJRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-3-nitro-N-[2-(4-pyridyl)-1,3-benzoxazol-5-yl]benzamide
  • EU-0037823
  • Oprea1_201963

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0051 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0193 0.0193
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.019 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Schistosoma mansoni glutaminase 0.0265 0.1177 0.1177
Brugia malayi wnt family protein 0.0015 0.004 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0193 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0023 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1136 0.9648
Onchocerca volvulus 0.003 0.0112 0.0492
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0017
Echinococcus granulosus geminin 0.0164 0.072 0.072
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0023 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0023 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Leishmania major DNA polymerase eta, putative 0.0048 0.0192 0.0298
Schistosoma mansoni cpg binding protein 0.003 0.0112 0.0112
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0068 0.0068
Brugia malayi steroid hormone receptor 0.0011 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0777 0.6589
Schistosoma mansoni smad1 5 8 and 0.0009 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0023 0.0023
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0151 0.0233
Brugia malayi Zinc finger, C2H2 type family protein 0.0331 0.1477 0.1477
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0017 0.0017
Trypanosoma brucei unspecified product 0.0014 0.0039 0.0056
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0193 0.0193
Brugia malayi Wnt-2 protein precursor 0.0015 0.004 0.004
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.2208 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1136 0.9648
Loa Loa (eye worm) hypothetical protein 0.015 0.0656 0.0656
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0192 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0023 0.0023
Brugia malayi ecdysteroid receptor 0.0011 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0048 0.019 0.019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0266 0.0266
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.2208 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0051 0.0075
Echinococcus multilocularis protein Wnt 2 0.0015 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0164 0.072 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0193 0.0193
Echinococcus multilocularis protein Wnt 1 0.0015 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0023 0.0023
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0151 1
Brugia malayi hypothetical protein 0.0195 0.0859 0.0859
Schistosoma mansoni wnt related 0.0015 0.004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0736 0.6239
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0023 0.0023
Mycobacterium ulcerans thymidylate synthase 0.0409 0.1834 0.1831
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0192 0.0298
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Echinococcus multilocularis WNT 0.0015 0.004 0.004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0068 0.0068
Echinococcus multilocularis cpg binding protein 0.0032 0.012 0.012
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.14 0.6333 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0051 0.0051
Echinococcus multilocularis dna polymerase eta 0.0048 0.0192 0.0192
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0068 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Hypothetical protein 0.0195 0.0859 0.0812
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0102
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0009 0.0009
Brugia malayi thymidylate synthase 0.0409 0.1834 0.1834
Schistosoma mansoni dihydrofolate reductase 0.2208 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0736 0.6239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Echinococcus granulosus smad 0.0009 0.0014 0.0014
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0409 0.1834 0.1724
Brugia malayi MH2 domain containing protein 0.0009 0.0014 0.0014
Brugia malayi nuclear receptor NHR-88 0.0011 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0039 0.0149 0.9777
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) Wnt2 protein 0.0015 0.004 0.004
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.2208 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0023 0.0023
Brugia malayi nuclear hormone receptor 0.0011 0.0023 0.0023
Schistosoma mansoni cpg binding protein 0.0032 0.012 0.012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0023 0.0023
Brugia malayi hypothetical protein 0.0039 0.0149 0.0149
Schistosoma mansoni smad 0.0009 0.0014 0.0014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0151 0.1243
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0023 0.0023
Brugia malayi Wnt-4 protein precursor 0.0015 0.004 0.004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0051 0.0075
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0409 0.1834 0.1834
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0023 0.0023
Loa Loa (eye worm) zinc finger protein 0.0331 0.1477 0.1477
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0151 0.0233
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0151 0.0151
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0151 0.1243
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0656 0.0656
Leishmania major DNA polymerase eta, putative 0.0034 0.0127 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0023 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0149 0.0149
Mycobacterium ulcerans glutaminase 0.0265 0.1177 0.1174
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0039 0.0149 0.9777
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0409 0.1834 0.1792
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0051 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0068 0.0065
Schistosoma mansoni wnt-5 0.0015 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0023 0.0023
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0014 0.0014
Schistosoma mansoni smad1 5 8 and 0.0009 0.0014 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0149 0.0149
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0068 0.0068
Chlamydia trachomatis dihydrofolate reductase 0.2208 1 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0555 0.0555
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0068 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.019 0.019
Echinococcus granulosus dna polymerase kappa 0.0021 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0023 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0068 0.0068
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0051 0.0075
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0151 0.0151
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0151 0.0233
Echinococcus multilocularis zinc finger transcription factor gli2 0.0331 0.1477 0.1477
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0164 0.072 0.072
Echinococcus granulosus dna polymerase eta 0.0048 0.0192 0.0192
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0048 0.019 0.019
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0023 0.0023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0151 0.0148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0009 0.0009
Echinococcus granulosus GPCR family 2 0.0048 0.019 0.019
Schistosoma mansoni wnt related 0.0015 0.004 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0151 0.1243
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0023 0.0023
Brugia malayi glutaminase DH11.1 0.0265 0.1177 0.1177
Brugia malayi Inositol-1 0.0039 0.0151 0.0151
Loa Loa (eye worm) glutaminase 0.0265 0.1177 0.1177
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0023 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0023 0.0023
Loa Loa (eye worm) Smad1 0.0009 0.0014 0.0014
Echinococcus multilocularis GPCR, family 2 0.0048 0.019 0.019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0193 0.0193
Schistosoma mansoni inositol monophosphatase 0.0039 0.0151 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0777 0.6589
Loa Loa (eye worm) wnt-4 protein 0.0015 0.004 0.004
Brugia malayi wnt family protein 0.0015 0.004 0.004
Loa Loa (eye worm) dihydrofolate reductase 0.2208 1 1
Schistosoma mansoni hypothetical protein 0.0103 0.0441 0.0441
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0051 0.0075
Schistosoma mansoni cpg binding protein 0.0032 0.012 0.012
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0051 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0014 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0014 0.0014
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.14 0.6333 1
Echinococcus granulosus zinc finger transcription factor gli2 0.0331 0.1477 0.1477
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.14 0.6333 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0068 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0051 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0235 0.0365
Echinococcus granulosus protein Wnt 1 0.0015 0.004 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Echinococcus granulosus thymidylate synthase 0.0409 0.1834 0.1834
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0736 0.6239
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0068 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0736 0.6239
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0023 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.019 0.019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0151 0.0233
Schistosoma mansoni hypothetical protein 0.0048 0.019 0.019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0023 0.0023
Schistosoma mansoni inositol monophosphatase 0.0039 0.0151 0.0151
Brugia malayi MH2 domain containing protein 0.0009 0.0014 0.0014
Brugia malayi wnt family protein 0.0015 0.004 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.019 0.019
Echinococcus granulosus cpg binding protein 0.0032 0.012 0.012
Echinococcus multilocularis wingless type MMTV integration site family 0.0015 0.004 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.019 0.019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0151 0.0233
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0051 0.0051
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0023 0.0023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0051 0.0075
Echinococcus multilocularis smad 0.0009 0.0014 0.0014
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0068 0.0535
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0068 0.0068
Schistosoma mansoni Smad4 0.0009 0.0014 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.019 0.019
Echinococcus multilocularis dihydrofolate reductase 0.2208 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.14 0.6333 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1136 0.9648
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Schistosoma mansoni wnt related 0.0015 0.004 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0023 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0656 0.0656
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.1136 0.1136
Echinococcus granulosus protein Wnt 2 0.0015 0.004 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0193 0.0193
Brugia malayi Latrophilin receptor protein 2 0.0048 0.019 0.019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0023 0.0023
Brugia malayi MH2 domain containing protein 0.0128 0.0555 0.0555
Echinococcus multilocularis Smad4 0.0009 0.0014 0.0014
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.1136 0.1136
Echinococcus multilocularis wnt family member wnt11 2 0.0015 0.004 0.004
Leishmania major dihydrofolate reductase-thymidylate synthase 0.14 0.6333 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0127 0.0196
Schistosoma mansoni hypothetical protein 0.0048 0.019 0.019
Onchocerca volvulus 0.0409 0.1834 1
Loa Loa (eye worm) inositol-1 0.0039 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0023 0.0023
Brugia malayi MH1 domain containing protein 0.0009 0.0014 0.0014
Loa Loa (eye worm) CWN-2 protein 0.0015 0.004 0.004
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0068 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0023 0.0023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0009
Echinococcus granulosus Protein Wnt-11b 0.0015 0.004 0.004
Echinococcus multilocularis thymidylate synthase 0.0409 0.1834 0.1834
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0039 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0192 0.0298
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0431 0.1931 0.1931
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0023 0.0023
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0051 0.0075
Brugia malayi CXXC zinc finger family protein 0.003 0.0112 0.0112
Echinococcus multilocularis WNT 0.0015 0.004 0.004
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0195 0.0859 0.1352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0048 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Echinococcus granulosus dihydrofolate reductase 0.2208 1 1
Schistosoma mansoni wnt related 0.0015 0.004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0736 0.6239
Loa Loa (eye worm) glutaminase 2 0.0265 0.1177 0.1177
Trypanosoma brucei unspecified product 0.0014 0.0039 0.0056
Brugia malayi Smad1 0.0009 0.0014 0.0014
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0151 0.5
Schistosoma mansoni hypothetical protein 0.0039 0.0149 0.0149
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0039 0.0149 0.9777
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0859 0.7285
Brugia malayi wnt family protein 0.0015 0.004 0.004
Echinococcus granulosus Smad4 0.0009 0.0014 0.0014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0051 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1136 0.9648
Echinococcus granulosus Protein Wnt-5 0.0015 0.004 0.004
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0014 0.0014
Echinococcus multilocularis geminin 0.0164 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0127 0.0196
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0133 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0039 0.0149 0.9777
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0102
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0051 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0039 0.0056
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0014 0.0014
Brugia malayi polk-prov protein 0.0006 0.0004 0.0004
Schistosoma mansoni coup transcription factor 0.0011 0.0023 0.0023
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0023 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0193 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0039 0.0056
Loa Loa (eye worm) hypothetical protein 0.0103 0.0441 0.0441
Schistosoma mansoni smad1 5 8 and 0.0009 0.0014 0.0014
Schistosoma mansoni DNA polymerase eta 0.0048 0.0192 0.0192
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0004 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0555 0.0555
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0023 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0193 0.0193
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0736 0.6239
Echinococcus granulosus dnaJ subfamily B 0.0431 0.1931 0.1931
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0068 0.0535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0023 0.0023
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1136 0.9648
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0149 0.0149
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0068 0.0102
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0736 0.3941
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0023 0.0023
Echinococcus granulosus Protein Wnt-04 0.0015 0.004 0.004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.1931 0.1931
Brugia malayi Dihydrofolate reductase 0.2208 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.14 0.6333 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1136 0.9648
Brugia malayi isocitrate dehydrogenase 0.0017 0.0051 0.0051
Trichomonas vaginalis glutaminase, putative 0.0265 0.1177 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0051 0.0051
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0051 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0023 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0023 0.0023
Leishmania major DNA polymerase kappa, putative 0.0021 0.0068 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0023 0.0023
Echinococcus granulosus Protein Wnt-111 0.0015 0.004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0736 0.6239
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0048 0.019 0.019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0014 0.0014
Trypanosoma brucei unspecified product 0.0021 0.0068 0.0102
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0023 0.0023
Brugia malayi MH1 domain containing protein 0.0009 0.0014 0.0014
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0051 0.0051
Loa Loa (eye worm) thymidylate synthase 0.0409 0.1834 0.1834

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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