Detailed information for compound 659248

Basic information

Technical information
  • TDR Targets ID: 659248
  • Name: N-(3-methoxyphenyl)-6-methyl-4-phenylquinazol in-2-amine
  • MW: 341.406 | Formula: C22H19N3O
  • H donors: 1 H acceptors: 2 LogP: 5.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)Nc1nc2ccc(cc2c(n1)c1ccccc1)C
  • InChi: 1S/C22H19N3O/c1-15-11-12-20-19(13-15)21(16-7-4-3-5-8-16)25-22(24-20)23-17-9-6-10-18(14-17)26-2/h3-14H,1-2H3,(H,23,24,25)
  • InChiKey: HIFLRTXPVVDUDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-methoxyphenyl)-6-methyl-4-phenyl-quinazolin-2-amine
  • N-(3-methoxyphenyl)-6-methyl-4-phenyl-2-quinazolinamine
  • (3-methoxyphenyl)-(6-methyl-4-phenyl-quinazolin-2-yl)amine
  • Oprea1_706770
  • NCGC00098676-01
  • (3-Methoxy-phenyl)-(6-methyl-4-phenyl-quinazolin-2-yl)-amine
  • STOCK3S-09941
  • ZINC00548990
  • Oprea1_250863

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0224 0.1475 0.1463
Mycobacterium ulcerans carboxylesterase, LipT 0.0224 0.1475 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0224 0.1475 0.7708
Onchocerca volvulus 0.0224 0.1475 0.7529
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0078 0.0399
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0071 0.0057
Onchocerca volvulus 0.005 0.0127 0.0583
Schistosoma mansoni BC026374 protein (S09 family) 0.0224 0.1475 0.1463
Brugia malayi beta-lactamase 0.0043 0.0078 0.0064
Brugia malayi Pre-SET motif family protein 0.0036 0.0021 0.0007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0854 0.6348 0.6342
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0634 0.0624
Loa Loa (eye worm) carboxylesterase 0.0224 0.1475 0.1463
Schistosoma mansoni chromobox protein 0.0084 0.0393 0.0379
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1326 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0207 0.0194
Echinococcus multilocularis BC026374 protein (S09 family) 0.0224 0.1475 0.1463
Echinococcus multilocularis carboxylesterase 5A 0.1326 1 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.1475 0.1463
Echinococcus granulosus acetylcholinesterase 0.1326 1 1
Schistosoma mansoni gliotactin 0.0224 0.1475 0.1463
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0014 0.0004
Onchocerca volvulus 0.0224 0.1475 0.7529
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0107 0.0545
Echinococcus granulosus peregrin 0.0035 0.0014 0.0004
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0393 0.2008
Onchocerca volvulus 0.0224 0.1475 0.7529
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0078 0.5
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1954 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0021 0.0007
Brugia malayi Pre-SET motif family protein 0.0251 0.1686 0.1674
Brugia malayi beta-lactamase family protein 0.0043 0.0078 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0134 0.0687
Loa Loa (eye worm) beta-lactamase 0.0043 0.0078 0.0064
Onchocerca volvulus 0.0043 0.0078 0.033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0021 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0021 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0078 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0207 0.0194
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0064
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0393 0.0379
Brugia malayi chromobox protein homolog 3 0.0047 0.0107 0.0093
Toxoplasma gondii ABC1 family protein 0.0043 0.0078 1
Brugia malayi Carboxylesterase family protein 0.0224 0.1475 0.1463
Plasmodium vivax SET domain protein, putative 0.0036 0.0021 0.1018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0207 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0078 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.1475 0.1463
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0121 0.0111
Onchocerca volvulus 0.0043 0.0078 0.033
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0224 0.1475 0.1463
Schistosoma mansoni neuroligin 3 (S09 family) 0.0224 0.1475 0.1463
Loa Loa (eye worm) hypothetical protein 0.006 0.0209 0.0195
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0121 0.0107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0071 0.0057
Brugia malayi Heterochromatin protein 1 0.0084 0.0393 0.0379
Brugia malayi Carboxylesterase family protein 0.0224 0.1475 0.1463
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0078 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0393 0.2008
Brugia malayi hypothetical protein 0.0224 0.1475 0.1463
Onchocerca volvulus 0.0224 0.1475 0.7529
Brugia malayi Carboxylesterase family protein 0.1326 1 1
Loa Loa (eye worm) acetylcholinesterase 1 0.1326 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0107 0.0093
Loa Loa (eye worm) hypothetical protein 0.1326 1 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.0078 0.5
Echinococcus granulosus para nitrobenzyl esterase 0.0224 0.1475 0.1466
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0078 0.0399
Onchocerca volvulus 0.0224 0.1475 0.7529
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0021 0.1018
Brugia malayi Carboxylesterase family protein 0.0224 0.1475 0.1463
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0078 0.0068
Loa Loa (eye worm) carboxylesterase 0.0224 0.1475 0.1463
Loa Loa (eye worm) carboxylesterase 0.1326 1 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.1475 0.1463
Echinococcus granulosus acetylcholinesterase 0.1326 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1686 0.1674
Brugia malayi jmjC domain containing protein 0.0043 0.0071 0.0057
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0134 0.0687
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0634 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0078 0.0399
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0127 0.0113
Schistosoma mansoni jumonji domain containing protein 0.0092 0.045 0.0437
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0134 0.0619
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0224 0.1475 0.7547
Trichomonas vaginalis esterase, putative 0.0043 0.0078 0.0399
Plasmodium falciparum phd finger protein, putative 0.0035 0.0014 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0064
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0071 0.0061
Loa Loa (eye worm) hypothetical protein 0.0224 0.1475 0.1463
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.189 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0224 0.1475 0.1463
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0071 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0078 0.5
Echinococcus multilocularis chromobox protein 1 0.0084 0.0393 0.0379
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.006 0.0046
Echinococcus granulosus carboxylesterase 5A 0.1326 1 1
Echinococcus granulosus chromobox protein 1 0.0084 0.0393 0.0383
Trichomonas vaginalis spcc417.12 protein, putative 0.0224 0.1475 0.7547
Echinococcus multilocularis para nitrobenzyl esterase 0.0224 0.1475 0.1463
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0207 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0078 0.5
Loa Loa (eye worm) hypothetical protein 0.1326 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0224 0.1475 0.1463
Onchocerca volvulus 0.0286 0.1954 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0021 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0304 0.029
Echinococcus multilocularis acetylcholinesterase 0.1326 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0107 0.0545
Echinococcus multilocularis neuroligin 0.0224 0.1475 0.1463
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0224 0.1475 0.7708
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0078 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0078 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0078 0.0064
Echinococcus granulosus neuroligin 0.0224 0.1475 0.1466
Onchocerca volvulus 0.0043 0.0078 0.033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0064
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0224 0.1475 0.7708
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0046
Echinococcus granulosus BC026374 protein S09 family 0.0224 0.1475 0.1466
Schistosoma mansoni acetylcholinesterase 0.0224 0.1475 0.1463
Brugia malayi beta-lactamase family protein 0.0043 0.0078 0.0064
Brugia malayi Carboxylesterase family protein 0.0224 0.1475 0.1463
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0064
Loa Loa (eye worm) hypothetical protein 0.0041 0.006 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0021 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0071 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0078 0.0399
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0064
Echinococcus multilocularis acetylcholinesterase 0.1326 1 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.1475 0.1463
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0224 0.1475 0.1466
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0107 0.0477
Echinococcus multilocularis chromobox protein 1 0.0084 0.0393 0.0379
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0078 0.0064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0224 0.1475 0.1463
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0064
Loa Loa (eye worm) hypothetical protein 0.0224 0.1475 0.1463
Leishmania major hypothetical protein, conserved 0.0043 0.0078 0.5
Giardia lamblia PHD finger protein 15 0.0035 0.0014 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0078 0.0399
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0021 0.0007
Onchocerca volvulus 0.0037 0.0028 0.007
Schistosoma mansoni chromobox protein 0.0084 0.0393 0.0379
Echinococcus granulosus chromobox protein 1 0.0084 0.0393 0.0383
Brugia malayi jmjC domain containing protein 0.0115 0.0634 0.062

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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