Detailed information for compound 65929

Basic information

Technical information
  • TDR Targets ID: 65929
  • Name: 2-[(4S)-4-amino-5-(3-aminoanilino)pentyl]-1-n itroguanidine
  • MW: 295.341 | Formula: C12H21N7O2
  • H donors: 5 H acceptors: 2 LogP: 0.08 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](CNc1cccc(c1)N)CCC/N=C(/N[N+](=O)[O-])\N
  • InChi: 1S/C12H21N7O2/c13-9-3-1-5-11(7-9)17-8-10(14)4-2-6-16-12(15)18-19(20)21/h1,3,5,7,10,17H,2,4,6,8,13-14H2,(H3,15,16,18)/t10-/m0/s1
  • InChiKey: COKZTIVDBVHOCZ-JTQLQIEISA-N  

Network

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Synonyms

  • 2-[(4S)-4-amino-5-(3-aminoanilino)pentyl]-1-nitro-guanidine
  • 2-[(4S)-5-[(3-aminophenyl)amino]-4-azanyl-pentyl]-1-nitro-guanidine
  • 2-[(4S)-4-amino-5-[(3-aminophenyl)amino]pentyl]-1-nitroguanidine
  • 2-[(4S)-4-amino-5-[(3-aminophenyl)amino]pentyl]-1-nitro-guanidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Nitric-oxide synthase, brain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi tailless protein 0.002 0.0058 0.0214
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0157 0.0649
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0313
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0027 0.0116 0.0475
Trichomonas vaginalis heat shock protein, putative 0.002 0.0057 0.0232
Onchocerca volvulus 0.002 0.0058 0.0214
Schistosoma mansoni nuclear receptor 0.002 0.0058 0.0101
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1238 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0157 0.0649
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0058 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Schistosoma mansoni DNA polymerase eta 0.0019 0.0051 0.0088
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.2297 1
Echinococcus multilocularis heat shock protein 90 0.0032 0.0157 0.0241
Echinococcus granulosus heat shock protein 0.0032 0.0157 0.0283
Brugia malayi EGF-like domain containing protein 0.0018 0.0044 0.0159
Brugia malayi Nuclear hormone receptor E75 0.002 0.0058 0.0214
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0115 0.0126
Echinococcus multilocularis protein jagged 2 0.0018 0.0044 0.0064
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0058 0.0101
Toxoplasma gondii flavodoxin domain-containing protein 0.0013 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Leishmania major hypothetical protein, conserved 0.0025 0.0099 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0239 0.0933
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.2297 0.2216
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0405
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1217
Loa Loa (eye worm) hypothetical protein 0.0022 0.0078 0.0302
Echinococcus multilocularis heat shock protein 0.0032 0.0157 0.0241
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1071 0.4495
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0353 0.1378
Echinococcus multilocularis methionine synthase reductase 0.0017 0.0032 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0099 0.5595
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0051 0.0088
Echinococcus granulosus notch 0.0018 0.0044 0.0075
Onchocerca volvulus Peroxidase homolog 0.0056 0.0353 0.1367
Loa Loa (eye worm) hypothetical protein 0.012 0.088 0.3432
Brugia malayi hypothetical protein 0.0056 0.0353 0.1367
Schistosoma mansoni laminin gamma-3 chain 0.0018 0.0044 0.0075
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0051 0.0203
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0353 0.1367
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0239 0.0434
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0075
Loa Loa (eye worm) hypothetical protein 0.0107 0.0772 0.3011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Loa Loa (eye worm) hypothetical protein 0.0327 0.2564 1
Echinococcus multilocularis geminin 0.0335 0.2632 0.4106
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Brugia malayi Nuclear hormone receptor E75 0.002 0.0058 0.0214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0115 0.0126
Loa Loa (eye worm) Notch2 0.0018 0.0044 0.0172
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0239 0.0434
Echinococcus multilocularis neurogenic locus notch protein 4 0.0018 0.0044 0.0064
Schistosoma mansoni heat shock protein 0.0032 0.0157 0.0283
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0107 0.0403
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0174 0.0314
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0115 0.009
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.5435 0.8485
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0239 0.0434
Loa Loa (eye worm) DR-78 0.002 0.0058 0.0227
Onchocerca volvulus Fatty acid synthase homolog 0.005 0.0302 0.1166
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0078 0.0289
Echinococcus multilocularis dna polymerase eta 0.0019 0.0051 0.0075
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0084 0.0084
Echinococcus granulosus protein jagged 2 0.0018 0.0044 0.0075
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0027 0.0116 0.0475
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0239 0.0434
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0239 0.0434
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Schistosoma mansoni zinc finger protein 0.002 0.0058 0.0101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0239 0.0368
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.0202
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0101 0.0107
Mycobacterium ulcerans hypothetical protein 0.016 0.1203 0.1182
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0051 0.0209
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0174 0.0313
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1026 0.1597
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0212 0.0263
Echinococcus multilocularis protein jagged 1 0.0018 0.0044 0.0064
Echinococcus granulosus slit 2 protein 0.0018 0.0044 0.0075
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0245 0.1019
Onchocerca volvulus 0.0018 0.0044 0.0159
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0699 0.128
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0044 0.0064
Schistosoma mansoni notch 0.0018 0.0044 0.0075
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0115 0.0126
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0058 0.0227
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0174 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0453
Plasmodium falciparum nitric oxide synthase, putative 0.0027 0.0116 0.6605
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0239 0.092
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1069 0.1047
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0051 0.0203
Schistosoma mansoni patched 1 0.0042 0.0236 0.0428
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0107 0.0416
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0104 0.0425
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0058 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0386
Trichomonas vaginalis endoplasmin, putative 0.002 0.0057 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0058 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0239 0.0933
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0003 0.0014
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0353 0.1367
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0174 0.0622
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0239 0.092
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0353 0.1378
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0058 0.0101
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0157 0.0649
Brugia malayi Muscle positioning protein 4 0.0018 0.0044 0.0159
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0027 0.0116 0.0475
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.2377 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0115 0.0126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0157 0.0649
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0058 0.0227
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0101 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0058 0.0101
Brugia malayi Endoplasmin precursor 0.0032 0.0157 0.0601
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0057 0.0194
Toxoplasma gondii hypothetical protein 0.0049 0.0297 0.107
Brugia malayi EGF-like domain containing protein 0.0018 0.0044 0.0159
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Onchocerca volvulus 0.0281 0.2191 0.8544
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Onchocerca volvulus 0.0018 0.0044 0.0159
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0058 0.0101
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0058 0.0085
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0239 0.0434
Schistosoma mansoni cytochrome P450 reductase 0.0027 0.0116 0.0207
Schistosoma mansoni peroxidasin 0.0056 0.0353 0.0644
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0051 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0058 0.0101
Onchocerca volvulus Putative cubilin 0.0018 0.0044 0.0159
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0239 0.0434
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0058 0.0101
Toxoplasma gondii flavodoxin domain-containing protein 0.0013 0.0006 0.0007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0057 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0104 0.0267
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0104 0.0112
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0051 0.0209
Brugia malayi FAD binding domain containing protein 0.0027 0.0116 0.044
Brugia malayi CHE-14 protein 0.0042 0.0236 0.0907
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0212 0.0263
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Loa Loa (eye worm) FAD binding domain-containing protein 0.0017 0.0032 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0027 0.0116 0.0475
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0051 0.0187
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Brugia malayi nuclear receptor RXR 0.0022 0.0078 0.0289
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Brugia malayi isocitrate dehydrogenase 0.0034 0.0174 0.0666
Giardia lamblia Grp94/Hsp90 0.0025 0.0104 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Echinococcus multilocularis fat cadherin tumor suppressor 0.0018 0.0044 0.0064
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0051 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0239 0.0933
Brugia malayi heat shock protein 90 0.0032 0.0157 0.0601
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0101 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0239 0.092
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0174 0.0664
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0104 0.0425
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Echinococcus granulosus microtubule associated protein 2 0.0679 0.5435 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0051 0.0075
Echinococcus granulosus delta-like protein 1 0.0018 0.0044 0.0075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0042 0.0142
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0044 0.0075
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0239 0.0434
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0174 1
Echinococcus granulosus peroxidasin 0.0056 0.0353 0.0644
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Echinococcus multilocularis expressed conserved protein 0.0091 0.0639 0.0993
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0115 0.0405
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0051 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0239 0.092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0239 0.092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0115 0.0126
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0018 0.0044 0.0159
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0044 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0239 0.092
Echinococcus multilocularis heat shock protein 90 0.0025 0.0104 0.0158
Giardia lamblia Nitric oxide synthase, inducible 0.0024 0.0091 0.0209
Brugia malayi ecdysteroid receptor 0.0042 0.0239 0.092
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0239 0.092
Loa Loa (eye worm) FAD binding domain-containing protein 0.0027 0.0116 0.0453
Echinococcus granulosus expressed conserved protein 0.0091 0.0639 0.117
Brugia malayi flavodoxin family protein 0.0027 0.0116 0.044
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0245 0.1019
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0157 0.0614
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0115 0.0126
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0239 0.0434
Leishmania major DNA polymerase eta, putative 0.0019 0.0051 0.0202
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0104 0.044
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Schistosoma mansoni nuclear receptor 0.002 0.0058 0.0101
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0078 0.0116
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0115 0.009
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0051 0.0198
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0495 0.192
Brugia malayi nuclear receptor RXR 0.002 0.0058 0.0214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.2297 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0855 0.3334
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0239 0.092
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0044 0.0064
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0099 0.0402
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0078 0.0289
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0772 0.3002
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0349 0.2745 0.3817
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.006 0.0049
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0058 0.0214
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0239 0.0434
Brugia malayi hypothetical protein 0.0022 0.0078 0.0289
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0104 0.0186
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1069 0.1466
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0027 0.0116 0.0475
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0236 0.0363
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0236 0.0919
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0027 0.0116 0.0176
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0889 0.7152 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0174 0.0664
Brugia malayi EGF-like domain containing protein 0.0018 0.0044 0.0159
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0027 0.0116 0.0475
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0239 0.0434
Brugia malayi ecdysone receptor 0.002 0.0058 0.0214
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0772 0.3002
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0027 0.0116 0.0207
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0078 0.0136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0174 0.0718
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0239 0.0933
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0174 0.0266
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0368 0.0671
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0239 0.0434
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.0202
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0239 0.0368
Onchocerca volvulus Chorion peroxidase homolog 0.0056 0.0353 0.1367
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0075
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0078 0.0136
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0058 0.0214
Echinococcus multilocularis endoplasmin 0.0025 0.0104 0.0158
Echinococcus granulosus neurogenic locus notch protein 4 0.0018 0.0044 0.0075
Onchocerca volvulus 0.0018 0.0044 0.0159
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0212 0.0263
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.0202
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.1203 0.1654
Brugia malayi Cadherin domain containing protein 0.0018 0.0044 0.0159
Echinococcus granulosus heat shock protein 90 0.0025 0.0104 0.0186
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0075
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0101 0.038
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.2377 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0058 0.0214
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0104 0.0425
Schistosoma mansoni notch 0.0018 0.0044 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Schistosoma mansoni heat shock protein 0.0032 0.0157 0.0283
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0349 0.2745 0.2727
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0212 0.0188
Echinococcus multilocularis protein dispatched 1 0.0047 0.0284 0.0438
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1071 0.4496
Onchocerca volvulus 0.0058 0.0368 0.1424
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0099 0.5595
Brugia malayi EGF-like domain containing protein 0.0018 0.0044 0.0159
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.2297 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0115 0.0126
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0322 0.1341
Brugia malayi steroid hormone receptor 0.0042 0.0239 0.092
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0058 0.0101
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0057 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0099 0.0402
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0058 0.0085
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0245 0.1019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0075
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0157 0.0503
Echinococcus granulosus heat shock protein 90 0.0032 0.0157 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0239 0.092
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0349 0.2745 0.2721
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0058 0.0214
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0051 0.0209
Onchocerca volvulus 0.0327 0.2564 1
Onchocerca volvulus 0.0042 0.0239 0.092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Schistosoma mansoni peroxidasin 0.0056 0.0353 0.0644
Onchocerca volvulus 0.0056 0.0353 0.1367
Echinococcus granulosus geminin 0.0335 0.2632 0.4839
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0236 0.0428
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0174 0.0266
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0855 0.3334
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0157 0.0649
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0174 0.0266
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0174 0.0666
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Brugia malayi nuclear hormone receptor 0.002 0.0058 0.0214
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0313
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0239 0.0368
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0044 0.0159
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0044 0.0075
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0174 0.0677
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0239 0.0434
Onchocerca volvulus Slit protein homolog 0.0018 0.0044 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Schistosoma mansoni hypothetical protein 0.0335 0.2632 0.4839
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Echinococcus granulosus protein jagged 1 0.0018 0.0044 0.0075
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0018 0.0044 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0772 0.3011
Brugia malayi Delta serrate ligand family protein 0.0018 0.0044 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0017 0.0032 0.0053
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0058 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0201
Plasmodium falciparum endoplasmin, putative 0.002 0.0057 0.3115
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Brugia malayi Cadherin domain containing protein 0.0018 0.0044 0.0159
Schistosoma mansoni cell polarity protein 0.0018 0.0044 0.0075
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1238 1 1
Brugia malayi conserved hypotetical protein 0.002 0.0058 0.0214
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0353 0.1378
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0104 0.044
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0349 0.2745 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0078 0.0302
Echinococcus granulosus GPCR family 2 0.0034 0.0174 0.0313
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0245 0.1019
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0024 0.0091 0.0382
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0239 0.0933
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0078 0.0302
Brugia malayi MH2 domain containing protein 0.0117 0.0855 0.3325
Leishmania major p450 reductase, putative 0.0027 0.0116 0.0475
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Onchocerca volvulus Huntingtin homolog 0.012 0.088 0.3423
Trichomonas vaginalis sulfite reductase, putative 0.0027 0.0116 0.0491
Loa Loa (eye worm) hypothetical protein 0.0022 0.0078 0.0302
Echinococcus granulosus X box binding protein 1 0.0283 0.2209 0.406
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0057 0.0032
Echinococcus multilocularis notch 0.0018 0.0044 0.0064
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0889 0.7152 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0687 0.2669
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0058 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Schistosoma mansoni septate junction protein 0.0018 0.0044 0.0075
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0157 0.0671
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0101 0.0076
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Brugia malayi hypothetical protein 0.012 0.088 0.3423
Schistosoma mansoni diflavin oxidoreductase 0.0013 0.0006 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0239 0.092
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0101 0.0076
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0027 0.0116 0.6605
Echinococcus granulosus neurogenic locus protein delta 0.0018 0.0044 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0078 0.0302
Echinococcus granulosus protein jagged 2 0.0018 0.0044 0.0075
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0174 1
Echinococcus multilocularis peroxidasin 0.0056 0.0353 0.0547
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0051 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0239 0.092
Schistosoma mansoni endoplasmin 0.0032 0.0157 0.0283
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.2377 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0687 0.1067
Echinococcus granulosus dna polymerase eta 0.0019 0.0051 0.0088
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0157 0.0562
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0405
Brugia malayi FAD binding domain containing protein 0.0017 0.0032 0.0112
Onchocerca volvulus 0.0056 0.0353 0.1367
Brugia malayi hypothetical protein 0.002 0.0058 0.0214
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0239 0.0368
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0174 0.0718
Onchocerca volvulus 0.0048 0.0288 0.1112
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0239 0.0434
Schistosoma mansoni notch 0.0018 0.0044 0.0075
Echinococcus granulosus neural cadherin 0.0018 0.0044 0.0075
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0687 0.2979
Echinococcus granulosus endoplasmin 0.0025 0.0104 0.0186
Echinococcus multilocularis X box binding protein 1 0.0283 0.2209 0.3445
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0078 0.0136
Loa Loa (eye worm) endoplasmin 0.0032 0.0157 0.0614
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0101 0.0076
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0157 0.0649
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0157 0.9029
Schistosoma mansoni hypothetical protein 0.0335 0.2632 0.4839
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Onchocerca volvulus Dual oxidase homolog 0.0056 0.0353 0.1367
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0027 0.0116 0.0475
Echinococcus granulosus tumor protein p63 0.0395 0.3118 0.5734
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0239 0.0434
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0174 0.0314
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0115 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Trypanosoma cruzi p450 reductase, putative 0.0027 0.0116 0.0475
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0051 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0239 0.092
Brugia malayi nuclear receptor NHR-88 0.0042 0.0239 0.092
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0236 0.0428
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0239 0.0434
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0107 0.0115
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0075
Schistosoma mansoni nuclear hormone receptor 0.002 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0919
Brugia malayi EGF-like domain containing protein 0.0018 0.0044 0.0159
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0353 0.1367
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0174 0.0718
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0239 0.0368
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0405
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0174 0.0313
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0239 0.092
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0118 0.0462
Trypanosoma brucei unspecified product 0.0019 0.0051 0.0203
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Brugia malayi hypothetical protein 0.002 0.0058 0.0214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Echinococcus granulosus dna polymerase kappa 0.0019 0.0051 0.0088
Leishmania major cytochrome P450 reductase, putative 0.0024 0.0091 0.0369
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0104 0.044
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Brugia malayi hypothetical protein 0.0327 0.2564 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1071 0.4495
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0353 0.1367
Schistosoma mansoni coup transcription factor 0.0042 0.0239 0.0434
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0157 0.0649
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0101 0.0107
Loa Loa (eye worm) hypothetical protein 0.0097 0.0687 0.2679
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Echinococcus granulosus protein jagged 1 0.0018 0.0044 0.0075
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.1378
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0239 0.0368
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0104 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Echinococcus multilocularis tumor protein p63 0.0395 0.3118 0.4865
Giardia lamblia Hypothetical protein 0.0024 0.0091 0.0209
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0075
Echinococcus multilocularis slit 2 protein 0.0018 0.0044 0.0064
Giardia lamblia DINP protein human, muc B family 0.0019 0.0051 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0099 0.0402
Brugia malayi nuclear receptor NHR-67 0.002 0.0058 0.0214
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1069 0.1466
Brugia malayi notch-like transmembrane receptor 0.0018 0.0044 0.0159
Schistosoma mansoni notch 0.0018 0.0044 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Echinococcus multilocularis GPCR, family 2 0.0034 0.0174 0.0266
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0044 0.0159
Onchocerca volvulus 0.002 0.0058 0.0214
Brugia malayi EGF-like domain containing protein 0.0018 0.0044 0.0159
Echinococcus granulosus fibropellin Ia 0.0018 0.0044 0.0075
Echinococcus multilocularis protein jagged 1 0.0018 0.0044 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0239 0.0368
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0058 0.0214
Onchocerca volvulus Peroxidase homolog 0.0056 0.0353 0.1367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Echinococcus granulosus methionine synthase reductase 0.0017 0.0032 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0051 0.0203
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.001 0.0025
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0044 0.0159
Trypanosoma brucei heat shock protein, putative 0.0032 0.0157 0.0649
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0239 0.0434
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0239 0.0434
Plasmodium falciparum heat shock protein 90 0.0032 0.0157 0.9029
Brugia malayi nuclear hormone receptor 0.0042 0.0239 0.092
Schistosoma mansoni hypothetical protein 0.0283 0.2209 0.406
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0101 0.0107
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.0044 0.0159
Onchocerca volvulus 0.0018 0.0044 0.0159
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0677
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0051 0.0038
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0174 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0051 0.0203
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0157 0.0562
Echinococcus multilocularis neural cadherin 0.0018 0.0044 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0239 0.092
Schistosoma mansoni hypothetical protein 0.0018 0.0044 0.0075
Onchocerca volvulus Neurogenic locus notch homolog 0.0018 0.0044 0.0159
Loa Loa (eye worm) notch protein 0.0018 0.0044 0.0172
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0353 0.1367
Schistosoma mansoni notch 0.0018 0.0044 0.0075
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.5435 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0174 0.0266
Schistosoma mansoni nuclear hormone receptor 0.002 0.0058 0.0101
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0353 0.1367
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0157 0.0649
Plasmodium vivax endoplasmin, putative 0.0032 0.0157 0.9029
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0051 0.0088
Mycobacterium ulcerans polyketide synthase 0.0025 0.0101 0.0076
Brugia malayi hypothetical protein 0.0016 0.0027 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Plasmodium vivax flavodoxin domain containing protein 0.0024 0.0091 0.5142
Mycobacterium ulcerans thioesterase 0.0023 0.0084 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0239 0.0368
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0239 0.092
Brugia malayi hypothetical protein 0.0022 0.0078 0.0289
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0027 0.0116 0.0092
Loa Loa (eye worm) pax transcription factor protein 2 0.0281 0.2191 0.8546
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0174 0.0266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0687 0.1258
Brugia malayi Blistered cuticle protein 3 0.0056 0.0353 0.1367
Schistosoma mansoni notch 0.0018 0.0044 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.2297 1
Onchocerca volvulus Huntingtin homolog 0.012 0.088 0.3423
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0174 0.0266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0099 0.5595
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0051 0.0075
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0058 0.0085
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0157 0.0671
Onchocerca volvulus 0.0026 0.0107 0.0403
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1238 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0101 0.0076
Loa Loa (eye worm) hypothetical protein 0.0044 0.0254 0.0989
Brugia malayi EGF-like domain containing protein 0.0018 0.0044 0.0159
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0174 0.0622
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0239 0.0933
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0044 0.0159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0239 0.0434
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0239 0.092
Leishmania major DNA polymerase kappa, putative 0.0019 0.0051 0.0202
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0353 0.1378
Brugia malayi nuclear receptor NHR-88 0.002 0.0058 0.0214
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0405
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Brugia malayi Pax transcription factor protein 2 0.0281 0.2191 0.8544
Loa Loa (eye worm) hypothetical protein 0.0073 0.0495 0.1931
Schistosoma mansoni slit 0.0018 0.0044 0.0075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.0933
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0084 0.0084
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0051 0.0201
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0313
Echinococcus multilocularis fibropellin Ia 0.0018 0.0044 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0239 0.0434
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.2377 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0058 0.0214
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0239 0.0434
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1026 0.1882
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0239 0.092
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0313
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Brugia malayi Peroxidasin 0.0056 0.0353 0.1367
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0099 0.0348
Onchocerca volvulus 0.0018 0.0044 0.0159
Echinococcus multilocularis protein patched 0.0042 0.0236 0.0363
Loa Loa (eye worm) hypothetical protein 0.0022 0.0078 0.0302
Schistosoma mansoni NADPH flavin oxidoreductase 0.0014 0.0007 0.0007
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0027 0.0116 0.0176
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0353 0.1367
Leishmania major heat shock protein 83-1 0.0032 0.0157 0.0649
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0027 0.0116 0.0207
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0174 0.0266
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0058 0.0101
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.0302 0.1166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0239 0.0933
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0174 0.021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0239 0.092
Loa Loa (eye worm) hypothetical protein 0.012 0.088 0.3432
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0051 0.0187
Toxoplasma gondii EGF family domain-containing protein 0.0018 0.0044 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0236 0.1012
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0084 0.006
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0051 0.0027
Loa Loa (eye worm) hypothetical protein 0.0058 0.0368 0.1436
Mycobacterium ulcerans polyketide synthase 0.0027 0.0115 0.009
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0157 0.0671
Brugia malayi hypothetical protein 0.0025 0.0099 0.0373
Schistosoma mansoni hypothetical protein 0.0073 0.0495 0.0905
Onchocerca volvulus 0.0056 0.0353 0.1367
Schistosoma mansoni endoplasmin 0.0032 0.0157 0.0283
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0051 0.0088
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0058 0.0101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0172
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.6405 1
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0104 0.008
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0174 0.0679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0239 0.0933
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0027 0.0116 0.0475
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0239 0.092
Loa Loa (eye worm) blistered cuticle protein 3 0.0056 0.0353 0.1378
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0239 0.0368
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0227
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0051 0.0203

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.2 uM Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS) ChEMBL. 12699384
Ki (binding) = 2.2 uM Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS) ChEMBL. 12699384
Ki (binding) = 78.6 uM Inhibitory activity against endothelial nitric oxide synthase (eNOS) ChEMBL. 12699384
Ki (binding) = 78.6 uM Inhibitory activity against endothelial nitric oxide synthase (eNOS) ChEMBL. 12699384
Ki (binding) = 279 uM Inhibitory activity against Inducible nitric oxide synthase (iNOS) ChEMBL. 12699384
Ki (binding) = 279 uM Inhibitory activity against Inducible nitric oxide synthase (iNOS) ChEMBL. 12699384
Selectivity (binding) = 36 Selectivity ratio of Ki value of eNOS to nNOS ChEMBL. 12699384
Selectivity (binding) = 127 Selectivity ratio of Ki value of iNOS to nNOS ChEMBL. 12699384

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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