Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0328 | 0.0273 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0328 | 0.0323 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.3796 | 0.7331 |
Onchocerca volvulus | 0.0029 | 0.2139 | 0.5 | |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.1453 | 0.2597 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.2463 | 0.4523 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0913 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.3796 | 0.7331 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0054 | 0.4402 | 0.437 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.029 | 0.0533 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0913 | 0.1677 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.4754 | 0.9267 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.023 | 0.0423 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0168 | 0.0308 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0328 | 0.0323 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.023 | 0.0175 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.023 | 0.0127 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.023 | 0.0175 |
Schistosoma mansoni | bromodomain containing protein | 0.0006 | 0.0056 | 0.0103 |
Schistosoma mansoni | ferritin | 0.0009 | 0.029 | 0.0533 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.3013 | 0.2849 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3796 | 0.6973 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.5974 | 0.5951 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.5117 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.5079 | 0.9329 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.5117 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.4701 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.1131 | 0.2077 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.023 | 0.0127 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.029 | 0.0533 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.2463 | 0.4523 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3796 | 0.6973 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.023 | 0.0423 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.023 | 0.0423 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.023 | 0.0127 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.029 | 0.0248 |
Schistosoma mansoni | ferritin | 0.0009 | 0.029 | 0.0533 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.1453 | 0.2669 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.4754 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.1131 | 0.1946 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0913 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.2797 | 0.5313 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.023 | 0.0127 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.023 | 0.0127 |
Echinococcus granulosus | ferritin | 0.0009 | 0.029 | 0.0248 |
Trypanosoma brucei | ISWI complex protein | 0.0016 | 0.0913 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0058 | 0.4754 | 1 |
Echinococcus granulosus | smad | 0.0008 | 0.023 | 0.0127 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.2139 | 0.2094 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.3796 | 0.365 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.1073 | 0.1972 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3236 | 0.3198 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.1073 | 0.183 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.1131 | 0.1946 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.2463 | 0.4637 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.3796 | 0.3761 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.1073 | 0.183 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0.029 | 0.5 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.029 | 0.0248 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.1453 | 0.2597 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.029 | 0.0248 |
Schistosoma mansoni | ferritin | 0.0009 | 0.029 | 0.0533 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.3796 | 0.7331 |
Schistosoma mansoni | smad | 0.0008 | 0.023 | 0.0423 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.3796 | 0.7331 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.14 | 0.1352 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.029 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.194 | 0.175 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.14 | 0.2572 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.023 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.302 | 0.298 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.2463 | 0.4637 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0058 | 0.4754 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.2139 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1131 | 0.108 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.023 | 0.0423 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0913 | 0.1677 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.1724 | 0.3145 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.1129 | 0.1079 |
Plasmodium falciparum | zinc finger protein, putative | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.5444 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0.029 | 0.5 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0492 | 0.0267 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.1131 | 0.2077 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.2139 | 0.3928 |
Entamoeba histolytica | hypothetical protein | 0.0005 | 0 | 0.5 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0058 | 0.4754 | 0.8733 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.023 | 0.0175 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.6514 | 0.6432 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.356 | 0.3523 |
Echinococcus multilocularis | smad | 0.0008 | 0.023 | 0.0127 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.1724 | 0.3145 |
Schistosoma mansoni | ferritin | 0.0009 | 0.029 | 0.0533 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.2797 | 0.5313 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.023 | 0.0423 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.1724 | 0.3167 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.1073 | 0.1972 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.029 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.029 | 0.0533 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0058 | 0.4754 | 0.9267 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.4754 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.3796 | 0.6973 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.4754 | 0.4631 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.029 | 0.0533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.