Detailed information for compound 659585

Basic information

Technical information
  • TDR Targets ID: 659585
  • Name: (E)-N-(4-chlorophenyl)-3-(4-methoxyphenyl)pro p-2-enamide
  • MW: 287.741 | Formula: C16H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 3.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=CC(=O)Nc1ccc(cc1)Cl
  • InChi: 1S/C16H14ClNO2/c1-20-15-9-2-12(3-10-15)4-11-16(19)18-14-7-5-13(17)6-8-14/h2-11H,1H3,(H,18,19)/b11-4+
  • InChiKey: QANKHJVPPFHYMQ-NYYWCZLTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-3-(4-methoxyphenyl)prop-2-enamide
  • (E)-N-(4-chlorophenyl)-3-(4-methoxyphenyl)acrylamide
  • N-(4-chlorophenyl)-3-(4-methoxyphenyl)acrylamide
  • ZINC00258804

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0202
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0484 0.1078
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0096 0.0114
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.005 0.001
Schistosoma mansoni hypothetical protein 0.0167 0.1095 0.1059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0501 0.0463
Giardia lamblia Hypothetical protein 0.0347 0.2458 1
Brugia malayi diaphorase 0.0045 0.0166 0.0457
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0392 0.2796 0.2767
Brugia malayi RNA, U transporter 1 0.0079 0.043 0.1415
Leishmania major NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Entamoeba histolytica protein kinase, putative 0.0037 0.0111 0.1153
Schistosoma mansoni hypothetical protein 0.0047 0.0181 0.0142
Schistosoma mansoni hypothetical protein 0.0167 0.1095 0.1059
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0291 0.2035 0.4532
Echinococcus granulosus cytochrome b5 reductase 4 0.0045 0.0166 0.0126
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0045 0.0166 0.0457
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0283
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0191 0.0151
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0615 0.449 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.015 0.0964 0.3446
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0181 0.0142
Loa Loa (eye worm) inositol-1 0.0036 0.0099 0.0214
Entamoeba histolytica hypothetical protein 0.0111 0.0667 0.6927
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0096 0.0202
Leishmania major cytochrome P450 reductase, putative 0.0347 0.2458 0.5475
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.0247
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0042 0.0002
Leishmania major oxidoreductase-like protein 0.0045 0.0166 0.0369
Onchocerca volvulus 0.0088 0.0496 0.29
Brugia malayi Inositol-1 0.0036 0.0099 0.0214
Mycobacterium leprae Probable lipase LipE 0.0035 0.0096 1
Echinococcus granulosus calpain 0.0037 0.0111 0.0071
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0111 0.016
Echinococcus multilocularis calpain 7 (C02 family) 0.0037 0.0111 0.0071
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0132 0.0827 0.079
Entamoeba histolytica hypothetical protein 0.0111 0.0667 0.6927
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0667 0.063
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.015 0.0964 0.2146
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0291 0.2035 0.4532
Mycobacterium tuberculosis Conserved hypothetical protein 0.0324 0.2284 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0096 0.0056
Onchocerca volvulus 0.0035 0.0096 0.0297
Brugia malayi FAD binding domain containing protein 0.0242 0.1661 0.5881
Loa Loa (eye worm) hypothetical protein 0.0392 0.2796 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0501 0.0463
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0202
Loa Loa (eye worm) hypothetical protein 0.0125 0.0778 0.2678
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0125 0.0778 0.0741
Loa Loa (eye worm) hypothetical protein 0.0147 0.0944 0.328
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0369
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0045 0.0166 0.0457
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0181 0.0142
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0111 0.0247
Echinococcus multilocularis snurportin 1 0.0298 0.2086 0.2054
Schistosoma mansoni cytochrome B5 0.0045 0.0166 0.0126
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0045 0.0166 0.0998
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0213
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.015 0.0964 0.3351
Loa Loa (eye worm) FAD binding domain-containing protein 0.0242 0.1661 0.5881
Toxoplasma gondii hypothetical protein 0.0099 0.058 0.4286
Echinococcus multilocularis tumor protein p63 0.0326 0.2302 0.2271
Schistosoma mansoni hypothetical protein 0.0111 0.0667 0.063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0181 0.0513
Treponema pallidum flavodoxin 0.015 0.0964 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0392 0.2796 0.6192
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.0247
Leishmania major p450 reductase, putative 0.0392 0.2796 0.6226
Leishmania major kinesin, putative 0.0037 0.0111 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0501 0.0463
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.015 0.0964 0.2146
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0132 0.0827 0.079
Trichomonas vaginalis sulfite reductase, putative 0.0392 0.2796 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0667 0.063
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0181 0.0142
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0484 0.1078
Trypanosoma brucei kinesin, putative 0.0037 0.0111 0.016
Leishmania major cytochrome-b5 reductase, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0105 0.0627 0.1397
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Echinococcus granulosus GPCR family 2 0.0047 0.0181 0.0142
Loa Loa (eye worm) calpain family protein 1 0.0125 0.0778 0.2678
Loa Loa (eye worm) diaphorase 0.0045 0.0166 0.0457
Trypanosoma cruzi oxidoreductase-protein, putative 0.0045 0.0166 0.0369
Loa Loa (eye worm) flavodoxin family protein 0.015 0.0964 0.3351
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0202
Trypanosoma cruzi p450 reductase, putative 0.0392 0.2796 0.6226
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0096 0.0056
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.3508 0.3482
Echinococcus multilocularis hypothetical protein 0.0037 0.0111 0.0071
Trypanosoma cruzi reductase, putative 0.0045 0.0166 0.0369
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0045 0.0166 0.0283
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0342
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0283
Brugia malayi Pre-SET motif family protein 0.0204 0.1373 0.4837
Echinococcus multilocularis GPCR, family 2 0.0047 0.0181 0.0142
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0096 0.0114
Schistosoma mansoni calpain C (C02 family) 0.0037 0.0111 0.0071
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0233 0.0194
Plasmodium vivax SET domain protein, putative 0.0029 0.005 0.0036
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0714 0.2447
Brugia malayi calpain family protein 1 0.0125 0.0778 0.2678
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.005 0.001
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0457
Onchocerca volvulus 0.0048 0.0191 0.0915
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0096 0.0114
Echinococcus granulosus cytochrome b5 reductase 4 0.0045 0.0166 0.0126
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0111 0.0247
Leishmania major cytochrome-b5 reductase, putative 0.0045 0.0166 0.0369
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0099 0.5
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0111 0.016
Loa Loa (eye worm) hypothetical protein 0.0145 0.0931 0.3232
Plasmodium falciparum nitric oxide synthase, putative 0.0392 0.2796 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0181 0.0142
Brugia malayi MH2 domain containing protein 0.0117 0.0714 0.2447
Mycobacterium ulcerans oxidoreductase 0.0045 0.0166 0.026
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0615 0.449 1
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0045 0.0166 0.0126
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.2086 0.7424
Echinococcus granulosus calpain A 0.0037 0.0111 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0096 0.0202
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0045 0.0166 0.0431
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0342
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0096 0.0056
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0283
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.015 0.0964 0.2146
Leishmania major hypothetical protein, conserved 0.0035 0.0096 0.0213
Schistosoma mansoni diflavin oxidoreductase 0.0194 0.1301 0.1266
Schistosoma mansoni hypothetical protein 0.0101 0.0591 0.0553
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0392 0.2796 1
Echinococcus granulosus neuropeptide s receptor 0.0486 0.3508 0.3482
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.0247
Brugia malayi beta-lactamase family protein 0.0035 0.0096 0.0202
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.015 0.0964 0.2075
Brugia malayi calpain family protein 1 0.0125 0.0778 0.2678
Toxoplasma gondii ABC1 family protein 0.0035 0.0096 0.0442
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1535 0.6618
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0099 0.0354
Mycobacterium tuberculosis Probable monooxygenase 0.0045 0.0166 0.0431
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0931 0.0894
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0944 0.328
Leishmania major nitrate reductase, putative 0.0045 0.0166 0.0369
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0667 0.063
Leishmania major mitochondrial DNA polymerase beta 0.0615 0.449 1
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0591 0.1999
Loa Loa (eye worm) FAD binding domain-containing protein 0.0392 0.2796 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0037 0.0111 0.1153
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0045 0.0166 0.0431
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.005 0.001
Schistosoma mansoni microtubule-associated protein tau 0.1343 1 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0132 0.0827 0.079
Brugia malayi hypothetical protein 0.0149 0.0958 0.333
Echinococcus multilocularis muscleblind protein 0.0145 0.0931 0.0894
Loa Loa (eye worm) calpain family protein 1 0.0088 0.0496 0.1653
Trypanosoma brucei nitrate reductase, putative 0.0045 0.0166 0.0283
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0045 0.0166 0.0369
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0501 0.0463
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0484 0.1078
Brugia malayi FAD binding domain containing protein 0.0392 0.2796 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0392 0.2796 0.2767
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1586 0.5674
Trypanosoma brucei NADH-dependent fumarate reductase 0.0045 0.0166 0.0283
Loa Loa (eye worm) hypothetical protein 0.0145 0.0931 0.3232
Loa Loa (eye worm) hypothetical protein 0.0047 0.0181 0.0513
Trypanosoma brucei antigen, putative 0.0037 0.0111 0.016
Schistosoma mansoni inositol monophosphatase 0.0036 0.0099 0.0059
Schistosoma mansoni hypothetical protein 0.0298 0.2086 0.2054
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0111 0.016
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0111 0.0247
Trypanosoma cruzi nitrate reductase, putative 0.0045 0.0166 0.0369
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0096 0.0342
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.3508 0.3482
Schistosoma mansoni lipoxygenase 0.0053 0.0233 0.0194
Entamoeba histolytica type A flavoprotein, putative 0.015 0.0964 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.015 0.0964 0.3446
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0392 0.2796 0.6192
Mycobacterium tuberculosis Probable oxidoreductase 0.0045 0.0166 0.0431
Trichomonas vaginalis esterase, putative 0.0035 0.0096 0.0342
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0392 0.2796 0.6226
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0096 0.0114
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.015 0.0964 0.3351
Brugia malayi Pre-SET motif family protein 0.0029 0.005 0.0036
Echinococcus multilocularis cytochrome b5 reductase 4 0.0045 0.0166 0.0126
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0096 0.0114
Trypanosoma cruzi p450 reductase, putative 0.0045 0.0166 0.0369
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0037 0.0111 0.0247
Loa Loa (eye worm) hypothetical protein 0.0125 0.0778 0.2678
Loa Loa (eye worm) calpain 5 0.0037 0.0111 0.0258
Echinococcus granulosus methionine synthase reductase 0.0242 0.1661 0.1627
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0484 0.0998
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0392 0.2796 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0958 0.333
Trypanosoma cruzi kinesin, putative 0.0037 0.0111 0.0247
Schistosoma mansoni cytochrome P450 reductase 0.0392 0.2796 0.2767
Echinococcus granulosus calpain 7 C02 family 0.0037 0.0111 0.0071
Echinococcus granulosus geminin 0.0167 0.1095 0.1059
Entamoeba histolytica type A flavoprotein, putative 0.015 0.0964 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0191 0.0546
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0501 0.0463
Mycobacterium ulcerans electron transfer protein FdxB 0.0045 0.0166 0.026
Echinococcus granulosus muscleblind protein 0.0145 0.0931 0.0894
Toxoplasma gondii flavodoxin domain-containing protein 0.0194 0.1301 1
Brugia malayi Muscleblind-like protein 0.0145 0.0931 0.3232
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.0247
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0045 0.0166 0.026
Plasmodium vivax calpain, putative 0.0037 0.0111 0.0258
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0944 0.328
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0501 0.1675
Echinococcus granulosus snurportin 1 0.0298 0.2086 0.2054
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.022
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0045 0.0166 0.0369
Mycobacterium tuberculosis Conserved protein 0.0035 0.0096 0.0114
Echinococcus granulosus tumor protein p63 0.0326 0.2302 0.2271
Entamoeba histolytica hypothetical protein 0.0111 0.0667 0.6927
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0096 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.016
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0369
Loa Loa (eye worm) hypothetical protein 0.0088 0.0496 0.1653
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0037 0.0111 0.016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0615 0.449 1
Schistosoma mansoni hypothetical protein 0.0047 0.0181 0.0142
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.005 0.008
Echinococcus multilocularis calpain 5 0.0037 0.0111 0.0071
Schistosoma mansoni calpain (C02 family) 0.0037 0.0111 0.0071
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.0247
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.3508 0.3482
Onchocerca volvulus 0.0149 0.0958 0.5908
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0045 0.0166 0.0457
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0392 0.2796 0.2767
Brugia malayi beta-lactamase 0.0035 0.0096 0.0202
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Toxoplasma gondii flavodoxin domain-containing protein 0.0194 0.1301 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0132 0.0827 0.079
Loa Loa (eye worm) calpain 0.0037 0.0111 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0202
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0045 0.0166 0.0126
Trichomonas vaginalis NADPH cytochrome P450, putative 0.015 0.0964 0.3446
Onchocerca volvulus 0.0045 0.0166 0.0754
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.001
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0242 0.1661 0.1627
Schistosoma mansoni calpain-7 (C02 family) 0.0037 0.0111 0.0071
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.0247
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0099 0.0354
Plasmodium falciparum ferredoxin--NADP reductase 0.0045 0.0166 0.0457
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0392 0.2796 0.6226
Giardia lamblia Nitric oxide synthase, inducible 0.0347 0.2458 1
Echinococcus multilocularis geminin 0.0167 0.1095 0.1059
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0291 0.2035 0.4482
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0392 0.2796 0.2767
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.005 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0944 0.328
Entamoeba histolytica type A flavoprotein, putative 0.015 0.0964 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0099 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0342
Trypanosoma cruzi kinesin, putative 0.0037 0.0111 0.0247
Brugia malayi calpain 5 0.0037 0.0111 0.0258
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.022
Leishmania major NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Brugia malayi flavodoxin family protein 0.015 0.0964 0.3351
Mycobacterium ulcerans monooxygenase 0.0045 0.0166 0.026
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0392 0.2796 0.6226
Loa Loa (eye worm) beta-lactamase 0.0035 0.0096 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0501 0.0463
Plasmodium vivax hypothetical protein, conserved 0.015 0.0964 0.3351
Entamoeba histolytica type A flavoprotein, putative 0.015 0.0964 1
Echinococcus granulosus calpain 5 0.0037 0.0111 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.001
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0099 0.1026
Plasmodium vivax flavodoxin domain containing protein 0.0347 0.2458 0.8776
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1373 0.4837
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0501 0.1675
Schistosoma mansoni hypothetical protein 0.0047 0.0181 0.0142
Entamoeba histolytica type A flavoprotein, putative 0.015 0.0964 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0099 0.0467
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0096 0.0125
Trypanosoma brucei oxidoreductase-protein, putative 0.0045 0.0166 0.0283
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0045 0.0166 0.026
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0099 0.0132
Mycobacterium tuberculosis Possible oxygenase 0.0045 0.0166 0.0431
Trypanosoma brucei calpain-like protein, putative 0.0037 0.0111 0.016
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0283
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0096 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0099 0.0059
Brugia malayi hypothetical protein 0.0111 0.0667 0.2277
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0714 0.2447
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.001
Brugia malayi beta-lactamase family protein 0.0035 0.0096 0.0202
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0392 0.2796 0.6192
Chlamydia trachomatis sulfite reductase 0.0242 0.1661 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0181 0.0513
Trichomonas vaginalis NADPH cytochrome P450, putative 0.015 0.0964 0.3446
Leishmania major NADH-dependent fumarate reductase-like protein 0.0045 0.0166 0.0369
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0283
Schistosoma mansoni calpain-7 (C02 family) 0.0037 0.0111 0.0071
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0111 0.0247
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0347 0.2458 0.8793
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0392 0.2796 0.6226
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0096 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0202
Echinococcus multilocularis calpain family protein 1, d 0.0088 0.0496 0.0457
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0111 0.0247
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0099 0.0059
Leishmania major NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0369
Loa Loa (eye worm) hypothetical protein 0.0101 0.0591 0.1999
Onchocerca volvulus 0.0035 0.0096 0.0297
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0369
Brugia malayi calpain 7 0.0037 0.0111 0.0258
Echinococcus multilocularis microtubule associated protein 2 0.1343 1 1
Entamoeba histolytica hypothetical protein 0.0111 0.0667 0.6927
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0045 0.0166 0.0126
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0096 0.0114
Echinococcus multilocularis calpain 0.0037 0.0111 0.0071
Onchocerca volvulus 0.0035 0.0096 0.0297
Mycobacterium tuberculosis Conserved protein 0.0035 0.0096 0.0114
Echinococcus multilocularis methionine synthase reductase 0.0242 0.1661 0.1627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0501 0.0463
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0202
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0099 0.0059
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0045 0.0166 0.0283
Leishmania major hypothetical protein, conserved 0.015 0.0964 0.2146
Loa Loa (eye worm) hypothetical protein 0.0088 0.0496 0.1653
Schistosoma mansoni Mername-AA248 (C02 family) 0.0037 0.0111 0.0071
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0111 0.0247
Schistosoma mansoni NADPH flavin oxidoreductase 0.0197 0.1323 0.1289
Leishmania major reductase, putative 0.0045 0.0166 0.0369
Schistosoma mansoni hypothetical protein 0.0047 0.0181 0.0142
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0045 0.0166 0.0457
Mycobacterium ulcerans oxygenase 0.0045 0.0166 0.026
Mycobacterium tuberculosis Conserved protein 0.0035 0.0096 0.0114
Echinococcus multilocularis calpain A 0.0132 0.0827 0.079
Brugia malayi flavodoxin family protein 0.0392 0.2796 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0096 0.0056
Onchocerca volvulus 0.0232 0.1586 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0181 0.0513
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0369
Trypanosoma brucei NADH-dependent fumarate reductase 0.0045 0.0166 0.0283
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.0036
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0099 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0213
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0392 0.2796 0.6192
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0045 0.0166 0.0998
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0096 0.0114
Echinococcus granulosus calpain A 0.0132 0.0827 0.079
Mycobacterium ulcerans hypothetical protein 0.0324 0.2284 0.8105
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0233 0.0194
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0045 0.0166 0.0283

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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