TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 679.763 | Formula: C34H45N7O8
H donors: 9 H acceptors: 9 LogP: 0.26 Rotable bonds: 23
Rule of 5 violations (Lipinski): 3
SMILES: NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]cn1)Cc1ccccc1)C(CC)C)NC(=O)c1cc(O)ccc1O
InChi: 1S/C34H45N7O8/c1-3-20(2)29(41-31(45)25(11-7-8-14-35)38-30(44)24-17-23(42)12-13-28(24)43)33(47)39-26(15-21-9-5-4-6-10-21)32(46)40-27(34(48)49)16-22-18-36-19-37-22/h4-6,9-10,12-13,17-20,25-27,29,42-43H,3,7-8,11,14-16,35H2,1-2H3,(H,36,37)(H,38,44)(H,39,47)(H,40,46)(H,41,45)(H,48,49)/t20?,25-,26-,27-,29-/m0/s1
InChiKey: XUBZJKQOLJQSQT-RTXLEBEMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0067	0.0398	0.3992
Brugia malayi	hypothetical protein	0.0103	0.1186	0.4802
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus granulosus	dro:myosuppressin receptor	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.0398	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0067	0.0398	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus multilocularis	allatostatin A receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0067	0.0398	0.1612
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0067	0.0398	0.0398
Brugia malayi	RE15519p	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	hypothetical protein	0.0067	0.0398	0.0767
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0067	0.0398	0.0398
Echinococcus multilocularis	sex peptide receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus multilocularis	neuropeptides capa receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	allatostatin A receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0164	0.247	0.6398
Schistosoma mansoni	amine GPCR	0.0067	0.0398	0.0767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Echinococcus granulosus	neuropeptide receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	adenoreceptor	0.0067	0.0398	0.0767
Echinococcus multilocularis	somatostatin receptor	0.0067	0.0398	0.0398
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.0398	0.0398
Brugia malayi	ORL1-like opioid receptor	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0229	0.386	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0164	0.247	0.247
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0225	0.3781	0.7282
Echinococcus multilocularis	G protein coupled receptor 139	0.0067	0.0398	0.0398
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0067	0.0398	0.0767
Brugia malayi	neuropeptide F receptor	0.0067	0.0398	0.1612
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0067	0.0398	0.1612
Brugia malayi	putative neuropeptide receptor NPR1	0.0067	0.0398	0.1612
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Echinococcus multilocularis	leucine aminopeptidase protein	0.0106	0.124	0.124
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0067	0.0398	0.0398
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.0398	0.0767
Schistosoma mansoni	opsin-like receptor	0.0067	0.0398	0.0767
Schistosoma mansoni	opsin-like receptor	0.0067	0.0398	0.0767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Brugia malayi	Dopamine receptor	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.0398	0.0398
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.0106	0.124	0.5
Brugia malayi	putative neuropeptide receptor	0.0067	0.0398	0.1612
Echinococcus granulosus	serotonin receptor	0.0067	0.0398	0.0398
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0067	0.0398	0.0767
Loa Loa (eye worm)	TYRA-2 protein	0.0067	0.0398	0.1031
Echinococcus granulosus	neuropeptides capa receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0067	0.0398	0.0767
Brugia malayi	G protein-coupled receptor	0.0067	0.0398	0.1612
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Echinococcus multilocularis	orexin receptor type 2	0.0067	0.0398	0.0398
Brugia malayi	Dopamine receptor protein 2	0.0067	0.0398	0.1612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0142	0.0573
Schistosoma mansoni	biogenic amine receptor	0.0067	0.0398	0.0767
Echinococcus multilocularis	serotonin receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	g protein coupled receptor	0.0067	0.0398	0.0398
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0067	0.0398	0.0767
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0067	0.0398	0.0398
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0067	0.0398	0.1031
Echinococcus multilocularis	sterol O acyltransferase 1	0.0229	0.386	0.386
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0067	0.0398	0.1612
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Schistosoma mansoni	amine GPCR	0.0067	0.0398	0.0767
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0225	0.3781	0.3781
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0067	0.0398	0.1031
Onchocerca volvulus		0.0095	0.0997	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0142	0.0273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Schistosoma mansoni	alpha-glucosidase	0.0141	0.1983	0.382
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0067	0.0398	0.3992
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0142	0.0367
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0206	0.3383	0.8765
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0067	0.0398	0.0398
Schistosoma mansoni	neuropeptide receptor	0.0067	0.0398	0.0767
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0067	0.0398	0.0398
Echinococcus granulosus	neuropeptides capa receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.0398	0.0398
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.0106	0.124	0.5
Echinococcus granulosus	orexin receptor type 2	0.0067	0.0398	0.0398
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0164	0.247	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Echinococcus multilocularis	neuropeptide receptor	0.0067	0.0398	0.0398
Brugia malayi	G-protein coupled receptor	0.0067	0.0398	0.1612
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus multilocularis	neuropeptide receptor A26	0.0516	1	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Brugia malayi	larval opioid receptor	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0067	0.0398	0.1612
Echinococcus granulosus	g protein coupled receptor	0.0067	0.0398	0.0398
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Onchocerca volvulus		0.0067	0.0398	0.3992
Echinococcus granulosus	hypothetical protein	0.0067	0.0398	0.0398
Echinococcus multilocularis	neuropeptide s receptor	0.0516	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.247	0.247
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.0398	0.0398
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.0398	0.0767
Echinococcus multilocularis	g-protein coupled receptor	0.0067	0.0398	0.0398
Schistosoma mansoni	biogenic amine receptor	0.0067	0.0398	0.0767
Loa Loa (eye worm)	MBCTL1	0.0055	0.0142	0.0367
Echinococcus granulosus	G protein coupled receptor 139	0.0067	0.0398	0.0398
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0067	0.0398	0.0398
Brugia malayi	Dopamine receptor protein 1	0.0067	0.0398	0.1612
Echinococcus granulosus	7tm_1 domain containing protein	0.0067	0.0398	0.0398
Plasmodium falciparum	M17 leucyl aminopeptidase	0.0106	0.124	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0067	0.0398	0.0398
Brugia malayi	follicle stimulating hormone receptor	0.0067	0.0398	0.1612
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.247	0.247
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0142	0.0142
Echinococcus multilocularis	serotonin receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus granulosus	g protein coupled receptor	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Schistosoma mansoni	amine GPCR	0.0067	0.0398	0.0767
Onchocerca volvulus		0.0067	0.0398	0.3992
Mycobacterium ulcerans	leucyl aminopeptidase	0.0106	0.124	0.5
Schistosoma mansoni	amine GPCR	0.0067	0.0398	0.0767
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.0398	0.0767
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.0106	0.124	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.0398	0.0767
Echinococcus granulosus	neuropeptide receptor	0.0067	0.0398	0.0398
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0067	0.0398	0.0767
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0067	0.0398	0.3992
Brugia malayi	Serotonin receptor	0.0067	0.0398	0.1612
Echinococcus granulosus	neuropeptide receptor A26	0.0516	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	biogenic amine receptor	0.0067	0.0398	0.0767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Schistosoma mansoni	myosin xvIII	0.0067	0.0398	0.0767
Schistosoma mansoni	neuropeptide receptor	0.0067	0.0398	0.0767
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Schistosoma mansoni	neuropeptide receptor	0.0067	0.0398	0.0767
Schistosoma mansoni	histamine h1 receptor	0.0067	0.0398	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.0398	0.0398
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.0106	0.124	0.5
Brugia malayi	neuropeptide F receptor	0.0067	0.0398	0.1612
Onchocerca volvulus		0.0067	0.0398	0.3992
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.0398	0.0398
Echinococcus granulosus	leucine aminopeptidase protein	0.0106	0.124	0.124
Echinococcus multilocularis	neuropeptides capa receptor	0.0067	0.0398	0.0398
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.0106	0.124	0.5
Schistosoma mansoni	amine GPCR	0.0067	0.0398	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus multilocularis	neuropeptide receptor	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.0398	0.0398
Schistosoma mansoni	neuropeptide f receptor 76f	0.0067	0.0398	0.0767
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0189	0.3006	0.3006
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0067	0.0398	0.1612
Schistosoma mansoni	sterol O-acyltransferase 1	0.0229	0.386	0.7434
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0067	0.0398	0.1612
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0067	0.0398	0.1031
Brugia malayi	Melatonin receptor type 1A	0.0067	0.0398	0.1612
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.0398	0.1031
Toxoplasma gondii	leucyl aminopeptidase LAP	0.0106	0.124	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0067	0.0398	0.0767
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.0398	0.0767
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.0106	0.124	0.5
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0225	0.3781	0.3781
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0067	0.0398	0.0767
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.0398	0.0398
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus multilocularis	dro:myosuppressin receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Chlamydia trachomatis	cytosol aminopeptidase	0.0106	0.124	0.5
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0142	0.0142
Onchocerca volvulus		0.0067	0.0398	0.3992
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.0398	0.0398
Echinococcus granulosus	7TM GPCR rhodopsin	0.0067	0.0398	0.0398
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.0398	0.0767
Brugia malayi	Serotonin receptor	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	hypothetical protein	0.0067	0.0398	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.0398	0.0398
Echinococcus granulosus	neuropeptide FF receptor 2	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.0106	0.124	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Echinococcus granulosus	sex peptide receptor	0.0067	0.0398	0.0398
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Brugia malayi	GnHR receptor homolog	0.0067	0.0398	0.1612
Schistosoma mansoni	hypothetical protein	0.0291	0.5193	1
Echinococcus granulosus	somatostatin receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	melatonin receptor type 1A	0.0067	0.0398	0.1031
Onchocerca volvulus		0.0067	0.0398	0.3992
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0067	0.0398	0.0767
Brugia malayi	AKH receptor	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0225	0.3781	0.9795
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.0398	0.0767
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.0398	0.1031
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.0398	0.0398
Brugia malayi	hypothetical protein	0.0067	0.0398	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Brugia malayi	G protein-coupled receptor F59B2.13	0.0067	0.0398	0.1612
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.0398	0.0398
Onchocerca volvulus		0.0067	0.0398	0.3992
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	growth hormone secretagogue receptor	0.0067	0.0398	0.0767
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0106	0.124	0.5
Schistosoma mansoni	hypothetical protein	0.0067	0.0398	0.0767
Brugia malayi	sulfakinin receptor protein	0.0067	0.0398	0.1612
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.0398	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.0398	0.0767
Echinococcus granulosus	fmrfamide receptor	0.0067	0.0398	0.0398
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0067	0.0398	0.0398
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.0398	0.0398
Schistosoma mansoni	hypothetical protein	0.0067	0.0398	0.0767
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.0398	0.0398
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0189	0.3006	0.3006
Brugia malayi	G-protein coupled receptor	0.0067	0.0398	0.1612
Schistosoma mansoni	neuropeptide receptor	0.0067	0.0398	0.0767
Echinococcus granulosus	g-protein coupled receptor	0.0067	0.0398	0.0398
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.0398	0.1031
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0067	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0398	0.1031
Schistosoma mansoni	opsin-like receptor	0.0067	0.0398	0.0767
Schistosoma mansoni	alpha-glucosidase	0.0141	0.1983	0.382
Echinococcus granulosus	sterol O acyltransferase 1	0.0229	0.386	0.386

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 uM	Anti-thrombin activity by competitive enzyme assay using the fluorogenic substrate Tos-Gly-Pro-Arg-AMC at pH 8.3.	ChEMBL.	9873411

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 167367

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 65972