Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0175 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1311 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.7985 | 0.7985 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1311 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1311 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1311 | 0.1311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1311 | 0.1311 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1311 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0175 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1311 | 0.1311 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.7985 | 0.7985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1311 | 0.1311 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1311 | 0.1642 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1311 | 0.1311 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.7985 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1311 | 0.1311 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1311 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1311 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.