Detailed information for compound 659948

Basic information

Technical information
  • TDR Targets ID: 659948
  • Name: 2-[(4-bromophenyl)sulfonyl-[(4-methylphenyl)m ethyl]amino]-N-cyclopropylacetamide
  • MW: 437.351 | Formula: C19H21BrN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccc(cc1)Br)Cc1ccc(cc1)C)NC1CC1
  • InChi: 1S/C19H21BrN2O3S/c1-14-2-4-15(5-3-14)12-22(13-19(23)21-17-8-9-17)26(24,25)18-10-6-16(20)7-11-18/h2-7,10-11,17H,8-9,12-13H2,1H3,(H,21,23)
  • InChiKey: WOJJQDMNXNBTMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-bromophenyl)sulfonyl-[(4-methylphenyl)methyl]amino]-N-cyclopropyl-acetamide
  • 2-[(4-bromophenyl)sulfonyl-(4-methylbenzyl)amino]-N-cyclopropyl-acetamide
  • 2-[(4-bromophenyl)sulfonyl-[(4-methylphenyl)methyl]amino]-N-cyclopropyl-ethanamide
  • ZINC02836853

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0023 0.013 0.0136
Loa Loa (eye worm) programmed cell death 8 0.0023 0.013 0.0301
Schistosoma mansoni hypothetical protein 0.0035 0.027 0.027
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0089 0.094 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0089 0.094 0.2803
Echinococcus multilocularis glutamate synthase 0.0023 0.013 0.0136
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0144 0.1628 0.5358
Schistosoma mansoni tar DNA-binding protein 0.0174 0.2 0.2
Mycobacterium ulcerans hypothetical protein 0.0038 0.0315 0.2287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0071 0.0717 0.0717
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0252 0.0252
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0065 0.0647 0.141
Loa Loa (eye worm) hypothetical protein 0.0054 0.0511 0.1224
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0089 0.094 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0315 0.0238
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.027 0.089
Schistosoma mansoni zinc finger protein 0.0015 0.0024 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0034 0.0068
Schistosoma mansoni hypothetical protein 0.0027 0.0177 0.0177
Entamoeba histolytica serine/threonine protein kinase, putative 0.0176 0.2029 1
Brugia malayi beta-lactamase family protein 0.0038 0.0315 0.0592
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0046 0.0406 0.0424
Echinococcus granulosus zinc finger protein 0.0015 0.0024 0.0079
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0292 0.0292
Schistosoma mansoni hypothetical protein 0.0187 0.2171 0.2171
Echinococcus granulosus SAM and MBT domain containing protein 0.0036 0.0292 0.0961
Brugia malayi glutamate synthase 0.0023 0.013 0.0136
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0086 0.091 0.0949
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0089 0.094 0.2803
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0086 0.0909 0.2188
Echinococcus multilocularis polycomb protein SCMH1 0.0036 0.0292 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.2029 0.413
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.2029 0.2029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0478
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.094 0.2803
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0023 0.013 0.0136
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0049 0.0454 0.1121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.027 0.0282
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0089 0.094 1
Toxoplasma gondii thioredoxin reductase 0.0255 0.3018 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0315 0.0238
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.2889 0.355
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0315 0.1037
Mycobacterium tuberculosis Conserved protein 0.0038 0.0315 0.0238
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0177 0.0414
Schistosoma mansoni hypothetical protein 0.0027 0.0177 0.0177
Echinococcus multilocularis histone acetyltransferase MYST2 0.0042 0.0355 0.037
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0177 0.0251
Brugia malayi Bromodomain containing protein 0.0057 0.0552 0.1175
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0071 0.0717 0.1723
Schistosoma mansoni tar DNA-binding protein 0.0174 0.2 0.2
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0177 0.0581
Echinococcus multilocularis jumonji domain containing protein 0.0037 0.0293 0.0306
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.013 0.0428
Leishmania major hypothetical protein, conserved 0.0038 0.0315 0.0641
Brugia malayi serine/threonine-protein kinase plk-2 0.0176 0.2029 0.4814
Mycobacterium tuberculosis Conserved protein 0.0038 0.0315 0.0238
Loa Loa (eye worm) hypothetical protein 0.0045 0.0399 0.0952
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0583 0.7092 0.8958
Echinococcus multilocularis thioredoxin glutathione reductase 0.0257 0.3039 0.3168
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0648 0.7901 1
Brugia malayi RNA recognition motif domain containing protein 0.0174 0.2 0.4743
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0023 0.013 0.0136
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0252 0.0252
Schistosoma mansoni bromodomain containing protein 0.0048 0.044 0.044
Giardia lamblia Kinase, PLK 0.0176 0.2029 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0089 0.094 0.098
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0315 0.0592
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0165 0.0121
Brugia malayi Pre-SET motif family protein 0.0345 0.4134 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0165 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.2029 0.413
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.2029 0.413
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0583 0.7092 0.8958
Echinococcus multilocularis PHD finger protein rhinoceros 0.0026 0.0165 0.0172
Loa Loa (eye worm) hypothetical protein 0.0027 0.0177 0.0414
Echinococcus granulosus polycomb protein SCMH1 0.0036 0.0292 0.0961
Brugia malayi jmjC domain containing protein 0.0033 0.0252 0.0437
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0176 0.2029 0.2115
Brugia malayi mbt repeat family protein 0.0036 0.0292 0.0535
Echinococcus granulosus tar DNA binding protein 0.0174 0.2 0.6582
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0089 0.094 0.3092
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0089 0.094 1
Loa Loa (eye worm) PHD-finger family protein 0.0026 0.0165 0.0386
Loa Loa (eye worm) hypothetical protein 0.0038 0.0315 0.0749
Loa Loa (eye worm) hypothetical protein 0.0059 0.057 0.1367
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0023 0.013 0.0301
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0023 0.013 0.0428
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0315 0.0403
Echinococcus granulosus fetal alzheimer antigen falz 0.0017 0.0052 0.0172
Onchocerca volvulus 0.0038 0.0315 0.0403
Onchocerca volvulus 0.0049 0.0454 0.0704
Plasmodium vivax SET domain protein, putative 0.0049 0.0454 0.1121
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0583 0.7092 0.8958
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0089 0.094 0.094
Brugia malayi PHD-finger family protein 0.0026 0.0165 0.0222
Brugia malayi Bromodomain containing protein 0.0029 0.0202 0.0314
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.094 0.2803
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0089 0.094 0.1042
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0036 0.0292 0.0352
Loa Loa (eye worm) hypothetical protein 0.0063 0.0616 0.1479
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0089 0.094 0.2803
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0315 0.0315
Brugia malayi jmjC domain containing protein 0.0086 0.091 0.2058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0315 0.0749
Loa Loa (eye worm) RNA binding protein 0.0174 0.2 0.483
Trypanosoma cruzi polo-like protein kinase, putative 0.0176 0.2029 0.6575
Loa Loa (eye worm) hypothetical protein 0.0023 0.013 0.0301
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.094 0.2803
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0071 0.0717 0.236
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0089 0.094 0.2803
Mycobacterium ulcerans lipase LipD 0.0038 0.0315 0.2287
Loa Loa (eye worm) mbt repeat family protein 0.0036 0.0292 0.0693
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0648 0.7901 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0174 0.2 0.483
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0023 0.013 0.0428
Echinococcus granulosus thioredoxin glutathione reductase 0.0257 0.3039 1
Entamoeba histolytica hypothetical protein 0.0035 0.027 0.0739
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0315 0.0641
Brugia malayi latrophilin 2 splice variant baaae 0.0059 0.057 0.122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0315 0.0749
Schistosoma mansoni tar DNA-binding protein 0.0174 0.2 0.2
Onchocerca volvulus Serine\/threonine kinase homolog 0.0176 0.2029 0.413
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0023 0.013 0.0428
Onchocerca volvulus 0.0038 0.0315 0.0403
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0036 0.0292 0.0292
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0177 0.0184
Schistosoma mansoni hypothetical protein 0.0026 0.0165 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0454 0.0454
Loa Loa (eye worm) thioredoxin reductase 0.0255 0.3018 0.7296
Entamoeba histolytica hypothetical protein 0.0035 0.027 0.0739
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0023 0.013 0.0136
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0023 0.013 0.0136
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0144 0.1628 0.1697
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.2029 0.413
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0065 0.0647 0.141
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0315 0.0238
Trichomonas vaginalis set domain proteins, putative 0.0393 0.4727 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0089 0.094 0.2803
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0086 0.091 0.2995
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.013 0.0136
Plasmodium vivax thioredoxin reductase, putative 0.0255 0.3018 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0315 0.0749
Echinococcus multilocularis geminin 0.0187 0.2171 0.2263
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0089 0.094 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0315 0.0403
Brugia malayi Thioredoxin reductase 0.0255 0.3018 0.725
Echinococcus multilocularis GPCR, family 2 0.0027 0.0177 0.0184
Loa Loa (eye worm) beta-lactamase 0.0038 0.0315 0.0749
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.018 0.0592
Brugia malayi mbt repeat family protein 0.0036 0.0292 0.0535
Schistosoma mansoni hypothetical protein 0.0023 0.013 0.013
Brugia malayi MH2 domain containing protein 0.0091 0.0975 0.2217
Schistosoma mansoni tar DNA-binding protein 0.0174 0.2 0.2
Schistosoma mansoni sulfide quinone reductase 0.0023 0.013 0.013
Schistosoma mansoni jumonji domain containing protein 0.0068 0.069 0.069
Echinococcus granulosus glutamate synthase 0.0023 0.013 0.0428
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0315 0.0238
Brugia malayi Bromodomain containing protein 0.0028 0.0188 0.0278
Trichomonas vaginalis mercuric reductase, putative 0.0089 0.094 0.1761
Echinococcus granulosus PHD finger protein rhinoceros 0.0026 0.0165 0.0543
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0315 0.0641
Entamoeba histolytica hypothetical protein 0.0035 0.027 0.0739
Trypanosoma cruzi trypanothione reductase, putative 0.0255 0.3018 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0315 0.0238
Schistosoma mansoni glutamate synthase 0.0023 0.013 0.013
Plasmodium falciparum thioredoxin reductase 0.0255 0.3018 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0071 0.0717 0.1583
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0089 0.094 0.2803
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0086 0.0909 0.2055
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0252 0.0597
Echinococcus multilocularis zinc finger protein 0.0015 0.0024 0.0025
Leishmania major trypanothione reductase 0.0255 0.3018 1
Echinococcus granulosus peregrin 0.0028 0.0188 0.0617
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0922 0.1723
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0315 0.0238
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.9591 1
Echinococcus granulosus lysine specific demethylase 5A 0.0033 0.0252 0.083
Loa Loa (eye worm) hypothetical protein 0.0033 0.0244 0.0576
Schistosoma mansoni glutamate synthase 0.0023 0.013 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0616 0.0616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0071 0.0717 0.0717
Schistosoma mansoni disulfide oxidoreductase 0.0023 0.013 0.013
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0315 0.0403
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0017 0.0052 0.0055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0089 0.094 0.213
Onchocerca volvulus 0.0038 0.0315 0.0403
Trypanosoma cruzi polo-like protein kinase, putative 0.0176 0.2029 0.6575
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0315 0.0238
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0616 0.0643
Echinococcus multilocularis SAM and MBT domain containing protein 0.0036 0.0292 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0091 0.0975 0.2347
Mycobacterium tuberculosis Probable reductase 0.0583 0.7092 0.8958
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0017 0.0052 0.0052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0315 0.0329
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0034
Onchocerca volvulus 0.0393 0.4727 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0583 0.7092 0.8958
Plasmodium falciparum glutathione reductase 0.0255 0.3018 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0315 0.0238
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.094 0.2803
Echinococcus granulosus histone acetyltransferase MYST2 0.0042 0.0355 0.1168
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0292 0.0292
Loa Loa (eye worm) glutathione reductase 0.0255 0.3018 0.7296
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0046 0.0406 0.1337
Schistosoma mansoni hypothetical protein 0.0027 0.0177 0.0177
Loa Loa (eye worm) MBCTL1 0.0042 0.0355 0.0845
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0049 0.0454 0.0473
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.013 0.0136
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0089 0.094 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Loa Loa (eye worm) hypothetical protein 0.0086 0.0909 0.2188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0071 0.0717 0.0748
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0255 0.3018 0.3716
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0023 0.013 0.0428
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Brugia malayi TAR-binding protein 0.0174 0.2 0.4743
Plasmodium falciparum phd finger protein, putative 0.0026 0.0165 0.0121
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0026 0.0165 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0071 0.0717 0.0748
Loa Loa (eye worm) hypothetical protein 0.0026 0.0165 0.0386
Giardia lamblia NADH oxidase lateral transfer candidate 0.0089 0.094 0.4263
Brugia malayi hypothetical protein 0.0035 0.027 0.0482
Toxoplasma gondii NADPH-glutathione reductase 0.0089 0.094 0.2803
Loa Loa (eye worm) hypothetical protein 0.0036 0.0292 0.0693
Schistosoma mansoni hypothetical protein 0.0222 0.2599 0.2599
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0071 0.0717 0.0717
Echinococcus granulosus geminin 0.0187 0.2171 0.7143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0071 0.0717 0.236
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0315 0.0749
Mycobacterium tuberculosis Probable oxidoreductase 0.0648 0.7901 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0315 0.0403
Loa Loa (eye worm) hypothetical protein 0.0038 0.0315 0.0749
Echinococcus multilocularis tar DNA binding protein 0.0174 0.2 0.2085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Toxoplasma gondii ABC1 family protein 0.0038 0.0315 0.0641
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.013 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0315 0.0749
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0042 0.0355 0.037
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0315 0.2287
Schistosoma mansoni sulfide quinone reductase 0.0023 0.013 0.013
Schistosoma mansoni kinase 0.0089 0.0951 0.0951
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.027 0.027
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0648 0.7901 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0315 0.0641
Brugia malayi RNA binding protein 0.0174 0.2 0.4743
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.2029 0.413
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0177 0.0251
Plasmodium falciparum glutathione reductase 0.0089 0.094 0.2803
Trichomonas vaginalis glutathione reductase, putative 0.0089 0.094 0.1761
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.018 0.0187
Echinococcus granulosus GPCR family 2 0.0027 0.0177 0.0581
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0176 0.2029 0.6677
Schistosoma mansoni glutamate synthase 0.0023 0.013 0.013
Trypanosoma brucei trypanothione reductase 0.0255 0.3018 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0086 0.0909 0.2055
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0315 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0174 0.2 0.2
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0177 0.0581
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0165 0.0121
Loa Loa (eye worm) hypothetical protein 0.0042 0.0355 0.0845
Treponema pallidum NADH oxidase 0.0089 0.094 1
Schistosoma mansoni hypothetical protein 0.0059 0.057 0.057
Mycobacterium leprae Probable lipase LipE 0.0038 0.0315 0.0238
Echinococcus multilocularis peregrin 0.0028 0.0188 0.0196
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0315 0.0238
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0089 0.094 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.094 0.2803
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0454 0.0454
Onchocerca volvulus 0.0036 0.0292 0.0352
Schistosoma mansoni hypothetical protein 0.0187 0.2171 0.2171
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.094 0.2803
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.013 0.0136
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0616 0.2028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0226 0.0532
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0176 0.2029 0.4901
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.013 0.0428
Schistosoma mansoni myelin transcription factor 1 myt1 0.0042 0.0355 0.0355
Brugia malayi Pre-SET motif family protein 0.0049 0.0454 0.0934
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.2029 0.413
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0315 0.2287
Mycobacterium tuberculosis Probable dehydrogenase 0.0583 0.7092 0.8958
Plasmodium vivax glutathione reductase, putative 0.0255 0.3018 1
Trypanosoma brucei polo-like protein kinase 0.0176 0.2029 0.6575
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0177 0.0184
Giardia lamblia PHD finger protein 15 0.0026 0.0165 0.0184
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0089 0.094 0.2803
Brugia malayi beta-lactamase family protein 0.0038 0.0315 0.0592
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0042 0.0355 0.069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0616 0.0616
Trichomonas vaginalis esterase, putative 0.0038 0.0315 0.0403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0345 0.4134 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0089 0.094 0.2803
Entamoeba histolytica hypothetical protein 0.0035 0.027 0.0739
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0514 0.123
Mycobacterium ulcerans beta-lactamase 0.0038 0.0315 0.2287
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0922 0.1723
Trichomonas vaginalis CAMK family protein kinase 0.0176 0.2029 0.413
Schistosoma mansoni hypothetical protein 0.0027 0.0177 0.0177
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0176 0.2029 0.6575
Echinococcus granulosus jumonji domain containing protein 0.0037 0.0293 0.0965
Brugia malayi glutathione reductase 0.0255 0.3018 0.725
Onchocerca volvulus Alhambra homolog 0.0026 0.0165 0.0076
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0042 0.0355 0.1168
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0583 0.7092 0.8958
Loa Loa (eye worm) transcription factor SMAD2 0.0091 0.0975 0.2347
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0315 0.0641
Brugia malayi beta-lactamase 0.0038 0.0315 0.0592
Loa Loa (eye worm) TAR-binding protein 0.0174 0.2 0.483
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0048 0.0431 0.1419
Echinococcus multilocularis lysine specific demethylase 5A 0.0032 0.0234 0.0244
Plasmodium falciparum thioredoxin reductase 0.0089 0.094 0.2803

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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