Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hexokinase type 2 | 0.1659 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0893 | 0.0893 |
Trypanosoma brucei | hexokinase, putative | 0.1659 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0225 | 0.0225 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0197 | 0.0197 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0356 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1287 | 0.1287 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.0192 | 0.4572 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Brugia malayi | hypothetical protein | 0.0228 | 0.1287 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0136 | 0.0723 | 0.0723 |
Toxoplasma gondii | hexokinase | 0.1659 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0197 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.162 | 0.9763 | 0.9763 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0144 | 0.0144 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0054 | 0.0054 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0356 | 0.0356 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0049 | 0.0192 | 0.314 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0121 | 0.0121 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0192 | 0.314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0179 | 0.0179 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0049 | 0.0192 | 0.9738 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0095 | 0.0475 | 0.0288 |
Echinococcus granulosus | expressed conserved protein | 0.0089 | 0.044 | 0.044 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0315 | 0.0315 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0192 | 0.0192 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0197 | 1 |
Brugia malayi | Hexokinase family protein | 0.1041 | 0.6235 | 0.6235 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Brugia malayi | Hexokinase family protein | 0.0513 | 0.3022 | 0.3022 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0144 | 0.0144 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0315 | 0.0315 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0136 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0225 | 0.0225 |
Echinococcus multilocularis | expressed conserved protein | 0.0089 | 0.044 | 0.044 |
Loa Loa (eye worm) | hexokinase type II | 0.1659 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1659 | 1 | 1 |
Onchocerca volvulus | 0.1659 | 1 | 1 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0095 | 0.0475 | 0.0475 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0225 | 0.0225 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Echinococcus granulosus | hexokinase type 2 | 0.1659 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1659 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0192 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0121 | 0.0121 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0356 | 0.0356 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0117 | 0.5934 |
Echinococcus granulosus | geminin | 0.0164 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0893 | 0.0893 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0049 | 0.0192 | 0.314 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0095 | 0.0475 | 0.0475 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hexokinase | 0.1659 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.1659 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.1659 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0356 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.3108 | 0.3108 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0356 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Echinococcus granulosus | hexokinase | 0.1659 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0179 | 0.0179 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Echinococcus multilocularis | hexokinase | 0.1659 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0049 | 0.0192 | 0.314 |
Loa Loa (eye worm) | hexokinase | 0.1041 | 0.6235 | 0.6235 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0192 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0192 | 0.0192 |
Trypanosoma cruzi | hexokinase, putative | 0.1659 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0225 | 0.0225 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0356 | 0.0356 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0192 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0192 | 0.0192 |
Trypanosoma cruzi | hexokinase, putative | 0.1659 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0.0192 | 0.314 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0049 | 0.0192 | 0.314 |
Loa Loa (eye worm) | hexokinase | 0.0513 | 0.3022 | 0.3022 |
Loa Loa (eye worm) | hypothetical protein | 0.1131 | 0.6787 | 0.6787 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0144 | 0.0144 |
Trypanosoma brucei | hexokinase | 0.1659 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0527 | 0.3108 | 0.3108 |
Treponema pallidum | hexokinase (hxk) | 0.1659 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.0192 | 0.4572 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0121 | 0.0121 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0192 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0893 | 0.0893 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0192 | 0.314 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0144 | 0.0144 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0192 | 0.314 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.0117 | 0.0117 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | hexokinase | 0.1659 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0475 | 0.0475 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.0484 | 0.0484 |
Entamoeba histolytica | hexokinase 2 | 0.1659 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0315 | 0.0315 |
Onchocerca volvulus | 0.0049 | 0.0192 | 0.0013 | |
Schistosoma mansoni | hexokinase | 0.1659 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.1659 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.1659 | 1 | 1 |
Onchocerca volvulus | 0.1659 | 1 | 1 | |
Onchocerca volvulus | Hexokinase homolog | 0.1041 | 0.6235 | 0.6166 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0197 | 0.0197 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0192 | 0.0192 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0197 | 0.4744 |
Trypanosoma brucei | hexokinase | 0.1659 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0144 | 0.0144 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0144 | 0.0144 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0356 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0144 | 0.0144 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0315 | 0.0315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.1287 | 0.1287 |
Onchocerca volvulus | 0.1041 | 0.6235 | 0.6166 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0144 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.1659 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.3108 | 0.3108 |
Echinococcus multilocularis | hexokinase | 0.1659 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.1659 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0192 | 0.0192 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0144 | 0.0144 |
Onchocerca volvulus | 0.1659 | 1 | 1 | |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0356 | 0.0356 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0095 | 0.0475 | 0.0475 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0049 | 0.0192 | 0.9738 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.02 | 0.02 |
Echinococcus granulosus | hexokinase | 0.1659 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.1287 | 0.1287 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.