Detailed information for compound 660042

Basic information

Technical information
  • TDR Targets ID: 660042
  • Name: 2-[2,6-dimethyl-1-(2-methylpropyl)pyridin-4-y lidene]indene-1,3-dione
  • MW: 307.386 | Formula: C20H21NO2
  • H donors: 0 H acceptors: 2 LogP: 4.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1c(C)cc(=C2C(=O)c3c(C2=O)cccc3)cc1C)C
  • InChi: 1S/C20H21NO2/c1-12(2)11-21-13(3)9-15(10-14(21)4)18-19(22)16-7-5-6-8-17(16)20(18)23/h5-10,12H,11H2,1-4H3
  • InChiKey: CINIXWVGHGMLHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1-isobutyl-2,6-dimethyl-4-pyridylidene)indane-1,3-dione
  • 2-(1-isobutyl-2,6-dimethyl-4-pyridylidene)indane-1,3-quinone
  • ZINC00106680
  • 2-(1-isobutyl-2,6-dimethyl-4(1H)-pyridinylidene)-1H-indene-1,3(2H)-dione
  • MLS000662077
  • SMR000292720

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0022 0.0131 0.0131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1139 0.1191
Brugia malayi hypothetical protein 0.0027 0.0303 0.0395
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.4404 0.4605
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0367 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1455 0.1455
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.5769 0.5769
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.5769 0.6033
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0131 0.0137
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.1123 0.1174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0367 0.0384
Entamoeba histolytica hypothetical protein 0.0023 0.0149 0.0165
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0077 0.0081
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0201 0.021
Echinococcus multilocularis snurportin 1 0.03 0.9563 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.1365 0.1427
Brugia malayi intermediate filament protein 0.0029 0.0367 0.0509
Schistosoma mansoni lamin 0.0029 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0027 0.0303 0.0316
Schistosoma mansoni hypothetical protein 0.03 0.9563 0.9563
Echinococcus granulosus zinc finger protein 0.0021 0.0092 0.0097
Schistosoma mansoni hypothetical protein 0.0148 0.4404 0.4404
Brugia malayi Importin beta-1 subunit 0.0028 0.0329 0.0443
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0329 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.9563 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.1123 0.1174
Echinococcus granulosus lamin 0.0029 0.0367 0.0384
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0329 1
Echinococcus multilocularis lamin dm0 0.0029 0.0367 0.0384
Entamoeba histolytica hypothetical protein 0.0148 0.4404 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0028 0.0329 0.0345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.5769 0.6033
Loa Loa (eye worm) hypothetical protein 0.0128 0.3709 0.3879
Loa Loa (eye worm) hypothetical protein 0.0128 0.3709 0.3879
Loa Loa (eye worm) hypothetical protein 0.0059 0.1365 0.1427
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.5769 0.6033
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.4404 0.4404
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.1123 0.1174
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0367 0.0509
Brugia malayi PHD-finger family protein 0.0027 0.0288 0.037
Brugia malayi mbt repeat family protein 0.0051 0.1123 0.1837
Schistosoma mansoni bromodomain containing protein 0.0068 0.1694 0.1694
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0149 0.3175
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.1123 0.1123
Echinococcus granulosus tar DNA binding protein 0.0061 0.1455 0.1521
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0303 1
Brugia malayi Bromodomain containing protein 0.0041 0.0778 0.1232
Schistosoma mansoni hypothetical protein 0.0035 0.0581 0.0581
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0303 0.8933
Schistosoma mansoni ran 0.0021 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0781 0.0817
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1139 0.1865
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.4404 0.4605
Schistosoma mansoni lamin 0.0029 0.0367 0.0367
Brugia malayi RNA, U transporter 1 0.008 0.2089 0.3534
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0077 0.0081
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0692 0.0723
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.1563 0.1634
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1139 0.1865
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.5769 0.5769
Echinococcus multilocularis musashi 0.0029 0.0367 0.0384
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.1365 0.1427
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0201 0.0201
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1455 0.1521
Leishmania major hypothetical protein, conserved 0.0027 0.0303 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.6263 0.6549
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0303 0.8933
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0201 0.021
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1455 0.242
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1455 0.1521
Echinococcus granulosus intermediate filament protein 0.0029 0.0367 0.0384
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0303 0.8933
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1455 0.1521
Echinococcus granulosus lamin dm0 0.0029 0.0367 0.0384
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0022 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0303 1
Schistosoma mansoni ran 0.0021 0.0077 0.0077
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0367 0.0384
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.6263 0.6549
Brugia malayi hypothetical protein 0.0128 0.3709 0.6381
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.1123 0.1123
Plasmodium falciparum importin beta, putative 0.0028 0.0329 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0149 0.3175
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.1123 0.1123
Onchocerca volvulus Huntingtin homolog 0.0128 0.3709 1
Brugia malayi Bromodomain containing protein 0.0081 0.2123 0.3594
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.1365 0.2262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.5769 0.6033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0349 0.0365
Brugia malayi RNA binding protein 0.0061 0.1455 0.242
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0077 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.1563 0.1634
Entamoeba histolytica hypothetical protein 0.0148 0.4404 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0303 0.8933
Brugia malayi hypothetical protein 0.0148 0.4404 0.7602
Echinococcus granulosus importin subunit beta 1 0.0028 0.0329 0.0345
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.1365 0.1427
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0692 0.0723
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0581 0.0884
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0077 0.0081
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.1365 0.1365
Loa Loa (eye worm) RNA binding protein 0.0061 0.1455 0.1521
Onchocerca volvulus 0.0051 0.1123 0.2261
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1455 0.1455
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.5769 0.6033
Schistosoma mansoni importin beta-1 0.0028 0.0329 0.0329
Schistosoma mansoni zinc finger protein 0.0021 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0052 0.1139 0.1191
Brugia malayi mbt repeat family protein 0.0051 0.1123 0.1837
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.1123 0.2261
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1455 0.1455
Entamoeba histolytica hypothetical protein 0.0148 0.4404 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0149 1
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.1123 0.1174
Loa Loa (eye worm) hypothetical protein 0.0076 0.1966 0.2056
Loa Loa (eye worm) hypothetical protein 0.0044 0.0868 0.0908
Loa Loa (eye worm) hypothetical protein 0.0046 0.0938 0.0981
Echinococcus granulosus snurportin 1 0.03 0.9563 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.5769 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.5769 0.5769
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0303 0.8933
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.1365 0.1427
Entamoeba histolytica hypothetical protein 0.0148 0.4404 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0329 0.0345
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.1123 0.1174
Loa Loa (eye worm) MBCTL1 0.0059 0.1365 0.1427
Plasmodium vivax importin-beta 2, putative 0.0028 0.0329 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0092 0.0097
Echinococcus multilocularis lamin 0.0029 0.0367 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1455 0.1455
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0149 1
Brugia malayi TAR-binding protein 0.0061 0.1455 0.242
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0149 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0329 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.3709 1
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.1123 0.1174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0581 0.0607
Schistosoma mansoni intermediate filament proteins 0.0029 0.0367 0.0367

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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