Detailed information for compound 660084

Basic information

Technical information
  • TDR Targets ID: 660084
  • Name: N-(1,3-benzothiazol-2-yl)-2-(2-bromo-4-ethylp henoxy)acetamide
  • MW: 391.282 | Formula: C17H15BrN2O2S
  • H donors: 1 H acceptors: 2 LogP: 5.07 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(c(c1)Br)OCC(=O)Nc1nc2c(s1)cccc2
  • InChi: 1S/C17H15BrN2O2S/c1-2-11-7-8-14(12(18)9-11)22-10-16(21)20-17-19-13-5-3-4-6-15(13)23-17/h3-9H,2,10H2,1H3,(H,19,20,21)
  • InChiKey: DNKJPTGZWNCSNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1,3-benzothiazol-2-yl)-2-(2-bromo-4-ethyl-phenoxy)acetamide
  • N-(1,3-benzothiazol-2-yl)-2-(2-bromo-4-ethyl-phenoxy)ethanamide
  • STK225455
  • ZINC04833738

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.2187 0.2187
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0064 0.1347 0.2507
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0064 0.1347 0.2495
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Entamoeba histolytica aldose reductase, putative 0.0222 0.5364 1
Schistosoma mansoni pol-related 0.0222 0.5364 0.5359
Leishmania major prostaglandin f synthase, putative 0.0222 0.5364 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0222 0.5364 1
Plasmodium falciparum aldehyde reductase, putative 0.0064 0.1347 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0665 0.0856
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0016
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0012 0.0012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0182 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0027 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0175 0.0306
Echinococcus granulosus peregrin 0.003 0.0483 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0746 0.1371
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0665 0.0856
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0665 0.0856
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0222 0.5364 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0665 0.0931
Trichomonas vaginalis aldo/keto reductase, putative 0.0222 0.5364 1
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0012 0.0042
Entamoeba histolytica alcohol dehydrogenase, putative 0.0064 0.1347 0.2495
Echinococcus granulosus hypothetical protein 0.0222 0.5364 0.5364
Onchocerca volvulus 0.0222 0.5364 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1036 0.1926
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0687 0.0687
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0222 0.5364 1
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0824 0.1518
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0064 0.1347 0.2495
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0665 0.0931
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0665 0.1234
Mycobacterium tuberculosis Probable oxidoreductase 0.0222 0.5364 0.9202
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Trypanosoma cruzi aldo/keto reductase, putative 0.0064 0.1347 0.2248
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.2187 0.4073
Loa Loa (eye worm) oxidoreductase 0.0222 0.5364 1
Brugia malayi beta-lactamase family protein 0.0038 0.0665 0.1234
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0175 0.0306
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1242 0.1231
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.1347 0.2495
Onchocerca volvulus 0.0038 0.0665 0.122
Leishmania major aldo-keto reductase-like protein 0.0222 0.5364 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0064 0.1347 0.2248
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Mycobacterium ulcerans hypothetical protein 0.0064 0.1347 0.2248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0665 0.1234
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Trichomonas vaginalis aldo/keto reductase, putative 0.0222 0.5364 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0182 0.0319
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0182 0.0334
Schistosoma mansoni aldo-keto reductase 0.0222 0.5364 0.5359
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0483 0.088
Schistosoma mansoni hypothetical protein 0.003 0.0483 0.0472
Schistosoma mansoni hypothetical protein 0.0167 0.3972 0.3965
Echinococcus granulosus chromobox protein 1 0.0073 0.1558 0.1558
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0064 0.1347 0.2507
Echinococcus granulosus chromobox protein 1 0.0073 0.1558 0.1558
Onchocerca volvulus Alhambra homolog 0.003 0.0483 0.088
Echinococcus multilocularis peregrin 0.003 0.0483 0.0483
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.2243 0.2243
Brugia malayi beta-lactamase family protein 0.0038 0.0665 0.1234
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0182 0.0182
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0665 0.0654
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0665 0.0931
Schistosoma mansoni chromobox protein 0.0073 0.1558 0.1548
Mycobacterium ulcerans beta-lactamase 0.0038 0.0665 0.0931
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0665 0.1234
Onchocerca volvulus 0.0013 0.0027 0.0029
Schistosoma mansoni aldo-keto reductase 0.0222 0.5364 0.5359
Echinococcus granulosus cpg binding protein 0.003 0.0473 0.0473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Plasmodium vivax hypothetical protein, conserved 0.003 0.0483 0.3555
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0182 0.1314
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0665 0.0856
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.01 0.0164
Brugia malayi chromobox protein homolog 3 0.0041 0.0746 0.1385
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0182 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0665 0.0931
Echinococcus granulosus chromobox protein 2 0.0012 0.0012 0.0012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0746 0.1371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.2187 0.2178
Onchocerca volvulus 0.0028 0.0432 0.0785
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0016
Echinococcus multilocularis aldo keto reductase 0.0222 0.5364 0.5364
Loa Loa (eye worm) hypothetical protein 0.0038 0.0665 0.1234
Echinococcus multilocularis chromobox protein 1 0.0073 0.1558 0.1558
Echinococcus multilocularis chromobox protein 1 0.0073 0.1558 0.1558
Entamoeba histolytica alcohol dehydrogenase, putative 0.0064 0.1347 0.2495
Onchocerca volvulus 0.0038 0.0665 0.122
Brugia malayi jmjC domain containing protein 0.0038 0.0687 0.1275
Brugia malayi Heterochromatin protein 1 0.0073 0.1558 0.29
Loa Loa (eye worm) oxidoreductase 0.0222 0.5364 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0665 0.0856
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0665 0.122
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0175 0.0306
Plasmodium falciparum phd finger protein, putative 0.003 0.0483 0.3555
Schistosoma mansoni cpg binding protein 0.003 0.0473 0.0462
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0222 0.5364 1
Echinococcus multilocularis cpg binding protein 0.003 0.0473 0.0473
Leishmania major hypothetical protein, conserved 0.0038 0.0665 0.0931
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0665 0.0654
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0824 0.1518
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0665 0.122
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0053 0.0041
Loa Loa (eye worm) oxidoreductase 0.0222 0.5364 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0665 0.122
Schistosoma mansoni hypothetical protein 0.0404 1 1
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1558 0.2889
Echinococcus multilocularis aldehyde reductase 0.0158 0.3726 0.3726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.2187 0.2178
Brugia malayi NADH-dependent xylose reductase 0.0064 0.1347 0.2507
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0646 0.0646
Schistosoma mansoni cpg binding protein 0.003 0.0473 0.0462
Loa Loa (eye worm) hypothetical protein 0.0032 0.0522 0.0967
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0064 0.1347 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0665 0.0931
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.2187 0.2187
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.5814 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.1347 0.2495
Brugia malayi jmjC domain containing protein 0.01 0.2243 0.4178
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0665 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.1347 0.2495
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0064 0.1347 0.1347
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Schistosoma mansoni hypothetical protein 0.0167 0.3972 0.3965
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Toxoplasma gondii aldose reductase, putative 0.0222 0.5364 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0088 0.0142
Schistosoma mansoni chromobox protein 0.0073 0.1558 0.1548
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0012 0.0042
Trypanosoma brucei aldo-keto reductase, putative 0.0222 0.5364 1
Echinococcus granulosus aldo keto reductase 0.0222 0.5364 0.5364
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.01 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0746 0.1371
Onchocerca volvulus 0.0222 0.5364 1
Mycobacterium ulcerans oxidoreductase 0.0222 0.5364 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0012 0.0012
Echinococcus granulosus aldehyde reductase 0.0158 0.3726 0.3726
Mycobacterium tuberculosis Conserved protein 0.0064 0.1347 0.2069
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0483 0.088
Trypanosoma brucei prostaglandin f synthase 0.0222 0.5364 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0665 0.1234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.2187 0.2187
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0665 0.0931
Loa Loa (eye worm) helicase 0.0012 0.0012 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.2187 0.2178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0175 0.0306
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0483 0.0483
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0053 0.0093
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1078 0.1992
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0141 0.013
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.1558 0.29
Onchocerca volvulus 0.0222 0.5364 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0222 0.5364 1
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0786 0.0786
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0665 0.0856
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Echinococcus granulosus aldo keto reductase 0.0222 0.5364 0.5364
Trichomonas vaginalis esterase, putative 0.0038 0.0665 0.122
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Mycobacterium tuberculosis Conserved protein 0.0038 0.0665 0.0856
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0483 0.0895
Echinococcus multilocularis aldo keto reductase 0.0222 0.5364 0.5364
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0012 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.2187 0.2187
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0665 0.491
Giardia lamblia Aldose reductase 0.0222 0.5364 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0012 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0182 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0012 0.0042
Loa Loa (eye worm) beta-lactamase 0.0038 0.0665 0.1234
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0222 0.5364 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0182 0.0319
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0016
Echinococcus granulosus Chromobox protein 3 0.0012 0.0012 0.0012
Loa Loa (eye worm) oxidoreductase 0.0222 0.5364 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0687 0.1275
Brugia malayi CXXC zinc finger family protein 0.0028 0.0432 0.0799
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0222 0.5364 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0183 0.0335
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Echinococcus multilocularis geminin 0.0167 0.3972 0.3972
Brugia malayi PHD-finger family protein 0.003 0.0483 0.0895
Echinococcus granulosus aldo keto reductase 0.0222 0.5364 0.5364
Onchocerca volvulus 0.0222 0.5364 1
Schistosoma mansoni jumonji domain containing protein 0.0079 0.1722 0.1713
Onchocerca volvulus 0.0032 0.0522 0.0953
Echinococcus granulosus voltage gated potassium channel subunit 0.0064 0.1347 0.1347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0175 0.0306
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0175 0.0306
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0746 0.1385
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0182 0.5
Schistosoma mansoni ap endonuclease 0.0019 0.0182 0.0171
Brugia malayi CHD4 protein 0.0014 0.0053 0.0093
Echinococcus granulosus Chromo domain 0.0012 0.0012 0.0012
Giardia lamblia Aldose reductase 0.0222 0.5364 1
Echinococcus multilocularis chromobox protein 2 0.0012 0.0012 0.0012
Mycobacterium leprae Conserved hypothetical protein 0.0158 0.3726 0.6515
Mycobacterium leprae Possible oxidoreductase 0.0064 0.1347 0.1452
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0665 0.0665
Echinococcus multilocularis voltage gated potassium channel subunit 0.0064 0.1347 0.1347
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0175 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0443 0.0806
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0182 0.0319
Giardia lamblia PHD finger protein 15 0.003 0.0483 0.058
Plasmodium vivax aldehyde reductase, putative 0.0064 0.1347 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.1347 0.2495
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Echinococcus multilocularis aldo keto reductase 0.0222 0.5364 0.5364
Schistosoma mansoni potassium channel beta 0.0064 0.1347 0.1337
Loa Loa (eye worm) hypothetical protein 0.0038 0.0665 0.1234
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0222 0.5364 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0012 0.0012
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Onchocerca volvulus 0.0222 0.5364 1
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0012 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0443 0.0806
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0687 0.0676
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0012 0.0016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0665 0.0856
Brugia malayi hypothetical protein 0.0012 0.0012 0.0016
Trypanosoma brucei aldo/keto reductase, putative 0.0064 0.1347 0.2248
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Loa Loa (eye worm) hypothetical protein 0.0222 0.5364 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0665 0.0665
Echinococcus multilocularis aldo keto reductase 0.0222 0.5364 0.5364
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0053 0.0053
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Onchocerca volvulus 0.0222 0.5364 1
Entamoeba histolytica aldose reductase, putative 0.0222 0.5364 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.2243 0.2243
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0222 0.5364 0.5364
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Echinococcus multilocularis Chromo domain 0.0012 0.0012 0.0012
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0053 0.0053
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0182 0.1314
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0483 0.0483
Brugia malayi Bromodomain containing protein 0.003 0.0483 0.0895
Trypanosoma cruzi aldo/keto reductase, putative 0.0222 0.5364 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0665 0.0931
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0222 0.5364 0.5364
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0012 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0824 0.1518
Trichomonas vaginalis aldo-keto reductase, putative 0.0222 0.5364 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0687 0.0676
Brugia malayi beta-lactamase 0.0038 0.0665 0.1234
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1558 0.2889
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1307 0.2431
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0222 0.5364 1
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0012 0.0016
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0222 0.5364 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0665 0.0856
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0182 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0665 0.122
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0665 0.1234
Schistosoma mansoni cpg binding protein 0.0028 0.0432 0.042
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0222 0.5364 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.2187 0.4073
Brugia malayi SET domain containing protein 0.0013 0.0027 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.0404 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0175 0.0306
Onchocerca volvulus 0.0064 0.1347 0.2495
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0432 0.0799
Trypanosoma cruzi aldo-keto reductase 0.0222 0.5364 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0483 0.0895
Toxoplasma gondii aldo-keto reductase 0.0064 0.1347 0.2495
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0016
Onchocerca volvulus 0.0038 0.0665 0.122
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0483 0.0472
Loa Loa (eye worm) hypothetical protein 0.0038 0.0665 0.1234
Echinococcus granulosus geminin 0.0167 0.3972 0.3972
Entamoeba histolytica aldose reductase, putative 0.0222 0.5364 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0016
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0012 0.0042
Loa Loa (eye worm) oxidoreductase 0.0222 0.5364 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0665 0.0856
Plasmodium falciparum aldo-keto reductase, putative 0.0064 0.1347 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0665 0.122
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0064 0.1347 0.2495
Brugia malayi Protein cec-1. 0.0012 0.0012 0.0016
Schistosoma mansoni ap endonuclease 0.0019 0.0182 0.0171

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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