Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0054 | 0.1098 | 0.0766 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0081 | 0.1889 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0054 | 0.1098 | 0.581 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0824 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0824 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0058 | 0.1197 | 0.6337 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0824 | 0.0483 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0054 | 0.1098 | 0.581 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0045 | 0.0831 | 0.4398 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0824 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0044 | 0.0785 | 0.4155 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0058 | 0.1197 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0053 | 0.1048 | 0.5551 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0054 | 0.1098 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0039 | 0.0647 | 0.3424 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0054 | 0.1098 | 0.581 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0051 | 0.0992 | 0.0777 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0039 | 0.0636 | 0.3708 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0031 | 0.0407 | 0.2155 |
Mycobacterium ulcerans | polyketide synthase | 0.0058 | 0.1197 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0054 | 0.1098 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0058 | 0.1197 | 0.6337 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0081 | 0.1889 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0058 | 0.1197 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0022 | 0.0144 | 0.0765 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0054 | 0.1098 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0045 | 0.0831 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0036 | 0.0555 | 0.2941 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0824 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0356 | 1 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0054 | 0.1098 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0081 | 0.1889 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0045 | 0.0831 | 0.4398 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0824 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.4865 | 0.4743 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0359 | 0.0129 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0824 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0036 | 0.0555 | 0.2941 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0824 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0356 | 1 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0044 | 0.0785 | 0.4155 |
Brugia malayi | AMP-binding enzyme family protein | 0.0051 | 0.0992 | 0.0657 |
Mycobacterium ulcerans | polyketide synthase | 0.0054 | 0.1098 | 0.581 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0054 | 0.1098 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0019 | 0.0047 | 0.0251 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0035 | 0.0535 | 0.2574 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0058 | 0.1197 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0058 | 0.1197 | 0.6337 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0058 | 0.1197 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0394 | 0.0165 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0053 | 0.1048 | 0.5551 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0058 | 0.1197 | 0.6337 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0824 | 0.0605 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0051 | 0.0992 | 0.5254 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0356 | 1 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0054 | 0.1098 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0036 | 0.0555 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0044 | 0.0785 | 0.4155 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0045 | 0.0831 | 0.4398 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0081 | 0.1889 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0053 | 0.1076 | 0.0863 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0058 | 0.1197 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0044 | 0.0806 | 0.4267 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2185 | 0.1999 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0103 | 0.253 | 0.2252 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0098 | 0.2382 | 1 |
Onchocerca volvulus | 0.0094 | 0.2282 | 0.9285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.