Detailed information for compound 660225

Basic information

Technical information
  • TDR Targets ID: 660225
  • Name: 2-(4-chlorophenoxy)-N-(2,4-dimethoxyphenyl)-2 -methylpropanamide
  • MW: 349.809 | Formula: C18H20ClNO4
  • H donors: 1 H acceptors: 1 LogP: 3.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NC(=O)C(Oc1ccc(cc1)Cl)(C)C
  • InChi: 1S/C18H20ClNO4/c1-18(2,24-13-7-5-12(19)6-8-13)17(21)20-15-10-9-14(22-3)11-16(15)23-4/h5-11H,1-4H3,(H,20,21)
  • InChiKey: WWUGTQLHCIGQOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenoxy)-N-(2,4-dimethoxyphenyl)-2-methyl-propanamide
  • 2-(4-chlorophenoxy)-N-(2,4-dimethoxyphenyl)-2-methyl-propionamide
  • STK167761
  • ZINC00462011

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.147 0.147
Schistosoma mansoni hypothetical protein 0.0047 0.147 0.2111
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.767 0.5
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0043
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.767 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.147 0.2111
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.2175 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.6132 0.6132
Echinococcus multilocularis cysteine protease 0.0016 0.0043 0.0043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1495 0.1495
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.3953 0.3953
Loa Loa (eye worm) hypothetical protein 0.0068 0.2476 0.2476
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.767 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0043 0.0061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0761 0.0761
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0043 0.0056
Echinococcus multilocularis tar DNA binding protein 0.0061 0.2155 0.2155
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2155 0.3094
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.1924 0.8847
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0043 0.0043
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.1344 0.1753
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0197
Loa Loa (eye worm) hypothetical protein 0.0118 0.4836 0.4836
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0761 0.0761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1495 0.1495
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.2155 0.2155
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0043 0.0061
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.1173 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.6094 0.6094
Loa Loa (eye worm) hypothetical protein 0.0031 0.0761 0.0761
Brugia malayi RNA binding protein 0.0061 0.2155 0.2155
Leishmania major cathepsin L-like protease 0.0062 0.2175 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0761 0.0761
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0197
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0486 0.0634
Leishmania major cathepsin L-like protease 0.0062 0.2175 1
Plasmodium vivax vivapain-2 0.0016 0.0043 0.0056
Echinococcus multilocularis geminin 0.0164 0.6963 0.6963
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.767 0.5
Echinococcus granulosus cathepsin l1 0.0016 0.0043 0.0043
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.1344 0.1753
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0486 0.0634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Plasmodium vivax vivapain-2 0.0016 0.0043 0.0056
Schistosoma mansoni hypothetical protein 0.0031 0.0761 0.1093
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0486 0.0634
Loa Loa (eye worm) fibroinase 0.0016 0.0043 0.0043
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.2175 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0043 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0761 0.0761
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.629 0.629
Schistosoma mansoni hypothetical protein 0.0031 0.0761 0.1093
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.2175 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1495 0.2147
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0043 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1495 0.2147
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.2476 0.2476
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0043 0.0197
Echinococcus granulosus geminin 0.0164 0.6963 0.6963
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0043 0.0056
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0043 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0118 0.4836 0.4836
Loa Loa (eye worm) hypothetical protein 0.01 0.3953 0.3953
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.767 1
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.1173 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0043 0.0043
Onchocerca volvulus Huntingtin homolog 0.0118 0.4836 0.7872
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.2155 0.2155
Schistosoma mansoni hypothetical protein 0.0031 0.0761 0.1093
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0043 0.0043
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0043 0.0043
Onchocerca volvulus 0.0047 0.147 0.2344
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2155 0.3094
Loa Loa (eye worm) acetyltransferase 0.0149 0.629 0.629
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0486 0.2236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1495 0.1495
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0486 0.2236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1495 0.1495
Echinococcus granulosus GPCR family 2 0.0031 0.0761 0.0761
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0486 0.0634
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.1556 0.7155
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.3953 0.3953
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0197
Loa Loa (eye worm) RNA binding protein 0.0061 0.2155 0.2155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.767 1
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.629 0.629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1495 0.2147
Trichomonas vaginalis hypothetical protein 0.0179 0.767 1
Brugia malayi hypothetical protein 0.0026 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0164 0.6963 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.1344 0.1706
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0043 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.2175 1
Brugia malayi hypothetical protein 0.0017 0.006 0.006
Toxoplasma gondii cathepsin CPL 0.0016 0.0043 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1495 0.1495
Schistosoma mansoni hypothetical protein 0.0068 0.2476 0.3555
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2155 0.3094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.3953 0.3953
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0761 0.0761
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0761 0.0761
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0197
Echinococcus multilocularis survival motor neuron protein 1 0.0228 1 1
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0197
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0043 0.0043
Echinococcus granulosus survival motor neuron protein 1 0.0228 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0043 0.0056
Loa Loa (eye worm) TAR-binding protein 0.0061 0.2155 0.2155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0761 0.0761
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.2175 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.1344 0.1706
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.767 0.5
Schistosoma mansoni hypothetical protein 0.0164 0.6963 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0043 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2155 0.3094
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.1344 0.1344
Echinococcus multilocularis cysteine protease 0.0016 0.0043 0.0043
Brugia malayi TAR-binding protein 0.0061 0.2155 0.2155
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0043
Leishmania major hypothetical protein, conserved 0.0026 0.0486 0.2236
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.629 0.9034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0061 0.2155 0.3094
Leishmania major cathepsin L-like protease 0.0062 0.2175 1
Loa Loa (eye worm) cysteine protease 0.0016 0.0043 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0486 0.2236
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.767 0.5
Brugia malayi hypothetical protein 0.0118 0.4836 0.4836
Onchocerca volvulus Huntingtin homolog 0.0118 0.4836 0.7872
Echinococcus granulosus tar DNA binding protein 0.0061 0.2155 0.2155
Loa Loa (eye worm) hypothetical protein 0.0228 1 1
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.1173 0.1529
Loa Loa (eye worm) hypothetical protein 0.0026 0.0486 0.0486
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.1344 0.1753
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0043 0.0043
Brugia malayi hypothetical protein 0.0146 0.6132 0.6132
Onchocerca volvulus 0.0146 0.6132 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0043
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0031 0.0761 0.1093
Echinococcus multilocularis GPCR, family 2 0.0031 0.0761 0.0761

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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