Detailed information for compound 660240

Basic information

Technical information
  • TDR Targets ID: 660240
  • Name: (4-ethoxycarbonylphenyl)methyl 2-(4-fluorophe nyl)-1,3-dioxoisoindole-5-carboxylate
  • MW: 447.412 | Formula: C25H18FNO6
  • H donors: 0 H acceptors: 4 LogP: 4.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)COC(=O)c1ccc2c(c1)C(=O)N(C2=O)c1ccc(cc1)F
  • InChi: 1S/C25H18FNO6/c1-2-32-24(30)16-5-3-15(4-6-16)14-33-25(31)17-7-12-20-21(13-17)23(29)27(22(20)28)19-10-8-18(26)9-11-19/h3-13H,2,14H2,1H3
  • InChiKey: FNCLDZOJOZSPNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-ethoxycarbonylphenyl)methyl 2-(4-fluorophenyl)-1,3-dioxo-isoindoline-5-carboxylate
  • 2-(4-fluorophenyl)-1,3-dioxo-5-isoindolinecarboxylic acid (4-ethoxycarbonylphenyl)methyl ester
  • 2-(4-fluorophenyl)-1,3-diketo-isoindoline-5-carboxylic acid (4-carbethoxybenzyl) ester
  • (4-ethoxycarbonylphenyl)methyl 2-(4-fluorophenyl)-1,3-dioxo-isoindole-5-carboxylate
  • STK327224

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0117 0.3713 0.5682
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0457 0.4028
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0457 0.4028
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0608 0.1025
Schistosoma mansoni DNA helicase recq5 0.001 0.0156 0.0282
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0156 0.0115
Loa Loa (eye worm) hypothetical protein 0.0013 0.027 0.037
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.027 0.0162
Loa Loa (eye worm) hypothetical protein 0.0038 0.109 0.1635
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0457 0.0721
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.1205 0.2228
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0997 0.0897
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.003 0.025
Leishmania major glycosyl hydrolase-like protein 0.0013 0.027 0.2262
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.109 0.1268
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0457 0.4028
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.4486 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0795 0.1181
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0265 0.2215
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.011 0.0167
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.109 0.1268
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.109 0.1635
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.1205 1
Schistosoma mansoni apoferritin-2 0.0008 0.011 0.0179
Brugia malayi Pre-SET motif family protein 0.0202 0.6513 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0608 0.0504
Schistosoma mansoni ferritin 0.0008 0.011 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0061 0.187 0.4128
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0997 0.1492
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1023 0.9365
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.1205 0.1107
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0156 0.0194
Brugia malayi Smad1 0.0008 0.0099 0.0106
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0457 0.0721
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.5063 0.7764
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0795 0.6514
Brugia malayi RNA binding protein 0.0061 0.187 0.2838
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.7836 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0457 0.0449
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0457 0.0958
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.109 0.2378
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0997 0.181
Trypanosoma brucei unspecified product 0.0013 0.0265 0.2215
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0997 0.0897
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1023 0.9365
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0997 0.0897
Schistosoma mansoni hypothetical protein 0.0017 0.0386 0.08
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.109 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0352 0.2925
Schistosoma mansoni ferritin light chain 0.0008 0.011 0.0179
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.109 0.1268
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.109 0.0991
Schistosoma mansoni hypothetical protein 0.0017 0.0386 0.08
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.187 0.2838
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.1023 0.1861
Brugia malayi Inositol-1 0.0036 0.1023 0.1531
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.187 0.2838
Loa Loa (eye worm) hypothetical protein 0.0017 0.0386 0.055
Schistosoma mansoni inositol monophosphatase 0.0036 0.1023 0.2227
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0156 0.1185
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0386 0.0579
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0795 0.1717
Schistosoma mansoni tar DNA-binding protein 0.0061 0.187 0.4128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.003 0.025
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.109 0.0991
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.027 0.2262
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.5063 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.187 0.4128
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.109 0.2221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0457 0.0658
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0997 0.0897
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0457 0.0449
Loa Loa (eye worm) hypothetical protein 0.0038 0.109 0.1635
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.1205 0.1107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0386 0.0579
Echinococcus granulosus expressed protein 0.0008 0.011 0.0022
Schistosoma mansoni apoferritin-2 0.0008 0.011 0.0179
Echinococcus multilocularis tar DNA binding protein 0.0061 0.187 0.3567
Mycobacterium tuberculosis Conserved protein 0.0038 0.109 0.1268
Trichomonas vaginalis set domain proteins, putative 0.023 0.7435 0.7407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0997 0.8278
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.4802 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.1023 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0154
Brugia malayi beta-lactamase 0.0038 0.109 0.1635
Trypanosoma brucei unspecified product 0.0019 0.0457 0.4028
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.003 0.025
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0898 0.1681
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0156 0.0126
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0249 0.2069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0386 0.055
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0386 0.0579
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.4802 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0997 0.181
Leishmania major DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Schistosoma mansoni ferritin 0.0008 0.011 0.0179
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0457 0.0721
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0099 0.0154
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0457 0.0457
Mycobacterium tuberculosis Conserved protein 0.0038 0.109 0.1268
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 1 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0898 0.1021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0795 0.1403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.187 0.4128
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0156 0.1293
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0156 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0265 0.2215
Echinococcus multilocularis GPCR, family 2 0.0017 0.0386 0.0579
Leishmania major hypothetical protein, conserved 0.0038 0.109 1
Onchocerca volvulus 0.0038 0.109 0.1144
Mycobacterium ulcerans hypothetical protein 0.0038 0.109 0.2221
Loa Loa (eye worm) RNA binding protein 0.0061 0.187 0.2838
Schistosoma mansoni hypothetical protein 0.0017 0.0386 0.08
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1571 0.2377
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.1205 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0514 0.4565
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1023 0.9365
Loa Loa (eye worm) Smad1 0.0008 0.0099 0.0106
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.1091 0.1064
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0106
Loa Loa (eye worm) hypothetical protein 0.0038 0.109 0.1635
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.1023 0.1023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.027 0.037
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0997 0.0897
Brugia malayi beta-lactamase family protein 0.0038 0.109 0.1635
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0446 0.0933
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.1023 0.0923
Echinococcus granulosus dna polymerase kappa 0.0019 0.0457 0.0721
Mycobacterium tuberculosis Conserved protein 0.0038 0.109 0.1268
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0997 0.0897
Brugia malayi Pre-SET motif family protein 0.0029 0.0795 0.1181
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0156 0.0115
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0154
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.1091 1
Onchocerca volvulus 0.0038 0.109 0.1144
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.1023 0.8486
Onchocerca volvulus 0.0038 0.109 0.1144
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0386 0.055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0997 0.0997
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1571 0.2377
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0457 0.0894
Onchocerca volvulus 0.023 0.7435 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0457 0.4028
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0795 0.6601
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.109 0.1635
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.4486 0.8838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0795 0.1403
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.4802 0.6073
Schistosoma mansoni hypothetical protein 0.0017 0.0386 0.08
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.109 0.1268
Loa Loa (eye worm) hypothetical protein 0.0019 0.0457 0.0658
Loa Loa (eye worm) RecQ helicase 0.0023 0.0608 0.0891
Echinococcus granulosus bloom syndrome protein 0.0023 0.0608 0.1025
Loa Loa (eye worm) inositol-1 0.0036 0.1023 0.1531
Treponema pallidum fructose-bisphosphate aldolase 0.0307 1 1
Brugia malayi beta-lactamase family protein 0.0038 0.109 0.1635
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0795 0.1717
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0457 0.0958
Schistosoma mansoni smad1 5 8 and 0.0008 0.0099 0.0154
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0457 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.4356 0.8576
Brugia malayi MH2 domain containing protein 0.0008 0.0099 0.0106
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.1023 0.1861
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1023 0.0923
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.1023 0.208
Schistosoma mansoni ferritin 0.0008 0.011 0.0179
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.109 0.2221
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0156 0.0194
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.109 0.0991
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.1091 0.1091
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.109 0.0991
Schistosoma mansoni ferritin 0.0008 0.011 0.0179
Onchocerca volvulus 0.0091 0.286 0.3615
Brugia malayi MH2 domain containing protein 0.0116 0.3667 0.561
Loa Loa (eye worm) hypothetical protein 0.0036 0.1023 0.1531
Mycobacterium ulcerans beta-lactamase 0.0038 0.109 0.2221
Echinococcus granulosus GPCR family 2 0.0017 0.0386 0.0579
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.027 0.0162
Echinococcus granulosus ferritin 0.0008 0.011 0.0022
Mycobacterium ulcerans lipase LipD 0.0038 0.109 0.2221
Plasmodium vivax hypothetical protein, conserved 0.0038 0.109 0.902
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0997 0.0897
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0608 0.0891
Echinococcus multilocularis expressed protein 0.0008 0.011 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.109 0.1268
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.027 0.0162
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.3667 0.561
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1023 0.1531
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0457 0.0351
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0249 0.0249
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.4486 0.6874
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0386 0.0579
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0156 0.1293
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.5063 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.027 0.2262
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.027 0.0162
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.1023 0.2228
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0457 0.4028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.027 0.0162
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0997 0.0897
Echinococcus multilocularis ferritin 0.0008 0.011 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.027 0.0162
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.109 0.1268
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0457 0.4028
Schistosoma mansoni smad 0.0008 0.0099 0.0154
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0997 0.1492
Schistosoma mansoni ferritin light chain 0.0008 0.011 0.0179
Trypanosoma brucei unspecified product 0.0013 0.0265 0.2215
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0457 0.4028
Schistosoma mansoni Smad4 0.0008 0.0099 0.0154
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.5063 0.7764
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.1023 0.0923
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.109 0.1268
Schistosoma mansoni alpha-glucosidase 0.0136 0.4336 0.9661
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0997 0.9129
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.109 0.1996
Schistosoma mansoni DNA helicase recq1 0.001 0.0156 0.0282
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0457 0.0658
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.076 0.1332
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6513 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.109 0.2088
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0997 0.0897
Trypanosoma brucei glucosidase, putative 0.0035 0.0997 0.9129
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.027 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0061 0.187 0.4128
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0997 0.9129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0795 0.1717
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0099 0.0106
Echinococcus granulosus dna polymerase eta 0.0019 0.0457 0.0721
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.5063 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0156 0.0115
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.1205 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0457 0.0894
Toxoplasma gondii ABC1 family protein 0.0038 0.109 0.9044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.109 0.1635
Giardia lamblia DINP protein human, muc B family 0.0019 0.0457 0.0428
Onchocerca volvulus 0.0029 0.0795 0.0733
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.109 0.0991
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.027 0.0162
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0249 0.2069
Schistosoma mansoni inositol monophosphatase 0.0036 0.1023 0.2227
Echinococcus granulosus tar DNA binding protein 0.0061 0.187 0.3567
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Loa Loa (eye worm) hypothetical protein 0.0052 0.1571 0.2377
Echinococcus multilocularis dna polymerase eta 0.0019 0.0457 0.0721
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0194
Loa Loa (eye worm) acetyltransferase 0.014 0.4486 0.6874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0795 0.1717
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0249 0.2069
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0099 0.0106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1571 0.2377
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.1023 0.9365
Schistosoma mansoni alpha-glucosidase 0.0136 0.4336 0.9661
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0457 0.4028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 1 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0359 0.2796
Loa Loa (eye worm) hypothetical protein 0.0038 0.109 0.1635
Mycobacterium leprae Probable lipase LipE 0.0038 0.109 0.2088
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0156 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0061 0.187 0.2838
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.109 0.2378
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0249 0.0141
Trichomonas vaginalis esterase, putative 0.0038 0.109 0.0991
Schistosoma mansoni DNA polymerase eta 0.0019 0.0457 0.0958
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.027 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0997 0.9129
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.109 1
Loa Loa (eye worm) beta-lactamase 0.0038 0.109 0.1635
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.011 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.109 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.3667 0.561
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0386 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0265 0.2215
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0997 0.0997
Brugia malayi TAR-binding protein 0.0061 0.187 0.2838
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.109 0.1996
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0608 0.0504
Brugia malayi MH1 domain containing protein 0.0008 0.0099 0.0106
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0795 0.1403
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.027 0.2262
Schistosoma mansoni alpha glucosidase 0.0035 0.0997 0.2171
Loa Loa (eye worm) hypothetical protein 0.0038 0.109 0.1635
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0457 0.0658

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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