Detailed information for compound 660640

Basic information

Technical information
  • TDR Targets ID: 660640
  • Name: N-(4-acetamido-3-methoxyphenyl)benzamide
  • MW: 284.31 | Formula: C16H16N2O3
  • H donors: 2 H acceptors: 2 LogP: 1.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1NC(=O)C)NC(=O)c1ccccc1
  • InChi: 1S/C16H16N2O3/c1-11(19)17-14-9-8-13(10-15(14)21-2)18-16(20)12-6-4-3-5-7-12/h3-10H,1-2H3,(H,17,19)(H,18,20)
  • InChiKey: JUZVWTSJJZHLMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-acetamido-3-methoxy-phenyl)benzamide
  • ZINC00467992

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.2958 0.5639
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.1062 0.1362
Loa Loa (eye worm) hypothetical protein 0.0076 0.4892 0.4841
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.1213 0.1702
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0293 0.0989
Loa Loa (eye worm) hypothetical protein 0.004 0.2274 0.2197
Echinococcus multilocularis muscleblind protein 0.0145 1 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.1062 0.359
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0023 0.1007 0.3405
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.2658 0.2317
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.1062 0.1362
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.2958 0.2895
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.4892 0.4846
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0548 0.0781
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.1062 0.1362
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0714 0.0576
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.4892 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.1084 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.4892 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.1944 0.6571
Onchocerca volvulus 0.0042 0.2382 0.9285
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.2958 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.4892 0.4846
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.1173 0.1612
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.1062 0.1362
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.4892 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.4892 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.1173 0.1612
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.1173 0.3964
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.4892 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.1062 0.359
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.1213 0.0337
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.1173 0.1612
Echinococcus granulosus muscleblind protein 0.0145 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.4892 1
Echinococcus multilocularis muscleblind protein 1 0.0145 1 1
Leishmania major hypothetical protein, conserved 0.0024 0.1084 0.5
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.1173 0.1612
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.1062 0.0646
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0714 0.0576
Brugia malayi hypothetical protein 0.0024 0.1084 0.067
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.1944 0.3351
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.4892 1
Onchocerca volvulus Fatty acid synthase homolog 0.0043 0.2493 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.056 0.1892
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.1084 0.1919
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.1173 0.1612
Toxoplasma gondii hypothetical protein 0.0026 0.1213 0.2192
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0436 0.0542
Loa Loa (eye worm) hypothetical protein 0.0145 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1084 0.5
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.1173 0.3964
Loa Loa (eye worm) hypothetical protein 0.0024 0.1084 0.0995
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.2958 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.4892 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1084 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0278 0.0181
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.1062 0.1362
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.1173 0.3964
Loa Loa (eye worm) fatty acid synthase 0.0024 0.1038 0.0949
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.1062 0.359
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.1944 0.6571
Mycobacterium ulcerans polyketide synthase 0.0026 0.1173 0.1612
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.4892 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0945 0.0524
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0945 0.3194
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0023 0.1007 0.3405
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.1173 0.2107
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.4892 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.4892 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.1062 0.1362
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.4892 0.5
Mycobacterium ulcerans polyketide synthase 0.0024 0.1062 0.1362
Mycobacterium ulcerans thioesterase TesA 0.002 0.0765 0.0692
Loa Loa (eye worm) hypothetical protein 0.0145 1 1
Brugia malayi Probable ClpP-like protease 0.0076 0.4892 0.4654
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0765 0.0692
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0765 0.2585
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0737 0.2492
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.1944 0.3351
Echinococcus granulosus peptidase Clp S14 family 0.005 0.2958 0.2895
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0714 0.0576
Mycobacterium ulcerans thioesterase 0.002 0.0765 0.0692
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.1213 0.0337
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0945 0.0854

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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