Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0074 | 0.0294 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0999 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.2509 | 0.3422 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0581 | 0.0712 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1 | 0.3985 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1 | 1 |
Brugia malayi | Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. | 0.0015 | 0.0074 | 0.0294 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1 | 0.0933 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0581 | 0.0712 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1 | 0.3985 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.2509 | 0.3422 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0581 | 0.2315 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0015 | 0.0074 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.1 | 0.0933 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.1 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0581 | 0.0712 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.1 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0015 | 0.0074 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.2509 | 0.3422 |
Onchocerca volvulus | 0.0035 | 0.1 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1 | 0.0933 |
Brugia malayi | beta-lactamase | 0.0035 | 0.1 | 0.3985 |
Onchocerca volvulus | 0.0026 | 0.0581 | 0.5474 | |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0581 | 0.2315 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0999 | 0.13 |
Giardia lamblia | Metallo-beta-lactamase superfamily protein | 0.0015 | 0.0074 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1 | 0.1301 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.1 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1 | 0.3985 |
Onchocerca volvulus | 0.0026 | 0.0581 | 0.5474 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0581 | 0.2315 |
Echinococcus granulosus | geminin | 0.0164 | 0.719 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0999 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0999 | 0.13 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0581 | 0.0712 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2509 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.2509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1 | 0.3985 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.1 | 0.0933 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.1 | 0.1301 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.1 | 0.3985 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.2509 | 0.3422 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0015 | 0.0074 | 0.0294 |
Onchocerca volvulus | 0.0035 | 0.1 | 1 | |
Loa Loa (eye worm) | metallo-beta-lactamase superfamily protein | 0.0015 | 0.0074 | 0.0294 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.1 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2509 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.1 | 0.0933 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.1 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1 | 0.3985 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1 | 0.1301 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0015 | 0.0074 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2509 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.2509 | 0.3422 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.1 | 0.0933 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1 | 0.3985 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.1 | 0.3985 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0074 | 0.0294 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0581 | 0.2315 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0581 | 0.0712 |
Brugia malayi | ethe1-prov protein | 0.0015 | 0.0074 | 0.0294 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1 | 0.0933 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0074 | 0.0294 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0015 | 0.0074 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.719 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0999 | 0.13 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1 | 0.3985 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0074 | 0.0294 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0999 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.0581 | 0.0712 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0999 | 0.13 |
Onchocerca volvulus | 0.0035 | 0.1 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.2509 | 0.3422 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0581 | 0.2315 |
Echinococcus granulosus | lamin | 0.0026 | 0.0581 | 0.0712 |
Chlamydia trachomatis | ribonuclease Z | 0.0015 | 0.0074 | 0.5 |
Echinococcus multilocularis | geminin | 0.0164 | 0.719 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0581 | 0.0712 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.1 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0015 | 0.0074 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2509 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.719 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.1 | 0.3985 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0999 | 0.398 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0999 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0074 | 0.0294 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase cytoplasmic | 0.0015 | 0.0074 | 0.0294 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.2509 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.2509 | 0.3422 |
Treponema pallidum | ribonuclease Z | 0.0015 | 0.0074 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0558 | 0.2223 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.1 | 0.1301 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1 | 0.3985 |
Schistosoma mansoni | lamin | 0.0026 | 0.0581 | 0.0712 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0015 | 0.0074 | 0.0294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.