Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0018 | 0.0788 | 0.2941 |
Mycobacterium ulcerans | polyketide synthase | 0.0027 | 0.1543 | 0.5834 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0043 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0018 | 0.0788 | 0.2981 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0022 | 0.1172 | 0.443 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0027 | 0.1543 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0028 | 0.1681 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0026 | 0.1475 | 0.5576 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0028 | 0.1681 | 0.6337 |
Echinococcus granulosus | smad | 0.0009 | 0.0043 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0043 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0022 | 0.1172 | 0.4398 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0027 | 0.1543 | 0.1543 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0027 | 0.1543 | 0.581 |
Brugia malayi | Smad1 | 0.0009 | 0.0043 | 0.0043 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0017 | 0.076 | 0.2574 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0009 | 0.0081 | 0.0306 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0028 | 0.1681 | 0.6357 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0025 | 0.1397 | 0.528 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0018 | 0.0788 | 0.2981 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0043 | 0.5 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0043 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0027 | 0.1543 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.004 | 0.2645 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0027 | 0.1543 | 0.581 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.005 | 0.3538 | 0.3538 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0021 | 0.1108 | 0.4155 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0021 | 0.1108 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0026 | 0.1475 | 0.5576 |
Schistosoma mansoni | smad | 0.0009 | 0.0043 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0028 | 0.1681 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0028 | 0.1681 | 0.6337 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0015 | 0.0056 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0028 | 0.1681 | 0.6337 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0027 | 0.1543 | 0.5834 |
Mycobacterium ulcerans | thioesterase TesA | 0.0022 | 0.1172 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0011 | 0.0216 | 0.0817 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0563 | 0.0523 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0021 | 0.1108 | 0.4188 |
Echinococcus multilocularis | smad | 0.0009 | 0.0043 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0043 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.3193 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0015 | 0.0582 | 0.2199 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0022 | 0.1137 | 0.4299 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0043 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0027 | 0.1543 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0027 | 0.1543 | 0.5834 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 1 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0022 | 0.1172 | 0.443 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0019 | 0.0901 | 0.3708 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0027 | 0.1543 | 0.5834 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1397 | 0.1397 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0043 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0028 | 0.1681 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0027 | 0.1543 | 0.5834 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0043 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.1681 | 0.6357 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0043 | 0.0043 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0015 | 0.0056 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0043 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0019 | 0.0915 | 0.3461 |
Mycobacterium ulcerans | polyketide synthase | 0.0028 | 0.1681 | 0.6357 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | acyl carrier protein | 0.0012 | 0.034 | 0.0298 |
Loa Loa (eye worm) | fatty acid synthase | 0.0026 | 0.1513 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3058 | 0.3028 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.004 | 0.2645 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.004 | 0.2645 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0048 | 0.3331 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.004 | 0.2645 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0043 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0043 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.1681 | 0.6357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0025 | 0.1397 | 0.136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.