TDR Targets

Basic information

Technical information

TDR Targets ID: 660847
Name: ethyl 4-(2-ethoxyphenyl)-6-phenyl-2-sulfanyli dene-3,4-dihydro-1H-pyrimidine-5-carboxylate
MW: 382.476 | Formula: C21H22N2O3S
H donors: 1 H acceptors: 1 LogP: 3.81 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(N=C(NC1c1ccccc1OCC)S)c1ccccc1
InChi: 1S/C21H22N2O3S/c1-3-25-16-13-9-8-12-15(16)19-17(20(24)26-4-2)18(22-21(27)23-19)14-10-6-5-7-11-14/h5-13,19H,3-4H2,1-2H3,(H2,22,23,27)
InChiKey: PQZFWIQPJAORKL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 4-(2-ethoxyphenyl)-6-phenyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
4-(2-ethoxyphenyl)-6-phenyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid ethyl ester
STK110819

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0036	0.0255	1
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0036	0.0255	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0833	0.133
Echinococcus granulosus	geminin	0.0183	0.2391	0.2391
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0025	0.0972
Schistosoma mansoni	hypothetical protein	0.0183	0.2391	0.2391
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0025	0.0297
Schistosoma mansoni	gliotactin	0.0076	0.0833	0.0833
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0036	0.0255	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Onchocerca volvulus		0.0076	0.0833	0.5
Loa Loa (eye worm)	hypothetical protein	0.0448	0.6264	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0076	0.0833	0.0833
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0076	0.0833	0.0833
Loa Loa (eye worm)	carboxylesterase	0.0076	0.0833	0.133
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0036	0.0255	0.0255
Echinococcus granulosus	dna polymerase kappa	0.002	0.0025	0.0025
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0388	0.0388
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0076	0.0833	0.0833
Echinococcus granulosus	acetylcholinesterase	0.0448	0.6264	0.6264
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0036	0.0255	1
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0025	0.004
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0025	0.0025
Echinococcus multilocularis	neuroligin	0.0076	0.0833	0.0833
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0025	0.0025
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0076	0.0833	1
Brugia malayi	hypothetical protein	0.0076	0.0833	0.133
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0025	0.1001
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0036	0.0255	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0388	0.0388
Brugia malayi	hypothetical protein	0.0036	0.0247	0.0395
Echinococcus granulosus	para nitrobenzyl esterase	0.0076	0.0833	0.0833
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0025	0.0025
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0025	0.0297
Onchocerca volvulus		0.0076	0.0833	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0247	0.0247
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0076	0.0833	0.0833
Trypanosoma brucei	unspecified product	0.002	0.0025	0.0972
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0025	0.004
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Brugia malayi	Carboxylesterase family protein	0.0076	0.0833	0.133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0388	0.0388
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Echinococcus granulosus	BC026374 protein S09 family	0.0076	0.0833	0.0833
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0076	0.0833	1
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0025	0.0297
Echinococcus granulosus	acetylcholinesterase	0.0448	0.6264	0.6264
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0448	0.6264	0.6264
Echinococcus multilocularis	carboxylesterase 5A	0.0448	0.6264	0.6264
Entamoeba histolytica	hypothetical protein	0.0036	0.0247	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0247	0.0247
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0076	0.0833	0.0833
Entamoeba histolytica	hypothetical protein	0.0036	0.0247	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0025	0.004
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0833	0.133
Trichomonas vaginalis	spcc417.12 protein, putative	0.0076	0.0833	1
Loa Loa (eye worm)	hepatopoietin HPO2	0.0036	0.0255	0.0407
Mycobacterium ulcerans	carboxylesterase, LipT	0.0076	0.0833	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0388	0.062
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0025	0.0297
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0025	0.0972
Brugia malayi	Carboxylesterase family protein	0.0448	0.6264	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0076	0.0833	0.0833
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0388	0.0388
Onchocerca volvulus		0.0076	0.0833	0.5
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0076	0.0833	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0833	0.133
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0833	0.133
Schistosoma mansoni	acetylcholinesterase	0.0076	0.0833	0.0833
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Brugia malayi	Carboxylesterase family protein	0.0448	0.6264	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0076	0.0833	0.0833
Echinococcus granulosus	neuroligin	0.0076	0.0833	0.0833
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0036	0.0255	1
Echinococcus multilocularis	dna polymerase eta	0.002	0.0025	0.0025
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0388	0.0388
Schistosoma mansoni	microtubule-associated protein tau	0.0705	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0025	0.0972
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0833	0.133
Echinococcus multilocularis	microtubule associated protein 2	0.0705	1	1
Giardia lamblia	DINP protein human, muc B family	0.002	0.0025	1
Leishmania major	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Leishmania major	DNA polymerase eta, putative	0.002	0.0025	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0833	0.133
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0025	0.0025
Loa Loa (eye worm)	carboxylesterase	0.0448	0.6264	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0025	0.004
Toxoplasma gondii	Erv1 / Alr family protein	0.0036	0.0255	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0388	0.062
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0448	0.6264	1
Echinococcus granulosus	carboxylesterase 5A	0.0448	0.6264	0.6264
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0833	0.133
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0036	0.0255	0.0255
Brugia malayi	Carboxylesterase family protein	0.0076	0.0833	0.133
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Loa Loa (eye worm)	carboxylesterase	0.0076	0.0833	0.133
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0025	0.0972
Echinococcus multilocularis	acetylcholinesterase	0.0448	0.6264	0.6264
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0025	0.0297
Echinococcus granulosus	dna polymerase eta	0.002	0.0025	0.0025
Onchocerca volvulus		0.0076	0.0833	0.5
Schistosoma mansoni	hypothetical protein	0.0036	0.0247	0.0247
Brugia malayi	Carboxylesterase family protein	0.0076	0.0833	0.133
Echinococcus multilocularis	acetylcholinesterase	0.0448	0.6264	0.6264
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0388	0.0388
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0076	0.0833	0.0833
Toxoplasma gondii	Erv1 / Alr family protein	0.0036	0.0255	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0	0.5
Schistosoma mansoni	DNA polymerase eta	0.002	0.0025	0.0025
Schistosoma mansoni	BC026374 protein (S09 family)	0.0076	0.0833	0.0833
Schistosoma mansoni	hypothetical protein	0.0183	0.2391	0.2391
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0247	0.0247
Brugia malayi	Carboxylesterase family protein	0.0076	0.0833	0.133
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0025	0.0025
Leishmania major	hypothetical protein, conserved	0.0036	0.0255	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Brugia malayi	Augmenter of liver regeneration	0.0036	0.0255	0.0407
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0025	0.0972
Onchocerca volvulus		0.0076	0.0833	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0388	0.0388
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0025	0.0972
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0076	0.0833	1
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0025	0.0297
Entamoeba histolytica	hypothetical protein	0.0036	0.0247	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0025	0.0972
Entamoeba histolytica	hypothetical protein	0.0036	0.0247	1
Echinococcus multilocularis	geminin	0.0183	0.2391	0.2391
Loa Loa (eye worm)	acetylcholinesterase 1	0.0448	0.6264	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 660847