Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.4745 | 0.4744 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0001 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0001 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0624 | 0.0624 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0003 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.4745 | 0.4745 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.6005 | 0.6004 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0001 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.6005 | 0.6004 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.4745 | 0.4744 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0001 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0001 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.4745 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.6005 | 0.6004 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0624 | 0.0623 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.4745 | 0.4744 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0001 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.4745 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0001 | 0.0001 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.4745 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.4745 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.4745 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.6005 | 0.6004 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3752 | 0.3752 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.4745 | 0.4744 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0001 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0001 | 0.0003 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0001 | 0.0001 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0001 | 0.5 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.873 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0624 | 0.0623 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0001 | 0.0003 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.6415 | 0.6415 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.4745 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0624 | 0.0624 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0001 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.6005 | 0.6004 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0001 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0001 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0001 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0001 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0001 | 0.0003 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3752 | 0.3752 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0001 | 0.0001 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.6415 | 0.6415 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.4745 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.6005 | 0.6004 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.6005 | 0.6004 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.4745 | 0.4745 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3752 | 0.3752 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0165 | 0.6005 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.