Detailed information for compound 661174

Basic information

Technical information
  • TDR Targets ID: 661174
  • Name: 2-methylpropyl 4-[[4-(1,3-dioxoisoindol-2-yl) benzoyl]amino]benzoate
  • MW: 442.463 | Formula: C26H22N2O5
  • H donors: 1 H acceptors: 4 LogP: 4.48 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(COC(=O)c1ccc(cc1)NC(=O)c1ccc(cc1)N1C(=O)c2c(C1=O)cccc2)C
  • InChi: 1S/C26H22N2O5/c1-16(2)15-33-26(32)18-7-11-19(12-8-18)27-23(29)17-9-13-20(14-10-17)28-24(30)21-5-3-4-6-22(21)25(28)31/h3-14,16H,15H2,1-2H3,(H,27,29)
  • InChiKey: UYVRUUFOUZPSBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isobutyl 4-[[4-(1,3-dioxoisoindolin-2-yl)benzoyl]amino]benzoate
  • 4-[[[4-(1,3-dioxo-2-isoindolinyl)phenyl]-oxomethyl]amino]benzoic acid isobutyl ester
  • 4-[[4-(1,3-diketoisoindolin-2-yl)benzoyl]amino]benzoic acid isobutyl ester
  • 2-methylpropyl 4-[[4-(1,3-dioxoisoindol-2-yl)phenyl]carbonylamino]benzoate
  • Oprea1_061794
  • Oprea1_791101
  • ZINC00951145

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0016 0.0012
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0134
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0041 0.0048 0.4744
Echinococcus multilocularis acetylcholinesterase 0.4221 1 1
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0121 0.1207
Leishmania major carnitine/choline acetyltransferase, putative 0.0029 0.0019 0.0164
Echinococcus granulosus Peptidase C54 0.0071 0.0121 0.0121
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0173 0.017
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.004
Schistosoma mansoni choline o-acyltransferase 0.0192 0.0408 0.0404
Brugia malayi hypothetical protein 0.0113 0.0219 0.0216
Echinococcus granulosus caspase 0.0102 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0018 0.0014
Brugia malayi Niemann-Pick C1 protein precursor 0.0204 0.0437 0.0434
Echinococcus multilocularis geminin 0.0161 0.0335 0.0335
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0029 0.0019 0.0164
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0016 0.0016
Brugia malayi Choline O-acetyltransferase 0.0192 0.0408 0.0404
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0028 0.0018 0.0014
Brugia malayi nuclear hormone receptor 0.0027 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0039
Echinococcus granulosus choline O acetyltransferase 0.0192 0.0408 0.0408
Echinococcus granulosus geminin 0.0161 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0047 0.0064 0.0064
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0694 0.1604 0.9722
Leishmania major metacaspase, putative 0.0027 0.0017 0.0134
Brugia malayi hypothetical protein 0.0115 0.0224 0.0221
Loa Loa (eye worm) hypothetical protein 0.0431 0.0976 0.0976
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0064 0.0294
Onchocerca volvulus 0.0029 0.0019 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.2264 0.5341 0.5341
Echinococcus granulosus acetylcholinesterase 0.4221 1 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0029 0.0019 0.0164
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0017 0.0013
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0713 0.1649 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0016 0.0012
Onchocerca volvulus 0.0221 0.0479 0.2835
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0108 0.0105
Brugia malayi hypothetical protein 0.0049 0.0068 0.0064
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0071 0.0121 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0158 0.0942
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0004 0.0082
Loa Loa (eye worm) hypothetical protein 0.4221 1 1
Trypanosoma brucei transcription factor BTF3, putative 0.0087 0.0158 0.1593
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0016 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0016 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0016 0.0012
Leishmania major carnitine palmitoyltransferase-like protein 0.0029 0.0019 0.0164
Echinococcus granulosus cysteine protease atg4b 0.0071 0.0121 0.0121
Brugia malayi Carboxylesterase family protein 0.0713 0.1649 0.1646
Loa Loa (eye worm) hypothetical protein 0.0192 0.0408 0.0408
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0017 0.0918
Brugia malayi intermediate filament protein 0.0042 0.0052 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0065 0.0105 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0016 0.0012
Brugia malayi CHE-14 protein 0.0088 0.016 0.0156
Echinococcus granulosus sentrin specific protease 7 0.0152 0.0314 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0016 0.0012
Brugia malayi Pre-SET motif family protein 0.0035 0.0034 0.0031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0034 0.0034
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0004 0.0082
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0713 0.1649 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0034 0.2063
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0121 0.0713
Brugia malayi RNA binding protein 0.0066 0.0108 0.0105
Brugia malayi Carboxylesterase family protein 0.4221 1 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0152 0.0314 0.0311
Schistosoma mansoni patched 1 0.0088 0.016 0.0156
Echinococcus granulosus peptidase Clp S14 family 0.0041 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.006 0.0095 0.0092
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Echinococcus granulosus nuclear factor of activated T cells 5 0.0149 0.0306 0.0306
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0017 0.0918
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0028 0.1676
Echinococcus granulosus X box binding protein 1 0.0274 0.0604 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0079
Loa Loa (eye worm) hypothetical protein 0.0107 0.0207 0.0207
Schistosoma mansoni neuroligin 3 (S09 family) 0.0713 0.1649 0.1646
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0011
Brugia malayi Carboxylesterase family protein 0.0713 0.1649 0.1646
Onchocerca volvulus 0.0713 0.1649 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0016 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0224 0.0221
Onchocerca volvulus 0.0713 0.1649 1
Trypanosoma cruzi transcription factor btf3, putative 0.0087 0.0158 0.1593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0016 0.0016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0016 0.0016
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0134
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0016 0.0012
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0071 0.0121 0.0117
Loa Loa (eye worm) hypothetical protein 0.007 0.0118 0.0118
Loa Loa (eye worm) choline O-acetyltransferase 0.0192 0.0408 0.0408
Brugia malayi Probable ClpP-like protease 0.0062 0.0099 0.0096
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0713 0.1649 0.1649
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0049 0.0068 0.0064
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.016 0.0332 0.0332
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0011 0.0011
Brugia malayi jmjC domain containing protein 0.016 0.0332 0.0329
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0016 0.0016
Schistosoma mansoni amine oxidase 0.0049 0.0068 0.0064
Leishmania major hypothetical protein, conserved 0.0025 0.0011 0.0072
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0224 0.0224
Onchocerca volvulus 0.0168 0.0351 0.2052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0016 0.0012
Brugia malayi solute carrier family 40, member 1 0.0221 0.0479 0.0475
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0713 0.1649 0.1646
Mycobacterium tuberculosis Carboxylesterase LipT 0.0713 0.1649 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0068 0.0184
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0028 0.0025
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0028 0.1676
Echinococcus granulosus intermediate filament protein 0.0042 0.0052 0.0052
Echinococcus multilocularis caspase 0.0102 0.0195 0.0195
Echinococcus granulosus caspase 3 0.0075 0.013 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0049 0.0068 0.0184
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Entamoeba histolytica peptidase, C54 family 0.0028 0.0017 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0016 0.0016
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0019 0.0016
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0011 0.0011
Leishmania major UDP-galactopyranose mutase 0.0049 0.0068 0.0661
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0108 0.0105
Echinococcus multilocularis chromobox protein 1 0.0084 0.0152 0.0152
Echinococcus granulosus neuropeptide receptor A26 0.0288 0.0638 0.0638
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.016 0.016
Echinococcus multilocularis acetylcholinesterase 0.4221 1 1
Echinococcus multilocularis caspase 3 0.0075 0.013 0.013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0088 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0318 0.0708 0.0704
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Echinococcus granulosus para nitrobenzyl esterase 0.0713 0.1649 0.1649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0016 0.0016
Echinococcus multilocularis musashi 0.0042 0.0052 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0016 0.0016
Schistosoma mansoni chromobox protein 0.0084 0.0152 0.0148
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.4221 1 1
Brugia malayi jmjC domain containing protein 0.0093 0.0173 0.017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0713 0.1649 0.1649
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0034 0.0031
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0713 0.1649 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Onchocerca volvulus 0.0029 0.0019 0.0024
Schistosoma mansoni importin beta-1 0.003 0.0022 0.0019
Trypanosoma cruzi UDP-galactopyranose mutase 0.0049 0.0068 0.0661
Brugia malayi TAR-binding protein 0.0066 0.0108 0.0105
Echinococcus multilocularis lamin dm0 0.0042 0.0052 0.0052
Schistosoma mansoni BC026374 protein (S09 family) 0.0713 0.1649 0.1646
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0018
Plasmodium falciparum basic transcription factor 3b, putative 0.0087 0.0158 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0065 0.0105 0.0101
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0134
Echinococcus granulosus lysine specific histone demethylase 1A 0.0049 0.0068 0.0068
Onchocerca volvulus 0.0029 0.0019 0.0024
Brugia malayi hypothetical protein 0.0168 0.0351 0.0347
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0029 0.0019 0.0164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0016 0.0012
Echinococcus multilocularis importin subunit beta 1 0.003 0.0022 0.0022
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0028 0.0028
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0431 0.0976 0.0973
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.0099 0.0374
Onchocerca volvulus 0.0713 0.1649 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0049 0.0068 0.4196
Onchocerca volvulus Huntingtin homolog 0.0113 0.0219 0.1247
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0068 0.6838
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Plasmodium falciparum metacaspase-like protein 0.0027 0.0017 0.0918
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0068 0.0667
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0062 0.0099 1
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0029 0.0019 0.0164
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0065 0.0105 0.0105
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0011 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0018 0.0018
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0029 0.0019 0.0164
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0049 0.0068 0.4196
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0022 0.0192
Echinococcus multilocularis cysteine protease atg4b 0.0071 0.0121 0.0121
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0029 0.0019 0.0164
Loa Loa (eye worm) hypothetical protein 0.0062 0.0099 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0108 0.0105
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0713 0.1649 0.1646
Onchocerca volvulus 0.0049 0.0067 0.0317
Trypanosoma brucei Metacaspase-4 0.0027 0.0017 0.0134
Onchocerca volvulus 0.0042 0.0052 0.0224
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0108 0.0108
Brugia malayi cytoplasmic intermediate filament protein 0.0023 0.0005 0.0002
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0149 0.0306 0.0306
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0028 0.0017 0.0976
Loa Loa (eye worm) carboxylesterase 0.0713 0.1649 0.1649
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0054 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0016 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0039
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0062 0.0099 0.6192
Mycobacterium ulcerans monoamine oxidase 0.0049 0.0068 0.018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0065 0.0105 0.0101
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0034 0.0034
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0049 0.0068 0.4196
Echinococcus granulosus peregrin 0.0032 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Brugia malayi Intermediate filament tail domain containing protein 0.0042 0.0052 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0016 0.0016
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0017 0.0134
Brugia malayi Cytochrome P450 family protein 0.0039 0.0043 0.004
Onchocerca volvulus Huntingtin homolog 0.0113 0.0219 0.1247
Entamoeba histolytica hypothetical protein 0.0087 0.0158 0.3573
Echinococcus multilocularis X box binding protein 1 0.0274 0.0604 0.0604
Echinococcus multilocularis para nitrobenzyl esterase 0.0713 0.1649 0.1649
Schistosoma mansoni memapsin-2 (A01 family) 0.0504 0.1152 0.1149
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0022 0.1279
Onchocerca volvulus 0.0042 0.0052 0.0224
Trichomonas vaginalis set domain proteins, putative 0.0277 0.0611 0.369
Brugia malayi Heterochromatin protein 1 0.0084 0.0152 0.0148
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0011
Schistosoma mansoni choline o-acyltransferase 0.0029 0.0019 0.0016
Onchocerca volvulus 0.0277 0.0611 0.3643
Schistosoma mansoni gliotactin 0.0713 0.1649 0.1646
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0062 0.0099 0.0099
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0019 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0042 0.0052 0.0052
Echinococcus multilocularis snurportin 1 0.0318 0.0708 0.0708
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0029 0.0019 0.0019
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0713 0.1649 0.1649
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0068 0.1496
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.0531 0.0531
Brugia malayi beta-NAC-like protein 0.0087 0.0158 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0019 0.0164
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0011 0.0011
Loa Loa (eye worm) acetylcholinesterase 1 0.4221 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0204 0.0437 1
Brugia malayi Peptidase family C54 containing protein 0.0071 0.0121 0.0117
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0034 0.0034
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0017 0.0918
Plasmodium falciparum protoporphyrinogen oxidase 0.0049 0.0068 0.4196
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0042 0.0052 0.0052
Onchocerca volvulus 0.0049 0.0068 0.032
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0011 0.0072
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.0099 0.6192
Loa Loa (eye worm) hypothetical protein 0.006 0.0095 0.0095
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0011 0.0532
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0023 0.0005 0.0005
Brugia malayi amine oxidase, flavin-containing family protein 0.0049 0.0068 0.0064
Schistosoma mansoni acetylcholinesterase 0.0713 0.1649 0.1646
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0016 0.0012
Mycobacterium ulcerans dehydrogenase 0.0049 0.0068 0.018
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.0082
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0102 0.0195 0.0195
Echinococcus granulosus Niemann Pick C1 protein 0.0204 0.0437 0.0437
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0028 0.1676
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Echinococcus granulosus transcription factor btf3 0.0087 0.0158 0.0158
Echinococcus multilocularis choline O acetyltransferase 0.0192 0.0408 0.0408
Echinococcus granulosus chromobox protein 1 0.0084 0.0152 0.0152
Brugia malayi Choline O-acetyltransferase 0.0192 0.0408 0.0404
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0095 0.0091
Brugia malayi hypothetical protein 0.0713 0.1649 0.1646
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.0708 0.0708
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0072 0.0417
Brugia malayi Pre-SET motif family protein 0.0243 0.0531 0.0527
Loa Loa (eye worm) hypothetical protein 0.0204 0.0437 0.0437
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0068 0.4196
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0011 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0108 0.0105
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0041 0.0048 0.0087
Echinococcus multilocularis peptidase Clp (S14 family) 0.0041 0.0048 0.0048
Entamoeba histolytica peptidase, C54 family 0.0028 0.0017 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.011 0.011
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.0173 0.0173
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0072 0.0347
Trichomonas vaginalis spcc417.12 protein, putative 0.0713 0.1649 1
Echinococcus multilocularis neuropeptide receptor A26 0.0288 0.0638 0.0638
Loa Loa (eye worm) carboxylesterase 0.0713 0.1649 0.1649
Echinococcus granulosus neuropeptide s receptor 0.0288 0.0638 0.0638
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0068 0.0213
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0004 0.0004
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.016 0.016
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0068 0.0065
Trypanosoma cruzi metacaspase, putative 0.0027 0.0017 0.0134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0016 0.0016
Plasmodium falciparum phd finger protein, putative 0.0032 0.0028 0.1676
Chlamydia trachomatis protoporphyrinogen oxidase 0.0049 0.0068 0.4817
Plasmodium vivax JmjC domain containing protein 0.0025 0.0011 0.0532
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0043 0.0043
Echinococcus multilocularis peregrin 0.0032 0.0028 0.0028
Loa Loa (eye worm) RNA binding protein 0.0066 0.0108 0.0108
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0694 0.1604 0.9722
Schistosoma mansoni coup transcription factor 0.0027 0.0016 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0016 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0068 0.0184
Entamoeba histolytica transcription factor BTF3, putative 0.0087 0.0158 0.3573
Mycobacterium ulcerans carboxylesterase, LipT 0.0713 0.1649 1
Echinococcus granulosus caspase 8 0.0027 0.0017 0.0017
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0011 0.0007
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0121 0.1207
Entamoeba histolytica peptidase, C54 family 0.0071 0.0121 0.2706
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0121 0.0713
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0108 0.0105
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0121 0.0713
Echinococcus multilocularis GPCR, family 2 0.0028 0.0018 0.0018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0713 0.1649 0.1646
Trypanosoma cruzi transcription factor btf3, putative 0.0087 0.0158 0.1593
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0079
Echinococcus granulosus carboxylesterase 5A 0.4221 1 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0029 0.0019 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0028 0.0017 0.0144
Schistosoma mansoni lamin 0.0042 0.0052 0.0049
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Trypanosoma brucei metacaspase MCA3 0.0027 0.0017 0.0134
Echinococcus multilocularis carboxylesterase 5A 0.4221 1 1
Echinococcus granulosus expressed conserved protein 0.0139 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0071 0.0121 0.0121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0224 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0034 0.0031
Plasmodium vivax basic transcription factor 3b, putative 0.0087 0.0158 1
Toxoplasma gondii histone lysine-specific demethylase 0.0049 0.0068 0.4196
Plasmodium falciparum importin beta, putative 0.003 0.0022 0.1279
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0019 0.0164
Echinococcus multilocularis Niemann Pick C1 protein 0.0204 0.0437 0.0437
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0017 0.0013
Onchocerca volvulus Alhambra homolog 0.0032 0.0028 0.0079
Brugia malayi chromobox protein homolog 3 0.0047 0.0064 0.006
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0072 0.0417
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0068 0.1496
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0011 0.0072
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0016 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0019 0.0164
Trypanosoma cruzi UDP-galactopyranose mutase 0.0049 0.0068 0.0661
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0049 0.0068 0.6776
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0108 0.0105
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0028 0.0017 0.0144
Echinococcus multilocularis sentrin specific protease 7 0.0152 0.0314 0.0314
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0028 0.0017 0.0144
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.0099 1
Echinococcus multilocularis 0.0049 0.0068 0.0068
Onchocerca volvulus 0.0037 0.0039 0.0146
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Giardia lamblia PHD finger protein 15 0.0032 0.0028 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0088 0.0161 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0034 0.0031
Toxoplasma gondii NAC domain-containing protein 0.0087 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0022
Onchocerca volvulus 0.0049 0.0068 0.0323
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0068 0.4196
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.0028
Echinococcus granulosus lamin dm0 0.0042 0.0052 0.0052
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.016 0.0332 0.0332
Brugia malayi Cell death protein 3 precursor 0.0027 0.0017 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0019 0.0164
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0065 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0031 0.0166
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0016 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0068 0.0667
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0068 0.0184
Loa Loa (eye worm) jmjC domain-containing protein 0.0093 0.0173 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0067 0.0064
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0646 0.1488 0.9002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0088 0.0161 0.0158
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0054 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0152 0.09
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0121 0.1207
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.0646 0.0646
Brugia malayi jmjC domain containing protein 0.0025 0.0011 0.0007
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.0099 0.0374
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0029 0.0019 0.0164
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0019 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0068 0.0667
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0011 0.0011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0047 0.0266
Schistosoma mansoni hypothetical protein 0.0084 0.0152 0.0149
Schistosoma mansoni hypothetical protein 0.0115 0.0224 0.0221
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0079
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0028 0.0017 0.0144
Echinococcus multilocularis protein dispatched 1 0.01 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0084 0.0152 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0016 0.0012
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0168 0.0351 0.0351
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0017 0.0134
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.0099 0.6192
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0016 0.0012
Schistosoma mansoni peptidase Clp (S14 family) 0.0062 0.0099 0.0096
Brugia malayi MH2 domain containing protein 0.0133 0.0267 0.0263
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0713 0.1649 0.1649
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0207 0.0445 0.0441
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0018 0.0018
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0011 0.0007
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0031 0.0031
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0064 0.0365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0158 0.0942
Echinococcus granulosus importin subunit beta 1 0.003 0.0022 0.0022
Echinococcus multilocularis chromobox protein 1 0.0084 0.0152 0.0152
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0017 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0039
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0009 0.0032
Entamoeba histolytica hypothetical protein 0.0115 0.0224 0.5084
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0017 0.0918
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0018 0.0014
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0018 0.0018
Trypanosoma brucei metacaspase MCA2 0.0027 0.0017 0.0134
Onchocerca volvulus 0.0713 0.1649 1
Loa Loa (eye worm) hypothetical protein 0.0713 0.1649 0.1649
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0016 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0011 0.0011
Brugia malayi nuclear receptor NHR-88 0.0027 0.0016 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0022 0.0192
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0011 0.0007
Schistosoma mansoni amine oxidase 0.0049 0.0068 0.0064
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0267 0.0267
Plasmodium falciparum cysteine protease ATG4, putative 0.0028 0.0017 0.0976
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0062 0.0099 0.0099
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0059 0.0059
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0039 0.2341
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.006 0.0095 0.0091
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0028 0.0028
Echinococcus multilocularis protoporphyrinogen oxidase 0.0049 0.0068 0.0068
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0029 0.0019 0.0164
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0068 0.0184
Entamoeba histolytica hypothetical protein 0.0115 0.0224 0.5084
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0079
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0029 0.0019 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0031 0.0166
Loa Loa (eye worm) hypothetical protein 0.0713 0.1649 0.1649
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0019 0.0164
Loa Loa (eye worm) hypothetical protein 0.0088 0.016 0.016
Brugia malayi RNA, U transporter 1 0.0085 0.0153 0.0149
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0039 0.2341
Echinococcus multilocularis caspase 8 0.0027 0.0017 0.0017
Plasmodium vivax SET domain protein, putative 0.0035 0.0034 0.2063
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0068 0.0065
Trypanosoma brucei C-8 sterol isomerase, putative 0.0431 0.0976 1
Echinococcus granulosus lysine specific demethylase 5A 0.0093 0.0173 0.0173
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0049 0.0068 0.4196
Schistosoma mansoni hypothetical protein 0.0032 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0713 0.1649 0.1649
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0011 0.0532
Entamoeba histolytica hypothetical protein 0.0115 0.0224 0.5084
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0063 0.006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0068 0.0209
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0173 0.017
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0152 0.0152
Schistosoma mansoni autophagin-1 (C54 family) 0.0071 0.0121 0.0117
Mycobacterium tuberculosis Possible oxidoreductase 0.0049 0.0068 0.0209
Schistosoma mansoni hypothetical protein 0.0161 0.0335 0.0332
Schistosoma mansoni transcription factor btf3 0.0087 0.0158 0.0155
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0121 0.0713
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0017 0.0134
Loa Loa (eye worm) hypothetical protein 0.0088 0.0161 0.0161
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0713 0.1649 0.1649
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0011 0.0072
Loa Loa (eye worm) hypothetical protein 0.0221 0.0479 0.0479
Schistosoma mansoni caspase-3 (C14 family) 0.0102 0.0195 0.0192
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0068 0.0184
Trypanosoma brucei metacaspase 0.0027 0.0017 0.0134
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0152 0.09
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0029 0.0019 0.0019
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0059 0.0059
Entamoeba histolytica peptidase, C54 family 0.0028 0.0017 0.0322
Entamoeba histolytica hypothetical protein 0.0024 0.0009 0.0122
Echinococcus granulosus tar DNA binding protein 0.0066 0.0108 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0019 0.0164
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.4221 1 1
Brugia malayi ecdysteroid receptor 0.0027 0.0016 0.0012
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0029 0.0019 0.0019
Echinococcus multilocularis expressed conserved protein 0.0139 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Echinococcus multilocularis BC026374 protein (S09 family) 0.0713 0.1649 0.1649
Schistosoma mansoni intermediate filament proteins 0.0042 0.0052 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0068 0.0065
Entamoeba histolytica hypothetical protein 0.0115 0.0224 0.5084
Schistosoma mansoni chromobox protein 0.0084 0.0152 0.0148
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0068 0.0184
Schistosoma mansoni caspase-7 (C14 family) 0.0102 0.0195 0.0192
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0041 0.0048 0.0087
Echinococcus multilocularis caspase 2 0.0027 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0084 0.0152 0.0149
Echinococcus granulosus Protein patched homolog 1 0.0088 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.022 0.0475 0.0475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0018 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Schistosoma mansoni jumonji domain containing protein 0.0138 0.028 0.0277
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0039
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2582 0.6096 0.6096
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0016 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0065 0.0105 0.0101
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0029 0.0019 0.0164
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0054 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0016 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0065 0.0105 0.0105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0009 0.0032
Leishmania major basic transcription factor 3a, putative 0.0087 0.0158 0.1593
Onchocerca volvulus 0.0029 0.0019 0.0024
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0049 0.0068 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0068 0.0184
Schistosoma mansoni hypothetical protein 0.0274 0.0604 0.0601
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0016 0.0012
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0011 0.0011
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0029 0.0019 0.0019
Mycobacterium ulcerans oxidoreductase 0.0049 0.0068 0.018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0016 0.0012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0039 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0064 0.0365
Loa Loa (eye worm) hypothetical protein 0.0113 0.0219 0.0219
Echinococcus multilocularis transcription factor btf3 0.0087 0.0158 0.0158
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0049 0.0068 0.0064
Schistosoma mansoni hypothetical protein 0.0028 0.0018 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0016 0.0016
Echinococcus granulosus snurportin 1 0.0318 0.0708 0.0708
Echinococcus granulosus BC026374 protein S09 family 0.0713 0.1649 0.1649
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0016 0.0016
Echinococcus granulosus expressed conserved protein 0.0192 0.0408 0.0408
Brugia malayi Carboxylesterase family protein 0.0713 0.1649 0.1646
Echinococcus multilocularis lamin 0.0042 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0713 0.1649 0.1649
Schistosoma mansoni microtubule-associated protein tau 0.2264 0.5341 0.534
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0016 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0068 0.1496
Loa Loa (eye worm) ICD-1 protein 0.0087 0.0158 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0068 0.0213
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.0099 1
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0039
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0049 0.0068 0.4196
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0016 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0065 0.0105 0.0101
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0431 0.0976 1
Schistosoma mansoni hypothetical protein 0.0161 0.0335 0.0332
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0011 0.0532
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0065 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0029 0.0019 0.0164
Brugia malayi Carboxylesterase family protein 0.0713 0.1649 0.1646
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.016 0.095
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0062 0.0099 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0062 0.0099 0.6192
Brugia malayi Importin beta-1 subunit 0.003 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0068 0.0068
Entamoeba histolytica peptidase, C54 family 0.0028 0.0017 0.0322
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0121 0.0713
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0102 0.0195 0.0195
Loa Loa (eye worm) carboxylesterase 0.4221 1 1
Echinococcus multilocularis Peptidase C54 0.0071 0.0121 0.0121
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0267 0.0267
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0011 0.0011
Echinococcus granulosus phd:f box containing protein 0.0025 0.0011 0.0011
Echinococcus granulosus neuroligin 0.0713 0.1649 0.1649
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0028 0.0028
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0016 0.0016
Leishmania major C-8 sterol isomerase-like protein 0.0431 0.0976 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.0009 0.0055
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0049 0.0068 0.0068
Brugia malayi jmjC domain containing protein 0.0025 0.0011 0.0007
Brugia malayi Bromodomain containing protein 0.0032 0.0028 0.0025
Echinococcus granulosus caspase 2 0.0027 0.0017 0.0017
Echinococcus multilocularis protein patched 0.0088 0.016 0.016
Brugia malayi jmjC domain containing protein 0.0025 0.0011 0.0007
Schistosoma mansoni hypothetical protein 0.0028 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0113 0.0219 0.0219
Brugia malayi steroid hormone receptor 0.0027 0.0016 0.0012
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0029 0.0019 0.0164
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0011 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0042 0.0052 0.0052
Echinococcus granulosus microtubule associated protein 2 0.2264 0.5341 0.5341
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0016 0.0012
Echinococcus granulosus lysine specific histone demethylase 1A 0.0049 0.0068 0.0068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0068 0.6838
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0152 0.0314 0.7163
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0029 0.0019 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0034 0.0034
Plasmodium falciparum metacaspase 1 0.0027 0.0017 0.0918
Echinococcus multilocularis neuroligin 0.0713 0.1649 0.1649
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0017 0.0079
Schistosoma mansoni lamin 0.0042 0.0052 0.0049
Plasmodium vivax importin-beta 2, putative 0.003 0.0022 0.1279
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0158 0.0942
Echinococcus granulosus lamin 0.0042 0.0052 0.0052
Echinococcus granulosus chromobox protein 1 0.0084 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0028 0.0018 0.0014
Echinococcus granulosus GPCR family 2 0.0028 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0084 0.0152 0.0149
Echinococcus granulosus acetylcholinesterase 0.4221 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0047 0.0266
Echinococcus multilocularis neuropeptide s receptor 0.0288 0.0638 0.0638
Onchocerca volvulus 0.0713 0.1649 1
Brugia malayi jmjC domain containing protein 0.0025 0.0011 0.0007
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0062 0.0099 0.5
Plasmodium vivax metacaspase 1, putative 0.0027 0.0017 0.0918
Brugia malayi SWIRM domain containing protein 0.0049 0.0068 0.0064
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0011 0.0011
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0016 0.0012
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0029 0.0019 0.0019
Echinococcus multilocularis expressed conserved protein 0.0192 0.0408 0.0408
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0009 0.0055
Brugia malayi PHD-finger family protein 0.0032 0.0028 0.0025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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