Detailed information for compound 661203

Basic information

Technical information
  • TDR Targets ID: 661203
  • Name: N-[4-[(1-ethyl-3-nitro-2-oxoquinolin-4-yl)ami no]phenyl]acetamide
  • MW: 366.371 | Formula: C19H18N4O4
  • H donors: 2 H acceptors: 4 LogP: 2.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c2ccccc2c(c(c1=O)[N+](=O)[O-])Nc1ccc(cc1)NC(=O)C
  • InChi: 1S/C19H18N4O4/c1-3-22-16-7-5-4-6-15(16)17(18(19(22)25)23(26)27)21-14-10-8-13(9-11-14)20-12(2)24/h4-11,21H,3H2,1-2H3,(H,20,24)
  • InChiKey: SGBRQZPYLBENHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[(1-ethyl-3-nitro-2-oxo-4-quinolyl)amino]phenyl]acetamide
  • N-[4-[(1-ethyl-2-keto-3-nitro-4-quinolyl)amino]phenyl]acetamide
  • N-[4-[(1-ethyl-3-nitro-2-oxo-quinolin-4-yl)amino]phenyl]ethanamide
  • BAS 05497207
  • N-[4-(1-Ethyl-3-nitro-2-oxo-1,2-dihydro-quinolin-4-ylamino)-phenyl]-acetamide
  • Oprea1_004137
  • ZINC04188299

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.006 0.0132
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0212 0.0489
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.13 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0091 0.0087
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0091 0.0204
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.006 0.0132
Onchocerca volvulus 0.0047 0.0389 0.6791
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.1418
Brugia malayi follicle stimulating hormone receptor 0.0224 0.2669 0.6214
Schistosoma mansoni hypothetical protein 0.0071 0.0703 0.1642
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.006 0.0132
Brugia malayi Carboxylesterase family protein 0.0059 0.0544 0.1153
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0242 0.056
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0012 0.0094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0212 0.0489
Echinococcus multilocularis snurportin 1 0.034 0.4165 0.4163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0104 0.1125 0.2636
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0059 0.0544 0.127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.006 0.0132
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Loa Loa (eye worm) hypothetical protein 0.0071 0.0703 0.1642
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0389 0.0783
Schistosoma mansoni ran 0.0023 0.0091 0.0204
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0088 0.1418
Echinococcus granulosus carboxylesterase 5A 0.0347 0.4258 1
Schistosoma mansoni hypothetical protein 0.0033 0.0212 0.0489
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0066
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1125 0.2538
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.2796 0.6563
Loa Loa (eye worm) hypothetical protein 0.0347 0.4258 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0358 0.0832
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0701
Schistosoma mansoni thyroid hormone receptor 0.0021 0.006 0.0132
Loa Loa (eye worm) carboxylesterase 0.0059 0.0544 0.127
Brugia malayi Bromodomain containing protein 0.0037 0.0271 0.0503
Leishmania major trypanothione reductase 0.0046 0.0385 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0091 0.0204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.006 0.0056
Onchocerca volvulus 0.0059 0.0544 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0091 0.211
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.0746
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.006 0.0132
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0541 0.1262
Echinococcus multilocularis BC026374 protein (S09 family) 0.0059 0.0544 0.0541
Loa Loa (eye worm) hypothetical protein 0.0059 0.0544 0.127
Trypanosoma brucei trypanothione reductase 0.0046 0.0385 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0385 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0096 0.1029 0.2409
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1148 0.8833
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.006 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0358 0.0354
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0199 0.3681
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1148 0.8833
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.006 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.006 0.0132
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0088 0.1418
Loa Loa (eye worm) hypothetical protein 0.004 0.0302 0.0701
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0122 0.0677
Echinococcus granulosus BC026374 protein S09 family 0.0059 0.0544 0.127
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1029 0.2308
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0544 0.4188
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.4165 0.9781
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.006 0.0132
Schistosoma mansoni gliotactin 0.0059 0.0544 0.127
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0091 0.0073
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0347 0.4258 1
Schistosoma mansoni bromodomain containing protein 0.0062 0.0586 0.1368
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0073 0.0069
Schistosoma mansoni patched 1 0.0041 0.0321 0.0746
Brugia malayi Carboxylesterase family protein 0.0347 0.4258 1
Entamoeba histolytica Ran family GTPase 0.0023 0.0091 0.0034
Schistosoma mansoni survival motor neuron protein 0.0047 0.0389 0.0905
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0385 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.273 0.6406
Schistosoma mansoni acetylcholinesterase 0.0059 0.0544 0.127
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1148 0.8833
Brugia malayi hypothetical protein 0.0228 0.273 0.6358
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.006 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0088 0.0674
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.006 0.0132
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0242 0.0238
Echinococcus multilocularis zinc finger protein 0.0019 0.0036 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0066
Brugia malayi hypothetical protein 0.0035 0.0242 0.0434
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0242 0.056
Loa Loa (eye worm) hypothetical protein 0.0347 0.4258 1
Brugia malayi Carboxylesterase family protein 0.0059 0.0544 0.1153
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.002
Brugia malayi PHD-finger family protein 0.0024 0.0103 0.0102
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0701
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0199 0.3681
Echinococcus granulosus FTZ F1 alpha 0.0021 0.006 0.0132
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.006 0.0132
Echinococcus granulosus neuroligin 0.0059 0.0544 0.127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.006 0.0056
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1048 0.2454
Trichomonas vaginalis spcc417.12 protein, putative 0.0059 0.0544 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0544 0.127
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1029 0.2409
Echinococcus granulosus acetylcholinesterase 0.0347 0.4258 1
Schistosoma mansoni zinc finger protein 0.0019 0.0036 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Echinococcus granulosus para nitrobenzyl esterase 0.0059 0.0544 0.127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0358 0.0832
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0459
Loa Loa (eye worm) hypothetical protein 0.0069 0.068 0.1588
Brugia malayi Bromodomain containing protein 0.0073 0.0734 0.1604
Loa Loa (eye worm) hypothetical protein 0.0051 0.0441 0.1027
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0073 0.0162
Echinococcus multilocularis protein patched 0.0041 0.0321 0.0317
Schistosoma mansoni hypothetical protein 0.0047 0.0389 0.0905
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0358 0.0832
Mycobacterium tuberculosis Carboxylesterase LipT 0.0059 0.0544 0.4188
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0385 0.0895
Brugia malayi Carboxylesterase family protein 0.0059 0.0544 0.1153
Loa Loa (eye worm) glutathione reductase 0.0046 0.0385 0.0895
Loa Loa (eye worm) hypothetical protein 0.0059 0.0544 0.127
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.006 0.0132
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0212 0.0489
Echinococcus multilocularis acetylcholinesterase 0.0347 0.4258 0.4256
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1561 0.1558
Mycobacterium ulcerans hypothetical protein 0.0023 0.0088 0.1418
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0544 0.127
Schistosoma mansoni hypothetical protein 0.0033 0.0212 0.0489
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.273 0.6406
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.006 0.0132
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0242 0.0559
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0197
Echinococcus granulosus expressed conserved protein 0.009 0.0954 0.2232
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0321 0.0746
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.1418
Loa Loa (eye worm) hypothetical protein 0.0059 0.0544 0.127
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.006 0.0132
Loa Loa (eye worm) acetylcholinesterase 1 0.0347 0.4258 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0122 0.0677
Echinococcus granulosus snurportin 1 0.034 0.4165 0.9781
Brugia malayi Importin beta-1 subunit 0.0032 0.0199 0.0331
Echinococcus granulosus importin subunit beta 1 0.0032 0.0199 0.0459
Loa Loa (eye worm) hypothetical protein 0.0033 0.0212 0.0489
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0122 0.0677
Echinococcus multilocularis carboxylesterase 5A 0.0347 0.4258 0.4256
Schistosoma mansoni hypothetical protein 0.0033 0.0212 0.0489
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0358 0.0832
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0212 0.0362
Loa Loa (eye worm) hypothetical protein 0.0059 0.0544 0.127
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0199 0.0195
Onchocerca volvulus 0.0059 0.0544 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0059 0.0544 0.127
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.006 0.0056
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0073 0.0162
Plasmodium falciparum glutathione reductase 0.0046 0.0385 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1148 0.8749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0358 0.0832
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1148 0.8833
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0385 0.2961
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0358 0.0709
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.13 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0059 0.0544 0.0541
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0106
Loa Loa (eye worm) carboxylesterase 0.0059 0.0544 0.127
Echinococcus multilocularis para nitrobenzyl esterase 0.0059 0.0544 0.0541
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0012 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0358 0.0832
Echinococcus granulosus GPCR family 2 0.0033 0.0212 0.0489
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.006 0.0132
Plasmodium vivax glutathione reductase, putative 0.0046 0.0385 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0544 0.127
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0059 0.0544 1
Brugia malayi CHE-14 protein 0.0041 0.0321 0.0622
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1561 0.366
Schistosoma mansoni coup transcription factor 0.0021 0.006 0.0132
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0122 0.1044
Plasmodium falciparum importin beta, putative 0.0032 0.0199 0.5014
Schistosoma mansoni thyroid hormone receptor 0.0021 0.006 0.0132
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Schistosoma mansoni importin beta-1 0.0032 0.0199 0.0459
Mycobacterium tuberculosis Probable reductase 0.0106 0.1148 0.8833
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0385 0.0895
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.006 0.0132
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0321 0.0746
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0321 0.0746
Entamoeba histolytica hypothetical protein 0.0026 0.0122 0.036
Brugia malayi glutathione reductase 0.0046 0.0385 0.0774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.006 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.2796 0.6563
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.006 0.0132
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0385 1
Echinococcus multilocularis acetylcholinesterase 0.0347 0.4258 0.4256
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.1418
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.006 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0197
Brugia malayi MH2 domain containing protein 0.0234 0.2796 0.6517
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.13 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0326 0.0758
Plasmodium falciparum thioredoxin reductase 0.0046 0.0385 1
Brugia malayi Thioredoxin reductase 0.0046 0.0385 0.0774
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0091 0.211
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.006 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0321 0.5079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0541 0.0537
Plasmodium vivax importin-beta 2, putative 0.0032 0.0199 0.5014
Schistosoma mansoni hypothetical protein 0.034 0.4165 0.9781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.006 0.0132
Loa Loa (eye worm) hypothetical protein 0.0038 0.0272 0.0631
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.002
Brugia malayi hypothetical protein 0.0059 0.0544 0.1153
Schistosoma mansoni hypothetical protein 0.0033 0.0212 0.0489
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0088 0.0674
Loa Loa (eye worm) carboxylesterase 0.0347 0.4258 1
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.273 0.2727
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0703 0.1531
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0049 0.0106
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0212 0.0362
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0242 0.0238
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1029 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0088 0.1418
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.006 0.0132
Brugia malayi Carboxylesterase family protein 0.0059 0.0544 0.1153
Echinococcus granulosus acetylcholinesterase 0.0347 0.4258 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0544 0.127
Leishmania major importin beta-1 subunit, putative 0.0026 0.0122 0.1139
Onchocerca volvulus 0.0023 0.0088 0.057
Schistosoma mansoni BC026374 protein (S09 family) 0.0059 0.0544 0.127
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.2669 0.6264
Echinococcus granulosus zinc finger protein 0.0019 0.0036 0.0075
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0212 0.0208
Schistosoma mansoni ran 0.0023 0.0091 0.0204
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0385 0.0381
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1029 0.1025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.006 0.0132
Echinococcus multilocularis expressed conserved protein 0.009 0.0954 0.095
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0091 0.5
Brugia malayi RNA, U transporter 1 0.0091 0.0955 0.2131
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.13 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0358 0.0354
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.006 0.0132
Onchocerca volvulus 0.0059 0.0544 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1125 0.2636
Schistosoma mansoni nuclear hormone receptor 0.0021 0.006 0.0132
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0544 0.4188
Mycobacterium ulcerans carboxylesterase, LipT 0.0059 0.0544 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.006 0.0056
Loa Loa (eye worm) hypothetical protein 0.0059 0.0544 0.127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.006 0.0132
Brugia malayi Carboxylesterase family protein 0.0347 0.4258 1
Leishmania major GTP-binding protein, putative 0.0023 0.0091 0.0106
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.006 0.0056
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1148 0.8833
Echinococcus multilocularis neuroligin 0.0059 0.0544 0.0541
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0701
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1125 0.2538
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.006 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0088 0.1418
Echinococcus multilocularis protein dispatched 1 0.0047 0.0396 0.0393
Schistosoma mansoni neuroligin 3 (S09 family) 0.0059 0.0544 0.127
Schistosoma mansoni hypothetical protein 0.0035 0.0242 0.056
Onchocerca volvulus 0.0059 0.0544 1
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0701
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0199 0.3681
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0212 0.0208
Onchocerca volvulus 0.0059 0.0544 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.006 0.0132
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.002
Echinococcus multilocularis GPCR, family 2 0.0033 0.0212 0.0208

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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