Detailed information for compound 661578

Basic information

Technical information
  • TDR Targets ID: 661578
  • Name: N'-(3-chloro-2-methylphenyl)-N-[(2-chlorophen yl)methyl]oxamide
  • MW: 337.201 | Formula: C16H14Cl2N2O2
  • H donors: 2 H acceptors: 2 LogP: 3.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)Nc1cccc(c1C)Cl)NCc1ccccc1Cl
  • InChi: 1S/C16H14Cl2N2O2/c1-10-12(17)7-4-8-14(10)20-16(22)15(21)19-9-11-5-2-3-6-13(11)18/h2-8H,9H2,1H3,(H,19,21)(H,20,22)
  • InChiKey: DRPWKKJHWGPACF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(3-chloro-2-methyl-phenyl)-N-[(2-chlorophenyl)methyl]oxamide
  • N-(2-chlorobenzyl)-N'-(3-chloro-2-methyl-phenyl)oxamide
  • N'-(3-chloro-2-methyl-phenyl)-N-[(2-chlorophenyl)methyl]ethanediamide
  • ZINC02993433

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.1232 0.5
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0375 0.0375
Echinococcus granulosus lamin dm0 0.0029 0.3537 1
Echinococcus multilocularis lamin dm0 0.0029 0.3537 1
Echinococcus multilocularis musashi 0.0029 0.3537 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.1232 0.5
Trichomonas vaginalis ap endonuclease, putative 0.002 0.1232 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.1232 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.3397 0.3397
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.1232 0.5
Trichomonas vaginalis ap endonuclease, putative 0.002 0.1232 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.1232 0.5
Onchocerca volvulus 0.0029 0.3537 0.5
Onchocerca volvulus 0.0029 0.3537 0.5
Echinococcus granulosus lamin 0.0029 0.3537 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.3537 0.3537
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.1232 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.5545 0.5545
Echinococcus granulosus intermediate filament protein 0.0029 0.3537 1
Schistosoma mansoni hypothetical protein 0.0036 0.5545 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0375 0.0375
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.1232 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.1232 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.3537 0.3537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0375 0.0375
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.1232 0.5
Echinococcus multilocularis lamin 0.0029 0.3537 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.3537 0.3537
Toxoplasma gondii exonuclease III APE 0.002 0.1232 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.1232 0.271
Schistosoma mansoni lamin 0.0029 0.3537 0.6116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 1 1
Brugia malayi intermediate filament protein 0.0029 0.3537 0.3537
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.1232 0.271
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.1232 0.1232
Schistosoma mansoni ap endonuclease 0.002 0.1232 0.1657
Schistosoma mansoni lamin 0.0029 0.3537 0.6116
Loa Loa (eye worm) hypothetical protein 0.0036 0.5545 0.5545
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.1232 0.5
Schistosoma mansoni ap endonuclease 0.002 0.1232 0.1657
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.3537 0.3537
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.1232 0.1232
Schistosoma mansoni intermediate filament proteins 0.0029 0.3537 0.6116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.1232 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0375 0.0375
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.1232 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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