Detailed information for compound 661719

Basic information

Technical information
  • TDR Targets ID: 661719
  • Name: 5-[(3,4-dichlorophenyl)methyl]-1,3-thiazol-2- amine
  • MW: 259.155 | Formula: C10H8Cl2N2S
  • H donors: 1 H acceptors: 1 LogP: 3.82 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncc(s1)Cc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C10H8Cl2N2S/c11-8-2-1-6(4-9(8)12)3-7-5-14-10(13)15-7/h1-2,4-5H,3H2,(H2,13,14)
  • InChiKey: ZGYKWDAYSHDBDW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(3,4-dichlorophenyl)methyl]thiazol-2-amine
  • 5-[(3,4-dichlorophenyl)methyl]-2-thiazolamine
  • [5-(3,4-dichlorobenzyl)thiazol-2-yl]amine
  • CBMicro_000861
  • BIM-0000838.P001
  • Oprea1_718443
  • ST5077639
  • ZINC00137449
  • 5-(3,4-Dichloro-benzyl)-thiazol-2-ylamine
  • BAS 07776799

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.1773 0.1773
Plasmodium vivax DNA repair protein REV1, putative 0.0011 0.0251 0.0763
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.1773 0.3464
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.4803 0.4803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0446 0.0819
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0251 0.0251
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.3292 1
Trichomonas vaginalis DNA polymerase eta, putative 0.006 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.5117 0.5117
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.6092 1
Brugia malayi Flap endonuclease-1 0.0026 0.3292 0.6043
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.5117 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.4803 0.8816
Mycobacterium ulcerans DNA polymerase IV 0.006 1 1
Echinococcus granulosus dna polymerase eta 0.0034 0.4803 0.4803
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0251 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0216 0.0216
Mycobacterium ulcerans DNA polymerase IV 0.006 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.4044 0.4044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0446 0.0235
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 1 1
Schistosoma mansoni flap endonuclease-1 0.0024 0.2803 0.5478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0251 0.0763
Loa Loa (eye worm) hypothetical protein 0.0037 0.5448 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0216 0.0422
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.1773 0.2909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0251 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.3292 0.5404
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.3292 0.5206
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.3292 0.6043
Echinococcus multilocularis dna polymerase eta 0.0034 0.4803 0.4803
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.4803 0.8816
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.4803 0.4803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.4803 0.9386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.1773 0.2909
Trypanosoma cruzi DNA polymerase eta, putative 0.0011 0.0251 0.0251
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.1773 0.5384
Leishmania major DNA damage repair protein, putative 0.0011 0.0251 0.0412
Leishmania major DNA polymerase kappa, putative 0.004 0.6092 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.6092 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.1773 0.3253
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.1773 0.1773
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.3292 0.3144
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.4803 0.4803
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.1773 0.1773
Entamoeba histolytica hypothetical protein 0.0025 0.3106 0.5896
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0251 0.0763
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Echinococcus multilocularis flap endonuclease 1 0.0026 0.3292 0.3292
Echinococcus multilocularis dna polymerase kappa 0.006 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0251 0.0251
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0251 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.1773 0.3176
Giardia lamblia DINP protein human, muc B family 0.004 0.6092 1
Trypanosoma brucei DNA polymerase IV, putative 0.006 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.2419 0.444
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.1773 0.3176
Echinococcus granulosus serine protein kinase ATM 0.0025 0.3106 0.3106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.2419 0.2419
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.1773 0.2909
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.4803 0.9386
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.1541 0.468
Trypanosoma brucei unspecified product 0.0023 0.2755 0.2755
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.3292 0.3292
Trypanosoma brucei chrX additional, unordered contigs 0.0011 0.0251 0.0251
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.1773 0.2909
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.1773 0.3253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Loa Loa (eye worm) hypothetical protein 0.0034 0.4803 0.8816
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.5117 1
Leishmania major DNA polymerase eta, putative 0.0011 0.0251 0.0412
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.8711 0.8711
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.1773 0.1773
Plasmodium falciparum flap endonuclease 1 0.0026 0.3292 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.1773 0.3253
Schistosoma mansoni DNA polymerase eta 0.0034 0.4803 0.9386
Leishmania major DNA polymerase kappa, putative 0.0011 0.0251 0.0412
Entamoeba histolytica hypothetical protein 0.0035 0.5117 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.1773 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0446 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.1773 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Brugia malayi hypothetical protein 0.0035 0.5117 0.9393
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.1773 0.1773
Brugia malayi polk-prov protein 0.0037 0.5448 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.3106 0.2954
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.5117 0.5117
Loa Loa (eye worm) hypothetical protein 0.001 0.0216 0.0397
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0251 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.1773 0.1773
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.1773 0.1773
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.4803 0.9359
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.3106 0.3106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.5448 0.5448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.1773 0.1773
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.1773 0.3464
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.001 0.0216 0.0216
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0251 0.0251
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.3106 0.5701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.6092 0.6092
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0446 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0446 0.0235
Leishmania major DNA polymerase eta, putative 0.0034 0.4803 0.7884
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.3106 0.6069
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.1773 0.1773
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0.0251 0.0763
Entamoeba histolytica hypothetical protein 0.0035 0.5117 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.1773 0.1773
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.4044 0.4044
Giardia lamblia GTOR 0.0018 0.1773 0.2604
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.3292 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.1773 0.1773
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0216 0.0397
Trypanosoma brucei unspecified product 0.0054 0.8711 0.8711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.1773 0.1773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Entamoeba histolytica hypothetical protein 0.0035 0.5117 1
Toxoplasma gondii FATC domain-containing protein 0.0025 0.3106 0.9434
Trypanosoma brucei DNA polymerase IV, putative 0.006 1 1
Entamoeba histolytica Flap nuclease, putative 0.0026 0.3292 0.6276
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.3106 0.3106
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.4044 0.4044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.1779 0.2921
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.1773 0.3253
Echinococcus granulosus flap endonuclease 1 0.0026 0.3292 0.3292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.3106 0.3106
Trypanosoma brucei unspecified product 0.0023 0.2755 0.2755
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.4803 0.4803
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.1779 0.1779
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0251 0.0251
Entamoeba histolytica hypothetical protein 0.0035 0.5117 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.1773 0.1591
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0216 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.5448 0.5448
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.3292 0.3292
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.1773 0.2909
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.4803 0.8816
Schistosoma mansoni DNA polymerase IV / kappa 0.0011 0.0251 0.0491

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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