Detailed information for compound 661835

Basic information

Technical information
  • TDR Targets ID: 661835
  • Name: 2-methyl-5-quinoxalin-2-ylaniline
  • MW: 235.284 | Formula: C15H13N3
  • H donors: 1 H acceptors: 2 LogP: 2.55 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1N)c1cnc2c(n1)cccc2
  • InChi: 1S/C15H13N3/c1-10-6-7-11(8-12(10)16)15-9-17-13-4-2-3-5-14(13)18-15/h2-9H,16H2,1H3
  • InChiKey: KIPPPIPUONNFEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-5-quinoxalin-2-yl-aniline
  • 2-methyl-5-(2-quinoxalinyl)aniline
  • (2-methyl-5-quinoxalin-2-yl-phenyl)amine
  • AK-918/40788894
  • EU-0046461
  • Enamine_003028
  • 2-Methyl-5-quinoxalin-2-yl-phenylamine
  • BAS 05043670
  • Oprea1_281956
  • ZINC00198813
  • SBB011730
  • 2-methyl-5-quinoxalin-2-ylphenylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0075 0.0546
Echinococcus multilocularis son of sevenless 1 0.0006 0.0048 0.0033
Echinococcus multilocularis expressed protein 0.0008 0.0146 0.0206
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.1088 0.1871
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0796 0.224
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0146 0.5
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0158 0.0147
Brugia malayi RasGEF domain containing protein 0.0006 0.0048 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0056 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0496 0.6071
Brugia malayi N-terminal motif family protein 0.0006 0.0048 0.0022
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0075 0.0081
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0158 0.0228
Schistosoma mansoni ferritin 0.0008 0.0146 0.0256
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0075 0.0546
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.013 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0595 0.7363
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0796 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0075 0.0591
Loa Loa (eye worm) hypothetical protein 0.0023 0.0796 0.0878
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0075 0.0053
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0158 0.0129
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0035 0.0061
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0084 0.3452 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0595 0.0648
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0084 0.3452 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0796 0.2239
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0538 0.6617
Schistosoma mansoni ferritin light chain 0.0008 0.0146 0.0256
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0158 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0538 0.0583
Schistosoma mansoni cpg binding protein 0.003 0.1082 0.1904
Schistosoma mansoni dishevelled 0.0009 0.0158 0.0278
Trypanosoma cruzi hypothetical protein 0.0006 0.0048 0.0054
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0538 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0029 0.0051
Onchocerca volvulus 0.0007 0.0075 0.0046
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0048 0.0033
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0048 0.0085
Loa Loa (eye worm) hypothetical protein 0.0017 0.0538 0.0583
Onchocerca volvulus 0.0006 0.0048 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0796 1
Schistosoma mansoni cpg binding protein 0.0028 0.1012 0.178
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.1088 0.1871
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0796 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0075 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Entamoeba histolytica hypothetical protein, conserved 0.0084 0.3452 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0048 0.0022
Loa Loa (eye worm) oxidoreductase 0.0007 0.0075 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.1088 0.1913
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0075 0.0132
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0029 0.0051
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0595 0.1047
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0146 0.5
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0158 0.0228
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0595 0.1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0538 0.4805
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.02 0.0196
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0595 0.1047
Leishmania major DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0022
Echinococcus granulosus dna polymerase kappa 0.0019 0.0595 0.1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0048 0.0022
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0075 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0075 0.0053
Loa Loa (eye worm) histone methyltransferase 0.001 0.0205 0.0202
Trypanosoma brucei unspecified product 0.0013 0.0341 0.0908
Echinococcus granulosus son of sevenless 1 0.0006 0.0048 0.0033
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0029 0.0051
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0075 0.0046
Onchocerca volvulus 0.0028 0.1012 0.0985
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0146 0.1471
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0341 0.0908
Schistosoma mansoni apoferritin-2 0.0008 0.0146 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0538 0.6633
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Schistosoma mansoni dep domain containing protein 0.0009 0.0158 0.0278
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0595 0.7376
Schistosoma mansoni cpg binding protein 0.003 0.1082 0.1904
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0029 0.0051
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0075 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0796 0.0878
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0158 0.0147
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0056 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0075 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.1088 0.1913
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.1088 0.1913
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0075 0.0132
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0075 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0056 0.0026
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0029 0.0051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0205 0.0311
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0158 0.0147
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0075 0.0546
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0158 0.0147
Echinococcus granulosus ferritin 0.0008 0.0146 0.0206
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0075 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0796 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0496 0.6071
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.013 0.0178
Onchocerca volvulus 0.003 0.1088 0.1061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.1088 0.1871
Schistosoma mansoni apoferritin-2 0.0008 0.0146 0.0256
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0158 0.0228
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0158 0.0228
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0056 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Trichomonas vaginalis ferritin, putative 0.0008 0.0146 0.0117
Brugia malayi DIX domain containing protein 0.0009 0.0158 0.0147
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0796 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Loa Loa (eye worm) hypothetical protein 0.0178 0.7547 0.8609
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0075 0.0212
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0075 0.0591
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0796 0.0878
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0595 0.1652
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.8762 1
Onchocerca volvulus 0.0009 0.0158 0.0129
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.0048 0.0019
Trichomonas vaginalis set domain proteins, putative 0.0234 1 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0796 1
Brugia malayi RasGEF domain containing protein 0.0006 0.0048 0.0022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0595 0.1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0146 0.1471
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0029 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0075 0.0053
Echinococcus granulosus cpg binding protein 0.003 0.1082 0.1862
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.1012 0.1125
Onchocerca volvulus 0.0007 0.0075 0.0046
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0048 0.0085
Giardia lamblia DINP protein human, muc B family 0.0019 0.0595 0.1652
Brugia malayi hypothetical protein 0.0009 0.0158 0.0147
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0075 0.0053
Schistosoma mansoni DNA polymerase eta 0.0019 0.0595 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0029 0.0051
Schistosoma mansoni ferritin 0.0008 0.0146 0.0256
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0595 0.0648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.5684 1
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0048 0.0033
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0048 0.0033
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0158 0.0147
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0496 0.6071
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0538 0.5
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0158 0.0228
Toxoplasma gondii hypothetical protein 0.0009 0.0158 0.06
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0048 0.0033
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0075 0.0132
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0075 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Entamoeba histolytica DNA repair and recombination protein, putative 0.0084 0.3452 1
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0048 0.0033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0538 0.0583
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0146 0.1512
Echinococcus multilocularis cpg binding protein 0.003 0.1082 0.1862
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0796 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Loa Loa (eye worm) hypothetical protein 0.0017 0.0538 0.0583
Trichomonas vaginalis helicase, putative 0.0006 0.0056 0.0026
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0048 0.0085
Brugia malayi N-terminal motif family protein 0.0178 0.7547 0.8609
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0075 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.5684 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0796 0.0878
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0796 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Trypanosoma brucei unspecified product 0.0013 0.0341 0.0908
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0029 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.5684 0.6476
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0075 0.0591
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0075 0.0591
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0146 0.1512
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0796 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0056 0.0026
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0158 0.0228
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0146 0.0978
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0796 0.224
Echinococcus granulosus expressed protein 0.0008 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0009 0.0158 0.0147
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Plasmodium vivax SET domain protein, putative 0.003 0.1088 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0075 0.0132
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0075 0.0546
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0075 0.0591
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0048 0.0019
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0075 0.0132
Brugia malayi RasGEF domain containing protein 0.0006 0.0048 0.0022
Schistosoma mansoni hypothetical protein 0.0084 0.3452 0.6073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0595 0.7363
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0075 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0341 0.0908
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0075 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0496 0.6071
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0084 0.3452 0.6053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0075 0.0053
Onchocerca volvulus 0.0007 0.0075 0.0046
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Onchocerca volvulus 0.0023 0.0796 0.0769
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0084 0.3452 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0075 0.0132
Echinococcus granulosus Protein son of sevenless 0.0006 0.0048 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0048 0.0033
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0029 0.0051
Giardia lamblia Rrm3p helicase 0.0084 0.3452 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0595 0.1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0796 0.2239
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0084 0.3452 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0595 0.1652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.5684 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0075 0.0053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0158 0.0147
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0075 0.0891
Schistosoma mansoni ferritin light chain 0.0008 0.0146 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0029 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Brugia malayi hypothetical protein 0.0009 0.0158 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0595 0.1652
Trypanosoma brucei unspecified product 0.0019 0.0595 0.1652
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0075 0.0591
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0048 0.0022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0595 0.0648
Onchocerca volvulus 0.0007 0.0075 0.0046
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.013 0.0178
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0029 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0075 0.0591
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0056 0.0026
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0048 0.0033
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0029 0.0051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.1088 0.4954
Entamoeba histolytica hypothetical protein 0.0006 0.0048 0.0055
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0075 0.0046
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0075 0.0546
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.003 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.1088 0.1212
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0048 0.0019
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0075 0.0053
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0158 0.0228
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.7547 0.754
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0595 0.7376
Schistosoma mansoni dishevelled 0.0009 0.0158 0.0278
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.2165 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0056 0.0026
Echinococcus multilocularis dna polymerase eta 0.0019 0.0595 0.1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.5684 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0796 0.224
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.3452 0.3433
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0075 0.0546
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0595 0.0567
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0595 0.1652
Brugia malayi Pre-SET motif family protein 0.0206 0.8762 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0796 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0796 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0056 0.0026
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0048 0.0085
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0158 0.0278
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0158 0.0228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.5684 1
Schistosoma mansoni ferritin 0.0008 0.0146 0.0256
Loa Loa (eye worm) hypothetical protein 0.0017 0.0538 0.0583
Trypanosoma cruzi hypothetical protein 0.0006 0.0048 0.0054
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0595 0.0567
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0075 0.0134
Leishmania major DNA polymerase eta, putative 0.0019 0.0595 0.1652
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0158 0.0278
Loa Loa (eye worm) hypothetical protein 0.0023 0.0796 0.0878
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0075 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.5684 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0205 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0056 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0796 0.0878
Brugia malayi CXXC zinc finger family protein 0.0028 0.1012 0.1125
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0595 0.1652
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.013 0.0228
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0796 0.2239
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0158 0.0228
Brugia malayi Pre-SET motif family protein 0.003 0.1088 0.1212
Brugia malayi polk-prov protein 0.0006 0.003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0075 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.5684 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0341 0.0908
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.013 0.0178
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0075 0.0212
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0075 0.0546
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0075 0.0546
Schistosoma mansoni ferritin 0.0008 0.0146 0.0256
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.0048 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.2445 0.4302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.1088 0.1913
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0075 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0595 0.0648
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0084 0.3452 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0075 0.0428
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0029 0.0051
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0019
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0595 0.1652
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.1013 0.174
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0796 1
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0048 0.0054
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0048 0.0055
Echinococcus multilocularis ferritin 0.0008 0.0146 0.0206
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0595 0.1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0048 0.0085
Loa Loa (eye worm) hypothetical protein 0.0009 0.0158 0.0147
Brugia malayi N-terminal motif family protein 0.0006 0.0048 0.0022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0595 0.1653
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0084 0.3452 0.6053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.5684 0.6476
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0084 0.3452 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0075 0.0132
Loa Loa (eye worm) hypothetical protein 0.0006 0.0048 0.0022
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0084 0.3452 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0158 0.0228
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0075 0.0591
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0595 0.1652

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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